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Elan Pharma International Limited Patents
Assignee:
Elan Pharma International Limited
Address:
Co. Clare, IR
No. of patents:
47
Patents:












Patent Number Title Of Patent Date Issued
RE41884 Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiologica October 26, 2010
Disclosed are methods of intravenous administration of nanoparticulate drug formulations to a mammal to avoid adverse hemodynamic effects: by reducing the rate and concentration of the nanoparticles in the formulations; or by pre-treating the subject with histamine; or by pretreating
D469865 Multi-vial drug reconstitution and injection device February 4, 2003
D454194 Drug reconstitution and injection device March 5, 2002
8148089 Alpha-synuclein kinase April 3, 2012
The invention provides agents and methods for treatment of diseases associated with Lewy body diseases (LBDs) in the brain of a patient. Preferred agents include inhibitors of PLK2 kinase.
8062839 Parkin substrate and assay November 22, 2011
The invention provides in vitro, ex vivo, and in vivo assays for Parkin activity, in which Parkin-mediated ubiquitination of a Sept4 protein is measured. The assays may be used to screen for agents that modulate Parkin protein ligase activity.
8017348 Assay for Parkinson's Disease therapeutics September 13, 2011
The invention provides to assays for agent useful for treatment of Parkinson's Disease. Included are cell-based assays for agents that modulate the effect of Parkin proteins on proteasome function.
8003127 Nanoparticulate corticosteroid and antihistamine formulations methods of making, and methods of August 23, 2011
Compositions comprising a nanoparticulate corticosteroid and an antihistamine are described. The compositions are useful in the prophylaxis and chronic treatment of asthma in adults and pediatric patients and for the relief of allergic conjunctivitis, symptoms of seasonal allergic rh
7998117 Drug delivery device August 16, 2011
A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to under
7910577 Injectable nanoparticulate olanzapine formulations March 22, 2011
Described are injectable formulations of nanoparticulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise nanoparticulate olanzapine.
7825087 Nanoparticulate and controlled release compositions comprising cyclosporine November 2, 2010
The present invention is directed to a composition comprising a nanoparticulate cyclosporine having improved bioavailability. The nanoparticulate cyclosporine particles of the composition have an effective average particle size of less than about 2000 nm in diameter and are useful in
7790365 Assays for modulators of parkin activity using S5a as a parkin substrate September 7, 2010
The invention provides in vitro and cell-based assays for parkin activity, in which parkin-mediated ubiquitination of the S5a subunit of the 26S proteasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase ac
7695739 In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate or April 13, 2010
Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions.
7588766 Treatment of amyloidogenic disease September 15, 2009
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A.beta. in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are usef
7582733 Humanized antibodies that recognize beta amyloid peptide September 1, 2009
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A.beta. in the brain of a patient. Preferred agents include humanized antibodies.
7575880 Method of screening an antibody for activity in clearing an amyloid deposit August 18, 2009
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A.beta. in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are usef
7553639 Alpha-synuclein kinase June 30, 2009
The invention provides agents and methods for treatment of diseases associated with Lewy body diseases (LBDs) in the brain of a patient. Preferred agents include inhibitors of PLK2 and GRK6 kinases.
7530964 Needle device and method thereof May 12, 2009
A needle device has a needle retraction mechanism that retracts the needle upon removing the device from the skin surface (either intentionally or unintentionally). Once the needle is retracted, the device is rendered inoperative. The needle can be further made inoperative by bending it
7465462 Multiparticulate controlled release selective serotonin reuptake inhibitor formulations December 16, 2008
A multiparticulate controlled release selective serotonin reuptate inhibitor (SSRI) formulation for oral administration is provided. The formulation includes particles of an SSRI or a pharmaceutically acceptable salt thereof, which are coated with a rate-controlling polymer that allo
7459283 Nanoparticulate compositions having lysozyme as a surface stabilizer December 2, 2008
The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making a
7384413 Drug delivery device June 10, 2008
A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The d
7101576 Nanoparticulate megestrol formulations September 5, 2006
The present invention is directed to nanoparticulate compositions comprising megestrol. The megestrol particles of the composition have an effective average particle size of less than about 2000 nm.
7021163 Apparatus and method for concurrently monitoring active release and physical appearance of solid April 4, 2006
An apparatus and method for monitoring the dissolution properties of a solid dosage form pharmaceutical or other material. The apparatus includes a hollow dissolution chamber for supporting the dosage form and subjecting it to a dissolution liquid so that the dosage form dissolves in
6991191 Method of using a small scale mill January 31, 2006
A small-scale or micro media-mill and a method of milling materials or products, especially pharmaceutical products, use a dispersion containing attrition milling media and the product to be milled. The milling media can be polymeric, formed of polystyrene or cross-linked polystyrene,
