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Eli Lilly and Company Patents
Assignee:
Eli Lilly and Company
Address:
Indianapolis, IN
No. of patents:
3814
Patents:












Patent Number Title Of Patent Date Issued
RE42274 Cyclic peptide CXCR4 antagonists April 5, 2011
Provided are lactam-cyclized peptide CXCR4 antagonists useful in the treatment of cancers, rheumatoid arthritis, pulmonary fibrosis, and HIV infection.
RE41133 Glucagon-like peptide-1 crystals February 16, 2010
The invention provides individual tetragonal flat rod shaped or plate-like crystals of glucagon-like peptide-1 related molecules, processes for their preparation, compositions and methods of use. The crystal preparations exhibit extended time action in vivo and are useful for treatin
RE40876 Method for treating non-insulin dependent diabetes using thiazolidinediones with glucagonlike pe August 18, 2009
Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus, optionally with other therapies, by improving glycemic control while minimizing side effects
RE40033 Process for preparing 2-methyl-thieno-benzodiazepine January 22, 2008
2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system. The compound has the following structure: ##STR00001##
RE39071 Anhydro-and isomer-a-21978c cyclic peptides April 18, 2006
Two new groups of A-21978C cyclic peptides, anhydro- and isomer-A21978C peptide derivatives, have antibacterial activity and are useful as intermediates. The two groups are prepared via transpeptidation of the parent cyclic peptides. Pharmaceutical formulations containing the new pep
RE39050 Methods of use for inhibiting bone loss and lowering serum cholesterol March 28, 2006
A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula ##STR00001## or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompassed by the in
RE39049 Methods for inhibiting bone loss March 28, 2006
The current invention provides methods and pharmaceutical formulations that are useful for inhibiting the loss of bone. These methods and formulations can be used without the associated adverse effects of estrogen therapy, and thus serve as an effective and acceptable treatment for o
RE39030 Fluoxetine enteric pellets and methods for their preparation and use March 21, 2006
A superior enteric formulation of the antidepressant drug, fluoxetine, is in the form of enteric pellets of which the enteric layer comprises hydroxypropylmethylcellulose acetate succinate.
RE38968 Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo- [b]thien-3-yl-4-[2-(p February 7, 2006
The current invention provides a method useful for inhibiting the loss of bone using 6-hydroxy-2-(4-hydroxyphenyl)-benzo(B)-thien-3-yl-4[2-piperidi- n-1-ethoxyphenol]methanone hydrochloride.
RE37971 Selective acylation of epsilon-amino groups January 28, 2003
The present invention relates to the acylation of proteins. More particularly, the invention relates to a one-step process for selectively acylating the free .epsilon.-amino group of insulin, insulin analog, or proinsulin in the presence of a free .alpha.-amino group.
RE37806 Method of using eukaryotic expression vectors comprising the BK virus enhancer July 23, 2002
The present invention is a method of using the BK enhances in tandem with a eukaryotic promoter to promote transcription of DNA that encodes a useful substance. The method of the present invention requires the presence of the E1A gene produce for maximum expression of the useful substanc
RE37720 Method of using eukaryotic expression vectors comprising the BK virus enhancer May 28, 2002
The present invention is a method of using the BK enhancer in tandem with a eukaryotic promoter to promote transcription of DNA that encodes a useful substance. The method of the present invention requires the presence of the E1A gene product for maximum expression of the useful substanc
RE34875 Method of selecting recombinant DNA-containing streptomyces March 14, 1995
A novel method of selecting Streptomyces recombinant DNA-containing host cells and vectors useful in the method are described. The vectors confer tylosin resistance to sensitive Streptomyces host cells and thus provide a convenient method of selecting Streptomyces transformants. The nove
RE33300 Oxiranes August 14, 1990
There are described compounds of formula ##STR1## in which n is 0, 1 or 2, R.sup.1 is a hydrocarbyl group optionally substituted with an optionally substituted phenyl group and containing from 5 to 30 carbon atoms, R.sup.2 is optionally substituted phenyl or C.sub.1-10 alkyl opti
RE32455 A-21978 antibiotics and process for their production July 7, 1987
Antibiotic A-21978C complexes, in particular the A-21978C complex, comprising microbiologically active, related factors, C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseo
RE32333 A-21978 Antibiotics and process for their production January 20, 1987
Antibiotic A-21978 complexes, in particular the A-21978C complex, comprising microbiologically active, related factors C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosp
RE32311 Derivatives of A-21978C cyclic peptides December 16, 1986
A-21978C cyclic peptide derivatives of the formula ##STR1## wherein R is hydrogen, a specified aminoacyl or N-alkanoylaminoacyl group, 8-methyldecanoyl, 10-methyldodecanoyl, 10-methylundecanoyl, the specific C.sub.10 -alkanoyl group of A-21978C.sub.0 or the specific C.sub.12 -alk
