| Patent Number |
Title Of Patent |
Date Issued |
| 5823671 |
Apparatus and method of mixing materials in a sterile environment |
October 20, 1998 |
| An apparatus for mixing a particulate material into a liquid includes a pair of variable volume receptacles interlinked by a communication passage. A combined volume of liquid and particulate material is received within the variable volumes, and the volume of the variable volumes is |
| 5807581 |
Collagen-based injectable drug delivery system and its use |
September 15, 1998 |
| Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. |
| 5800541 |
Collagen-synthetic polymer matrices prepared using a multiple step reaction |
September 1, 1998 |
| The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer |
| 5752974 |
Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
May 19, 1998 |
| Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, |
| 5744545 |
Biocompatible adhesive compositions |
April 28, 1998 |
| Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred comp |
| 5693341 |
Affinity bound collagen matrices for the delivery of biologically active agents |
December 2, 1997 |
| Affinity bound collagen matrices for the delivery of biologically active agents, and methods for preparing such matrices, are disclosed. A preferred method for preparing the matrices of the invention comprises mixing a binding ligand and an active agent together, allowing the resulti |
| 5667839 |
Human recombinant collagen in the milk of transgenic animals |
September 16, 1997 |
| Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected into fertilized oocytes and re |
| 5643464 |
Process for preparing a sterile, dry crosslinking agent |
July 1, 1997 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5616689 |
Method of controlling structure stability of collagen fibers produced form solutions or dispersi |
April 1, 1997 |
| In accordance with the present invention, stabilized dispersions of collagen fibers that have been treated in order to inactivate infectious agents and methods of stabilizing such collagen fibers are provided. |
| 5614587 |
Collagen-based bioadhesive compositions |
March 25, 1997 |
| Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred comp |
| 5580923 |
Anti-adhesion films and compositions for medical use |
December 3, 1996 |
| Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of |
| 5565519 |
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications |
October 15, 1996 |
| Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in |
| 5550188 |
Polymer conjugates ophthalmic devices comprising collagen-polymer conjugates |
August 27, 1996 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type |
| 5550187 |
Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
August 27, 1996 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5543441 |
Implants coated with collagen-polymer conjugates |
August 6, 1996 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5540657 |
Delivery device for injectable materials |
July 30, 1996 |
| The invention pertains to a delivery device for controlling the injection of discrete quantities of fluid injectable materials through a conduit such as a hypodermic needle or a catheter. The delivery device is coupled to a pressurized driving fluid source, and the control means provides |
| 5527856 |
Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
June 18, 1996 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5523348 |
Method of preparing collagen-polymer conjugates |
June 4, 1996 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5510418 |
Glycosaminoglycan-synthetic polymer conjugates |
April 23, 1996 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5476666 |
Glycosaminoglycan-synthetic polymer conjugates |
December 19, 1995 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5475052 |
Collagen-synthetic polymer matrices prepared using a multiple step reaction |
December 12, 1995 |
| The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer |
| 5470911 |
Glycosaminoglycan-synthetic polymer conjugates |
November 28, 1995 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5446091 |
Collagen-polymer conjugates containing an ether linkage |
August 29, 1995 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type |
| 5428024 |
High concentration homogenized collagen compositions |
June 27, 1995 |
| High concentration collagen compositions having improved persistence when administered for soft tissue augmentation are prepared from both cross-linked and non-cross-linked collagen starting materials. Suspensions of the starting materials are subjected to vigorous mechanical disruption |
| 5428022 |
Composition of low type III content human placental collagen |
June 27, 1995 |
| A human placental collagen composition for use in soft tissue augmentation comprising an aqueous suspension of a homogenized nonirradiation-sterilized mixture of type I and type III human placental collagen, wherein the type III collagen constitutes less than about 10% by weight of t |
| 5425770 |
Calcium phosphate/atelopeptide collagen compositions for bone repair |
June 20, 1995 |
| Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted |
| 5413791 |
