| Patent Number |
Title Of Patent |
Date Issued |
| RE38688 |
Sheet-like diagnostic device |
January 18, 2005 |
| A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates throu |
| RE37596 |
Monoclonal antibodies against tumor-associated antigens, a process for the preparation thereof a |
March 19, 2002 |
| The invention relates to monoclonal antibodies (MAbs) and fragments thereof which bind to defined tumor-associated antigens, principally of small cell lung carcinoma (SCLC), of melanoma, of neuroblastoma and other tumors of neuroectodermal origin, to hybridoma cell lines for the preparat |
| RE37437 |
Sheet-like diagnostic device |
November 6, 2001 |
| A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates throu |
| 7338770 |
Human procalcitonin and the preparation and use thereof |
March 4, 2008 |
| The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host |
| 7306949 |
Combination of CRP and D-dimer for in vitro diagnosis of deep venous thrombosis (DVT) |
December 11, 2007 |
| The present invention relates to an in vitro diagnostic method for patients with suspected deep venous thrombosis wherein by combined testing of patients' samples for D-dimer and CRP both the sensitivity and the negative predictive value of DVT diagnostics can be increased up to 100% |
| 7291479 |
Method for detecting the von Willebrand factor-cleaving protease activity of ADAMTS-13 |
November 6, 2007 |
| The invention relates to a diagnostic method for determining the von Willebrand factor (VWF) cleaving activity of ADAMTS-13 in a test medium during which the test medium is mixed with 0.5 to 5 U/ml of a von Willebrand factor (VWF) that does not contain ADAMTS-13, and after incubation |
| 7276376 |
Analyzing method of a blood coagulation reaction |
October 2, 2007 |
| An analyzing method of a blood coagulation reaction by detecting an optical change of a blood sample with an elapse of time, the method includes: setting at least one checkpoint or check region between a starting point of the blood coagulation reaction and the endpoint thereof; and m |
| 7258989 |
Carbohydrate deficient transferrin (CDT) -specific antibodies, their preparation and use |
August 21, 2007 |
| The present invention relates to antibodies which, in agueous solution, selectively bind to a transferrin-homologous carbohydrate deficient transferrin (CDT) without the latter needing to be bound to a solid phase. CDT is characterized by at least one of the two oligosaccharide chain |
| 7252961 |
Competitive immunoassay using complexed analyte derivatives |
August 7, 2007 |
| The invention relates to a method for the detection of an analyte in a competitive immunoassay in the presence of an analyte derivative and first and second receptor molecules, and to a kit for carrying out this detection method. |
| 7229842 |
Metal chelate containing compositions for use in chemiluminescent assays |
June 12, 2007 |
| Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl grou |
| 7179660 |
Carriers coated with polysaccharides, their preparation and use |
February 20, 2007 |
| A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and, optionally, the carrier. Each successive layer of polysaccharide spontaneously associa |
| 7169613 |
Method for avoiding the contamination of negative sampling material by samples containing analyt |
January 30, 2007 |
| The invention relates to a method for reducing the contamination of reaction containers which are empty or already fitted with analyte-free sampling material or sampling material having a low analyte concentration, inside a configuration of reaction containers which are spatially clo |
| 7135186 |
Varicella zoster virus (VZV) immunoreactive protein VP26 and its diagnostic use |
November 14, 2006 |
| Varicella zoster virus (VZV) inimunoreactive protein VP26 and its diagnostic use are described. The invention relates to immunoreactive peptides which are homologous with the region of amino acid positions 12 to 235 (SEQ ID NO: 7) of the varicella zoster virus protein VP26, to nuclei |
| 7101682 |
Simultaneous screening of multiple analytes |
September 5, 2006 |
| Methods, compositions and kits are disclosed. The methods are directed to determining the presence of one or more analytes in a sample suspected of containing any one of a plurality of the analytes. A combination is provided comprising in a medium (i) the sample, (ii) a binding partner |
| 7050167 |
Nephelometric detection unit with optical in-process control |
May 23, 2006 |
| The present invention relates to the field of the use of automated measurement systems in analysis and in in-vitro diagnosis. In particular, the apparatus described enables automatic quality control and validation of characteristic process engineering parameters, in particular charac |
| 7033775 |
Simultaneous screening of multiple analytes |
April 25, 2006 |
| Methods, compositions and kits are disclosed. The methods are directed to determining the presence of one or more analytes in a sample suspected of containing any one of a plurality of the analytes. A combination is provided comprising in a medium (i) the sample, (ii) a binding partner |
| 7022529 |
Particles for diagnostic and therapeutic use |
April 4, 2006 |
| Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of decrease in the in |
| 6974866 |
Retrovirus from the HIV type O and its use (MVP-2901/94) |
December 13, 2005 |
| A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European collection of animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can |
| 6960442 |
Immunoreactive regions of glycoprotein gpII of varicella zoster virus (VZV) |
November 1, 2005 |
| The present invention relates to immunoreactive peptides that are homologous with the region encompassing amino acid positions 450 to 655 of glycoprotein II of varicella zoster virus. In this context, preference is given to those peptides corresponding to segments of amino acids 505 to |
| 6949524 |
Polysaccharide conjugates of biomolecules |
September 27, 2005 |
| Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed |
| 6932968 |
Erythropoietin (EPO) peptides and antibodies directed against these |
August 23, 2005 |
| Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibodies are suitable |
| 6916667 |
Metal chelate containing compositions for use in chemiluminescent assays |
July 12, 2005 |
| Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, |
| 6905687 |
Human procalcitonin and the preparation and use thereof |
June 14, 2005 |
| The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host |
| 6887669 |
Reagents for assays for ligands |
May 3, 2005 |
| The present invention relates to a method for releasing a ligand from a complex of the ligand with an endogenous protein using a releasing agent. |
