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Chiron Corporation Patents
Assignee:
Chiron Corporation
Address:
Emeryville, CA
No. of patents:
671
Patents:


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Patent Number Title Of Patent Date Issued
RE39708 Estrogen receptor modulators June 26, 2007
Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor ac
RE37343 Expression and secretion of heterologous proteins in yeast employing truncated alpha-factor lead August 28, 2001
A yeast .alpha.-factor expression system is provided comprised of a truncated leader sequence, containing the .alpha.-factor signal peptide and one glycosylation site, linked by a processing site to a non-yeast protein-encoding sequence.
RE35749 Constructs of glyceraldehyde-3-phosphate dehydrogenase promoter and methods for expressing genes March 17, 1998
Yeast promoters of glycolytic enzymes are modified by isolating a fragment encompassing the RNA polymerase binding site and joining to the 5' end of this fragment a DNA sequence providing for enhanced inducible or constitutive transcription of a structural gene. Constructs are prepared
D389572 Eight vaned crown for a solid-phase reaction support pin January 20, 1998
8114830 Polypeptoid pulmonary surfactants February 14, 2012
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs.
7705117 EGFH2 genes and gene products April 27, 2010
This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
7423148 Small molecule PI 3-kinase inhibitors and methods of their use September 9, 2008
Compounds having formula I are provided where the variables have the values described herein. ##STR00001## Pharmaceutical formulations include the compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and combinations with other agents. A me
7368459 Heterocyclic compounds May 6, 2008
Organic compounds having the structural formula I are provided where the variables have the values described herein and R.sup.1 and R.sup.2 join together to form a 6 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group. #
7368453 Quinazolinone compounds with reduced bioaccumulation May 6, 2008
A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the formula IA and IB. IA and IB have the following structures
7361484 GSK3 polypeptides April 22, 2008
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3.alpha. and GSK3.beta. polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid tha
7345046 Heteroaryl-fused pyrimidinyl compounds as anticancer agents March 18, 2008
Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at least one additional
7338935 Chromatographic separation of therapeutic polypeptides March 4, 2008
The present invention is directed to the purification and commercialization of therapeutic polypeptides that have. In one aspect of the invention, a method of purifying Interferon .beta.-1b using size exclusion chromatography is provided. In another aspect of the invention, a method
7329741 Polynucleotides that hybridize to DP-75 and their use February 12, 2008
The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic assays, expression vectors, control sequences, antisense molecules, ribozymes, and host
7326711 Pyridino[1,2-a]pyrimidin-4-one compounds as anticancer agents February 5, 2008
Pyridin[1,2-a]pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the pyridino[1,2-a]pyrimidinyl compounds, either alone or in combination with at least one additional thera
7291725 Sos1 inhibitors November 6, 2007
Inhibitors of human Sos1, including antisense oligonucleotides, methods, and compositions specific for human Sos1, are provided. Methods of using the compositions for modulating Sos1 expression and for regulating cell growth, particularly tumor cell growth, are also provided.
7285539 Activation of HCV-specific T cells October 23, 2007
The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4.sup.+ and CD8.sup.+ T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a, and NS5b polypeptides, polynucleotides encoding such fusion prote
7279554 Notch receptor ligands and uses thereof October 9, 2007
The invention provides polynucleotides encoding Notch receptor ligands, encoded polypeptides, and antibodies specific to the polypeptides. Also provided are methods and compositions for enhancing or inhibiting angiogenesis as well as modulating immune responses.
7279307 Metastatic breast and colon cancer regulated genes October 9, 2007
Gene sequences as shown in SEQ ID NO:1-18 have been discovered and isolated, and found to be significantly associated with metastatic spread of breast and colon cancer cells to other organs. Methods are provided for determining the risk of metastasis of a breast or colon tumor, which
7276587 Antibodies to EGFH2 polypeptides October 2, 2007
This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
7273618 Method for administering agents to the central nervous system September 25, 2007
The present invention is directed to a method for delivering agents to the central nervous system by way of a tissue innervated by the trigeminal nerve that is outside the nasal cavity. Such a method of delivery can be useful in the treatment of central nervous system and/or brain disord
7265089 KGF polypeptide compositions September 4, 2007
Compositions comprising keratinocyte growth factor (KGF) polypeptides and methods of using the same are described. The KGF polypeptides of the present invention display enhanced bioactivity relative to full-length KGF.sub.163. Accordingly, the KGF polypeptides of the present invention
7262168 Compositions providing for increased IGF-I solubility August 28, 2007
Novel IGF-I compositions are described. The compositions include a solubilizing compound comprising a guanidinium group that provides for IGF-I compositions in which IGF-I is highly soluble at pHs of about 5.5 or greater and at refrigerated temperatures.
7259248 Human FGF-21 polypeptides August 21, 2007
This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to met
7250443 Pyrrole based inhibitors of glycogen synthase kinase 3 July 31, 2007
New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination
7250256 Human cyclin-dependent kinase (hPNQALRE) July 31, 2007
A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.
