| Patent Number |
Title Of Patent |
Date Issued |
| RE37947 |
Aromatic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof |
December 31, 2002 |
| Novel pharmaceutically/cosmetically-active aromatic polyenic compounds have the structural formula (I): ##STR1##and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone |
| 6515021 |
Bicyclic aromatic compounds |
February 4, 2003 |
| The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1##as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and |
| 6506796 |
Use of a RAR-.gamma.-specific agonist ligand for increasing the rate of apoptosis |
January 14, 2003 |
| Methods of cosmetically or therapeutically treating diseases or disorders in cell populations whose pathology is linked to an inadequate rate of apoptosis by administering a therapeutically effective amount of 6-3-(1-adamantyl)-4-hydroxyphenyl)-2-naphthanoic acid. |
| 6258775 |
Bi-aromatic compounds, pharmaceutical and cosmetic compositions containing same and uses |
July 10, 2001 |
| The invention relates to novel biaromatic compounds having general formula I ##STR1##and their use in pharmaceutical compositions for use in human and veterinary medicine, in particular for treating dermatological, rheumatic, respiratory, cardiovascular, and ophthalmological disorder |
| 6248791 |
Stimulating the differentiation of preadipocytic cells and therapies based thereon |
June 19, 2001 |
| The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulate |
| 6248749 |
Use of inhibitors of the activity of retinoic acid for treating sensit ive skin and/or acute dam |
June 19, 2001 |
| The invention concerns tye use of a inhibitor of retinoic acid as sole ingredient in a pharmaceutical or cosmetic composition comprising administering effective amount of the composition to treat sensitive skin or skin damage induced by UV radiation. |
| 6211239 |
Method for treating or preventing breast cancer or leukemia using 6-[3-[1-adamantyl]-4-hydroxyph |
April 3, 2001 |
| Methods for treating or preventing breast cancer or leukemia in subjects in need of such treatment are provided which involve the administration of 6-[3-[1-adamantyl]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN), a retinoid which induces G.sub.0 /G.sub.1 arrest and apoptosis. Th |
| 6194450 |
Polyaromatic heterocyclic compounds and pharmaceutical compositions comprised thereof |
February 27, 2001 |
| Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1##in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following structural formula (II): ##STR2##or |
| 6171603 |
Bioaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof |
January 9, 2001 |
| Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1##in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2##and are useful for the treatment of a wide variety of disease states, wheth |
| 6162815 |
RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said |
December 19, 2000 |
| Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## which are useful for the treatment of a wide variety of disease states, whether human or v |
| 6162445 |
Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof |
December 19, 2000 |
| Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheum |
| 6156788 |
Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof |
December 5, 2000 |
| Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veter |
| 6156750 |
Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof |
December 5, 2000 |
| Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular a |
| 6147255 |
Bicyclic-aromatic compounds |
November 14, 2000 |
| The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular |
| 6057341 |
Bi-aromatic dibenzofuran derivatives and their use in human and veterinary medicine and in cosme |
May 2, 2000 |
| The invention concerns novel bi-aromatic dibenzofuran derivatives of formula (I),and their use in pharmaceutical compositions for human or veterinary medicine (skin, rheumatic respiratory, cardiovascular, and ophthalmologic disorders), or in cosmetic compositions as well. The X, Ar, |
| 6046220 |
Propynyl or dienyl biaromatic compounds |
April 4, 2000 |
| The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I) ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, car |
| 6015569 |
Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof |
January 18, 2000 |
| Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veter |
| 6004987 |
Use of ligands which are specific for RXR receptors |
December 21, 1999 |
| The present invention relates to the use of at least one ligand which is specific for RXR receptors, in the preparation of a pharmaceutical composition to be administered systemically and intended to increase the cellular proliferation and/or differentiation modulatory activity of a |
| 5985928 |
Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof |
November 16, 1999 |
| Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular a |
| 5981776 |
Heterocyclic biaryl compounds, pharmaceutical and cosmetic compositions containing them and uses |
November 9, 1999 |
| The invention relates to novel heterocyclic biaryl compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascul |
| 5973007 |
Use of inhibitors of retinoic acid activity for wound healing |
October 26, 1999 |
| A method for promoting healing by administration of an inhibitor of the activity of retinoic acid is provided. Preferred compounds for use in such treatment include antagonists of retinoic acid. The method is particularly applicable for promoting skin healing and treatment of surgical an |
| 5952382 |
Adamantyl-substituted retinoids and pharmaceutical/cosmetic compositions comprised thereof |
September 14, 1999 |
| Pharmaceutically/cosmetically-active adamantyl-substituted retinoid compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formula (a) - (d): ##STR2## and are useful for the treatment of disorders and/or ailments manifesting an overregul |
| 5939083 |
Nongreasy/nonsticky fatty cosmetic/dermatological compositions |
August 17, 1999 |
| Nongreasy, nonsticky cosmetic and/or dermatological compositions for topical application to human skin and/or hair, characteristically without imparting a shiny appearance thereto, contain at least one fatty substance and an amount of deformable hollow particulates effective to avoid the |
| 5935585 |
Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof |
August 10, 1999 |
| Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, |
| 5910508 |
Polycyclic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof |
June 8, 1999 |
| Novel pharmaceutically/cosmetically-active polycyclic polyenic compounds have the structural formula (I): ##STR1## and are useful for modulating cellular hormone receptors. |
| 5905088 |
Heterocyclic biaryl compounds and pharmaceutical/cosmetic compositions comprised thereof |
May 18, 1999 |
| Novel pharmaceutically/cosmetically-active heterocyclic biaryl compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(h): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veter |
