| Patent Number |
Title Of Patent |
Date Issued |
| 5962497 |
Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenos |
October 5, 1999 |
| The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of tre |
| 5962475 |
Substituted benzo(B)thiophene compounds having activity as selective estrogen receptor modulator |
October 5, 1999 |
| The present invention provides compounds with nitrogen, sulfur or carbon linked basic side chains of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen, halo, hydroxy, alkoxy, alkylcarbonyloxy, alkoxycarbonyl, alkoxycarbonyloxy, arylcarbonyloxy, aryloxycarbonyl |
| 5962474 |
5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and 3-(piperidin-4-yl)-1h-indoles: 5-HT.sub.1F |
October 5, 1999 |
| This invention provides novel 5-HT.sub.1F agonists of Formula I ##STR1## where A--B, R,R.sup.1 and X are as defined in the specification, which are useful for the treatment of migraine and associated disorders. |
| 5962473 |
Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with seroto |
October 5, 1999 |
| This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT.sub.1F agonist. |
| 5962446 |
Therapetutic treatment for human T cell lymphotrophic virus type 1 infection |
October 5, 1999 |
| A method for treating human T cell lymphotrophic virus type 1 infection using an isozyme selective PKC inhibitor, particularly using the isozyme selective PKC inhibitor, (S)-3,4-[N,N'-1,1'-((2"-ethoxy)-3'"(O)-4'"-(N,N-dimethylamino)-butane)-bis -(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione |
| 5959121 |
Process for preparing 3-substituted indazoles |
September 28, 1999 |
| The invention provides a method of preparing compounds of formula I and VIII: ##STR1## which are useful intermediates to compounds that are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4. |
| 5959103 |
Naphthofluorene compounds, intermediates, compositions, and methods |
September 28, 1999 |
| The invention provides naphthofluorene compounds, intermediates, formulations, processes, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia, and estrogen-dependent cancer. |
| 5958969 |
Benzo[b]thiophene compounds, intermediates, formulations, and methods |
September 28, 1999 |
| This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods. |
| 5958960 |
Excitatory amino acid receptor modulators |
September 28, 1999 |
| Compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function. |
| 5958921 |
Method for treating depression with olanzapine |
September 28, 1999 |
| This invention relates to the use of the antipsychotic drug olanzapine for the treatment of depression, including depressive signs and symptoms and Major Depression. |
| 5958917 |
Benzofluorene compounds, intermediates, compositions, and methods |
September 28, 1999 |
| The present invention provides compounds of formula I ##STR1## wherein R.sub.1 is --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCO(C.sub.1 -C.sub.6 alkyl), --OCOO(C.sub.1 -C.sub.6 alkyl), --OCOAr, --OCOOAr, or --OSO.sub.2 (C.sub.2 -C.sub.6 alkyl);R.sub.2 is --OH, --O(C.sub.1 -C.sub.4 al |
| 5958916 |
Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
September 28, 1999 |
| The instant invention provides dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods for use in the treatment of bone loss or bone resorption. |
| 5958730 |
Streptococcus pneumoniae gene sequence FtsY |
September 28, 1999 |
| The invention provides isolated nucleic acid compounds encoding FtsY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein. |
| 5958429 |
Potentiation of serotonin response |
September 28, 1999 |
| The availability of serotonin, norepinephrine and dopamine in the brain is increased by administering a serotonin reuptake inhibitor with a serotonin 1A antagonist and L-tryptophan or 5-hydroxy-L-tryptophan. |
| 5955608 |
Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical ag |
September 21, 1999 |
| Novel processes for producing benzothiophenes employing ethylene carbonate or propylene carbonate are provided. |
| 5952513 |
Benzo[b] thiophene compounds |
September 14, 1999 |
| The instant invention provides novel benzo[b]thiophene compounds, intermediates, compositions, pharmaceutical formulations, and methods of use. |
| 5952466 |
Reductive alkylation of glycopeptide antibiotics |
September 14, 1999 |
| This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycopeptide antibiotic. Reductive alkylation of this |
| 5952364 |
Methods for inhibiting smooth muscle cell proliferation |