6976647 System and method for milling materials December 20, 2005
A system for milling at least one material, e.g., a drug, is described. The system includes a milling apparatus. In another embodiment of the invention, the system includes at least one milling medium. The milling apparatus includes a chamber having a rotary milling head located in it.
6974588 Transdermal patch for delivering volatile liquid drugs December 13, 2005
A transdermal patch for administering a volatile liquid drug, such as nicotine, transdermally to a patient comprising a four-layer laminated composite of: a top drug impermeable backing layer; a pressure sensitive silicone adhesive layer containing the drug; a pressure sensitive acrylic
6824529 Pre-filled drug-delivery device and method of manufacture and assembly of same November 30, 2004
A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially pa
6811767 Liquid droplet aerosols of nanoparticulate drugs November 2, 2004
There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The na
6745962 Small-scale mill and method thereof June 8, 2004
A small-scale or micro media-mill and a method of milling materials or products, especially pharmaceutical products, use a dispersion containing attrition milling media and the product to be milled. The milling media can be polymeric, formed of polystyrene or cross-linked polystyrene,
6742734 System and method for milling materials June 1, 2004
A system for milling at least one material, e.g., a drug. The system includes a milling apparatus and at least one milling medium. The milling apparatus includes a chamber having a rotary milling head located in it. The milling head is rotated within the chamber by a magnetic drive syste
6723068 Drug delivery systems and methods April 20, 2004
The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The hous
6689108 Device for measuring a volume of drug February 10, 2004
A device for measuring a volume of liquid drug. The device includes a first chamber containing liquid drug, a measurement chamber in liquid communication with the first chamber, and a measurement assembly.
6645181 Drug delivery systems and methods November 11, 2003
The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The hous
6641565 drug delivery systems and methods November 4, 2003
The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The hous
6585707 Drug delivery device having improved adhesion and attachment system for drug delivery device July 1, 2003
A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or
6572740 Electrolytic cell June 3, 2003
Improved electrolytic cells are described. The cells comprise the novel electrolyte K.sub.2 HPO.sub.4, or a less alkaline phosphate buffer solution, electrodes having a modified composition, or a combination of the new electrolyte and a modified composition electrode. The K.sub.2 HPO
6530900 Drug delivery device March 11, 2003
A drug delivery device having a housing having an internal reservoir in communication with a drug delivery outlet via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the outlet when supplied with a gas. A flow regulating chamber, i
6500150 Pre-filled drug-delivery device and method of manufacture and assembly of same December 31, 2002
A drug delivery device having a base member defining a skin-contacting surface, a syringe serving as a reservoir for the drug, and means for expelling drug from the syringe. The syringe is connected to the base member such that the longitudinal axis of the syringe is substantially pa
6478771 Drug delivery systems and methods November 12, 2002
The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The hous
6432381 Methods for targeting drug delivery to the upper and/or lower gastrointestinal tract August 13, 2002
Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.
6364865 Drug delivery systems and methods April 2, 2002
The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The hous
6270806 Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions August 7, 2001
Nanoparticulate compositions comprising an insoluble organic drug and at least one polyethylene glycol-derivatized lipid adsorbed on the surface of the drug are described. The polyethylene glycol-derivatized lipid can be a PEG-phospholipid, PEG-cholesterol, PEG-cholesterol derivative, PE
6221400 Methods of treating mammals using nanocrystalline formulations of human immunodeficiency virus ( April 24, 2001
The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio v
6157858 Device for the delivery of a substance to a subject and improved electrode assembly December 5, 2000
The invention is directed to a device for delivering a pharmaceutically active compound or cosmetic substance to a subject comprises a flexible substrate sheet attached to an electronic controller. The controller is provided with a pair of electrical contacts on the underside thereof and
6153225 Injectable formulations of nanoparticulate naproxen November 28, 2000
Described are an injectable formulation of nanoparticulate naproxen that produces minimal or no pain or burning sensation upon administration, and methods of making and using such a formulation. The injectable formulation comprises nanoparticulate naproxen having a povidone polymer adsor
6149938 Process for the preparation of a granulate suitable to the preparation of rapidly disintegrable November 21, 2000
A process for making a granulate composition suitable to the preparation of an oral solid form that can disintegrate rapidly inside the buccal cavity is provided as well as the granulate compositions and obtained.
6068858 Methods of making nanocrystalline formulations of human immunodeficiency virus (HIV) protease in May 30, 2000
The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio v
6045829 Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cel April 4, 2000
The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increase rate of absorption in vivo, a decreased fed/fasted ratio va

 
 
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