| 6869608 |
Peptides derived from a retrovirus of the HIV group and their use |
March 22, 2005 |
| Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnost |
| 6866820 |
Closure appliance for reagent containers |
March 15, 2005 |
| The invention relates to an appliance for opening and closing a reagent-container stopper in a partially or fully automatic analysis apparatus, and to the method, which is applied by means of this appliance, for opening and closing a reagent-container stopper in a partially or fully |
| 6797481 |
Simultaneous screening of multiple analytes |
September 28, 2004 |
| Methods, compositions and kits are disclosed. The methods are directed to determining the presence of one or more analytes in a sample suspected of containing any one of a plurality of the analytes. A combination is provided comprising in a medium (i) the sample, (ii) a binding partner f |
| 6791676 |
Spectrophotometric and nephelometric detection unit |
September 14, 2004 |
| A method and apparatus for spectrophotometric and/or nephelometric analyses. The apparatus can be used in in-vitro diagnosis. |
| 6783947 |
Protecting groups for biological labeling |
August 31, 2004 |
| Alpha-haloketones are useful alkylating agents for coupling to sulfhydryl-containing biomolecules. However, they react spontaneously with water, alkali and organic bases and therefore cannot be stored for extended periods of time in aqueous solutions, particularly in the presence of |
| 6773923 |
Induced aggregation and agglutination of platelets |
August 10, 2004 |
| The invention relates to a method for measuring the aggregation or agglutination of platelets, where a reaction mixture is mixed in a first reaction phase, and is mixed less vigorously or not at all in a second reaction phase following the first, and the measurement is preferably car |
| 6773915 |
Retrovirus from the HIV group and its use |
August 10, 2004 |
| A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for |
| 6750032 |
Method and diagnostic agent for hemostasis diagnosis |
June 15, 2004 |
| The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an intera |
| 6733989 |
Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereo |
May 11, 2004 |
| Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereofExpression of an SmaI fragment, which is about 1.0 kb in size, on the left-hand end of the HindIII R fragment makes it possible to synthesize, by genetic manipulation, a structural phosphopro |
| 6723317 |
Antibodies specific for seroreactive regions on HPV 16 protein E1 |
April 20, 2004 |
| The invention relates to seroreactive regions on proteins E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the seroreactive regions. The invention likewise embraces compositions for diagnostic purposes which |
| 6703248 |
Particles for diagnostic and therapeutic use |
March 9, 2004 |
| Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of decrease in the in |
| 6692975 |
Metal chelate containing compositions for use in chemiluminescent assays |
February 17, 2004 |
| Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, |
| 6664070 |
Washing solution for solid-phase immunometric methods which contains stabilizers for the labelin |
December 16, 2003 |
| A washing solution for solid-phase immunometric methods which contains stabilizers for the labeling system, and the use thereof |
| 6632682 |
One-step immunoassay for the determination of antigen-specific antibodies of one of the immunogl |
October 14, 2003 |
| An immunochemical method for the determination of antibodies which are specific for an antigen and are of one of the immunoglobulin classes: A, M, D or E in a fluid, with this fluid being contacted with a solid phase to which the antibodies against this immunoglobulin class, or a fragmen |
| 6632599 |
Detection and determination of solid phase-associated factors |
October 14, 2003 |
| The present invention relates to procedures for the detection or for the determination of solid phase-associated factors, which are multiply associated with the same solid phase. According to the invention, the sample is brought into contact with a transmitter particle, on which at l |
| 6610291 |
Ready-to-use ristocetin cofactor test reagent possessing long-term stability |
August 26, 2003 |
| The present invention relates to a ready-to-use ristocetin cofactor test reagent possessing long-term stability for use in coagulation tests. |
| 6593453 |
Activated peptides and conjugates |
July 15, 2003 |
| Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed. |
| 6566085 |
Synthetic peptides, antibodies directed against them, and the use thereof |
May 20, 2003 |
| The invention relates to synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic, to the use thereof for the immunization of an animal and for the purification of specific antibodies, to antibod |
| 6562946 |
Human procalcitonin and the preparation and use thereof |
May 13, 2003 |
| The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host |
| 6555317 |
Detection of differences in nucleic acids |
April 29, 2003 |
| A method is disclosed for detecting the presence of a difference between two related nucleic acid sequences. In the method a complex is formed comprising both strands of each sequence. Each member of at least one pair of non-complementary strands within the complex have labels. The a |
| 6551824 |
Retrovirus from the HIV group and its use |
April 22, 2003 |
| A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for |
| 6548635 |
Retrovirus from the HIV type O and its use (MVP-2901/94) |
April 15, 2003 |
| A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can |
| 6538113 |
Methods of obtaining antibody directed against prothrombin fragments F2/F1+2 |
March 25, 2003 |
| The invention relates to synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic, to the use thereof for the immunization of an animal and for the purification of specific antibodies, to antibod |
| 6531587 |
Retrovirus from the HIV group and its use |
March 11, 2003 |
| A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for |
| 6531137 |
Retrovirus from the HIV group and its use |
March 11, 2003 |
| A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for |
| 6531127 |
Antibodies that specifically react with seroreactive regions on HPV 16 proteins E1 and E2 |
March 11, 2003 |
| The invention relates to seroreactive regions on the E1 and E2 proteins of human papillomavirus 16 (HPV 16). The invention also relates to a vaccine that contains peptides comprising at least one seroreactive region of the E1 and/or E2 proteins. The invention likewise embraces compositio |