September 14, 1999 |
| The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of tre |
| 5952360 |
Method for treating neuropathic pain |
September 14, 1999 |
| The present invention provides a method for treating neuropathic pain comprising administering an analgesic dosage of a compound of formula I to an animal in need of such treatment certain phenyl oxazoles or phenyl thiazoles. |
| 5952350 |
Naphthyl compounds and compositions, as estrogen receptor binding agents |
September 14, 1999 |
| The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions containing a compound of formula I, and methods of using a compound of formula I for inhibiting bone loss or bone resorption, particularl |
| 5952310 |
Glycopeptide hexapeptides |
September 14, 1999 |
| The present invention is directed to glycopeptides and more particularly to derivatives of the glycopeptide A82846B. In these derivatives, the leucyl has been removed to create "hexapeptides" of A82846B and its N.sup.DISACC variations. These hexapeptides are useful as antibacterials and |
| 5952297 |
Monomeric insulin analog formulations |
September 14, 1999 |
| The present invention discloses various parenteral pharmaceutical formulations having a protracted effect, which comprise: a sterile aqueous suspension of about 20 U/mL to about 500 U/mL insulin analog, about 5 mg/mL to about 10 mg/mL sodium chloride, about 0.2 to about 2.0 mg/mL phy |
| 5948907 |
Synthesis of bisindolylmaleimides |
September 7, 1999 |
| The present invention provides for the reaction of optionally substituted indole-3-acetamides with optionally substituted methyl indole-3-glyoxyl reagent to prepare potent PKC inhibitors. |
| 5948796 |
Benzo[B]thiophene compounds, intermediates, formulations, and methods |
September 7, 1999 |
| This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods. |
| 5948795 |
Benzothiopene compounds, and uses and formulations thereof |
September 7, 1999 |
| Novel benzothiophenes, ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently --OH, --OCO(C.sub.1 -C.sub.6 alkyl), --O(CO)O(C.sub.1 -C.sub.6 alkyl), --OCO--Ar, where Ar is phenyl or substituted phenyl, or --O(CO)O--phenyl; and R.sub.4 is N-pyrrolidinyl, N-piperidinyl, o |
| 5948645 |
Biosynthetic gene muri from Streptococcus pneumoniae |
September 7, 1999 |
| The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibi |
| 5945547 |
Imtermediate in process to make 2', 2'-difluoronucleosides |
August 31, 1999 |
| The compound 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate is described and claimed. |
| 5945416 |
Method for treating pain |
August 31, 1999 |
| The present invention provides a method for treating pain using a composition comprising olanzapine and Drug Useful in the Treatment of Pain. |
| 5945324 |
Multiple drug resistance gene ATRC of aspergillus nidulans |
August 31, 1999 |
| The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrC are also provided. The invention further pr |
| 5945320 |
Platenolide synthase gene |
August 31, 1999 |
| A DNA molecule isolated from Streptomyces ambofaciens encodes the multi-functional proteins which direct the synthesis of the polyketide platenolide. |
| 5942536 |
N-[2-substituted-3-(2-aminoethyl)-1H-indol-5-YL]-Amides: new 5-HT.sub.1F agonists |
August 24, 1999 |
| The invention provides novel 5-HT.sub.1f agonists of formula (I) where X, R.sup.1, R.sup.2, and R.sup.3 are defined in the specification, which are useful for the treatment of migraine and associate disorders. ##STR1## |
| 5942530 |
Method for treating pain |
August 24, 1999 |
| The present invention provides a method for treating pain using a composition comprising certain phenyl oxazoles or phenyl thiazoles in combination with a Drug Useful in the Treatment of Pain. |
| 5942387 |
Combinatorial process for preparing substituted thiophene libraries |
August 24, 1999 |
| This invention relates to a novel solid phase process for the preparation of thiophene combinatorial libraries. These libraries have use for drug discovery and are used to form wellplate components of novel assay kits. |
| 5939443 |
Selective .beta.3 adrenergic agonists |
August 17, 1999 |
| The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention prov |
| 5939387 |
Method of treating insulin resistance |
August 17, 1999 |
| The present invention is in the field of human medicine, particularly in the treatment of Non-insulin Dependent Diabetes Mellitus (NIDDM) and other insulin resistant states such as those associated with obesity and aging. The invention provides a method of treating insulin resistant mamm |
