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Elan Corporation, plc Patents
Assignee:
Elan Corporation, plc
Address:
Dublin, IE
No. of patents:
62
Patents:


1 2










Patent Number Title Of Patent Date Issued
D455207 Drug conversion device April 2, 2002
D447229 Drug reconstitution and injection device August 28, 2001
D437930 Drug conversion device February 20, 2001
7135457 Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related metho November 14, 2006
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivativ
6902742 Multiparticulate modified release composition June 7, 2005
The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release composition comprises an immediate release component and a modified release component; the imm
6830560 Automatic syringe December 14, 2004
A syringe comprises a barrel containing an internal cylindrical body containing a liquid and communicating with a delivery needle. The needle is covered before use by a removable sheath, and after the sheath is removed, the needle is concealed by a displaceable sleeve. In use the sle
6793936 Multiparticulate modified release composition September 21, 2004
The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release composition comprises an immediate release component and a modified release component; the imm
6780846 Membrane translocating peptide drug delivery system August 24, 2004
The present invention relates to a novel membrane translocating full-length peptide sequence, fragment, motif, derivative, analog or peptidomimetic thereof (MTLPs), to nucleotide sequences coding therefor, and to compositions comprising a MTLP-active agent complex and a MTLP-active p
6730325 Multiparticulate modified release composition May 4, 2004
The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release composition comprises an immediate release component and a modified release component; the imm
6703362 Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related metho March 9, 2004
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivativ
6699973 Antibodies to peptides that target GIT receptors and related methods March 2, 2004
The invention provides an antibody or antibody fragment specific to a domain of a GIT targeting agent, such as a polyclonal antibody, monoclonal antibody, chimeric antibody, single chain antibody, a Fab fragment or a Fab expression library. In particular, the invention provides an antibo
6521737 Peptides which enhance transport across tissues and methods of identifying and using the same February 18, 2003
A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or preselected phage library is plated unto or brought into contact with a first side, prefera
6423334 Composition and method for enhancing transport across gastrointestinal tract cell layers July 23, 2002
A composition for enteral administration having a non-ionic vegetable oil GIT absorption enhancer capable of increasing the enteral absorbability of drugs, especially oral absorbability of hydrophilic and macromolecular drugs. The non-ionic vegetable oil GIT absorption enhancer, particul
6399100 Controlled release pharmaceutical compositions containing tiagabine June 4, 2002
Controlled release oral pharmaceutical preparations are provided which comprise a therapeutically effective amount of tiagabine or a pharmaceutically acceptable salt thereof dispersed in a rate controlling polymeric matrix comprising at least one rate controlling polymer. The prepara
6361938 Peptides which enhance transport across tissues and methods of identifying and using the same March 26, 2002
A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or a preselected phage library is administered in vivo or in situ to a site in an animal, such
6346613 Composition and method for enhancing paracellular transport across cell layers February 12, 2002
A composition and method for enhancing paracellular transport across cell layers in an animal comprising an antisense oligonucleotide hybridizable with a region of the messenger RNA coding for the protein occludin which, when hybridized to the occludin mRNA, interferes with its translati
6312409 Device for generating a pulsatile fluid drug flow November 6, 2001
A device (10) for generating a pulsatile fluid drug flow comprises a housing (11) containing an expandable-contractible chamber (12) having an inlet (14) and an outlet (15), a valve (16) associated with the outlet (15) which is actuated by the expansion and contraction of the chamber
6275717 Device and method of calibrating and testing a sensor for in vivo measurement of an analyte August 14, 2001
A method of calibrating an analyte sensor in vivo, by providing a first predetermined stimulus to the sensor when the sensor is applied to a subject to produce a first sensor signal, measuring the first sensor signal, and determining a calibration function based on the first measured
6261272 Needle for subcutaneous delivery of fluids July 17, 2001
