| Patent Number |
Title Of Patent |
Date Issued |
| 5008240 |
Method of treating inflammation |
April 16, 1991 |
| Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or systemically, depending upon the indication, and does not require coadministration or activator or cofactor for efficacy. |
| 5001169 |
Inductive collagen-based bone repair preparations |
March 19, 1991 |
| A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with an carrier having a percentage of mineral carrier. The resulting implants are sufficiently hypoimmunogenic to be effective when implanted |
| 4992226 |
Method of making molds with xenogeneic collagen/mineral preparations for bone repair |
February 12, 1991 |
| A process for coating the pores of a mineral matrix with collagen by pumping collagen through the molded matrix is disclosed. The resulting coated matrix can be used as a prosthesis in bone repair. |
| 4971952 |
Method of treating inflammation with cartilage inducing factor |
November 20, 1990 |
| Inflammation, acute and/or chronic, is treated with a CIF (TGF-beta). The CIF may be administered locally or systemically, depending upon the indication, and does not require coadministration of activator or cofactor for efficacy. |
| 4959205 |
Composition and method for treatment of dermal inflammation |
September 25, 1990 |
| Mild dermal inflammation, such as mild eczema and seborrhea, is treated by daily application of a composition comprising 0.25%-0.5% hydrocortisone, a protective amount of a sunscreen agent, and a pharmaceutically acceptable carrier. |
| 4950483 |
Collagen wound healing matrices and process for their production |
August 21, 1990 |
| Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average p |
| 4888366 |
Inductive collagen-based bone repair preparations |
December 19, 1989 |
| An improved process for the preparation of mineral/collagen/OF (osteogenic factor) inductive implants for bone repair utilizes drying, under ambient pressure conditions, a suspension of 75-95% mineral particles, 5-25% collagen, and an effective amount of OF, such as 0.5-4% partially puri |
| 4865602 |
Gamma irradiation of collagen/mineral mixtures |
September 12, 1989 |
| A process for sterilization of collagen/mineral compositions using .gamma. radiation is conducted under conditions which produce a product of desired handling and biocompatibility properties. |
| 4863732 |
Injectable composition for inductive bone repair |
September 5, 1989 |
| Aqueous suspensions of fibrillar atelopeptide collagen and osteogenic factor are effective injectable preparations for the repair of bone defects. |
| 4843063 |
Polypeptide cartilage-inducing factors found in bone |
June 27, 1989 |
| Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 dalto |
| 4816442 |
Method of inhibiting tumor growth sensitive to CIF-.beta.treatment |
March 28, 1989 |
| Polypeptides called cartilage-inducing factors (CIFs) that are found in bone and have heretofore been identified as having in vitro cartilage-inducing activity. TGF-.beta. activity, and anti-inflammatory activity have now been found to possess potent oncostatic activity. The CIFs sho |
| 4810691 |
Polypeptide cartilage-inducing factors found in bone |
March 7, 1989 |
| Two proteins that are found is bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 dalto |
| 4806523 |
Method of treating inflammation |
February 21, 1989 |
| Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or symstemically, depending upon the indication, and does not require coadministraion of activator or cofactor for efficacy. |
| 4803075 |
Injectable implant composition having improved intrudability |
February 7, 1989 |
| Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue. |
| 4795467 |
Xenogeneic collagen/mineral preparations in bone repair |
January 3, 1989 |
| A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host b |
| 4789663 |
Methods of bone repair using collagen |
December 6, 1988 |
| A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen |
| 4776890 |
Preparation of collagen hydroxyapatite matrix for bone repair |
October 11, 1988 |
| An improved process for obtaining a matrix of mineral particles in reconstituted atelopeptide collagen comprises reconstituting a mixture of mineral particles with collagen in solution. This process results in a matrix of collagen containing the mineral particles which, when wetted, is |
| 4774322 |
Polypeptide cartilage-inducing factors found in bone |
September 27, 1988 |
| Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 dalto |
| 4774228 |
Polypeptide cartilage-inducing factors found in bone used in tissue proliferation |
September 27, 1988 |
| Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 dalto |
| 4774227 |
Collagen compositions for bone repair containing autogeneic marrow |
September 27, 1988 |
| A composition which combines autogenic bone marrow with a suspension of purified atelopeptide reconstituted collagen is used to repair bone defects in mammals. |
| 4760131 |
Wound-healing composition |
July 26, 1988 |
| A soft tissue wound healing composition comprising an aqueous mixture of fibrillar collagen, heparin, and undegranulated platelets or platelet releasate. The composition is applied topically to the wound site in conjunction with means to keep it at the site and hydrated or in the form |
| 4743229 |
Collagen/mineral mixing device and method |
May 10, 1988 |
| A mixing device for preparing inductive and conductive bone repair compositions is disclosed, along with a method for using the device for preparing such compositions. The device provides a simple and rapid method of making a substantially uniform collagen/mineral bone implant prepar |
| 4725671 |
Collagen membranes for medical use |
February 16, 1988 |
| Collagen membranes with desired properties are prepared by using a variety of gel-forming techniques in combination with methods for converting the gels to solid forms. The properties of these membranes or other solid forms may be further altered by cross-linking the collagen preparation |
| 4699186 |
Laser fill-level indicator for blank syringes |
October 13, 1987 |
| A device for indicating the proper fill level for unmarked syringes is disclosed. This device employs the intersection of a perpendicular defracted sheet of low power visible laser light with the barrel of the syringe being filled as the indication of the proper fill level. A method |
| 4689399 |
Collagen membranes for medical use |
August 25, 1987 |
