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Duquesne University of the Holy Ghost Patents
Assignee:
Duquesne University of the Holy Ghost
Address:
Pittsburgh, PA
No. of patents:
56
Patents:


1 2










Patent Number Title Of Patent Date Issued
8563763 Composition, synthesis and use of isonitriles October 22, 2013
The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulf
8269032 Composition, synthesis, and use of isonitriles September 18, 2012
The present invention relates to isonitrile compounds, methods of synthesis, and uses in a variety of fields. In one aspect, the present invention includes sulfinyl methyl isonitriles and methods for their preparation. In another aspect, the present invention includes the use of sulf
8258143 Methods of using substituted pyrrolo[2,3-d]pyrimidines for targeting tumor cells and treating ca September 4, 2012
A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing cancerous tumor.
8163521 Self-assembled proteins and related methods and protein structures April 24, 2012
The present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of gene sequences that transcribe peptide sequences that form links between proteins, where the peptide seq
8030319 Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis October 4, 2011
The present invention provides methods for treating cancer and other pathological proliferating conditions by inhibiting mitosis using at least one pyrrolo[2,3-d]pyrimidine having the general formula (16): ##STR00001## where X is selected from the group consisting of lower alkyls,
7981902 Substituted pyrrolo[2,3-d]pyrimidines for selectively targeting tumor cells with FR type recepto July 19, 2011
A compound for treating cancer tumors, particularly ovarian cancer tumors, is described, where a fused cyclic pyrimidine having a cancer treating ability is effective to allow selective delivery to a cancerous tumor. ##STR00001##
7960400 Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof June 14, 2011
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angioge
7879578 Self-assembled proteins and related methods and protein structures February 1, 2011
The present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of gene sequences that transcribe peptide sequences that form links between proteins, where the peptide seq
7135175 Compositions and methods for eliciting an immune response to gram-negative bacterial infections November 14, 2006
Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the pilin being glycosylated with the O-antigen of a target Gram-negative bacteria of interest.
7132101 Compositions and methods for eliciting an immune response to gram-negative bacterial infections November 7, 2006
Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the pilin being glycosylated with the O-antigen of a target Gram-negative bacteria of interest.
6962920 Pyrimidine derivatives and methods of making and using these derivatives November 8, 2005
This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and
6790673 Speciated isotope dilution mass spectrometry of reactive species and related methods September 14, 2004
A method of speciated isotope dilution mass spectrometry (SIDMS) which will permit determination of concentrations of one or more species from a sample even if the sample has been subjected to species conversion prior to species separation or degradation or incomplete separation exists.
6770652 Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same August 3, 2004
This invention discloses pyrrolo pyrimidine compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, of the following formula (3): ##STR1##These compounds are useful in therapeutically and/or prophylactically treating patients with cancer by inhibiting recepto
6716880 Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the April 6, 2004
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using t
6696455 Pyrimidine derivatives and methods of making and using these derivatives February 24, 2004
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i
6566347 Controlled release pharmaceutical May 20, 2003
The present invention provides a controlled release pharmaceutical composition comprising a polydextrose, a drug that is complexed with the polydextrose, and a polymer matrix having the drug complexed with the polydextrose, wherein the polymer matrix and the polydextrose provide for
6537999 Pyrimidine derivatives and methods of making and using these derivatives March 25, 2003
This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, of the following formula: ##STR1## wherein L and M are selected from the group consisting of carbon and CH, the chemical bond between L and M is selected from the group consist
6518426 Pyrimidine derivatives and methods of making and using these derivatives February 11, 2003
Novel pyrrolo[3,2-d]pyrimidine derivatives of the following general formula ##STR1##are disclosed. These compounds are useful in the treatment of bacterial infections such as Toxoplasmosis gondii and Pneumocystis carinii, and various types of cancer, through their action on dihydrofolate
6436918 Steroid sulfatase inhibitors and methods for making and using the same August 20, 2002
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic
6433000 Compounds for the treatment of estrogen-dependent illnesses and methods of making and using the August 13, 2002
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using t
6423720 Pyrimidine compounds and methods for making and using the same July 23, 2002
This invention discloses compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii, Toxop
6420370 Pyrimidine derivatives and method of making and using derivatives July 16, 2002
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i
6399595 Steroid sulfatase inhibitors and methods for making and using the same June 4, 2002
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic
6397205 Document categorization and evaluation via cross-entrophy May 28, 2002
A computerized data processing system for categorizing documents that applies candidate functions, such as entropy, cross-entropy, and KL-distance, to data classification is disclosed. A computerized method for categorizing documents employing the candidate functions is also disclose
6376687 Steroid sulfatase inhibitors and methods for making and using the same April 23, 2002
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic
6288107 Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the September 11, 2001
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using t
6288050 Steroid sulfatase inhibitors and methods for making and using the same September 11, 2001
Sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatm
6262043 Estra-1,3,5(10),16-tetraene derivatives July 17, 2001
Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I): ##STR1##(wherein R.sup.1 represents hydroxy, alkoxy, or NR.sup.2 R.sup.3 (wherein R.sup.2 and R.sup.3 are the same or different, and each represents hydrogen, straight-chain lower alkyl having 1 to 3 ca
6248780 Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the June 19, 2001
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using t
6221872 Pyrimidine derivatives and methods of making and using these derivatives April 24, 2001
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i
6156340 Orally administrable time release drug containing products December 5, 2000
A time release orally administrable drug containing product comprising a core, a drug layer attached to the core, and first and second coating layers is disclosed. The first coating layer is directly adjacent to the drug layer, and has a limited permeability to water. The second coating
6114339 Derivatives of pyrido [2,3-D] and [3,2-D] pyrimidine method of using these derivatives September 5, 2000
The invention also discloses compounds and pharmaceutically acceptable salts having the generic formula (2) ##STR1## wherein X and Y may be the same or different and are selected from the group consisting of OH and NH.sub.2 ; wherein Z is one of either nitrogen or carbon and Q is
6103727 Pyrimidine derivatives and methods of making and using these derivatives August 15, 2000
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i
6096750 Furopyrimidines and methods of making and using the same derivatives August 1, 2000
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i
6077844 Pyrimidine derivatives and methods of making and using these derivatives June 20, 2000
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i
5958930 Pyrrolo pyrimidine and furo pyrimidine derivatives September 28, 1999
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i
5939420 Pyrrolo[2,3d]derivatives August 17, 1999
Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness are disclosed.
