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E. R. Squibb & Sons, Inc. Patents
Assignee:
E. R. Squibb & Sons, Inc.
Address:
Princeton, NJ
No. of patents:
1537
Patents:


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Patent Number Title Of Patent Date Issued
4594199 Method for making phosphinic acid intermediates June 10, 1986
A method is provided for preparing phosphinic acid prodrug intermediates which are useful in preparing phosphinic acid angiotensin-converting enzyme inhibitors which method includes the step of coupling a phosphonous acid or its ester of the structure ##STR1## wherein R is H or l
4594188 Use of diamino ketones as analgesic agents June 10, 1986
An enkephalin-degrading aminopentidase enzyme is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, me
4592751 Incontinence pad June 3, 1986
The cover sheet includes a moisture permeable top section and moisture impermeable side and bottom sections. The edges of the interior surface of the impermeable section overlap and are joined to the edges of the exterior surface of the permeable section to form an enclosure. A layer of
4591603 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic dise May 27, 1986
7-Oxabicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## wherein A is O or S and R is CH.sub.2 OH, ##STR2## or CO.sub.2 H, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in
4589877 Male incontinence device May 20, 1986
A method and apparatus for providing a male incontinence shield for use with a user's undergarment including partially overlapping inner and outer moisture absorbent pad portions coupled together at opposite ends whereby a penile opening is formed to allow normal urination for the lightl
4588828 Acetylenic antibiotics May 13, 1986
Antimicrobial activity is exhibited by compounds having the formula ##STR1## wherein R.sub.1 is hydrogen or aryl;R.sub.2 is hydroxymethyl, carboxyaldehyde, propenalyl, 3-hydroxy-1-propenyl, or 3-hydroxy-1,2-epoxypropyl; andn is 2 and m is 1 or n is 3 and m is 0; with the proviso that if
4588819 Process and intermediates for preparing trans-4-substituted-s-prolines May 13, 1986
4-Substituted proline derivatives having the formula ##STR1## can be prepared by reacting the compound having the formula ##STR2## with a compound having the formula ##STR3## to obtain a compound having the formula ##STR4## (a novel intermediate), alkylating that comp
4588743 7-oxabicycloheptane-substituted oxa prostaglandin analogs and their use in the treatment of thro May 13, 1986
7-Oxabicycloheptane substituted oxa prostaglandin analogs are provided having the structural formula ##STR1## wherein R is OH, ##STR2## (wherein R.sup.3 is lower alkyl, aryl, arylalkyl or lower alkylamino), ##STR3## (wherein R.sup.4 and R.sup.5 are the same or different a
4588742 Thiabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disea May 13, 1986
Thiabicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
4588741 Platelet aggregation inhibiting and bronchoconstriction inhibiting thiabicycloheptane substitute May 13, 1986
7-Thiabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal, glucamine salt or trihydroxymethylaminomethane salt, R.sup.1 is H (where X.noteq.O), lower alkyl, aryl, aralkyl, cycl
4588588 Antibiotic EM5487 May 13, 1986
A novel antifungal antibiotic which has been designated EM5487 is prepared by cultivating Lysobacter gummosus A.T.C.C. No. 39472 under submerged aerobic conditions in an aqueous nutrient medium containing an assimilable carbohydrate and nitrogen source.
