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Corvas International, Inc. Patents
Assignee:
Corvas International, Inc.
Address:
San Diego, CA
No. of patents:
75
Patents:


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Patent Number Title Of Patent Date Issued
6872808 Nematode-extracted serine protease inhibitors and anticoagulant proteins March 29, 2005
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
6818616 Neutrophil inhibitors November 16, 2004
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comp
6777431 Non-convalent thrombin inhibitors August 17, 2004
The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and an optionally substituted heteroaryl group at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutica
6756211 Neutropohil inhibitors June 29, 2004
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions are useful in the therapy of conditions wh
6677473 Plasminogen activator inhibitor antagonists January 13, 2004
Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl ethers, benzoate esters, sulfones
6638977 Plasminogen activator inhibitor antagonists October 28, 2003
Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers are provided.
6608204 Aromatic heterocyclic derivatives as enzyme inhibitors August 19, 2003
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized b
6586405 Non-covalent inhibitors of urokinase and blood vessel formation July 1, 2003
Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have P1 a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for
6576613 Title inhibitors of urokinase June 10, 2003
Novel inhibitors of urokinase are provided which have an arginine or arginine mimic aldehyde or an arginine ketoamide group at P1. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition
6541467 Thrombin inhibitors having a lactam at P3 April 1, 2003
The present invention provides compounds having a lactam ring at P3 and at P1 have a six-membered heterocyclic ring having two ring nitrogen ring atoms and the remainder of the ring atoms carbon atoms. These compounds have biological activity as active and potent inhibitors of thrombin.
6534629 Nematode-extracted serine protease inhibitors and anticoagulant proteins March 18, 2003
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
6506761 Substituted hydrazinyl heteroaromatic inhibitors of thrombin January 14, 2003
Compound of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: ##STR1##as described herein.
6506760 Substituted hydrazinyl heteroaromatic inhibitors of thrombin January 14, 2003
Compounds of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: ##STR1##as described herein.
6506754 Non-covalent thrombin inhibitors January 14, 2003
The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and which feature a six member heterocyclic ring having two ring nitrogen atoms and the remainder of the ring atoms carbon atoms at P1. These compounds have biological activity as active and potent
6432922 Inhibitors of urokinase and blood vessel formation August 13, 2002
Novel compounds having activity inhibitors of urokinase and in reducing or inhibiting blood vessel formation are provided. These compounds have an arginine or arginine mimic aldehyde or an arginine ketoamide group at P1. These compounds are useful in vitro for monitoring plasminogen acti
6376649 Methods for the synthesis of .alpha.- hydroxy-.beta.-amino acid and amide derivatives April 23, 2002
Methods for the synthesis of .alpha.-hydroxy-.beta.-amino acid and amide derivatives and .alpha.-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehyde with an isonitrile and a ca
6342504 Aromatic heterocyclic derivatives as enzyme inhibitors January 29, 2002
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized b
6204384 Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II) March 20, 2001
The present invention provides peptide aldehydes having an 3-amino-2-hydro yenyl acetamide group as part of the peptide backbone d an arginine group or analog at P1. These compounds e potent and specific or inhibitors of thrombin. Ther pharmaceutically acceptable salts, pharmaceutic ly
6203816 Tissue factor based prothrombin time reagent March 20, 2001
The present disclosure relates to novel liposome compositions in which tissue factor is incorporated and methods for their preparation. The composition of the phospholipids in the liposomes has been adjusted to allow maximum coagulant activity and sensitivity to extrinsic coagulation
6121435 Nematode-extracted serine protease inhibitors and anticoagulant proteins September 19, 2000
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
6096877 Nematode-extracted serine protease inhibitors and anticoagulant proteins August 1, 2000
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
6090916 Nematode-extracted serine protease inhibitors and anticoagulant proteins July 18, 2000
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
6087487 Nematode-extracted serine protease inhibitors and anticoagulant proteins July 11, 2000
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
6046318 Nematode-extracted serine protease inhibitors and anticoagulant proteins April 4, 2000
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
6040441 Nematode-extracted serine protease inhibitors and anticoagulant proteins March 21, 2000
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
6034215 3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors March 7, 2000
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized b
6025472 N-substituted glycine derivatives as enzyme inhibitors February 15, 2000
The present invention discloses peptide aldehydes which are potent inhibitors of factor Xa, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnorm
6011158 Aromatic heterocyclic derivatives as enzyme inhibitors January 4, 2000
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized b
6011047 Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors January 4, 2000
The present invention provides peptide aldehydes having a 3-amino-2-hydroxyphyenyl-acetamide group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pha
6008351 Aromatic hetherocyclic derivatives as enzyme inhibitors December 28, 1999
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized b
5955576 Inhibitors of thrombosis September 21, 1999
This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
5955294 Nematode-extracted serine protease inhibitors and anticoagulant proteins September 21, 1999
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from
5945275 Nematode-extracted anticoagulant protein August 31, 1999
Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
5932733 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors August 3, 1999
The present invention discloses peptide aldehydes having a lactam group as part of the peptide backbone and having an original mimic group such as an amidinopiperidine or amidinophengyl tail. These compounds are potent and specific inhibitors of thrombin, their pharmaceutically acceptabl
5919900 Modified hookworm neutrophil inhibitors July 6, 1999
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comp
5886146 Inhibitors of thrombosis March 23, 1999
This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
5883107 Arginine mimic derivatives as enzyme inhibitors March 16, 1999
The present invention provides peptide aldehydes having an azetidinyl, prolyl or pipecolyl group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pharm
5883077 Inhibitors of factor Xa March 16, 1999
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The novel compounds include peptide aldehyde analogues having substantial potency and specificity as inhibitors of mammalian factor Xa are further disclosed. The c
5872098 Nematode-extracted anticoagulant protein February 16, 1999
Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
5869454 Arginine keto-amide enzyme inhibitors February 9, 1999
The present invention is directed to novel arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, described are me
5866543 Nematode-extracted anticoagulant protein February 2, 1999
Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
5866542 Nematode-extracted anticoagulant protein February 2, 1999
Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
5864009 Nematode-extracted anticoagulant protein January 26, 1999
Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
5863894 Nematode-extracted anticoagulant protein January 26, 1999
Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
5843442 Blood coagulation protein antagonists and uses therefor December 1, 1998
Coagulation protein antagonists are disclosed, which include monoclonal-type antibodies and related cell lines disclosed for the production of specific, neutralizing antibodies against factors VII and VIIa and the tissue factor/factor VIIa bimolecular complex, which antibodies are us
5807980 Bovine pancreatic trypsin inhibitor derived inhibitors of factor VIIa-tissue factor complex September 15, 1998
Compounds derived from BPTI which inhibit factor VIIa-TF complex with an inhibition constant of less than 500 nM, their pharmaceutical compositions, and methods of use. Also disclosed are isolated nucleic acid segments encoding for the compounds, vectors comprising the nucleic acid s
5789178 Neutrophil inhibitors August 4, 1998
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comp
5776927 Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors July 7, 1998
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mam
5770600 Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors June 23, 1998
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mam
5747449 Bovine pancreatic trypsin inhibitor derived inhibitors of factor XA May 5, 1998
A compound derived from BPTI which inhibits Factor Xa with an inhibition constant less than 50 nM.
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