5900408 Methods of creating a unique chitosan and employing the same to form complexes with drugs, deliv May 4, 1999
A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of
5883349 Method and apparatus for microwave assisted chemical reactions March 16, 1999
A method of microwave assisted chemical reaction includes providing a microwavable reaction vessel which contains at least one material in a sample. The sample is heated by microwave energy to elevate the temperature of the reagent and at least partially volatilize the sample to esta
5880115 Steroid sulfatase inhibitors and methods for making and using the same March 9, 1999
Sulfatase inhibitor compounds having the formula: ##STR1## wherein X, Y, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification. The compounds are useful in the treatment of estrogen dependent illnesses. Methods for synthesizing these compounds are also disclosed.
5877178 Pyrimidine derivatives and methods of making and using these derivatives March 2, 1999
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i
5866603 Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use February 2, 1999
This invention discloses compounds useful as steroid sulfatase inhibitors. The compounds comprise the formula (1) ##STR1## wherein (a) R is selected from the group consisting of hydrogen, a lower alkyl group, an alkoxy group, halogen, NH.sub.2, NO.sub.2, C.tbd.N and N.dbd.C.dbd.S
5863920 Furo-pyrimidine derivatives and methods of making and using these derivatives January 26, 1999
This invention discloses furo-pyrimidine compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasm
5830883 Methods of creating a unique chitosan and employing the same to form complexes with drugs, deliv November 3, 1998
A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of
5830417 Method and apparatus for microwave assisted chemical reactions November 3, 1998
A method of microwave assisted chemical reaction includes providing a microwavable reaction vessel which contains at least one material in a sample. The sample is heated by microwave energy to elevate the temperature of the reagent and at least partially volatilize the sample to esta
5750996 Apparatus for nondestructively inspecting a coated article and associated method May 12, 1998
Apparatus and an associated method are provided for nondestructively inspecting a coated article which may be a coated drug unit to determine the extent of coating on the exterior thereof. A probe may be received within a housing wherein the article is coated and transported as in a
5736547 Derivatives of pyrido [2,3-D] and [3,2-D] Pyrimidine and quinazoline and method of using these d April 7, 1998
The invention discloses species compounds (4) and (5) and methods of using these compounds for therapeutically treating a patient for an illness selected from the group consisting of infection by Pneumocystis carinii and Toxoplasmosis gondii. ##STR1## In compounds (4) and (5) X a
5677292 Derivatives of estra 1,3,5(10)triene-17-one,3-amino compounds and their use October 14, 1997
This invention discloses compounds useful as steroid sulfatase inhibitors. The compounds comprise the formula (1) ##STR1## wherein (a) R is selected from the group consisting of hydrogen, a lower alkyl group, an alkoxy group, halogen, NH.sub.2, NO.sub.2, C.tbd.N and N.dbd.C.dbd.S
5571933 Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use November 5, 1996
This invention discloses compounds useful as steroid inhibitors. The compounds comprise the formula (5) ##STR1## wherein (a) R.sub.1 is hydrogen and R.sub.2 is selected from the group consisting of SO.sub.2 CF.sub.3, SO.sub.2 NH.sub.2, SO.sub.2 (C.sub.1 -C.sub.6 -alkyl), COCF.sub
5556847 Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors September 17, 1996
This invention discloses a method for treating a patient for an illness selected from the group consisting of amnesia, head injuries, Alzheimer's disease, epileptic dementia, presenile dementia, post traumatic dementia, senile dementia, vascular dementia and post stroke dementia or indiv
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