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E. R. Squibb & Sons, Inc. Patents
Assignee:
E. R. Squibb & Sons, Inc.
Address:
Princeton, NJ
No. of patents:
1537
Patents:


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Patent Number Title Of Patent Date Issued
4444883 Method for the isolation and presumptive diagnosis of Bacillus cereus and tellurite medium there April 24, 1984
A method is provided for the isolation and presumptive diagnosis of Bacillus cereus which method is useful in the assay of antibiotic preparations, food products such as milk, drug products and cosmetics. A medium for use in such method is also provided which medium includes tellurit
4444765 Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension April 24, 1984
Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
4443374 Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]a April 17, 1984
Disclosed herein is a process for preparing a compound having the formula ##STR1## which comprises coupling a compound having the formula ##STR2## or a salt thereof, with a compound having the formula ##STR3## to obtain a compound having the formula ##STR4## reacting
4442089 Method for treating glaucoma with topical or systemic ACE inhibitor compositions April 10, 1984
A method is provided for treating glaucoma by topical or systemic administration of an ACE inhibitor such as captopril.
4435326 Intermediates useful in the preparation of 17,17-bis(substituted thio)androstenes March 6, 1984
Androstenes having the formula ##STR1## wherein R.sub.1 hydrogen and R.sub.2 is alkyl, cycloalkyl, aryl, arylalkyl, alkylthioalkyl, alkoxyalkyl, alkanoyloxyalkyl, aroyloxyalkyl, alkoxycarobnylalkyl, carboxyalkyl, or arylalkyl, or R.sub.1 is alkanoyl or aroyl and R.sub.2 is alkyl;
4432972 Phosphonamidate compounds February 21, 1984
Phosphonamidates of the formula ##STR1## wherein X is an amino acid or ester. These compounds possess angiotensin converting enzyme inhibition activity and enkephalinase inhibition activity. Thus they are useful as hypotensive and analgesic agents.
4432971 Phosphonamidate compounds February 21, 1984
Phosphonamidates of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.
4427737 Microporous adhesive tape January 24, 1984
A breathable tape comprising a porous backing layer and a microporous adhesive layer. The adhesive layer includes a rubbery elastomer, one or more water soluble or swellable hydrocolloids, and other optional substances and has a porosity of from about 1 to about 100 cc/sec/in.sup.2.
4427665 Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions January 24, 1984
Phosphinylalkanoyl imino acids of the formula ##STR1## wherein X is tetrahydroisoquinoline carboxylic acid, dihydroindole or dihydroisoindole carboxylic acid are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition acti
4427592 Androstene-17-dithioketals January 24, 1984
Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, and 6,7-dehydro derivatives thereof, wherein one of R.sub.1 and R.sub.2 is alkyl, aryl, arylalkyl, or cycloalkyl, and the other is alkenyl, substituted alkenyl, alkynyl, su
4424376 Prostacyclin intermediates January 3, 1984
A method is provided for preparing intermediates for use in prostacyclin syntheses which method includes the steps of aceylating ketopinic acid or its acid halide to form the corresponding ketopinoyl diene ester intermediate, subjecting the diene ester to a Diels-Alder reaction by re
4424354 Inhibitors of mammalian collagenase January 3, 1984
Mammalian collagenase is inhibited by compounds of the formula ##STR1## or salts thereof, wherein R is hydrogen, alkanoyl of 2 to 10 carbon atoms or arylcarbonyl;R.sub.1 is of 3 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, aryl or arylalkyl;R.sub.2 is hydrogen, ##STR2##
4422945 Stabilization of pleuromutilin derivatives against oxidation by sodium hypochlorite in aqueous s December 27, 1983
A composition and method which provides a compound of the formula I: ##STR1## wherein either R.sub.1 is ethyl or vinyl,n is an integer from 2 to 5 andeach of R.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms.Also provided is a hypochlorite scavenger in solution with the formula I comp
4421686 4-Norbornyl-sulfonyl azetidinone intermediates and process for preparing (S)-3-acylamino-4-subst December 20, 1983
Compounds having the formula ##STR1## can be prepared by reacting a compound having the formula ##STR2## with a Grignard reagent having the formulawherein R.sub.1 is phenylacetyl or phenoxyacetyl;R.sub.2 is a not readily enolyzable alkyl group, aryl or norbornyl;R.sub.3 is alkyl, alk
4420626 Dioxatricyclic prostacyclin analogs December 13, 1983
New dioxatricyclic prostacyclin analogs are provided which have the general formula ##STR1## wherein R is hydrogen or lower alkyl, Q is a single bond or --CH.sub.2 --, m is 1 to 9 and n is 3 or 4, and all stereoisomers thereof, and are useful as cardiovascular agents.
