| Patent Number |
Title Of Patent |
Date Issued |
| 4707494 |
7-oxabicyclo(2.2.1)heptane compounds useful in the treatment of inflammation |
November 17, 1987 |
| 7-Oxabicyclo(2.2.1)heptane analogs are disclosed having the general formula ##STR1## wherein R.sub.1 is lower alkyl, alkenyl, substituted alkenyl or alkynyl; R.sub.2 is lower alkyl, alkenyl or alkynyl; A is --CH.sub.2 --CH.dbd.CH-- or a single bond; X is --CH.sub.2, --CH(CH.sub.3) or |
| 4705849 |
Boronic acid adducts of technetium-99m dioxime complexes |
November 10, 1987 |
| Boronic acid adducts of technetium-99m dioxime complexes are useful for imaging the myocardium, hepatobiliary system, brain and blood pool in humans and other mammalian species. |
| 4704457 |
Process for the preparation of (3S)-3-[[[2-(protected amino)-4-thiazolyl]-oxoacetyl]amino]-2-oxo |
November 3, 1987 |
| A compund having the formula ##STR1## can be prepared by coupling a compound having the formula ##STR2## or a salt thereof, with a compound having the formula ##STR3## to yield a compound having the formula ##STR4## and oxidizing that compound to yield the desired com |
| 4703043 |
Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive |
October 27, 1987 |
| Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents. |
| 4695586 |
7-oxabicyclo(2.2.1)heptane-based derivatives useful as antiinflammatory, antiasthma and antipsor |
September 22, 1987 |
| 7-Oxabicyclo(2.2.1)heptane-based N-hydroxy-N-alkyl (or aryl) ureas, carbamic acids and carbamothioic acids are disclosed having the general formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, alkenyl, aryl or aralkyl; R.sub.2 is hydrogen, lower alkyl, aralkyl, alkanoyl or |
| 4695585 |
7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of 5-lipoxygenase and cyclooxygenase |
September 22, 1987 |
| A compound of the formula ##STR1## wherein R.sub.1 is hydrogen, hydroxy, alkoxy or aryloxy; R.sub.2 is hydrogen, hydroxy, alkoxy or aryloxy; or wherein R.sub.1 and R.sub.2 taken together is an aromatic ring; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is lower alkyl, substituted |
| 4694083 |
Certain carbamate ester derivatives forming salts with pyridinium or picolinium cations which ar |
September 15, 1987 |
| Disclosed herein is a process for preparing a compound having the formula ##STR1## which comprises sulfonating a compound having the formula ##STR2## with a complex having the formula ##STR3## and cyclizing the resulting compound having the formula ##STR4## by treatme |
| 4694002 |
Benzothiazepine derivatives |
September 15, 1987 |
| Calcium channel blocking activity is exhibited by compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein the stereochemistry at the chiral centers in the 3 and 4-positions of the benzothiazepine nucleus is cis, and whereinR.sub.1 is alkyl, ar |
| 4692455 |
Certain acyclic, alicyclic, aromatic or heterocyclic derivatives of 3-benzoylamino-2-oxo- butyl- |
September 8, 1987 |
| Compounds of the formula ##STR1## wherein Y is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of R.sub.1 may also be useful as analgesics due to thei |
| 4689414 |
2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids an |
August 25, 1987 |
| Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3 or halo substituted alkyl;R.sub.2 is hydrog |
| 4687865 |
Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxa |
August 18, 1987 |
| A process is provided for preparing a 7-oxabicycloheptane amino alcohol intermediate of the general structure ##STR1## (wherein the above structures represents (D) or (L) isomers) which is useful in preparing thromboxane A.sub.2 receptor antagonists. This intermediate is prepared |
| 4686299 |
Aerocavin antibiotics |
August 11, 1987 |
| Aerocavin, a novel antibiotic substance having the structure ##STR1## and aerocyanidin, a novel antibiotic substance having the structure ##STR2## can be prepared by cultivation of the microorganism Aerocavin caviae SC 14,030 A.T.C.C. No. 53434. |
| 4686298 |
Intermediates for alpha-acyloxy phosphonate angiotensin converting enzyme inhibitors |
August 11, 1987 |
| Compounds of the formula ##STR1## are useful in the preparation of .alpha.-acyloxy phosphonate compounds. The final products are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity. |
| 4685990 |
Ostomy bag coupling |
August 11, 1987 |
| An ostomy device comprises an ostomy bag with a first coupling member attached thereto. A second coupling member for mating engagement with the first is attached to an adhesive backed label for adhering to the skin of the wearer around a stoma by a flexible mounting member comprising fir |
| 4684722 |
Monosulfactams |
August 4, 1987 |
