| Patent Number |
Title Of Patent |
Date Issued |
| RE34387 |
Method for restoring depleted purine nucleotide pools |
September 21, 1993 |
| A method of increasing the rate of repletion of purine nucleotide pools in tissue deficient in the nucleotides, which comprises administering to a human or animal a therapeutically effective amount of 5-amino-4-imidazolecarboxamide riboside, 5-amino-4-imidazolecarboxamide, or a pharm |
| 7625907 |
Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
December 1, 2009 |
| A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease, Parkinson's disease, |
| 7625714 |
Modulators of odorant receptors |
December 1, 2009 |
| The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, t |
| 7618300 |
Method of synthesizing small-diameter carbon nanotubes with electron field emission properties |
November 17, 2009 |
| Carbon nanotube material having an outer diameter less than 10 nm and a number of walls less than ten are disclosed. Also disclosed are an electron field emission device including a substrate, an optionally layer of adhesion-promoting layer, and a layer of electron field emission mat |
| 7616306 |
Compressive sampling and signal inference |
November 10, 2009 |
| An optical wavemeter includes a slit, a diffraction grating, a mask, a complementary grating, and a detector. A monochromatic source is incident on the slit. The diffraction grating produces an image of the slit in an image plane at a horizontal position that is wavelength dependent. The |
| 7615610 |
Modified trafficking patterns for arrestin and G-protein-coupled receptors via arrestin-ubiquiti |
November 10, 2009 |
| The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compou |
| 7615535 |
Inhibiting GS-FDH to modulate no bioactivity |
November 10, 2009 |
| Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase. |
| 7613509 |
Systems, methods, and computer program products for transmitting neural signal information |
November 3, 2009 |
| Systems, Methods, and Computer Program Products for Transmitting Neural Signal Information. Systems, method, and computer program products are provided for neural signal transmission. A system according to one embodiment can include a signal receiver operable to receive a neural sign |
| 7609808 |
Application specific emission and transmission tomography |
October 27, 2009 |
| A compact and mobile gantry for 3-dimensional Application Specific Emission and/or Transmission Tomography (ASETT) imaging of the breast in single photon or coincidence emission modes, and single photon, or coincidence, or x-ray transmission modes. While the ASETT gantry was designed |
| 7601343 |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with |
October 13, 2009 |
| Disclosed are cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells (e.g., dendritic cells or macrophage) that have been loaded with RNA derived from tumors or pathogens. By administ |
| 7598355 |
Characterization of GRP94-ligand interactions and purification, screening, and therapeutic metho |
October 6, 2009 |
| The present invention discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domain of GRP94 elicits a conformational change that converts the GRP94 from an inactive to an active conf |
| 7598057 |
Use of cytokine receptors as biomarkers and therapeutic targets in human cancer |
October 6, 2009 |
| Nucleic acids encoding erythropoietin receptor isoforms are described, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer. |
| 7595889 |
Systems and methods for endoscopic angle-resolved low coherence interferometry |
September 29, 2009 |
| Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one sca |
| 7595047 |
Compositions and methods for promoting or inhibiting angiogenesis |
September 29, 2009 |
| Compounds, compositions and methods for promoting or inhibiting angiogenesis, and screening methods for identifying compounds are disclosed. The compounds bind to F1 ATP synthase particularly to the alpha and/or beta subunits of F1 ATP synthase. When bound to these subunits, they can |
| 7593559 |
Method and system of coregistrating optical coherence tomography (OCT) with other clinical tests |
September 22, 2009 |
| A method/system preserves annotations of different pathological conditions or changes that are recognized on cross-sections within a three dimensional volume of a patient's eye so that the annotations are maintained in a visible state in an en face projection produced with a SVP tech |
| 7592141 |
Methods of identifying individuals at reduced risk of sepsis |
September 22, 2009 |
| The present invention provides a method of identifying a subject having a reduced risk of developing sepsis, comprising detecting at least one APOE3 allele in nucleic acid from the subject. |
| 7585627 |
Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis |
September 8, 2009 |
| A method of screening a subject for a serotonergic neurotransmission dysregulation disorder comprises detecting the presence or absence of an Tph2 mutation in the subject; and then determining that the subject is at increased risk of a serotonergic neurotransmission dysregulation disorde |