4587234 Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides May 6, 1986
Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
4587051 Desulfonation process for preparing 2-azetidinones May 6, 1986
A compound having the formula ##STR1## can be prepared by heating an anion having the formula ##STR2## with a cation having the formula ##STR3## or a cation having the formula ##STR4##
4587047 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines May 6, 1986
Antibacterial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5,6 or 7-membered
4586927 Irrigation sleeve and attachment therefor May 6, 1986
An irrigation sleeve for colostomy patients is adapted such that it can be selectively and removeably attached to any one of a plurality of different snap-on attachments, such as an irrigation attachment or a rinsing or flushing attachment. The sleeve is basically funnel-shaped so that i
4585941 Dosimetry system for strontium-rubidium infusion pump April 29, 1986
The dosimetry system used with a strontium-rubidium infusion system is a very high speed circuit capable of measuring the radioactive dosage infused into a patient in real time. The dosimetry system is capable of receiving very short duration input pulses generated by a photomultiplier
4585009 Strontium-rubidium infusion pump with in-line dosimetry April 29, 1986
The dosimetry system used with a strontium-rubidium infusion system is a very high speed circuit capable of measuring the radioactive dosage infused into a patient in real time. The dosimetry system is capable of receiving very short duration input pulses generated by a photomultiplier
4584131 Benzothiazepine derivatives April 22, 1986
Vasodilating activity is exhibited by compounds having the formula ##STR1## n is 2 or 3; X is oxygen or sulfur;R.sub.1 and R.sub.2 are each independently hydrogen alkyl, cycloalkyl, or allyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached are pyrrol
4583976 Catheter support April 22, 1986
A catheter support comprising an anchoring pad and a flexible strap, a portion of which is attached thereto, is disclosed. One side of the anchoring pad carries an adhesive compatible for use with human skin. One side of the strap carries a fastener material. With the pad in place, a
4582854 7-oxabicycloheptane substituted oxa prostaglandin analgos useful in the treatment of thrombolyti April 15, 1986
7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal or trihydroxymethylaminomethane, R.sup.1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, R.sup.2 is hydroge
4581170 N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1- April 8, 1986
Processes for preparing the useful intermediates having the formula ##STR1## are disclosed herein, utilizing novel chemical compounds having the formula ##STR2##
4580816 Quick disconnect tube coupling April 8, 1986
A tube coupling having a male body, a female body for receiving at least a portion of the male body and at least one peripheral member made from a relatively compressible plastic material molded into a groove within either the relatively rigid male or female body. The peripheral member i
4578474 Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids March 25, 1986
Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension.
4576749 3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones March 18, 1986
Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and a 1-substituent of the formula ##STR1## (or a salt or ester thereof).
4575539 Drug delivery systems including novel interpenetrating polymer networks and method March 11, 1986
A drug delivery system is provided which is in the form of hydrogel beads employed in a new interpenetrating polymer network which is formed by swelling hydrogel beads with an acrylic swelling agent and reacting the swelling agent with a cross-linking agent. The drug delivery system has
4575512 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their anti-thrombotic compositions March 11, 1986
7-Oxabicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
4575239 Apparatus for detecting defects in capsule shells March 11, 1986
Apparatus is provided for use in detecting defects, such as pin holes, cracks and/or uneven gelatin distribution, in capsule shells. The apparatus is comprised of a light box which includes one or a plurality of light bulbs disposed within the box, one or more opaque panels which are
4574153 8-Oxo-2-oxa-1-azabicyclo(4.2.0)octane-3-carboxylic acids March 4, 1986
Antibacterial activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein, R.sub.1 is an acyl group derived from a carboxylic acid;R.sub.2 is hydrogen, methoxy, or formamido ##STR2## and one of R.sub.3 and R'.sub.3 is hyd
4568675 Phenazine ACE inhibitor produced from streptomyces species February 4, 1986
3,6-Dihydroxyphenazine-1-carboxylic acid, a hypotensive agent, and its production by culturing aerobically Streptomyces species A.T.C.C. No. 39460 are disclosed herein.
4568489 N-Acyl-.gamma.-glutamyl imino and amino acids and esters February 4, 1986
Compounds of the formula ##STR1## wherein X is various imino or amino acids or esters are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and depending upon the definition of X also possess enkephalinase inhibition activity.
4567167 Certain 3-phosphinyl-2-oxo-piperidine-1-acetic acid derivatives having anti-hypertensive activit January 28, 1986
Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.
4567166 Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension January 28, 1986
Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
4567034 Esters of diatrizoic acid as X-ray contrast agents January 28, 1986
New X-ray contrast agents are provided which are esters of diatrizoic acid having the structure ##STR1## wherein R is an alkyl group of 10 to 22 carbons or a group of the structure ##STR2## wherein R.sup.1 is an alkyl group of 2 to 15 carbons. X-ray contrast medium contai
4565326 Method and apparatus for removing veneer from reworked medicine tablets January 21, 1986
The invention is a method and apparatus for removing veneer coating shards from granular, medicinal formulations which are being reworked. The formulation is ground up, sifted to remove the smaller pieces which do not contain veneer shards, and then placed into an air suspension under an
4564118 Adjustable slide tray January 14, 1986
An adjustable slide tray made of a base and a sliding tray which fits within the base is described. The slide tray unit may be used for holding such objects as medicines in a pharmacist's refrigerator. The slide tray unit also includes interlock means for holding trays together.
