| Patent Number |
Title Of Patent |
Date Issued |
| 7442522 |
Nucleic acids encoding chromo or fluorescent proteins and method for using the same |
October 28, 2008 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins |
| 7442521 |
Nucleic acids encoding chromophores/fluorophores and methods for using the same |
October 28, 2008 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins |
| 7354721 |
Highly sensitive proteomic analysis methods, and kits and systems for practicing the same |
April 8, 2008 |
| Methods of determining whether a sample includes one or more analytes, particularly proteinaceous analytes, of interest are provided. In the subject methods, an array of binding agents, where each binding agent includes an epitope binding domain of an antibody, is contacted with the |
| 7344862 |
Nucleic acids encoding chromophores/fluorophores and methods for using the same |
March 18, 2008 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins |
| 7338785 |
Nucleic acids encoding chromophores/fluorophores and methods for using the same |
March 4, 2008 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins |
| 7338784 |
Nucleic acids encoding chromophores/fluorophores and methods for using the same |
March 4, 2008 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins |
| 7338783 |
Nucleic acids encoding chromophores/fluorophores and methods for using the same |
March 4, 2008 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins |
| 7338782 |
Nucleic acids encoding chromophores/fluorophores and methods for using the same |
March 4, 2008 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins |
| 7297782 |
Chromophores/fluorophores and methods for using the same |
November 20, 2007 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded the same, are provided. The proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of |
| 7294614 |
Phosphoprotein affinity resins and methods for making and using the same |
November 13, 2007 |
| Phosphorylated protein (i.e., phosphoprotein) affinity resins and methods for making and using the same are provided. The subject resins include a substrate bonded to aspartate-based tetradentate ligand/metal ion complexes, where the tetradentate ligand/metal ion complexes have high |
| 7258981 |
Sensitive proteasome sensor constructs and methods for their design and use |
August 21, 2007 |
| Provided are means and methods for sensing proteasome activity and other degradation pathways with a high level of sensitivity. |
| 7217789 |
Fluorescent timer proteins and methods for their use |
May 15, 2007 |
| Fluorescent timer proteins, which undergo a spectral shift over time after synthesis, as well as nucleic acid compositions encoding the same, are provided. Also provided are fragments of the subject proteins and nucleic acids encoding the same, as well as antibodies to the subject protei |
| 7193041 |
Method for purification of recombinant proteins |
March 20, 2007 |
| Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2.sup.+ and a coordination number of 6. A method for synthesizing the metal ion- |
| 7183399 |
Nucleic acids encoding linked chromo/fluorescent domains and methods for using the same |
February 27, 2007 |
| Nucleic acid compositions encoding polypeptide products having at least two linked chromo/fluorescent domains, as well as the proteins encoded by the same, are provided. Also provided are the polypeptides encoded by the subject nucleic acids, as well as antibodies to the subject proteins |
| 7179644 |
Recombinase-based methods for producing expression vectors and compositions for use in practicin |
February 20, 2007 |
| Methods are provided for producing an expression vector. In the subject methods, donor and acceptor vectors are combined in the presence of a recombinase to produce an expression vector that includes a first and second recombinase recognition site oriented in the same direction, wher |
| 7176298 |
Polynucleotides encoding metal ion affinity peptides and related products |
February 13, 2007 |
| The present invention provides metal ion affinity peptides, fusion proteins comprising metal ion affinity peptides, and polynucleotides encoding the fusion proteins. A feature of the subject invention is that the metal ion affinity peptide has a formula selected from the group consis |
| 7166444 |
Nucleic acids encoding chromophores/fluorophores and methods for using the same |
January 23, 2007 |
| Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the encoded proteins, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of |
| 7157565 |
Far red shifted fluorescent proteins |
January 2, 2007 |
| Nucleic acid compositions encoding Stichodactylidaen chromoproteins and fluorescent mutants thereof. The proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. Also of interest are |
| 7150979 |
Nucleic acids encoding non-aggregating fluorescent proteins and methods for using the same |
December 19, 2006 |
| Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the encoded proteins, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the non-aggregating feature arises |
| 7041445 |
Long oligonucleotide arrays |
May 9, 2006 |
| Long oligonucleotide arrays, as well as methods for their preparation and use in hybridization assays, are provided. The subject arrays are characterized in that at least a portion of the probes of the array, and usually all of the probes of the array, are long oligonucleotides, e.g. |
| 6977165 |
Sequence specific recombinase-based methods for producing intron containing vectors and composit |