Collagen-polymer conjugates |
May 9, 1995 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type |
| 5383930 |
Method for treating fine superficial facial lines |
January 24, 1995 |
| A device for correcting fine superficial facial lines which comprises a syringe fitted with a 31-33 gauge needle and an aqueous suspension of noncrosslinked fibrillar atelopeptide collagen contained within the syringe barrel, the concentration of collagen in the suspension being in t |
| 5376375 |
Method of augmenting tissue using collagen-polymer conjugates |
December 27, 1994 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5366498 |
Device for treating fine superficial facial lines |
November 22, 1994 |
| A device for correcting fine superficial facial lines which comprises a syringe fitted with a 31-33 gauge needle and an aqueous suspension of noncrosslinked fibrillar atelopeptide collagen contained within the syringe barrel, the concentration of collagen in the suspension being in t |
| 5352715 |
Injectable ceramic compositions and methods for their preparation and use |
October 4, 1994 |
| Injectable implant compositions comprise a biocompatible ceramic matrix present in a fluid carrier, where the ceramic matrix comprises particles having a size distribution in the range from 50 .mu.m to 250 .mu.m. Optionally, the compositions may further comprise collagen, where the r |
| 5328955 |
Collagen-polymer conjugates |
July 12, 1994 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type |
| 5324775 |
Biologically inert, biocompatible-polymer conjugates |
June 28, 1994 |
| Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthet |
| 5308889 |
Dehydrated collagen-polymer strings |
May 3, 1994 |
| Medical articles in the form of strings are formed by covalently binding collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugate formulations which are extruded to make the strings. The collagen may be |
| 5306500 |
Method of augmenting tissue with collagen-polymer conjugates |
April 26, 1994 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5304595 |
Collagen-polymer conjugates |
April 19, 1994 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5292802 |
Collagen-polymer tubes for use in vascular surgery |
March 8, 1994 |
| Medical articles in the form of tubes are formed by covalently binding collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugate formulations which are used to make the tubes. The collagen may be reco |
| 5264214 |
Composition for bone repair |
November 23, 1993 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5258029 |
Method for improving implant fixation |
November 2, 1993 |
| Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optiona |
| 5246457 |
Xenogeneic collagen/mineral preparations in bone repair |
September 21, 1993 |
| A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bo |
| 5219576 |
Collagen wound healing matrices and process for their production |
June 15, 1993 |
| Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average p |
| 5207710 |
Method for improving implant fixation |
May 4, 1993 |
| Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optiona |
| 5204382 |
Injectable ceramic compositions and methods for their preparation and use |
April 20, 1993 |
| Injectable implant compositions comprise a biocompatible ceramic matrix present in a fluid carrier, where the ceramic matrix comprises particles having a size distribution in the range from 50 .mu.m to 250 .mu.m. Optionally, the compositions may further comprise collagen, where the r |
| 5162430 |
Collagen-polymer conjugates |
November 10, 1992 |
| Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer. |
| 5123925 |
Gamma irradiation of collagen/mineral mixtures |
June 23, 1992 |
| The present invention is a method for treating bony defects. The method involves contacting the bony defect with a formable composition and allowing the formable composition to solidify. The formable composition is comprised of 2-40% of reconstituted fibrillar atelopeptide collagen and |
| 5110604 |
Processes for producing collagen matrixes and methods of using same |
May 5, 1992 |
| Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average p |
| 5108436 |
Implant fixation |
April 28, 1992 |
| Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optiona |
| 5071351 |
Dental implant system |
December 10, 1991 |
| The dental implant system of the present invention has a decreased surface contact angle and includes a biocompatible titanium implant which has been treated by the plasma cleaning and sterilization process of the present invention.An implant that has experienced plasma cleaning and ster |
| 5035715 |
Gamma irradiation of collagen/mineral mixtures |
July 30, 1991 |
| A biocompatible collagen/mineral composition which comprises a mixture of 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight, exclusive of water, is disclosed. The composition has a sterility assurance factor of at least as low as 10.su |
| 5024841 |
Collagen wound healing matrices and process for their production |
June 18, 1991 |
| Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm.sup.3 and a pore population in which at least about 80% of the pores have an average p |
