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Dana-Farber Cancer Institute, Inc. Patents
Assignee:
Dana-Farber Cancer Institute, Inc.
Address:
Boston, MA
No. of patents:
228
Patents:


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Patent Number Title Of Patent Date Issued
8275595 Computer-based methods of designing molecules September 25, 2012
The invention features a method of generating an immunogenic compound with the ability to induce an immune response to a molecule produced by a pathogenic agent, e.g., a infectious agent or a tumor cell. Also included in the invention are an immunogenic compound generated by the method o
8268572 Methods to identify inhibitors of Runx1-mediated expression of nociceptive receptors and ion cha September 18, 2012
Methods are provided for identifying candidate agents for use in inhibiting expression of certain receptors and ion channels in nociceptors. Also provided are methods for identifying candidates agents for use in inhibiting neurophathic and other types of pain.
8222423 Bifunctional histone deacetylase inhibitors July 17, 2012
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts an
8222244 Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity July 17, 2012
The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving deregulated FLT3 receptor tyrosine kinase activity, especially for the curative and/or prophylactic treatment of leukemias and myelodysplastic
8211634 Compositions, kits, and methods for identification, assessment, prevention, and therapy of cance July 3, 2012
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs an
8198405 Stabilized alpha helical peptides and uses thereof June 12, 2012
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides
8197817 Regulation of mink in thymocytes and T lymphocytes June 12, 2012
The invention relates to compositions and methods used to assess and alter the expression and activity of MINK in cells of the immune system, particularly thymocytes and T lymphocytes. The methods and compositions are used in a variety of clinical applications including vaccination,
8178317 Compositions and methods for identifying transforming and tumor suppressor genes May 15, 2012
Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complementing genes directl
8168602 Compositions, kits and methods for identification, assessment, prevention and therapy of cancer May 1, 2012
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs an
8148084 Diagnosis of autoimmune disease April 3, 2012
Methods and compositions for diagnosing and treating autoimmune disease, e.g., acute disseminated encephalomyelitis (ADEM), are described.
8129506 Modulation of the interaction of MUC1 with MUC1 ligands March 6, 2012
The present invention provides for chimeric proteins comprising a MUC1 extracellular (MUC1-EC) polypeptide and a carrier polypeptide that function as traps for MUC1 ligands.
8129345 MUC1-I.kappa.B kinase complexes and their activities March 6, 2012
The disclosure provides methods of identifying and making compounds and pharmaceutical compositions containing the compounds that inhibit the interaction between MUC1 and an IKK. The disclosure also provides in vivo and in vitro methods of inhibiting such an interaction. Also embraced by
8119684 Thiophene derivatives for up-regulating HLA-DM activity February 21, 2012
Compounds of formula (I), compositions, methods and kits are provided. The compounds and compositions may be particularly useful for modulating immunological responses. Formula (I) wherein, R.sub.1 is alkyl, aryl, or heterocyclyl; R.sub.2 is H, alkyl, aryl, heterocyclyl, OR.sub.3 or
8110370 IBC-1 (Invasive Breast Cancer-1), a putative oncogene amplified in breast cancer February 7, 2012
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of identifying and manufacturing therapeutic compounds, and methods of treating patients wi
8105774 PGC-1.beta., PGC-1 homologue and uses therefor January 31, 2012
The invention provides isolated nucleic acid molecules, designated PGC-1.beta. nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1.beta. nucleic a
8105769 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treat January 31, 2012
The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyros
8101176 Compositions and methods related to TIM-3, a TH1-specific cell surface molecule January 24, 2012
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discover
8034561 HIN-1, a tumor suppressor gene October 11, 2011
The invention encompasses isolated DNAs encoding HIN-1 polypeptides, vectors containing such DNAs, cells containing the vectors, and isolated HIN-1 polypeptides. The invention also features methods of making and using HIN-1 polypeptides.
8026230 Methods and compositions for treating cancer using proteasome inhibitors September 27, 2011
The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resi
8026224 Tumor cells with increased immunogenicity and uses therfor September 27, 2011
Tumor cells modified to express a T cell costimulatory molecule are disclosed. In one embodiment, the costimulatory molecule is a CD28/CTLA4 ligand, preferably a B lymphocyte antigen B7. The tumor cells of the invention can be modified by transfection with nucleic acid encoding a T c
8017315 Mitochondrial localization of MUC1 September 13, 2011
The invention provides methods of identifying and making compounds that inhibit the interaction between MUC1 and either or both of HSP70 and HSP90. Also embraced by the invention are in vivo and in vitro methods of inhibiting such an interaction.
8012695 Methods and compositions relating to promoter regulation by MUC1 and KLF proteins September 6, 2011
This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or inflammatory cell growth and/or activation. The invention provides methods of, and compositions useful for, inhibiting interactions between MUC1 and a kruppel-like
7985563 HIF.alpha.prolyl hydroxylation assay July 26, 2011
The present invention provides methods of identifying compounds that decrease proline hydroxylation of the alpha subunit of hypoxia inducible factor (HIF.alpha.).
7981609 Methods for identifying and using SNP panels July 19, 2011
Described are methods for identifying single nucleotide polymorphism (SNPs) that are useful for analyzing genetic samples, and for using said SNPs to determine genetic identity of samples.
