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E. R. Squibb & Sons, Inc. Patents
Assignee:
E. R. Squibb & Sons, Inc.
Address:
Princeton, NJ
No. of patents:
1537
Patents:


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Patent Number Title Of Patent Date Issued
4551490 Adhesive composition resistant to biological fluids November 5, 1985
Medical grade pressure sensitive adhesive compositions comprising a homogeneous mixture of one or more polyisobutylenes or blends of one or more polyisobutylenes and butyl rubber, one or more styrene radial or block type copolymers, mineral oil, one or more water soluble hydrocolloid
4551277 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid November 5, 1985
Antibacterial activity is exhibited by (3-acylamino)-2-azetidinones having in the 1-position a group of the formula ##STR1## or a salt or ester thereof wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen or alkyl.
4551276 2-Oxoazetidin-1-yloxymethyl sulfonic acid and analogs November 5, 1985
Antibiotic activity is exhibited by .beta.-lactams having an ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position.
4550120 7-Oxabicycloheptane substituted ethers and their use in treating thrombolytic disease October 29, 1985
7-Oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein A is O or ##STR2## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic di
4548751 (2-Oxo-1-azetidinyloxy)-2-propenoic acid October 22, 1985
Antibacterial activity is exhibited by 3-acylamino-2-azetidinones having in the 1-position a group of the formula ##STR1## or an ester of salt thereto, wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen, alkyl, phenyl or substituted phenyl.
4548747 3-Acylamino-1-sulfonylaminocarbonylmethoxy-2-azetidinones October 22, 1985
Antibacterial activity is exhibited by .beta.lactams having a 3-acylamino substituent and in the 1-position a group of the formula ##STR1## wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen, alkyl, alkenyl, alkynyl, phenyl, substituted phenyl, cycloalkyl
4543095 Visual flow indicator September 24, 1985
The indicator includes a transparent hollow cylindrical chamber with co-linearly aligned inlet and outlet ports located at spaced points along the cylindrical wall, on opposite sides thereof. An element is freely rotatably mounted within the chamber. The element includes an axle and a
4542160 Method of use of bicycloheptane substituted prostaglandin analogs as cardiovascular agents September 17, 1985
Bicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4542157 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thro September 17, 1985
7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R.sup.1 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is
4542156 7-Oxabicycloheptane substituted prostaglandin alcohols and their use in the treatment of thrombo September 17, 1985
7-Oxabicycloheptane substituted prostaglandin alcohols are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH--(CH.sub.2).sub.n -- or (CH.sub.2).sub.q ; B is a single bond or --CH.dbd.CH--; n is 1 to 5; q is 1 to 6; Q is --CH.dbd.CH-- or (CH.sub.2).sub.2 ; a
4542155 Tetrahydrofuranyl substituted prostaglandin analogs September 17, 1985
Tetrahydrofuranyl substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4542151 Tetrahydrothienyl substituted ethers September 17, 1985
Tetrahydrothienyl substituted ethers are provided having the structural formula ##STR1## wherein A is (CH.sub.2).sub.2, CH.dbd.CH or a single bond, m is 1 to 5, B is a single bond or CH.dbd.CH, n is 1 to 4, X is O or ##STR2## wherein n' is 0, 1 or 2, R is H, lower alkyl or al
4542020 Long-lasting adhesive antifungal suppositories September 17, 1985
Antifungal suppositories are provided which preferably include nystatin as the antifungal agent, together with a hydrocolloid, such as sodium carboxymethylcellulose or hydroxypropylmethylcellulose and a low melting suppository base. The antifungal suppositories of the invention function
4539852 Vial cap torque tester September 10, 1985
A device for testing the torque required to break the seal of a medicine vial is comprised of a torque gauge mounted on a base. The torque gauge has an armature which is adapted to hold the bottom of a medicine vial. A torque arm is attached to a cylindrical unit made up of a housing and
4539312 Use of diamino ketones as analgesic agents September 3, 1985
An enkephalin-degrading aminopeptidase enzyme is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, me
4538603 Dressings, granules, and their use in treating wounds September 3, 1985
This invention is directed to an occlusive dressing useful for treating skin lesions and a granular material capable of interacting with wound exudate. Wounds emitting a large amount of fluid can be treated by first packing with the granular material and then covering the wound with the
4537981 7-Oxabicycloheptane and 7-oxabicycloheptene compounds August 27, 1985
7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4537904 Compositions of 7-oxabicycloheptane and 7-oxabicycloheptene compounds and a method for their use August 27, 1985
7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4537858 Plastatin August 27, 1985
Plastatin, an inhibitor of the enzyme phospholipase A.sub.2, can be prepared by cultivating Penicillium chermesinum under submerged aerobic conditions.