| 5939382 |
Reducing agent for reductive alkylation of glycopeptide antibiotics |
August 17, 1999 |
| This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics, the improvement residing in employing pyridine.borane as reducing agent. |
| 5938642 |
Multiple dose medication dispensing device |
August 17, 1999 |
| A multi-use pen-shaped medication dispensing device made of a plastic material that is recyclable after the contents of the medication cartridge have been exhausted. The device is made of a minimal number of parts, which include a housing, a dial assembly, a generally cylindrical button |
| 5936084 |
Halo-substituted bisindolemaleimide protein kinase C inhibitors |
August 10, 1999 |
| The present invention is directed to novel halo-substituted bis-indolemaleimide compounds of the formula: ##STR1## The invention further provides a method of preparing the disclosed compounds and the preparation of pharmaceutical formulation for use in inhibiting Protein Kinase C |
| 5936074 |
Teicoplanin deacylation process and product |
August 10, 1999 |
| The present invention is directed to deacyl teicoplanin, and to a process for preparing deacyl teicoplanin by reacting teicoplanin with ECB deacylase. Deacyl teicoplanin can be alkylated to produce compounds useful for their antibacterial activity. |
| 5935992 |
Substituted 1,2,3,4-tetrahydro-2-dibenzofuranamines and 2-aminocyclohepta[6,]benzofurans |
August 10, 1999 |
| The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocyclohepta[b]benzo-furans useful as 5-HT.sub.1F agonists. |
| 5935928 |
Modified platelet factor-4 |
August 10, 1999 |
| The present invention is based of the discovery of two modified forms of human platelet factor-4, herein named MPF-4 and CPF-4, which were isolated from serum free culture medium of lipopolysaccharide-stimulated peripheral blood leukocytes. Amino acid sequence determination revealed that |
| 5935366 |
Process for environmentally safe cleaning using water-soluble polymer based packages |
August 10, 1999 |
| A process for preparing two connected powder transfer conduits for cleaning without releasing powder from the conduits. The conduits are connected to each other by flexible tube of a water-dissolvable material to enable powder communication between the two conduits. A sealing operation i |
| 5932739 |
Substituted 1,2,3,4-tetrahydro-2-dibenzofuranamines and 2-aminocyclohepta[6,]benzofurans |
August 3, 1999 |
| The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocyclohepta[b]benzo-furans useful as 5-HT.sub.1F agonists. |
| 5932543 |
Cyclic peptide antifungal agents and process for preparation thereof |
August 3, 1999 |
| Provided are compounds of the formula (1): ##STR1## wherein R' is hydrogen, methyl or NH.sub.2 C(O)CH.sub.2 --;R" and R'" are independently methyl or hydrogen;R and R.sup.Y are independently hydroxy or hydrogen;R.sub.1 is hydroxy, hydrogen, or hydroxysulfonyloxy;R.sub.7 is hydroxy, hydrogen, |
| 5932464 |
Glucosltransferase gene GTFE from amycolatopsis orientalis |
August 3, 1999 |
| The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode the enzyme, transformed heterologous host cells for expressing the enzyme, and methods for producing glycopep |
| 5929247 |
Heterocyclic compounds and their preparation and use |
July 27, 1999 |
| The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunct |
| 5929092 |
Lipophilic benzothiophenes for treating estrogen deficiency |
July 27, 1999 |
| The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R.sub.1 is N-pyrrolidinyl or N-piperidinyl;R.sub.2 and R.sub.3 are independently hydrogen, --CO--(C.sub.10 -C.sub.22 alkyl), --CO--(C.sub.10 -C.sub.22 branched alkyl), --CO--(C.sub.10 -C.sub.22 alkenyl) |
| 5929090 |
2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods |
July 27, 1999 |
| The present invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; having activity as a selective estrogen receptor modulator, pharmaceutical compositions containing a compound of formula I, and methods of using a compound of |
| 5929070 |
Method for treating migraine pain with olanzapine |
July 27, 1999 |
| The present invention provides a method for treating migraine pain comprising administering an analgesic dosage of olanzapine. |
| 5928898 |
Multiple drug resistance gene atrD of Aspergillus nidulans |
July 27, 1999 |
| The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrD are also provided. The invention further pr |