RE32310 Derivatives of A-21978C cyclic peptides December 16, 1986
A-21978C cyclic peptide derivatives of the formula ##STR1## wherein R is a substituted benzoyl group of the formula ##STR2## R.sup.2 is C.sub.8 -C.sub.15 alkyl; X is hydrogen, chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkoxy, or C.sub.1 -C.
RE31396 A-21978 Antibiotics and process for their production September 27, 1983
Antibiotic A-21978 complexes, in particular the A-21978C complex, comprising microbiologically active, related factors C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosp
RE31227 4-Trifluoromethyl-2,6-dinitroanilines May 3, 1983
This invention relates to a group of novel substituent anilines, useful in eliminating germinating and seedling weed grasses and selected broadleaf weeds.
RE31226 4-Trifluoromethyl-2,6-dinitroanilines May 3, 1983
This invention relates to a group of novel substituent anilines, useful in eliminating germinating and seedling weed grasses and selected broadleaf weeds.
RE30563 Preparation of benzoylureas March 31, 1981
Benzoylureas are prepared from a benzamide, an alkyllithium, a phenyl chloroformate, and an amine. Two reaction sequences are described. The benzoylureas obtained by the process are useful as insecticides.
RE30561 Vinca alkaloid intermediates March 31, 1981
3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
RE30560 Oxazolidinedione derivatives of Vinca alkaloids March 31, 1981
3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
RE30415 Substituted pyrroloquinoxalinones and diones October 7, 1980
Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
RE30314 Substituted pyrroloquinoxalinones and diones June 24, 1980
Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
RE30219 Method of preparing 8,8-disubstituted-6-methylergolines and related compounds February 19, 1980
8,8-Disubstituted-6-methylergolines and 9-ergolenes, are prepared by alkylation of lysergic, or isolysergic acid or their 9,10-dihydro analogues.
RE30218 8,8-Disubstituted-6-methylergolines and related compounds February 19, 1980
8,8-Disubstituted-6-methylergolines and 9-ergolenes, prepared by alkylation of lysergic, isolysergic or their 9,10-dihydro analogues, optionally followed by chemical modification of an 8-substituent.
RE29508 Ring-substituted N-(2,2-difluoroalkanoyl)-o-phenylenediamine compounds January 3, 1978
Ring-substituted N-(2,2-difluoroalkanoyl)-o-phenylenediamine compounds useful as herbicides and as insecticides; and combinations of these compounds with known herbicides.
RE29465 Psoriasis treatment with mycophenolic acid November 1, 1977
Psoriasis is treated orally .[.and topically.]. with mycophenolic acid or its .beta.-D-glucuronide.
RE29367 Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents August 23, 1977
There is disclosed a class of fluoroalkoxyphenylsubstituted nitrogen-containing heterocycles which are useful as herbicides, plant fungicides, and plant growth regulators. Internodal elongation of plants is inhibited by treatment with compounds of this invention.
RE28865 Selective dehalogenation June 15, 1976
An improved process for removal of halogen from the pyrimidine ring only of a compound of the formula ##SPC1##WhereinAt least one of X is chlorine or bromine, the remainder hydrogen; .[.or lower alkyl.].Q is chlorine or fluorine; andN is an integer from 1 to 5.The dehalogenation process
H2085 Penicillin binding protein from Streptococcus pneumoniae October 7, 2003
The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzy
H2071 Streptococcus pneumoniae gene HI0454 July 1, 2003
The invention provides isolated nucleic acid compounds encoding the 454 gene of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
H2070 Streptococcus pneumoniae gene sequence for DNA ligase July 1, 2003
The invention provides isolated nucleic acid compounds encoding a DNA ligase of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
H2023 Streptococcus pneumoniae sequence GrpE May 7, 2002
The invention provides isolated nucleic acid compounds encoding GrpE of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
H2022 Inositolphosphoryl ceramide (IPC) synthase genes from fungi May 7, 2002
The invention provides isolated nucleic acid compounds encoding IPC synthase or subunit thereof from fungal cells. Also provided are vectors and transformed heterologous host cells for expressing IPC synthase and a method for identifying compounds that inhibit a fungal IPC synthase.
H2021 Penicillin binding protein from Streptococcus pneumoniae May 7, 2002
The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzy
D464734 Well plate seal October 22, 2002
D462760 Medication delivery apparatus September 10, 2002
D456896 Medication reconstituting apparatus May 7, 2002
D426299 Medication delivery instrument June 6, 2000
D414271 Reaction vessel for combining chemicals September 21, 1999
D399313 Syringe alignment device October 6, 1998
D390702 Barrel top tray February 17, 1998
D380827 Multi-cartridge medication injector July 8, 1997
D351466 Medication injector October 11, 1994
D351465 Medication injector October 11, 1994
D290229 Fragrance container June 9, 1987
D284548 Fragrance container July 8, 1986

 
 
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