4536514 7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic di August 20, 1985
7-Oxabicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4536513 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful in the treatment of August 20, 1985
7-Oxabicycloheptane substituted interphenylene prostaglandin ethers are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4536501 Substituted 4-phenoxy or 4-phenylthio prolines August 20, 1985
Compounds of the formula ##STR1## are disclosed. They possess angiotensin converting enzyme inhibition activity and diuretic activity and are therefore useful as antihypertensive agents.
4535176 Intermediates for substituted peptide compounds August 13, 1985
Intermediates of the formula ##STR1## are disclosed. These compounds are useful in preparing substituted peptide compounds which possess hypotensive and analgesic activity.
4534896 3-Acylamino-2-oxoazetidine-1-(.beta.-oxopropionic acid) August 13, 1985
Antibacterial activity and .beta.-lactamase inhibitory activity is exhibited by .beta.-lactams having a 3-acylamino substituent and in the 1-position a group having the formula ##STR1## wherein R.sub.5 is hydrogen, methyl or ethyl.
4533673 7-Oxabicycloheptane substituted enaminone prostaglandin analogs and their use in treatment of th August 6, 1985
7-Oxabicycloheptane substituted enaminone prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4533661 Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive a August 6, 1985
Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.
4533660 Antibacterial O-sulfated .beta.-lactam hydroxamic acids August 6, 1985
Antibacterial activity is exhibited by .beta.-lactams having a sulfate substituent in the 1-position and an acylamino substituent in the 3-position.
4533354 Medical drainage bag and non-return valve assembly August 6, 1985
A drainage bag employs a non-return valve assembly including at least one baffle positioned between the top and bottom of the bag. Each baffle extends completely across the interior of the bag and includes an upper portion which is continuously attached to one face of the bag and a lower
4529698 Process for preparing a 2-oxo-1-azetidinesulfonic acid salt July 16, 1985
A pharmaceutically acceptable salt of (R)-3-(acetylamino)-3-methoxy-2-oxo-1-azetidinesulfonic acid can be prepared by culturing Chromobacterium violaceum A.T.C.C. No. 31532 at about 25.degree. C. under submerged aerobic conditions on an aqueous nutrient medium containing an assimilab
4529548 17.beta.-(substituted thio)androstenes July 16, 1985
Antiinflammatory activity is exhibited by steroids having the formula ##STR1## or the 1,2-dehydro derivative thereof, wherein R.sub.1 is alkyl, alkanoyloxyalkyl, arylcarbonyloxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl or arylalkyl;R.sub.2 is hydrogen, hydroxy, alkoxy, aryloxy, methy
4529547 17-(substituted thio)-17-(substituted dithio)androstenes July 16, 1985
Topical antiinflammatory activity is by steroids having the formula ##STR1## and the 1,2-dehydro derivatives thereof wherein R.sub.1 and R.sub.2 are the same or different and each is alkyl, aryl, arylalkyl or cycloalkyl;R.sub.3 is carbonyl or .beta.-hydroxymethylene;R.sub.4 is hydrogen o
4528138 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes July 9, 1985
Antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro derivative thereof, wherein R.sub.1 is alkyl, mono-, di- or trifluoroalkyl, ##STR2## aryl or alkylthioalkyl, wherein R.sub.6 is alkyl or aryl and m is 1, 2, 3 or 4;R.sub.2 is
4526901 7-Oxabicycloheptane substituted oxamide prostaglandin analogs and their use in treating thrombol July 2, 1985
7-Oxabicycloheptane substituted oxamide prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4526900 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thro July 2, 1985
7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R.sup.1 and R.sup.2 may be the same or different and are hydrogen or lower alkyl, R.s
4525479 7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs useful as cardiovascular age June 25, 1985
7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4524212 Acyloxyketone substituted imino and amino acids June 18, 1985