December 20, 2005 |
| Methods are provided for producing a vector that includes at least one splicable intron. In the subject methods, intron containing vectors are produced from donor and acceptor vectors that each include a site specific recombinase site, where the subject donor and acceptor vectors further |
| 6969597 |
Nucleic acids encoding non aggregating fluorescent proteins and methods for using the same |
November 29, 2005 |
| Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the encoded proteins, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the non-aggregating feature arises fr |
| 6956112 |
Rapidly degrading GFP-fusion proteins and methods of use |
October 18, 2005 |
| Green fluorescent protein (GFP) is widely used as a reporter in determining gene expression and protein localization. The present invention provides fusion proteins with a half life of ten hours or less with several embodiments having half lives of 4 hours or less. Such proteins may be |
| 6703498 |
Water-soluble polymeric metal ion affinity compositions and methods for using the same |
March 9, 2004 |
| Water-soluble metal ion affinity compounds and methods for using the same are provided. The subject compounds include an aspartate based metal chelating ligand bonded to a water-soluble polymeric substrate, where the ligand is complexed with a metal ion. In certain embodiments, the subje |
| 6489455 |
Methods of assaying differential expression |
December 3, 2002 |
| Methods and compositions are provided for analyzing differences in the RNA profiles between a plurality of different physiological samples. In the subject methods, a set of a representational number of distinct gene specific primers is used to generate labeled nucleic acids from each of |
| 6489159 |
Polymeric arrays and methods for their use in binding assays |
December 3, 2002 |
| Arrays of a plurality of different heterogeneous polymeric target compositions immobilized on the surface of a solid support are provided. In the subject arrays, the constituent polymeric targets of the heterogeneous target compositions are generally biopolymeric compounds, e.g., nuc |
| 6475440 |
Applicator for use in deposition of fluid samples onto a substrate surface |
November 5, 2002 |
| Applicator devices for depositing a fluid sample onto a substrate, as well as methods for their use, are provided. The subject devices are elongate in shape and have a first end and a second end. The first end has a planar surface of substantially circular shape with a conical protuberan |
| 6410317 |
Recombinase-based methods for producing expression vectors and compositions for use in practicin |
June 25, 2002 |
| Methods are provided for producing an expression vector. In the subject methods, donor and acceptor vectors are combined in the presence of a recombinase to produce an expression vector that includes a first and second recombinase recognition site oriented in the same direction, wher |
| 6383755 |
Methods and kits for determining the fidelity of polymerase chain reaction conditions |
May 7, 2002 |
| Methods are provided for evaluating the fidelity of a given set of polymerase chain reaction conditions. In the subject methods, a template polydeoxyribonucleotide is amplified under the to be evaluated polymerase chain reaction conditions, where the template polydeoxyribonucleotide |
| 6383749 |
Methods of labeling nucleic acids for use in array based hybridization assays |
May 7, 2002 |
| Methods and kits are provided for labeling nucleic acids, e.g. for use in array based hybridization assays. In the subject methods, target nucleic acid is generated from an initial nucleic acid source, e.g. mRNA, where the target nucleic acid is characterized by having at least one react |
| 6352829 |
Methods of assaying differential expression |
March 5, 2002 |
| Methods and compositions are provided for analyzing differences in the RNA profiles between a plurality of different physiological samples. In the subject methods, a set of a representational number of distinct gene specific primers is used to generate labeled nucleic acids from each of |
| 6306600 |
Rapidly degrading GFP-fusion proteins and methods of use |
October 23, 2001 |
| Green fluorescent protein (GFP) is widely used as a reporter in determining gene expression and protein localization. The present invention provides fusion proteins with a half life of ten hours or less with several embodiments having half lives of 4 hours or less. Such proteins may be |
| 6300073 |
One step RT-PCR methods, enzyme mixes and kits for use in practicing the same |
October 9, 2001 |
| Enzyme compositions, kits comprising the same and methods for their use in one-step RT-PCR are provided. The subject enzyme compositions at least include a mutant thermostable DNA polymerase and a mutant reverse transcriptase. In preferred embodiments, the mutant thermostable DNA pol |
| 6287768 |
Polymeric arrays and methods for their use in binding assays |
September 11, 2001 |
| Arrays of polymeric targets stably associated with the surface of a rigid solid support are provided. In the subject arrays, the polymeric targets are arranged at least according to size. The polymeric targets of the subject arrays are generally biopolymeric compounds, e.g. nucleic acids |
| 6242581 |
Method for purification of recombinant proteins |
June 5, 2001 |
| Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2.sup.+ and a coordination number of 6. A method for synthesizing the metal ion-CM-A |
