| Patent Number |
Title Of Patent |
Date Issued |
| 7135175 |
Compositions and methods for eliciting an immune response to gram-negative bacterial infections |
November 14, 2006 |
| Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the pilin being glycosylated with the O-antigen of a target Gram-negative bacteria of interest. |
| 7132101 |
Compositions and methods for eliciting an immune response to gram-negative bacterial infections |
November 7, 2006 |
| Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the pilin being glycosylated with the O-antigen of a target Gram-negative bacteria of interest. |
| 6962920 |
Pyrimidine derivatives and methods of making and using these derivatives |
November 8, 2005 |
| This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and |
| 6790673 |
Speciated isotope dilution mass spectrometry of reactive species and related methods |
September 14, 2004 |
| A method of speciated isotope dilution mass spectrometry (SIDMS) which will permit determination of concentrations of one or more species from a sample even if the sample has been subjected to species conversion prior to species separation or degradation or incomplete separation exists. |
| 6770652 |
Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same |
August 3, 2004 |
| This invention discloses pyrrolo pyrimidine compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, of the following formula (3): ##STR1##These compounds are useful in therapeutically and/or prophylactically treating patients with cancer by inhibiting recepto |
| 6716880 |
Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the |
April 6, 2004 |
| Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using t |
| 6696455 |
Pyrimidine derivatives and methods of making and using these derivatives |
February 24, 2004 |
| This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i |
| 6566347 |
Controlled release pharmaceutical |
May 20, 2003 |
| The present invention provides a controlled release pharmaceutical composition comprising a polydextrose, a drug that is complexed with the polydextrose, and a polymer matrix having the drug complexed with the polydextrose, wherein the polymer matrix and the polydextrose provide for |
| 6537999 |
Pyrimidine derivatives and methods of making and using these derivatives |
March 25, 2003 |
| This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, of the following formula: ##STR1## wherein L and M are selected from the group consisting of carbon and CH, the chemical bond between L and M is selected from the group consist |
| 6518426 |
Pyrimidine derivatives and methods of making and using these derivatives |
February 11, 2003 |
| Novel pyrrolo[3,2-d]pyrimidine derivatives of the following general formula ##STR1##are disclosed. These compounds are useful in the treatment of bacterial infections such as Toxoplasmosis gondii and Pneumocystis carinii, and various types of cancer, through their action on dihydrofolate |
| 6436918 |
Steroid sulfatase inhibitors and methods for making and using the same |
August 20, 2002 |
| Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic |
| 6433000 |
Compounds for the treatment of estrogen-dependent illnesses and methods of making and using the |
August 13, 2002 |
| Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using t |
| 6423720 |
Pyrimidine compounds and methods for making and using the same |
July 23, 2002 |
| This invention discloses compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii, Toxop |
| 6420370 |
Pyrimidine derivatives and method of making and using derivatives |
July 16, 2002 |
| This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i |
| 6399595 |
Steroid sulfatase inhibitors and methods for making and using the same |
June 4, 2002 |
| Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic |
| 6397205 |
Document categorization and evaluation via cross-entrophy |
May 28, 2002 |
| A computerized data processing system for categorizing documents that applies candidate functions, such as entropy, cross-entropy, and KL-distance, to data classification is disclosed. A computerized method for categorizing documents employing the candidate functions is also disclose |
| 6376687 |
Steroid sulfatase inhibitors and methods for making and using the same |
April 23, 2002 |
| Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic |
| 6288107 |
Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the |
September 11, 2001 |
| Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using t |
| 6288050 |
Steroid sulfatase inhibitors and methods for making and using the same |
September 11, 2001 |
| Sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatm |
| 6262043 |
Estra-1,3,5(10),16-tetraene derivatives |
July 17, 2001 |
| Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I): ##STR1##(wherein R.sup.1 represents hydroxy, alkoxy, or NR.sup.2 R.sup.3 (wherein R.sup.2 and R.sup.3 are the same or different, and each represents hydrogen, straight-chain lower alkyl having 1 to 3 ca |
| 6248780 |
Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the |
June 19, 2001 |
| Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using t |
| 6221872 |
Pyrimidine derivatives and methods of making and using these derivatives |
April 24, 2001 |
| This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i |
| 6156340 |
Orally administrable time release drug containing products |
December 5, 2000 |
| A time release orally administrable drug containing product comprising a core, a drug layer attached to the core, and first and second coating layers is disclosed. The first coating layer is directly adjacent to the drug layer, and has a limited permeability to water. The second coating |
| 6114339 |
Derivatives of pyrido [2,3-D] and [3,2-D] pyrimidine method of using these derivatives |
September 5, 2000 |
| The invention also discloses compounds and pharmaceutically acceptable salts having the generic formula (2) ##STR1## wherein X and Y may be the same or different and are selected from the group consisting of OH and NH.sub.2 ; wherein Z is one of either nitrogen or carbon and Q is |
| 6103727 |
Pyrimidine derivatives and methods of making and using these derivatives |
August 15, 2000 |
| This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i |
| 6096750 |
Furopyrimidines and methods of making and using the same derivatives |
August 1, 2000 |
| This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i |
| 6077844 |
Pyrimidine derivatives and methods of making and using these derivatives |
June 20, 2000 |
| This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i |
| 5958930 |
Pyrrolo pyrimidine and furo pyrimidine derivatives |
September 28, 1999 |
| This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i |