| A process for preparing collagen membranes useful in tissue repair, and wound healing and related membranous implant materials useful in both hard and soft tissue applications is disclosed. The resulting membranes and materials have properties which can be varied as desired to suit inten |
| 4671794 |
Laryngeal injector |
June 9, 1987 |
| An injector is disclosed for administering fluids such as medications and tissue-augmenting suspensions of collagen to laryngeal tissues. The injector includes a needle, a hollow connector tube, and a syringe receiver into which syringes of collagen or a like low-viscosity fluid are |
| 4655980 |
Process of making collagen membranes for medical use |
April 7, 1987 |
| A process for preparing collagen membranes useful in tissue repair, and wound healing and related membranous implant materials useful in both hard and soft tissue applications is disclosed. The resulting membranes and materials have properties which can be varied as desired to suit inten |
| 4642117 |
Mechanically sheared collagen implant material and method |
February 10, 1987 |
| An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers. The material is prepared by passing reconstituted collagen fibers repeatedly through a rigid mesh screen, until a substantial reduction in fiber size and size-heterogeneity is |
| 4627982 |
Partially purified bone-inducing factor |
December 9, 1986 |
| A partially purified proteinaceous bone-inducing factor of 10,000 to 30,000 daltons is described. It is derived from demineralized bovine bone by extraction with a chaotropic agent, gel filtration, cation exchange chromatography using carboxymethyl cellulose at pH 4.8 and gradient el |
| 4600533 |
Collagen membranes for medical use |
July 15, 1986 |
| A process for preparing collagen membranes useful in tissue repair, and wound healing and related membranous implant materials useful in both hard and soft tissue applications is disclosed. The resulting membranes and materials have properties which can be varied as desired to suit inten |
| 4582640 |
Injectable cross-linked collagen implant material |
April 15, 1986 |
| Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in |
| 4563350 |
Inductive collagen based bone repair preparations |
January 7, 1986 |
| A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with an carrier having a percentage of non-fibrillar collagen. The resulting implants are sufficiently hypo-immunogenic to be effective when im |
| 4557764 |
Process for preparing malleable collagen and the product thereof |
December 10, 1985 |
| A collagen preparation having unique properties of elasticity and malleability which is associated with a microscopic structure having an intertwining rope-like characteristic, and a process for preparing same are disclosed. The collagen thus formed is the second nucleation product o |
| 4501306 |
Automatic syringe filling system |
February 26, 1985 |
| An automatic syringe filling system includes a pump for supplying liquid under pressure to a manifold that distributes the liquid to each of a plurality of syringes. Microswitches disposed at predetermined positions detect when the plunger of each syringe connected to the manifold has be |
| 4481001 |
Human skin model for intradermal injection demonstration or training |
November 6, 1984 |
| A skin model for use in demonstrating or practicing intradermal injection of fluids is disclosed. The model is a composite laminate of: (1) a subcutaneous tissue-simulating layer made of a foamed elastomer of low compression deflection and hardness; (2) a dermis-simulating layer of a |
| 4465478 |
Syringe force amplification device |
August 14, 1984 |
| A syringe assist device including a frame and moveable carriage that are respectively attached to a conventional syringe and its plunger. The frame has a toothed rack and the carriage contains a force amplifying gear and lever mechanism. A thumb ring transmits the force applied by the us |
| 4440750 |
Osteogenic composition and method |
April 3, 1984 |
| A plastic dispersion of demineralized bone powder and reconstituted native atelopeptide collagen fibers in a continuous aqueous phase having a substantially physiologic pH and ionic strength is used to repair or construct bone by injecting or implanting it at the repair or construction |
| 4434094 |
Partially purified osteogenic factor and process for preparing same from demineralized bone |
February 28, 1984 |
| A process for partially purifying an osteogenic factor from demineralized bone particles in which nonfibrous proteins are extracted from the demineralized bone with a dissociative extractant for nonfibrous proteins, such as urea or guanidine hydrochloride, the extracted nonfibrous protei |
| 4430760 |
Nonstress-bearing implantable bone prosthesis |
February 14, 1984 |
| A flexible, nonstress-bearing bone prosthesis is disclosed that comprises demineralized bone powder contained within a medical grade porous flexible casing made from polymeric fibers or a micro-porous membrane. The pores of the casing are smaller than the particle size of the bone powder |
| 4424208 |
Collagen implant material and method for augmenting soft tissue |
January 3, 1984 |
| An injectable implant material for soft tissue augmentation comprising a dispersion of (a) particles of cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen in a (c) physiological aqueous carrier. Implants of this material have improved persistence rela |
| 4288498 |
Method of making leather fiber insulation by drying-case hardening and product thereof |
September 8, 1981 |
| Chrome tanned leather scrap is converted into thermal insulation by shredding the tanned leather scrap into leather fibers, without damaging the structural fiber integrity, and case hardening the shredded leather fibers. The shredded leather fibers are case hardened by reducing the m |
| 4250139 |
Microwave sterilization of dry protein |
February 10, 1981 |
| Method for decontaminating proteinaceous host materials from microorganisms, while retaining chemical, physical and physiological properties of said host proteinaceous materials, said method comprising substantially dehydrating said host proteinaceous material, preferably by lyophili |
| 4233360 |
Non-antigenic collagen and articles of manufacture |
November 11, 1980 |
| Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS). The naturally occurring coll |
| 4140537 |
Aqueous collagen composition |
February 20, 1979 |
| The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or |