4420474 Synergistic antifungal compositions December 13, 1983
Synergistic activity against Candida albicans and Trichomonas vaginalis is obtained when an antifungal imidazole is combined with an antimicrobial agent selected from the group anisomycin, ascomycin, azalomycin F, brefeldin A, copiamycin, EM4940A, or EM4940B.
4420428 16-Ketoandrostene-17-dithioketals December 13, 1983
Steroids having the formual ##STR1## and the 1,2-dehydro and 6,7-dehydro derivatives thereof, wherein R.sub.1 and R.sub.2 are the same or different and each is alkyl, cycloalkyl or aryl;R.sub.3 is carbonyl, .beta.-hydroxymethylene or .beta.-acetyloxymethylene;R.sub.4 is hydrogen or h
4419339 Formulation and method of making cationic lipophilic complexes December 6, 1983
A method for the preparation of a technetium-99m complex having the formulawhich comprises adding technetium-99m to a complex having the formulaand heating the mixture in the presence of a source of anion X.sup..crclbar., wherein each L is the same or different lipophilic ligand, each X is t
4419174 Apparatus for manufacturing ostomy pouches December 6, 1983
Ostomy pouches are manufactured by partially contour welding two pouch walls one of which has a stoma aperture over an area extending from the top edge of the pouch past the region of the weld seam around the aperture. A separator member is inserted into the partially welded pouch an
4418208 N-Substituted iminodiacetic acids November 29, 1983
Complexes of technetium-99m and a compound selected from the group having the formula ##STR1## or a pharmaceutically acceptable, water soluble salt thereof wherein R.sub.1 and R.sub.4 are each independently hydrogen, methyl or ethyl;one of R.sub.2 and R.sub.3 is alkyl of 1 to 4 carbo
4418076 7-Oxabicycloheptane hydrazone prostaglandin analogs useful in treating thrombolytic diseases November 29, 1983
7-Oxabicycloheptane hydrazone prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. pa The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4416896 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombol November 22, 1983
7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4416833 Substituted carbonyl phosphinyl-alkanoyl compounds November 22, 1983
Compounds of the formula ##STR1## wherein X is an imino acid or ester are disclosed as useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
4416831 Amino and substituted amino phosphinylalkanoyl compounds November 22, 1983
Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
4406877 .sup.82 Rb Generating method and eluent September 27, 1983
The present invention provides a low .sup.82 Sr breakthrough eluent and method of generating .sup.82 Rb from .sup.82 Sr from a .sup.82 Sr charged inorganic adsorbant column. Eluting is done with a pharmaceutically acceptable saline and buffer solution, which is preferably isotonic .s
4405716 Process for preparing 1-carba-2-penem-3-carboxylic acid September 20, 1983
Culturing aerobically Erwinia carotovora SC 12,637 A.T.C.C. No. 39048 or Erwinia herbicola SC 12,638 A.T.C.C. No. 39049 in a culture medium containing assimilable carbon and nitrogen sources yields 1-carba-2-penem-3-carboxylic acid.
4403991 Closures for open ended ostomy pouch September 13, 1983
An open ended ostomy pouch having a folding bar attached to the bottom of the pouch. The folding bar extends on both sides beyond the width of the pouch at the bottom opening and includes interlocking closure components on opposite ends.
4402976 Method for treating glaucoma with systemic nadolol compositions September 6, 1983
A method is provided for treating glaucoma by systemic administration of nadolol or esters of nadolol.
4401677 Enkephalinase inhibitors August 30, 1983
The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##
4400358 Method and adsorbant composition for .sup.82 Rb generation August 23, 1983
A composition comprising .sup.82 Sr and an adsorbant selected from the group consisting of tin oxide, hydrated tin oxide, polyantimonic acid, titanium oxide, and ferric oxide.A low .sup.82 Sr breakthrough method of generating .sup.82 Rb from a .sup.82 Sr charged adsorbant comprising elut
4397782 Antiinflammatory 17-spiroandrostenes August 9, 1983
Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro and 15,16-dehydro derivatives thereof, wherein R.sub.1 is hydrogen, alkyl, carboxyl, or alkoxycarbonyl;R.sub.2 is hydrogen, chlorine, bromine, fluorine, methyl, hydroxyl or a
4395556 Nitrobenzofurazan derivatives July 26, 1983
Nitrobenzofurazan derivatives having the formula ##STR1## are provided wherein R.sub.1 and R.sub.2 each is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.3 is hydrogen, hydroxy or lower alkyl; R.sub.4 is hydrogen or lower alkyl; m is 2 or 3; and n is 0, 1 or 2; these compound
4393080 Adhesive compositions July 12, 1983
Medical grade adhesive compositions comprising a homogeneous blend of one or more pressure sensitive adhesive materials and one or more natural or synthetic polymers capable of developing elastomeric properties when hydrated such as gluten and long chain polymers of methyl vinyl ethe
4391755 Steroid monohydrates, formulations containing same and method July 5, 1983
A monohydrate of a steroid having the structure ##STR1## and the 1,2-dehydro derivatives thereof, is provided which monohydrate is in the form of a particulate material having a stable average particle size of less than about 20 microns. Cream and lotion formulations containing t
4390695 Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids June 28, 1983
Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension.