| 6159727 |
Hybridization chamber |
December 12, 2000 |
| Hybridization chambers suitable for use in binding, e.g. hybridization, assays are provided. The subject chambers comprise an elongate container, a block element and a cap, where each of the components is preferably injection molded. Also provided are methods of using the subject chamber |
| 6130313 |
Rapidly degrading GFP-fusion proteins |
October 10, 2000 |
| Green fluorescent protein (GFP) is widely used as a reporter in determining gene expression and protein localization. The present invention provides fusion proteins with a half life of ten hours or less. Such proteins may be constructed by fusing C-terminal amino acids of the degradation |
| 6130045 |
Thermostable polymerase |
October 10, 2000 |
| A thermostable enzyme having polymerase activity and substantially no nuclease activity is provided. The thermostable enzyme is characterized by comprising a sequence of nine amino acid residues at least proximal to the N-terminus that has less than 50% but greater than 40% amino acid se |
| 6093808 |
I.kappa.BEGFP constructs, cell lines and methods of use |
July 25, 2000 |
| The present invention provides fusion protein comprising I.kappa.B and green fluorescent protein. Also provided is DNA encoding this protein and vector expressing such DNA and various methods of using a fusion protein comprising I.kappa.B and green fluorescent protein. |
| 6087102 |
Polymeric arrays and methods for their use in binding assays |
July 11, 2000 |
| Arrays of polymeric targets stably associated with the surface of a rigid solid support are provided. In the subject arrays, the polymeric targets are arranged at least according to size. The polymeric targets of the subject arrays are generally biopolymeric compounds, e.g. nucleic acids |
| 6077673 |
Mouse arrays and kits comprising the same |
June 20, 2000 |
| Mouse arrays and methods for their use are provided. The subject arrays include a plurality of polynucleotide spots, each of which is made up of a polynucleotide probe composition of unique polynucleotides corresponding to a key mouse gene. The subject arrays find use in hybridization as |
| 6037133 |
I.kappa.BEGFP constructs, cell lines and methods of use |
March 14, 2000 |
| The present invention provides fusion protein comprising I.kappa.B and green fluorescent protein. Also provided is DNA encoding this protein and vector expressing such DNA and various methods of using a fusion protein comprising I.kappa.B and green fluorescent protein. |
| 5994076 |
Methods of assaying differential expression |
November 30, 1999 |
| Methods and compositions are provided for analyzing differences in the RNA profiles between a plurality of different physiological samples. In the subject methods, a set of a representational number of distinct gene specific primers is used to generate labeled nucleic acids from each of |
| 5989872 |
Methods and compositions for transferring DNA sequence information among vectors |
November 23, 1999 |
| Methods and compositions are provided for transferring DNA sequence information from a first vector to a second vector. In the subject methods, a first vector comprising a region of DNA having a sequence of interest is contacted with a set of three pairs of oligonucleotide primers un |
| 5976842 |
Methods and compositions for use in high fidelity polymerase chain reaction |
November 2, 1999 |
| Methods and compositions are provided for performing high fidelity polymerase chain reactions. In the subject methods, primer extension products are produced with a low error frequency rate through the use of at least one of unequal concentrations of dNTPs or a melting point reducing |
| 5962641 |
Method for purification of recombinant proteins |
October 5, 1999 |
| Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2.sup.+ and a coordination number of 6. A method for synthesizing the metal ion-CM- |
| 5962272 |
Methods and compositions for full-length cDNA Cloning using a template-switching oligonucleotide |
October 5, 1999 |
| The present invention pertains to methods for the synthesis and cloning of full-length cDNA, or cDNA fragments, that correspond to the complete sequence of 5'-ends of mRNA molecules. The method of the present invention comprises contacting RNA with a cDNA synthesis primer which can annea |
| 5942610 |
Non-nucleoside 1,3-diol reagents and their use to label or modify synthetic oligonucleotides |
August 24, 1999 |
| The subject invention concerns novel reagents and methods useful for introducing functional groups and labels at multiple sites of a nucleotide. The reagents are useful, for example, in constructing labeled oligonucleotide hybridization probes for detecting the presence of a target p |
| 5759822 |
Method for suppressing DNA fragment amplification during PCR |
June 2, 1998 |
| The subject invention pertains to novel materials and methods for suppressing amplification of particular DNA fragments during polymerase chain reaction (PCR). The PCR suppression method uses novel adapters that are ligated to the end of a DNA fragment prior to PCR amplification. Upon |
| 5663316 |
BBC6 gene for regulation of cell death |
September 2, 1997 |
| The subject invention provides new proteins which are involved in the regulation of cell death. Also provided are nucleotide sequences which encode the novel proteins. Further aspects of the invention include antibodies to the novel proteins, and diagnostic and therapeutic methods. |