| Antibacterial activity is exhibited by monocyclic .beta.-lactam antibiotics having in the 1-position an --O--SO.sub.3 H activating group and in the 3-position an acylamino group of the formula ##STR1## wherein R.sub.3 and R.sub.4 are each independently hydrogen or alkyl. |
| 4684660 |
Mercaptoacyldepeptides |
August 4, 1987 |
| Compounds having the formula ##STR1## and alkyl esters and salts thereof. R.sub.1 is hydrogen, alkanoyl or ##STR2## R.sub.2 is hydrogen, alkyl, or phenylalkyl; n is 0 or 1; andA.sub.1 and A.sub.2 each is an .alpha.-amino or .alpha.-imino acid residue joined through a peptide bond |
| 4684656 |
1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidineca |
August 4, 1987 |
| Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.1, or halo substituted alkyl;R.sub.2 is hydrogen, alky |
| 4684655 |
1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic ac |
August 4, 1987 |
| Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;R.sub.1 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3 or halo substitute |
| 4681937 |
3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid e |
July 21, 1987 |
| Antimicrobial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position, or a pharmaceutically acceptable salt thereof; wherein Y is oxygen or sulfur and R.sub.5 is hydroxyl, alkyl, substituted alkyl, ph |
| 4681886 |
Substituted 4-phenoxy or 4-phenylthio prolines |
July 21, 1987 |
| This invention is directed to substituted 4-phenoxy and 4-phenylthio prolines of the formula ##STR1## which possess useful hypotensive activity. |
| 4680409 |
Hydrazide containing derivatives of 2-amino-4-thiazole-acetic acid |
July 14, 1987 |
| Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen or alkyl of 1 to 4 carbon atoms, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cycloalkyl ring;R.sub.3 is hydrogen or alkyl;R.sub.4 is hydrogen o |
| 4680388 |
O-sulfated spiro .beta.-lactam hydroxamic acids |
July 14, 1987 |
| Antibacterial activity is exhibited by compounds having the formula and pharmaceutically acceptable salts thereof. |
| 4679557 |
Electrodynamic transluminal angioplasty system |
July 14, 1987 |
| An electromechanical system which may be used in conjunction with spinning catheters, such as those which have differential cutting burrs, includes an electric prime mover which attaches to an advancer assembly. The advancer assembly has an off-axis drive and apparatus for loading a |
| 4675398 |
Copper-mediated oximation reaction |
June 23, 1987 |
| The presence of a copper salt during the oximation of a .beta.-lactam containing compound having glyoxylamino substituents of the formula ##STR1## by reaction with an aminooxy compound having the formulaor a salt or ester thereof, results in a product wherein the ratio of syn isomer |
| 4673685 |
Hydroximic acids of 7-oxabicycloheptane substituted ethers and thioethers useful in the treatmen |
June 16, 1987 |
| Hydroximic acids of 7-oxabicycloheptane substituted ether and thioether prostaglandin analogs are provided having the structural formula ##STR1## wherein Y is O or ##STR2## and including all stereoisomers thereof. The compounds are inhibitors of prostaglandin and biosynthesis |
| 4670554 |
((3-Acylamino-2-oxo-1-azetidinyl)oxy)methyl)phosphinic acids |
June 2, 1987 |
| Antibacterial activity is exhibited by .beta.-lactams having a 3-acylamino substituent and in the 1-position a substituent having the formula ##STR1## wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen, alkyl, alkenyl, alkynyl, phenyl, substituted phenyl, cycl |
| 4670553 |
2-oxo-1-(aminocarbonylaminosulfonyl-aminocarbonyl)azetidines |
June 2, 1987 |
| Antibacterial activity is exhibited by compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is acyl;R.sub.2 is hydrogen or methoxy;R.sub.3 and R.sub.4 are the same or different and each is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl or a 5,6 or 7-membered hete |
| 4670541 |
Use of diamino alcohols as analgesic agents |
June 2, 1987 |
| An enkephalin-degrading aminopeptidase enzyme is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, me |
| 4670453 |
7-oxabicycloheptane substituted amido-carbamoyl prostaglandin analogs useful in the treatment of |
June 2, 1987 |
| 7-Oxabicycloheptane substituted amidocarbamoyl prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R.sup.1 is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhy |
| 4670422 |
.alpha.-acyloxy phosphonate angiotensin converting enzyme inhibitors |
June 2, 1987 |
| Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as |
| 4670193 |
Process for preparing phosphonic acids |
June 2, 1987 |
| A process for preparing phosphonic acids of the structure ##STR1## wherein R.sub.1 is lower alkyl, aryl, cycloalkyl or arylalkyl, and R.sub.2 is H, benzyl or ##STR2## by oxidizing the corresponding phosphonous acid ##STR3## employing as the oxidizing agent potassium perma |
| 4666705 |
Controlled release formulation |