Acyloxyketone substituted imino and amino acids of the formula ##STR1## are disclosed. These compounds are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
4524151 7-Oxabicycloheptane thio ethers useful as cardiovascular agents June 18, 1985
7-Oxabicycloheptane ethers of prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4522949 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular ag June 11, 1985
7-Oxabicycloheptane substituted interphenylene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4521539 Tetrahydrofuranyl substituted ethers June 4, 1985
Tetrahydrofuranyl substituted ethers are provided having the structural formula ##STR1## wherein A is (CH.sub.2).sub.2, CH.dbd.CH or a single bond, m is 1 to 5, B is a single bond or CH.dbd.CH, n is 1 to 4, X is O or ##STR2## wherein n' is 0, 1 or 2, R is H, lower alkyl or al
4515972 Intermediates and method for producing intermediates useful in the preparation of 7-oxabicyclohe May 7, 1985
A method is provided for preparing intermediates for use in preparing 7-oxabicycloheptane prostaglandin derivatives which method includes the steps of reducing (exo)hexa hydro-4,5-epoxyisobenzofuran-1,3-dione to the corresponding diol, subjecting the diol to a chloroformylation reaction
4514391 Hydroxy substituted peptide compounds April 30, 1985
Hydroxy substituted peptide compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkeph
4513103 7-Oxabicycloheptane ethers useful in the treatment of thrombolytic disease April 23, 1985
7-Oxabicycloheptane ethers of prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4512988 Acylamino oxo or hydroxy substituted alkylamino thiazines and thiazepines April 23, 1985
Compounds of the formula ##STR1## and X is an oxo substituted thiazine or thiazepine are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.
4505890 Controlled release formulation and method March 19, 1985
A controlled release pharmaceutical formulation which undergoes substantially zero order release of active drug is provided, preferably in the form of a coated tablet, containing a core portion from which the angiotensin converting enzyme inhibitor (S)-1-[3-(benzoylthio)-2-methyl-1-o
4503241 7-Oxabicycloheptane prostaglandin intermediates March 5, 1985
7-Oxabicycloheptane prostaglandin intermediates are provided having the general structure ##STR1## wherein one of R.sup.1 and R.sup.2 is ##STR2## and the other is hydrogen. A method for preparing the above intermediates is also provided. The final products are used in the tre
4503218 Antibiotic cepacin March 5, 1985
Cultivation of a strain of the microorganism Pseudomonas cepacia SC 11,783, A.T.C.C. No. 39356 yields a novel antibiotic substance which is made up of two compounds, i.e., 5-[3-[3-(hepta-1,2-dien-4,6-diynyl)oxiran-2-yl]-3-hydroxy-1-propanyl]dihyd ro-2(3H)-furanone and 5-[[3-[3-(he
4501901 Method for making substituted prolines February 26, 1985
A method is provided for making substituted prolines of the structure ##STR1## wherein X is lower alkyl or aryl, R is H, lower alkyl or an alkali metal and Z is an N-protecting group, which method includes the step of reacting a compound of the structure ##STR2## wherein Z an
4501743 Iminothiazolyl ureido cephalosporins February 26, 1985
Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, ##STR2## X is hydrogen, ##STR3## R.sub.4 is hydrogen or lower alkyl; R.sub
4501697 4-[[(Amidomethyl)oxy]methyl]-2-oxo-1-azetidinesulfonic acid salts February 26, 1985
Antibacterial activity is exhibited by .beta.-lactams having the formula ##STR1## wherein R is hydrogen or methoxy;R.sub.1 is an acyl group derived from a carboxylic acid;R.sub.2 and R.sub.3 are each independently hydrogen, alkyl, or aryl or R.sub.2 and R.sub.3 when taken together with t
4501494 Apparatus for detecting defects in capsule shells February 26, 1985
Apparatus is provided for use in detecting defects, such as pin holes, cracks and/or uneven gelatin distribution, in capsule shells. The apparatus is comprised of a light box which includes one or a plurality of light bulbs disposed within the box, one or more opaque panels which are
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