7973031 Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity July 5, 2011
The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving deregulated FLT3 receptor tyrosine kinase activity, especially for the curative and/or prophylactic treatment of leukemias and myelodysplastic
7972870 Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3 July 5, 2011
This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or inflammatory cell growth and/or activation. The invention provides methods of inhibiting interactions between MUC1 and a heat shock factor, method of inhibiting i
7964700 Inhibitors of Taspase1 protease activity June 21, 2011
A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase
7964349 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treat June 21, 2011
The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyros
7955845 Modified antigen-presenting cells June 7, 2011
The invention relates to antigen-presenting cells having specificity against a selected antigen and methods for making the cells. The invention also relates to a method of selecting efficient antigen-presenting cells using reporter fusion constructs. The highly efficient antigen-pres
7947652 Compositions and methods for modulating PGC-1.alpha. to treat huntington's disease May 24, 2011
The present invention provides methods for modulating mitochondrial function, modulating lesion formation in the brain, modulating neurite growth, modulating neuronal degeneration, and treating and preventing neurological diseases or disorders comprising modulating the expression or
7931904 Modulation of MUC1 activity April 26, 2011
The invention provides methods of identifying and making compounds that inhibit the interaction between MUC1 and either p53 or TBP. Also embraced by the invention are in vivo and in vitro methods of inhibiting such an interaction and of inhibiting the expression of MUC1 by a cell.
7919274 Light-emitting fusion proteins and diagnostic and therapeutic methods therefor April 5, 2011
Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of th
7910325 Method for determination and quantification of radiation or genotoxin exposure March 22, 2011
The present invention discloses methods for detecting exposure of a living subject to genotoxic agents, testing sensitivity to a genotoxic agent, and determining DNA damage caused by exposure to an agent, comprising detecting the presence of FANCD2-containing foci from a sample collected
7892767 Phosphospecific chemokine receptor antibodies February 22, 2011
The present invention provides chemokine receptor antibodies that selectively bind to an activated form of the receptor but not to a non activated form of the receptor. In particular, the current invention provides phosphospecific chemokine receptor antibodies. The antibodies can be
7871784 Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proa January 18, 2011
This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or immune cell growth. The invention provides methods of inhibiting interactions between MUC1 and BH3-containing proapoptotic proteins, methods of inhibiting MUC1 ex
7868133 BH3 peptides and method of use thereof January 11, 2011
The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.
7858331 Compositions and methods for the treatment of cancer December 28, 2010
Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention discloses inhibitors of the Fanconi anemia pathway and methods using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the
7851591 Cancer immunotherapy and diagnosis using universal tumor associated antigens, including hTERT December 14, 2010
The invention provides methods for conducting cancer immunotherapy and diagnosis using universal tumor associated antigens, such as the telomerase catalytic subunit (hTERT), and methods for identifying and characterizing universal tumor associated antigens.
7847240 Mass spectroscopy system and method including an excitation gate December 7, 2010
An ion extraction method and system includes: i) confining ions within an ion trap extending along a longitudinal axis; ii) exciting a subset of the ions to cause them to oscillate along at least one transverse coordinate; iii) after the transverse excitation, applying a first field
7829662 Method of treating apoptosis and compositions thereof November 9, 2010
Disclosed herein are novel polypeptides and the nucleic acid sequences that encode them. Also disclosed are antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific
7786269 Antibody to latent membrane proteins and uses thereof August 31, 2010
The present invention provides antibodies and antibody fragments directed against extracellular domains of the EBV LMP proteins, including LMP1, LMP2A and LMP2B. The invention also provides methods of treating EBV-associated malignancies using these LMP specific antibodies.
7781393 Methods for inhibiting tumor cell growth August 24, 2010
The invention methods using a insulin-like growth factor receptor inhibitor to inhibit tumor cell growth in a subject in need thereof.
7776520 Use of microphthalmia for diagnosis, prognosis and/or treatment of melanoma August 17, 2010
Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the probe identifies Mi in
7750123 Antibodies against SARS-CoV and methods of use thereof July 6, 2010
The invention provides scFv antibodies and monoclonal antibodies that neutralize SARS-CoV. Also provided are methods of treating and/or preventing a coronavirus-related disease or disorder such as SARS. The invention also provides methods of vaccinating a patient against SARS-CoV. Al
7741024 Immunogenic proteoliposomes, and uses thereof June 22, 2010
An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant such as streptavidin
7732658 Composition and method for imaging cells June 8, 2010
The invention relates to compositions containing a polynucleotide encoding for a reporter gene, a selectable marker and a regulatory element, that provide a method for imaging cells in vivo.
7723469 Stabilized alpha helical peptides and uses thereof May 25, 2010
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides
7722868 Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof May 25, 2010
Disclosed are methods for modulating an immune response including a method for inhibiting the interaction between a B7 polypeptide and a PD-1 ligand, the method comprising contacting an immune cell bearing a PD-1 ligand, or an immune cell bearing a B7 polypeptide, with an agent that
7709214 Methods for upregulating an immune response with agents that inhibit the intereaction between PD May 4, 2010
The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid
7700301 Methods for screening for compounds that modulate PD-1 signaling April 20, 2010
Disclosed are screening assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule.
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