4390558 Stabilization of pleuromutilin derivatives against oxidation by sodium hypochlorite in aqueous s June 28, 1983
A composition and method which provides a compound of the formula I: ##STR1## wherein either R.sub.1 is ethyl or vinyl. n is an integer from 2 to 5 and each of R.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms.Also provided is a hypochlorite scavenger in solution with the formula I
4388135 Method of manufacturing ostomy pouches June 14, 1983
Ostomy pouches are manufactured by partially contour welding two pouch walls one of which has a stoma aperture over an area extending from the top edge of the pouch past the region of the weld seam around the aperture. A separator member is inserted into the partially welded pouch an
4386199 Cephalosporins having an imino substituted piperazindioncarbonylamino acyl sidechain May 31, 1983
Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, substituted or unsubstituted
4386034 Sulfamated amino acid amides May 31, 1983
The process of this invention provides for the conversion of amino acid amides having the formula ##STR1## to 3-amino-2-oxo-1-azetidinesulfonic acid salts having the formula ##STR2## wherein one of R.sub.2 and R.sub.3 is hydrogen and the other is hydrogen, alkyl, cycloalkyl,
4384649 Dispensing package May 24, 1983
A medicament dispensing package comprising a blister pack and cover, and an outer shell, wherein the blister pack has multiple pockets for receiving medicament, and the outer shell has means for sealing the cover around each pocket of the blister pack.
4384123 Phosphinylalkanoyl substituted prolines May 17, 1983
Esters of phosphinylalkanoyl prolines and phosphinylalkanoyl substituted prolines are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.
4382081 Inhibitors of mammalian collagenase May 3, 1983
Mammalian collagenase is inhibited by compounds of the formula ##STR1## or salts thereof, wherein R is hydrogen, alkanoyl of 2 to 10 carbon atoms or arylcarbonyl;R.sub.1 is of 3 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, aryl or arylalkyl; ##STR2## R.sub.4 is hydro
4381297 Substituted carbonyl phosphinyl-alkanoyl compounds April 26, 1983
Compounds of the formula ##STR1## wherein X is an imino acid or ester are disclosed as useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
4377701 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid March 22, 1983
Compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is a readily hydrolyzable acyl protecting group;R.sub.2 is hydrogen or alkyl;R.sub.3 is hydrogen, alkyl or arylalkyl;n is 1 or 2; andp is 1 or 2inhibit the action of angiotensin converting enzyme.
4375397 Process for preparing 3-methylene cephalosporins March 1, 1983
Photolysis of azetidin-2-one derivatives having the formula ##STR1## wherein R.sub.1 is acyl, R.sub.2 is hydrogen or .alpha.-methoxy, R.sub.3 is hydrogen, alkyl, 2,2,2-trichloroethyl, trimethylsilyl, diphenylmethyl, benzyl, 4-methoxybenzyl, or 4-nitrobenzyl, and R.sub.4 is an aromati
4374821 Myocardial imaging agent and method February 22, 1983
A myocardial imaging agent is provided having the structure ##STR1## wherein Q, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and A are as defined herein. A method for scanning the heart, liver or kidneys employing the above agent is also provided.
4374131 Amino and substituted amino phosphinyl-alkanoyl compounds February 15, 1983
Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
4371543 Bis-amidine indene ketones, compositions containing same and method of use February 1, 1983
Bis-amidine indene ketones are provided having the structure ##STR1## wherein R is hydrogen, lower alkyl or aryl; and R.sup.1 is hydrogen, lower alkyl, halogen, carboxy, trifluoromethyl, lower alkoxy, hydroxy or acyl, and acid-addition salts thereof. In addition, pharmaceutical compo
4371526 Phosphinylalkanoyl substituted 4,5-dihydropyrazole-5-carboxylic acid derivatives and hypotensive February 1, 1983
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity.
4362872 6,6-Difluoro-5-hydroxy-4-(3-oxoalk-1-enyl)hexahydro cyclopenta[b] furan-2-ols December 7, 1982
A method is provided for preparing intermediates for use in prostacyclin syntheses which method includes the steps of aceylating ketopinic acid or its acid halide to form the corresponding ketopinoyl diene ester intermediate, subjecting the diene ester to a Diels-Alder reaction by re
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