4562829 Strontium-rubidium infusion system January 7, 1986
The strontium-rubidium infusion system includes means for generating a solution containing rubidium-82, measuring the radioactivity in the solution, and infusing it into a patient in order to perform various studies on the patient's heart. The system includes a wash syringe which can
4560698 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment in thr December 24, 1985
7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein p is 0 to 4; A is CH.dbd.CH, (CH.sub.2).sub.2, or a single bond; m is 0 to 8; R is H, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane; n is 1 to 4;
4560681 Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension December 24, 1985
This invention is directed to phosphinylmethylaminocarbonyl imino acid compounds of the formula ##STR1## wherein X represents various unsubstituted or substituted imino acids or esters.
4560680 Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors December 24, 1985
Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.
4560506 Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides December 24, 1985
Compounds of the formula ##STR1## wherein A is a cycloalkyl ring, a substituted cycloalkyl ring, a phenyl ring, or a substituted phenyl ring and ##STR2## are various dipeptide groups are disclosed. The compounds possess angiotensin converting enzyme inhibition activity and de
4559335 3-Acylamino-1-carboxymethyloxy (or thio) carbonyl-2-azetidinones December 17, 1985
Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and a 1-substituent of the formula ##STR1## (or a salt or ester thereof), wherein Z.sub.1 and Z.sub.2 are each independently oxygen or sulfur.
4558150 Intermediates for preparing amino thiol dipeptides December 10, 1985
Intermediates of the formula ##STR1## are disclosed. These compounds are useful in the preparation of amino thiol dipeptides possessing angiotensin converting enzyme inhibition activity and enkephalinase inhibition activity.
4556675 7-Oxabicycloheptane and 7-oxabicycloheptene compounds December 3, 1985
7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
4555579 Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors November 26, 1985
Angiotensin converted enzyme inhibitor activity if exhibited by compounds having the formula ##STR1## and salts thereof wherein R.sub.1 is hydrogen, aryl, or heteroaryl; R.sub.2 is hydrogen, amino, alkanoylamino, arylcarbonylamino, or heteroarylcarbonylamino;R.sub.3 is hydrogen,
4555523 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thr November 26, 1985
7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl or alkali metal, R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl, X is O, S or NH, A is --CH.dbd.CH-- or --(CH.
4555520 2-Pyridylcarboxamides which inhibit arachidonic acid release November 26, 1985
2-Pyridylcarboxamides are provided having the structure ##STR1## wherein n is 1 to 10; R is hydrogen, lower alkyl, alkali metal or an amine salt; andR.sup.1 is C.sub.6 -C.sub.20 alkyl, C.sub.6 -C.sub.20 alkenyl, C.sub.6 to C.sub.20 alkoxy or phenyl. These compounds are useful as inhi
4555506 Phosphorus containing compounds and use as hypotensives November 26, 1985
Phosphorus containing compounds of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid and A is ##STR2## These compounds possess angiotensin converting enzyme activity and are thus useful as hypertensive agents.
4554250 Method of increased production of penicillin acylase and plasmid employed therein November 19, 1985
A method is provided for enhancing penicillin acylase production wherein a Bacillus subtilis plasmid containing an insert of a chromosomal DNA fragment of Bacillus megaterium which includes the appropriate gene for enhancing penicillin acylase production is cloned into Bacillus megateriu
4553967 Wound care and drainage system having hand access port November 19, 1985
A pouch having a bottom wall secured to an adhesive layer that can be cut to fit around a wound or surgical opening, gusseted side walls, and a top wall provided with one or more access openings. An irrigation port and a catheter access port can be secured to these top wall openings. The
4552866 Use of diamino alcohols as analgesic agents November 12, 1985
An enkephalin-degrading aminopeptidase enzyme is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, me
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