| 5939420 |
Pyrrolo[2,3d]derivatives |
August 17, 1999 |
| Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness are disclosed. |
| 5900408 |
Methods of creating a unique chitosan and employing the same to form complexes with drugs, deliv |
May 4, 1999 |
| A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of |
| 5883349 |
Method and apparatus for microwave assisted chemical reactions |
March 16, 1999 |
| A method of microwave assisted chemical reaction includes providing a microwavable reaction vessel which contains at least one material in a sample. The sample is heated by microwave energy to elevate the temperature of the reagent and at least partially volatilize the sample to esta |
| 5880115 |
Steroid sulfatase inhibitors and methods for making and using the same |
March 9, 1999 |
| Sulfatase inhibitor compounds having the formula: ##STR1## wherein X, Y, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification. The compounds are useful in the treatment of estrogen dependent illnesses. Methods for synthesizing these compounds are also disclosed. |
| 5877178 |
Pyrimidine derivatives and methods of making and using these derivatives |
March 2, 1999 |
| This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in i |
| 5866603 |
Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
February 2, 1999 |
| This invention discloses compounds useful as steroid sulfatase inhibitors. The compounds comprise the formula (1) ##STR1## wherein (a) R is selected from the group consisting of hydrogen, a lower alkyl group, an alkoxy group, halogen, NH.sub.2, NO.sub.2, C.tbd.N and N.dbd.C.dbd.S |
| 5863920 |
Furo-pyrimidine derivatives and methods of making and using these derivatives |
January 26, 1999 |
| This invention discloses furo-pyrimidine compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasm |
| 5830883 |
Methods of creating a unique chitosan and employing the same to form complexes with drugs, deliv |
November 3, 1998 |
| A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of |
| 5830417 |
Method and apparatus for microwave assisted chemical reactions |
November 3, 1998 |
| A method of microwave assisted chemical reaction includes providing a microwavable reaction vessel which contains at least one material in a sample. The sample is heated by microwave energy to elevate the temperature of the reagent and at least partially volatilize the sample to esta |
| 5750996 |
Apparatus for nondestructively inspecting a coated article and associated method |
May 12, 1998 |
| Apparatus and an associated method are provided for nondestructively inspecting a coated article which may be a coated drug unit to determine the extent of coating on the exterior thereof. A probe may be received within a housing wherein the article is coated and transported as in a |
| 5736547 |
Derivatives of pyrido [2,3-D] and [3,2-D] Pyrimidine and quinazoline and method of using these d |
April 7, 1998 |
| The invention discloses species compounds (4) and (5) and methods of using these compounds for therapeutically treating a patient for an illness selected from the group consisting of infection by Pneumocystis carinii and Toxoplasmosis gondii. ##STR1## In compounds (4) and (5) X a |
| 5677292 |
Derivatives of estra 1,3,5(10)triene-17-one,3-amino compounds and their use |
October 14, 1997 |
| This invention discloses compounds useful as steroid sulfatase inhibitors. The compounds comprise the formula (1) ##STR1## wherein (a) R is selected from the group consisting of hydrogen, a lower alkyl group, an alkoxy group, halogen, NH.sub.2, NO.sub.2, C.tbd.N and N.dbd.C.dbd.S |
| 5571933 |
Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
November 5, 1996 |
| This invention discloses compounds useful as steroid inhibitors. The compounds comprise the formula (5) ##STR1## wherein (a) R.sub.1 is hydrogen and R.sub.2 is selected from the group consisting of SO.sub.2 CF.sub.3, SO.sub.2 NH.sub.2, SO.sub.2 (C.sub.1 -C.sub.6 -alkyl), COCF.sub |
| 5556847 |
Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors |
September 17, 1996 |
| This invention discloses a method for treating a patient for an illness selected from the group consisting of amnesia, head injuries, Alzheimer's disease, epileptic dementia, presenile dementia, post traumatic dementia, senile dementia, vascular dementia and post stroke dementia or indiv |
| 5508281 |
Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods of using these derivatives |
April 16, 1996 |
| The invention discloses generic compound (2) and its analog (6) and pharmaceutically acceptable salts and methods of using these compounds for therapeutically and prophylactically treating a patient for an illness consisting of the group of Pneumocystis carinii and Toxoplasmosis gondii |
| 5469846 |
Implantable non-enzymatic electrochemical glucose sensor |
November 28, 1995 |
| A non-enzymatic implantable blood glucose detector. The detector makes use of a non-reactive tin oxide semiconductor measurement electrode which is suitably energized by an electrical power source. Variations in current density at the measurement electrode are related to variations in gl |
| 5414259 |
Method of speciated isotope dilution mass spectrometry |
May 9, 1995 |
| The method of determining the concentration of a specie in a sample includes providing at least one predetermined, enriched isotope in the same speciated form as the species to be measured, spiking the sample containing the species to be measured, equilibrating the spiked species wit |
| 5387327 |
Implantable non-enzymatic electrochemical glucose sensor |
February 7, 1995 |
| A non-enzymatic implantable glucose blood detector. The detector makes use of a non-reactive tin oxide semiconductor measurement electrode which is suitably energized by an electrical power source. Variations in current density at the measurement electrode are related to variations in gl |
| 5346900 |
5-alkyl-6-[[amino]methyl]pyrido[2,3-D]pyrimidine derivatives and methods of using these derivati |
September 13, 1994 |
| This invention discloses a compound and pharmaceutically acceptable salts having the formula: ##STR1## wherein X and Y are the same or different and are selected from the group consisting of OH and NH.sub.2 ; wherein R.sub.1 is selected from the group consisting of hydrogen, a fi |
| 5169645 |
Directly compressible granules having improved flow properties |
December 8, 1992 |
| Directly compressible, wax-containing granules having improved flow properties are obtained when waxes are admixed in the melt with certain flow improving additives, followed by cooling and granulation of the admixture. In certain embodiments of the invention, only the wax itself mel |