A needle (10) for the delivery of a liquid to a subject comprises a shaft (11) having an internal surface defining a longitudinally extending internal bore open at one end (15) to receive a liquid supply, the other end (16) being sharpened for penetration of the skin of the subject. A
6245349 Drug delivery compositions suitable for intravenous injection June 12, 2001
The present invention provides drug delivery compositions in both concentrated and diluted forms for use as vehicles in the administration of various active agents. The drug delivery compositions are primarily designed for use with lipophilic, amphipathic, and sparingly water soluble
6241969 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery June 5, 2001
The present invention provides compositions containing corticosteroid compounds as active agents for the treatment of ailments and diseases of the respiratory tract, particularly the lungs, by way of nasal and pulmonary administration. The corticosteroid compounds are present in a di
6228398 Multiparticulate modified release composition May 8, 2001
The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release composition comprises an immediate release component and a modified release component; the imm
6186982 Subcutaneous drug delivery device with improved filling system February 13, 2001
A subcutaneous drug delivery device having a housing having an internal reservoir in communication with a drug delivery needle via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the needle when supplied with a gas. A flow regulati
6153220 Taste-masked formulations November 28, 2000
A taste-masked micromatrix powder in which the ratio of a cationic copolymer synthesized form dimethylaminoethyl methacrylate and neutral methacrylic acid esters compared to a drug having poor organoleptic properties is greater than 2 to 1, preferably 4 to 1, most preferably 6 to 1 (
6117632 Peptides which enhance transport across tissues and methods of identifying and using the same September 12, 2000
A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or preselected phage library is plated unto or brought into contact with a first side, prefera
6110494 Cisapride mini-tablet formulations August 29, 2000
A sustained release cisapride oral dosage formulation suitable for once-daily administration comprises a plurality of mini-tablets containing cisapride or a salt thereof with an organic acid and capable of releasing cisapride at different sites along the gastrointestinal tract. The m
6099504 Pre-filled injection delivery device August 8, 2000
A syringe (10) comprises a barrel (11) containing an internal cylindrical body (12) containing a liquid (14) and communicating with a delivery needle (15). The needle (15) is covered before use by a removable sheath (16), and after the sheath (16) is removed, the needle (15) is concealed
6078842 Electrode and iontophoretic device and method June 20, 2000
An improved electrode and iontophoretic device and method where the electrode exhibits varied resistance. The electrode is made of a conductive material and applied to a flexible substrate. The variation in resistance can be achieved by varying the thickness of the electrode across i
6066339 Oral morphine multiparticulate formulation May 23, 2000
An oral morphine multiparticulate formulation for once-daily administration to a patient, comprising sustained release particles each having a core containing water soluble morphine and an osmotic agent, the core being coated with a rate-controlling polymer coat comprised of ammonio
6000548 Drug delivery kit and method of packaging the same December 14, 1999
An improved drug delivery kit and method of packaging the same. The method includes providing a tray having first and second recesses for receiving a drug delivery device and drug cartridge respectively, and an opening in the tray within the second recess, placing the drug delivery devic
5997501 Intradermal drug delivery device December 7, 1999
An intradermal drug delivery device comprises a housing (301a, 301b) having a drug reservoir (312) therewithin and a gas generation chamber (313) separated from the reservoir (312) by a displaceable membrane (311). A microprocessor-controlled electrolytic cell (316a, 316b, 319) provides
5925030 Orally administrable delivery device July 20, 1999
Oral drug delivery device having a housing with walls of water permeable material and having at least two chambers separated by a displaceable membrane. The first chamber receives drug and has an orifice through which the drug is expelled under pressure. The second chamber contains at le
5641745 Controlled release biodegradable micro- and nanospheres containing cyclosporin June 24, 1997
A controlled release pharmaceutical formulation which comprises cyclosporin entrapped in a biodegradable polymer to form microspheres or nanospheres such that the cyclosporin is substantially in an amorphous state and the biodegradable polymer comprises greater than 12.5% w/w poly(lactid
5641515 Controlled release biodegradable nanoparticles containing insulin June 24, 1997