| 7573579 |
Coded aperture imaging photopolarimetry |
August 11, 2009 |
| An imaging polarimeter includes a polarization dispersing element, a spatial light modulator, a complementary polarization dispersing element, a polarization analyzer, an electronic detection plane, and a processor. The polarization dispersing element polarimetrically disperses an image |
| 7572888 |
Methods of assaying receptor activity and constructs useful in such methods |
August 11, 2009 |
| Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR |
| 7561274 |
Optical spectroscopy utilizing planar spectral filters |
July 14, 2009 |
| An optical spectrometer and/or a method of optical spectroscopy is described herein. One exemplary spectrometer includes a planar spectral filter, a dispersion system, and a detector array having at least two dimensions. The planar spectral filter filters incident light to generate a |
| 7541151 |
Single-cell biosensor for the measurement of GPCR ligands in a test sample |
June 2, 2009 |
| The present invention is related to the detection of GPCR ligands in a test sample by using a single cell biosensor expressing a GPCR. Preferably, the test sample is derived from a biological or environmental sample. This invention may be used to detect the presence of a disease or t |
| 7538193 |
NO-modified hemoglobins and uses therefor |
May 26, 2009 |
| S-nitrosohemoglobin can liberate NO by transfer to a low molecular weight thiol in the circulatory system, allowing the delivery of NO to the tissues. The effect of administering isolated S-nitrosohemoglobin and low molecular weight thiol to a mammal is to increase delivery of oxygen and |
| 7537911 |
ATM related kinase, ATX, nucleic acids encoding same and methods of use |
May 26, 2009 |
| The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypepti |
| 7534573 |
Method of identifying therapeutic agents for the treatment of epilepsy |
May 19, 2009 |
| The present invention relates to a method of identifying agents suitable for use in treating epilepsy and other brain disorders, including but not limited to bipolar disorder, schizophrenia and depression. The invention further relates to methods of treatment based on the use of agents s |
| 7532772 |
Coding for compressive imaging |
May 12, 2009 |
| Embodiments of the present invention can estimate an image using an encodement provided by an optical component, an encodement provided by a detector array, or both an encodement provided by an optical component and an encodement provided by a detector array. The original image can be |
| 7532705 |
Systems and methods for localizing a target for radiotherapy based on digital tomosynthesis |
May 12, 2009 |
| Systems and methods for localizing a target for radiotherapy based on digital tomosynthesis are provided. According to one method, DTS verification image data of a target located within or on a patient is generated. The DTS verification image data is compared with DTS reference image |
| 7531164 |
Preventing bacterial or viral infectivity and composition containing infection preventing additi |
May 12, 2009 |
| A nitric oxide synthesis inhibitor or nitric oxide scavenger is administered to prevent development of infection, to prevent development of a cancer where overstimulation of a receptor contributes to the cancer development, and to prevent loss of beta agonist responsivity and as a tr |
| 7524640 |
Inhibiting Smad2/3 signaling promotes neurite outgrowth in dorsal root ganglia |
April 28, 2009 |
| Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon. |
| 7517908 |
Method for augmenting the effects of serotonin reuptake inhibitors |
April 14, 2009 |
| A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydro |
| 7512206 |
Batch target and method for producing radionuclide |
March 31, 2009 |
| In a method for producing a radionuclide, a target chamber is filled with target fluid and pressurized. A particle beam is applied to the target chamber to irradiate target material of the target fluid, and the target fluid becomes heated. The heated target liquid may expand out from the |
| 7505130 |
Static two-dimensional aperture coding for multimodal multiplex spectroscopy |
March 17, 2009 |
| A class of aperture coded spectrometer is optimized for the spectral characterization of diffuse sources. The instrument achieves high throughput and high spatial resolution by replacing the slit of conventional dispersive spectrometers with a spatial filter or mask. A number of mask |
| 7498332 |
Therapy for cerebral vasospasm |
March 3, 2009 |
| The present invention relates to a method of treating or preventing cerebral vasospasm that accompanies sub-arachnoid hemorrhage. |
| 7485721 |
Substituted porphyrins |
February 3, 2009 |
| A series of ortho isomers of meso tetrakis N-alkylpyridylporphyrins (alkyl being methyl, ethyl, n-propyl, n-butyl, n-hexyl, and n-octyl) and their Mn(III) complexes were synthesized and characterized by elemental analysis, uv/vis spectroscopy, electrospray ionization mass spectrometry |