| 5869067 |
Bi-aromatic compounds and pharmaceutical and cosmetic compositions |
February 9, 1999 |
| The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions. |
| 5863544 |
Cosmetic/dermatological w/o emulsions highly concentrated in hydroxy acids |
January 26, 1999 |
| Topically applicable cosmetic/dermatological compositions well suited for the therapeutic treatment or care of human skin, nails, hair and/or of the scalp, in particular for treating and/or preventing xerosis, ichthyosis, actinic keratosis and/or photoinduced cutaneous aging, comprise a |
| 5854292 |
Stimulating the differentiation of preadipocytic cells and therapies based thereon |
December 29, 1998 |
| The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulate |
| 5849798 |
Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof |
December 15, 1998 |
| Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following structural formula (II): ##STR |
| 5849776 |
Medicaments based on metronidazole or on a synergic mixture of metronidazole and clindamycin |
December 15, 1998 |
| The invention relates to the use of metronidazole, or preferably of a combination of metronidazole and clindamycin, as active principle for the manufacture of pharmaceutical compositions, more particularly dermatological compositions, intended for an anti-inflammatory treatment by th |
| 5827897 |
Stimulating the differentiation of predipocytic cells and therapies based thereon |
October 27, 1998 |
| The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulate |
| 5827500 |
Process for identifying RAR-receptor-antagonist compounds |
October 27, 1998 |
| The present invention relates to a process for identifying RAR-antagonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of an RAR-agonist molecule is applied topically to a part of the skin of a mammal, (ii) a molecule capable of having an |
| 5798354 |
Use of adamantyl-substituted polycyclic acetylene compounds in skin and hair treatment |
August 25, 1998 |
| Novel pharmaceutically/cosmetically-active adamantyl-substituted polycyclic acetylene compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(f): ##STR2## and are useful for the treatment of a wide variety of disease states, |
| 5786379 |
Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised th |
July 28, 1998 |
| Novel pharmaceutically/cosmetically-active adamantyl-substituted biaromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a')-(f'): ##STR2## and are useful for the treatment of a wide variety of disease states, whether |
| 5767148 |
Synergistic therapeutic compositions comprising at least one ligand specific for RXRs at least o |
June 16, 1998 |
| Pharmaceutical/dermatological compositions comprising (a) at least one first ligand displaying selective activity for the RXR receptors and (b) at least one second ligand displaying selective activity for the RAR-.alpha. receptor, are useful for modulating the proliferation and/or di |
| 5766610 |
Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof |
June 16, 1998 |
| Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veter |
| 5763487 |
Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof |
June 9, 1998 |
| Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular a |
| 5747530 |
Aromatic dibenzofuran compounds and pharmaceutical/cosmetic compositions comprised thereof |
May 5, 1998 |
| Novel pharmaceutically/cosmetically-active dibenzofuran compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (II) to (VI): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterin |
| 5744499 |
Apoptosis-modulating factors influencing the intracellular concentration of methional/malondiald |
April 28, 1998 |
| Apoptosis (programmed cell death) in mammalian organisms is modulated, whether initiated or suppressed, for example for preventing and/or combating photoinduced or chronologic aging of the skin or for treating a wide variety of human afflictions, by administering thereto, for such pr |
| 5728739 |
Stimulating the differentiation of preadipocytic cells and therapies based thereon |
March 17, 1998 |
| The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulate |
| 5709867 |
Polyaromatic amide compounds and pharmaceutical/cosmetic compositions comprised thereof |
January 20, 1998 |
| Novel pharmaceutically/cosmetically-active polyaromatic amides have the structural formula (I): ##STR1## wherein Z is a radical --CO--NH-- or --NH--CO--, and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, |
| 5705167 |
Aromatic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof |
January 6, 1998 |
| Novel pharmaceutically/cosmetically-active aromatic polyenic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, |
| 5702710 |
Dibenzofuran compounds and pharmaceutical/cosmetic compositions comprised thereof |
December 30, 1997 |
| Novel pharmaceutically/cosmetically-active dibenzofuran compounds have the structural formula (I): ##STR1## wherein A is a radical having one of the formulae (IIa), (IIb) or (IIc): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or |
| 5696104 |
Process for identifying RXR-receptor-agonist compounds |
December 9, 1997 |
| The present invention relates to a process for identifying RXR-agonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of a compound which is an active ligand for at least one receptor of the super-family of steroidal/thyroidal receptors, other |
| 5686586 |
Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic |
November 11, 1997 |
| A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis.In the formula, X represents --CH.dbd.CH--, O or S,R.sub.1 represents hydrogen, branched alkyl having 3-15 carbon atoms, alkoxy having 1-6 ca |
| 5668156 |
Di (aromatic) compounds and their use in human and veterinary medicine and in cosmetics |
September 16, 1997 |
| Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a divalent radical, and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent a h |
| 5654331 |
Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicin |
August 5, 1997 |
| Diaromatic compounds, characterised in that they correspond to the following general formula: ##STR1## in which: R.sub.1 is --CH.sub.3, --CH.sub.2 OH, --COR.sub.8 or --CH.sub.2 OCOR.sub.9, R.sub.8 is H, OH, --OR.sub.10, --N(rr') or alkyl, R.sub.10 is alkyl, alkenyl, aryl or aralk |
| 5602104 |
Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic |
February 11, 1997 |
| A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula,X represents --CH.dbd.CH--, O or S,R.sub.1 represents hydrogen, branched alkyl having 3-15 carbon atoms, alkoxy having 1-6 ca |
| 5597839 |
Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics |
January 28, 1997 |
| Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## X represents a divalent radical, Z represents O, S or a divalent radical,and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent a hydrogen atom or various organic |