A controlled release pharmaceutical formulation comprises nanoparticles formed of a biodegradable polycyanoacrylate polymer in which insulin is entrapped, the insulin being complexed to the polycyanoacrylate. These particles are capable of releasing bioactive insulin in vivo at a slower
5637320 Controlled absorption naproxen formulation for once-daily administration June 10, 1997
A once-daily naproxen formulation for oral administration having a first portion of the naproxen as a multi-particulate pellet form, each pellet having a core of naproxen or a pharmaceutically acceptable salt thereof in association with an organic acid, the core being surrounded by a
5616345 Controlled absorption diltiazen formulation for once-daily administration April 1, 1997
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable f
5580580 Formulations and their use in the treatment of neurological diseases December 3, 1996
Pharmaceutical formulations comprise a mono- or di-aminopyridine active agent for administration on a once- or twice-daily basis for use in the treatment of neurological diseases, in particular multiple sclerosis and Alzheimer's disease. The formulations, which are suitable for oral or
5540938 Formulations and their use in the treatment of neurological diseases July 30, 1996
Pharmaceutical formulations comprise a mono- or di-aminopyridine active agent for administration on a once- or twice-daily basis for use in the treatment of neurological diseases, in particular multiple sclerosis and Alzheimer's disease. The formulations, which are suitable for oral or
5533995 Passive transdermal device with controlled drug delivery July 9, 1996
A transdermal device for the controlled administration of a drug to the skin comprises a reservoir (12) for the drug and an electric circuit which includes an electrode system (13, 14) which is operable to actively transport the drug in a controlled manner from the reservoir (12) towards
5505962 Controlled release pharmaceutical formulation April 9, 1996
An improved controlled release tablet formulation for the release of potassium chloride through a differentially permeable membrane from which the release of potassium chloride can be accurately controlled to minimize the likelihood of producing high localized concentrations of potassium
5370879 Formulations and their use in the treatment of neurological diseases December 6, 1994
Pharmaceutical formulations comprise a mono- or di-aminopyridine active agent for administration on a once- or twice-daily basis for use in the treatment of neurological diseases, in particular multiple sclerosis and Alzheimer's disease. The formulations, which are suitable for oral or
5364620 Controlled absorption diltiazem formulation for once daily administration November 15, 1994
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable f
5354556 Controlled release powder and process for its preparation October 11, 1994
A controlled release powder containing discrete micro-particles for use in edible, pharmaceutical and other controlled release compositions is disclosed. The micro-particles have an average size in the range of from 0.1 to 125 .mu.m. Each of the micro-particles is in the form of a mi
5336504 Diltiazem formulations and methods of treatment August 9, 1994
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable f
5219621 Methods of treatment with diltiazem formulations June 15, 1993
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable f
5156842 Liquid suspension for oral administration October 20, 1992
A non-aqueous pharmaceutical liquid suspension having improved bioavailability for oral administration comprises an active ingredient suspended in an edible, non-aqueous carrier vehicle such as an oil, wherein the active ingredient is in the form of controlled release particles conta
5128142 Sustained release drug delivery system July 7, 1992
A controlled release formulation comprising an adsorbate of a mixture of a pharmaceutically useful active ingredient and an inactive substance adsorbed on a cross-linked polymer. The inactive substance is selected to modify the dissolution of the active ingredient from the cross-linked
5069904 Method of using nicotine in the treatment of conditions susceptible to said treatment December 3, 1991
A method of using nicotine in the treatment of various conditions susceptible to alleviation by nicotine therapy such as disease states characterized by reduced central cholinergic function. Nicotine is administered to a subject initially having a blood supply substantially free of n
5002776 Controlled absorption diltiazem formulations March 26, 1991
A controlled absorption diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmac
4973469 Drug delivery system November 27, 1990
A controlled release formulation comprising an adsorbate of a mixture of a pharmaceutically useful active ingredient and an inactive substance adsorbed on a cross-linked polymer. The inactive substance is selected to modify the dissolution of the active ingredient from the cross-linked
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