7247452 Truncated keratinocyte growth factor (KGF) having increased biological activity July 24, 2007
The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mi
7211659 Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof May 1, 2007
The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV
7199226 Antibodies to EGFH2 polypeptides April 3, 2007
This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
7198899 Use of NRG4, or inhibitors thereof, in the treatment of colon and pancreatic cancers April 3, 2007
This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and pancreatic cancer. This invention also relates to therapeutic agents based on or derived f
7195886 GSK3 polypeptides March 27, 2007
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3.alpha. and GSK3.beta. polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid tha
7193042 Methods for purifying authentic IGF from yeast hosts March 20, 2007
Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a variety of yeast strains.
7189727 Guanidino compounds March 13, 2007
Compounds having the general structure III are provided: ##STR00001## where D is N or C; W is selected from ##STR00002## Z.sup.1, Z.sup.2, and Z.sup.3 are independently selected from CR.sup.8 and N; and the other variables have the values described herein. Compounds of formula III have
7186530 Protein associated with cell stress response March 6, 2007
A stress-phosphorylated endoplasmic reticulum protein, Nogo B, is provided. The protein is hyperphosphorylated as a result of exposure of cells to stress. Two transcripts of Nogo B are identified in human tissues, and the longer transcript is predominant in human brain tumor samples.
7186407 Methods and compositions for the treatment of peripheral artery disease March 6, 2007
Compositions and methods for treating peripheral artery disease in a patient are provided. Compositions comprise recombinant fibroblast growth factor-2. Fibroblast growth factor, such as FGF-2, is administered in therapeutically effective amounts to treat or prevent peripheral artery
7167819 Method of determining the three-dimensional shape of a macromolecule January 23, 2007
The present invention provides a fast and efficient method for determining the three-dimensional conformation of a protein. The steps of the method of the invention include: 1) formation of physical distance constraints, e.g., forming intramolecular chemical crosslinks of known size betw
7166446 Method for expression of heterologous proteins in yeast January 23, 2007
Compositions and methods for expression of heterologous mammalian proteins and their secretion in the biologically active mature form using a yeast host cell as the expression system are provided. Compositions of the invention are nucleotide sequences encoding a signal peptide sequence f
7163924 Ketolide derivatives January 16, 2007
Antimicrobial ketolide compounds are provided having the formula (A): ##STR00001## as well as pharmaceutically acceptable salts, esters or prodrugs thereof, pharmaceutical compositions comprising such compounds, methods of treating bacterial infections by the administration of such
7153682 Microarrays on mirrored substrates for performing proteomic analyses December 26, 2006
Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The invention contemplates peptidomimetic array element library
7148058 Protein microarrays on mirrored surfaces for performing proteomic analyses December 12, 2006
Provided are protein microarrays, their manufacture, use, and application. Protein microarrays in accordance with the present invention are useful in a variety preoteomic analyses. Various protein arrays in accordance with the present invention may immobilize large arrays of proteins tha
7138497 Biosynthetic binding proteins for immuno-targeting November 21, 2006
Disclosed is a formulation for targeting an epitope on an antigen expressed in a mammal. The formulation comprises a pharmaceutically acceptable carrier together with a dimeric biosynthetic construct for binding at least one preselected antigen. The biosynthetic construct contains tw
7138409 Heterocyclic compounds November 21, 2006
Organic compounds having the structural formula I are provided where the variables have the values described herein and R.sup.1 and R.sup.2 join together to form a 6 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group. #
7135321 GSK3 polypeptides November 14, 2006
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3.alpha. and GSK3.beta. polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid tha
7112560 Angiogenically effective unit dose of FGF-2 and method of use September 26, 2006
The present invention has multiple aspects. In particular, in one aspect, the present invention is directed to a unit dose composition comprising 0.2 .mu.g/kg to 48 .mu.g/kg of an FGF-2 of SEQ ID NO: 2, or an angiogenically active fragment or mutein thereof in a pharmaceutically acce
7112330 Method for producing yeast expressed HPV types 6 and 16 capsid proteins September 26, 2006
Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the prod
7094752 Peptide ligands of the urokinase receptor August 22, 2006
Novel peptides that are capable of binding to uPAR and inhibiting the binding of an integrin and vitronectin are described. Also provided are nucleic acid sequences encoding the novel peptides. Methods for screening for small molecules, other peptides, or peptoids that mimic the anta
7084262 Analysis and separation of platelet-derived growth factor proteins August 1, 2006
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of these proteins is achieved using TSK sulfopropyl cation exchange chromatography and reverse
7084119 Truncated keratinocyte growth factor (KGF) having increased biological activity August 1, 2006
The present invention relates to a keratinocyte growth factor fragment, KGF.sub.des1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF.sub.163. The fragment exhibits at least a 2-fold increase in mi
7081517 Genes differentially expressed in breast cancer July 25, 2006
A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypepti
7071313 Methods of purifying authentic IGF from yeast hosts July 4, 2006
Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a variety of yeast strains.
7071216 Substituted benz-azoles and methods of their use as inhibitors of Raf kinase July 4, 2006
New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinas
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