May 19, 1987 |
| A controlled release pharmaceutical formulation which undergoes slow release of active drug is provided, preferably in the form of a tablet containing medicament, such as captopril, is slowly released over a controlled length of time. The tablet also includes an acrylic acid polymer |
| 4665193 |
Amino acid ester renin inhibitors |
May 12, 1987 |
| Compounds of the formula ##STR1## wherein A is ##STR2## intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents. |
| 4664661 |
Modified accordion flange |
May 12, 1987 |
| An ostomy device for releasably connecting an ostomy bag to an adhesive backed label including a mounting member for connecting one of two coupling parts to the label. The mounting member comprises an expandable portion for facilitating displacement of the connected coupling part bet |
| 4663337 |
7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease |
May 5, 1987 |
| 7-Oxabicycloheptane substituted amides are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, ##STR2## wh |
| 4663336 |
7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the tre |
May 5, 1987 |
| 7-Oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO. |
| 4661506 |
7-oxabicycloheptane substituted ox prostaglandin analogs |
April 28, 1987 |
| 7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R.sup.1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --, n is 1 to 4, m is 1 to 8, and R.sup.2 is ## |
| 4656185 |
7-oxabicycloheptane substituted aminoalkyl amide prostaglandin analogs |
April 7, 1987 |
| 7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxya |
| 4654426 |
Acetylenic antibiotics |
March 31, 1987 |
| Antimicrobial activity is exhibited by compounds having the formula ##STR1## wherein R.sub.1 is hydrogen or aryl;R.sub.2 is hydroxymethyl, carboxyaldehyde, propenalyl, 3-hydroxy-1-propenyl, or 3-hydroxy-1,2-epoxypropyl; andn is 2 and m is 1 or n is 3 and m is 0; with the proviso that if |
| 4654367 |
Hydroxamic acids of 7-oxabicycloheptane substituted ethers useful as anti-allergy and anti-infla |
March 31, 1987 |
| Hydroxamic acids of 7-oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein Q is --CH.sub.2 --A--(CH.sub.2).sub.n --; X is S or O, Y is O or ##STR2## and including all stereoisomers thereof. The compounds are inhibit |
| 4654366 |
Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ethers useful as anti-thrombotic agen |
March 31, 1987 |
| 7-Oxabicycloheptane substituted ether or thio ether prostaglandin analogs are provided having the structural formula ##STR1## wherein A is O or ##STR2## and X is O or ##STR3## and including all stereoisomers thereof. The compounds are inhibitors of .DELTA..sup.5 -lipo |
| 4654364 |
Hydroxamic acids of 7-oxabicycloheptane substituted ethers |
March 31, 1987 |
| Hydroxamic acids of 7-oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein Y is O or ##STR2## and including all stereoisomers thereof. The compounds are inhibitors of .DELTA..sup.5 -lipoxygenase and inhibitors o |
| 4654357 |
7-oxabicycloheptane substituted sulfonamide prostaglandin analogs |
March 31, 1987 |
| 7-Oxabicycloheptane substituted sulfonamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 |
| 4654356 |
7-oxabicycloheptane substituted diacid diamide prostaglandin analogs |
March 31, 1987 |
| 7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub |
| 4654355 |
7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs |
March 31, 1987 |
| 7-Oxabicycloheptane substituted amide-thioamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub. |
| 4654335 |
Antihypertensive 1,5-benzothiazepine derivatives, compositions, and method of use therefor |
March 31, 1987 |
| Compounds of formula ##STR1## wherein X is S or SO.sub.2, R.sub.4 is aryl or hetero, and R.sub.1 is hydrogen or ##STR2## are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents. |
| 4652578 |
7-oxabicycloheptane substituted amide prostaglandin analogs |
March 24, 1987 |
| Cis-exo 7-oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --C |
| 4652576 |
7-oxabicycloheptane substituted amide-carbamate prostaglandin analogs |
March 24, 1987 |
| 7-Oxabicycloheptane substituted amide-carbamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.su |
| 4650797 |
Substituted 1,5-benzodiazepine compounds |
March 17, 1987 |
| Compounds of the formula ##STR1## wherein R.sub.1 is alkyl, alkenyl, alkynyl, cycloalkyl, or substituted alkyl, and R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents. |
| 4648875 |
Ostomy bag coupling |
March 10, 1987 |
| An ostomy device comprises an ostomy bag with a first coupling member attached thereto. A second coupling member for mating engagement with the first is attached to an adhesive backed label for adhering to the skin of the wearer around a stoma by a flexible mounting member comprising fir |