| 7467046 |
Geranylgeranyl transferase type I (GGTase-I) structure and uses thereof |
December 16, 2008 |
| Protein geranylgeranyl transferase type I (GGTase-I), a Ca.sub.1a.sub.2X prenyltransferase, is an essential enzyme in eukaryotes. GGTase-I catalyzes the carboxyl-terminal lipidation of over one hundred proteins, including many GTP-binding regulatory proteins (G proteins). The present |
| 7463179 |
Compressive sampling and signal inference |
December 9, 2008 |
| An optical signal is compressively sampled using an optical component to encode multiplex measurements. A mapping from the optical signal to a detector array is created using spatial and/or spectral dispersion. Signals transmitted by a plurality of transmissive elements of the optica |
| 7463174 |
Compressive sampling and signal inference |
December 9, 2008 |
| An optical signal is compressively sampled. An optical component with a plurality of transmissive elements and a plurality of opaque elements is created. The location of the plurality of transmissive elements and the plurality of opaque elements is determined by a transmission function. |
| 7460101 |
Frame buffer pixel circuit for liquid crystal display |
December 2, 2008 |
| An enhanced frame buffet pixel circuit with two control transistors and a separate capacitor put in as a memory capacitor before the memory transistor yields a high contrast ratio by removing induced charge and solving a charge sharing problem between the memory capacitor and the liq |
| 7449449 |
Particle-mediated transformation of vertebrate tissue cells |
November 11, 2008 |
| A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the sequences comprising, in the 5' to 3' direction, a regulatory sequence operable in the ti |
| 7439019 |
Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction |
October 21, 2008 |
| The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding.The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying |
| 7439014 |
Droplet-based surface modification and washing |
October 21, 2008 |
| The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of providing a droplet in contact with a surface with a reduced concentration of a substance is provided, wherein the method includes: (a) providing a droplet microa |
| 7432843 |
Compressive sampling and signal inference |
October 7, 2008 |
| A signal is temporally compressively sampled. A plurality of analog to digital converters are assembled to sample the signal. Each analog to digital converter of the plurality of analog to digital converters is configured to sample the signal at a time step determined by a temporal s |
| 7432052 |
Method and identification of downstream mRNA ligands to FMRP and their role in fragile X syndrom |
October 7, 2008 |
| Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for fragile X mental retardation protein (FMRP) have been identified by a novel monoclonal an |
| 7429580 |
Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for af |
September 30, 2008 |
| Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a psychotherapeutic agent and the second compound is a anticonvulsant. Also disclosed are methods of affecting weight loss, increasing energy expenditur |
| 7429458 |
Methods of using bioelastomers |
September 30, 2008 |
| Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In general, the bioelas |
| 7427932 |
Compressive sampling and signal inference |
September 23, 2008 |
| An optical signal is copressively sampled using an imaging system. The imaging system is created from a plurality of subimaging systems. Each subimaging system comprises a subaperture and a plurality of sensors. The optical signal is collected at each subaperture of the plurality of |
| 7425445 |
Modulators that promote cell surface expression of odorant receptors |
September 16, 2008 |
| The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, t |
| 7420724 |
Scanner apparatus having electromagnetic radiation devices coupled to MEMS actuators |
September 2, 2008 |
| A disclosed scanner apparatus includes a member having spaced apart proximal and distal portions. An electromagnetic radiation device is configured to direct electromagnetic radiation therefrom and is moveably coupled to the distal portion of the member. The electromagnetic radiation |
| 7417109 |
Polymers for delivering nitric oxide in vivo |
August 26, 2008 |
| Disclosed are novel polymers derivatized with at least one --NO.sub.x group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under cond |
| 7415143 |
Methods and systems for the detection of malignant melanoma |
August 19, 2008 |
| The present invention relates to the detection of malignant melanoma. In particular, the present invention relates to systems and methods for the early detection of cancerous lesions. |
| 7413906 |
Quantitative, high-throughput screening method for protein stability |
August 19, 2008 |
| In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashion. The method emp |
