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Carnegie Institution of Washington Patents
Assignee:
Carnegie Institution of Washington
Address:
Washington, DC
No. of patents:
53
Patents:


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Patent Number Title Of Patent Date Issued
RE41189 Method of making enhanced CVD diamond April 6, 2010
Single crystal CVD diamond is heated to temperatures of 1500.degree. C. to 2900.degree. C. under a pressure that prevents significant graphitization. The result is a CVD diamond with improved optical properties.
8580754 Genetic inhibition by double-stranded RNA November 12, 2013
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequen
8287831 Ordered oxynitride perovskites October 16, 2012
This invention relates to partially ordered and ordered oxynitride perovskites of the general formula ABO.sub.2N that are polar insulators. A comprises one or more cations or set of cations that sit in sites derived from the A-site in the perovskite structure. B comprises one or more
8246746 Laser uses for single-crystal CVD diamond August 21, 2012
The present invention is directed to new laser-related uses for single-crystal diamonds produced by chemical vapor deposition. One such use is as a heat sink for a laser; another such use is as a frequency converter. The invention is also directed to a .chi..sup.(3) nonlinear crystal
8189877 Remote sensing analysis of forest disturbances May 29, 2012
The present invention provides systems and methods to automatically analyze Landsat satellite data of forests. The present invention can easily be used to monitor any type of forest disturbance such as from selective logging, agriculture, cattle ranching, natural hazards (fire, wind
8173863 Sucrose biosensors and methods of using the same May 8, 2012
Sucrose biosensors are disclosed, which comprise a sucrose binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon sucrose binding. Such biosensors are useful for real time monitoring of sucrose
8124056 High throughput genetic screening of lipid and cholesterol processing using fluorescent compound February 28, 2012
The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid and/or cholesterol processing in a vertebrate; screening for genetic mutations that lead to disor
8071744 TRP/HIS exchange and kynurenin induced TRP transport December 6, 2011
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between trypt
8066968 X-ray-induced dissociation of H.sub.2O and formation of an O.sub.2-H.sub.2 alloy at high pressur November 29, 2011
A novel molecular alloy of O.sub.2 and H.sub.2 and a method of producing such a molecular alloy are provided. When subjected to high pressure and extensive x-radiation, H.sub.2O molecules cleaved, forming O--O and H--H bonds. In the method of the present invention, the O and H framework
8039131 Class of pure piezoelectric materials October 18, 2011
A modification of PbTiO.sub.3 perovskite wherein at least part of Pb is replaced by a smaller atom with a similar ionic charge.
8003855 Production of hydroxylated fatty acids in genetically modified plants August 23, 2011
This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty
7935494 Trp/his exchange and kynurenine induced Trp transport May 3, 2011
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between trypt
7883684 Colorless single-crystal CVD diamond at rapid growth rate February 8, 2011
The present invention relates to a method for producing colorless, single-crystal diamonds at a rapid growth rate. The method for diamond production includes controlling temperature of a growth surface of the diamond such that all temperature gradients across the growth surface of th
7820131 Diamond uses/applications based on single-crystal CVD diamond produced at rapid growth rate October 26, 2010
The present invention is directed to new uses and applications for colorless, single-crystal diamonds produced at a rapid growth rate. The present invention is also directed to methods for producing single crystal diamonds of varying color at a rapid growth rate and new uses and appl
7777016 Neurotransmitter sensors and methods of using the same August 17, 2010
Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotr
7754180 Ultrahard diamonds and method of making thereof July 13, 2010
A single crystal diamond grown by microwave plasma chemical vapor deposition annealed at pressures in excess of 4.0 GPa and heated to temperature in excess of 1500 degrees C. that has a hardness of greater than 120 GPa. A method for manufacture a hard single crystal diamond includes
7713507 Tough diamonds and method of making thereof May 11, 2010
A single crystal diamond grown by microwave plasma chemical vapor deposition has a hardness of 50-90 GPa and a fracture toughness of 11-20 MPa m.sup.1/2. A method for growing a single crystal diamond includes placing a seed diamond in a holder; and growing single crystal diamond at a
7622633 Genetic inhibition by double-stranded RNA November 24, 2009
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequen
7594968 Ultratough CVD single crystal diamond and three dimensional growth thereof September 29, 2009
The invention relates to a single-crystal diamond grown by microwave plasma chemical vapor deposition that has a toughness of at least about 30 MPa m.sup.1/2. The invention also relates to a method of producing a single-crystal diamond with a toughness of at least about 30 MPa m.sup.
7574868 Mixture including hydrogen and hydrocarbon having pressure-temperature stability August 18, 2009
The invention relates to a method of storing hydrogen that employs a mixture of hydrogen and a hydrocarbon that can both be used as fuel. In one embodiment, the method involves maintaining a mixture including hydrogen and a hydrocarbon in the solid state at ambient pressure and a tem
7510850 Isolation of the mitotic spindle matrix and its methods of use March 31, 2009
The invention encompasses a purified preparation of the mitotic spindle matrix essential for mitotic spindle assembly, which allows for identifying an agent that modulates a cell division and/or differentiation signaling pathway comprising determining the effect of the agent on spind
7452420 Apparatus and method for diamond production November 18, 2008
An apparatus for producing diamond in a deposition chamber including a heat-sinking holder for holding a diamond and for making thermal contact with a side surface of the diamond adjacent to an edge of a growth surface of the diamond, a noncontact temperature measurement device posit
7402665 Nucleic acid encoding a poly-(ADP) ribose polymerase enzyme and uses thereof July 22, 2008
Poly(ADP)-ribose polymerase (PARP) becomes activated at sites of DNA damage and is thought to promote repair by modifying local chromatin proteins and transcription factors. Disclosed is an isoform of PARP, PARP-e, which lacks enzymatic function and which is encoded by a gene having
7309477 Ultrahard diamonds and method of making thereof December 18, 2007
A single crystal diamond grown by microwave plasma chemical vapor deposition annealed at pressures in excess of 4.0 GPa and heated to temperature in excess of 1500 degrees C. that has a hardness of greater than 120 GPa. A method for manufacture a hard single crystal diamond includes
7235130 Apparatus and method for diamond production June 26, 2007
An apparatus for producing diamond in a deposition chamber including a heat-sinking holder for holding a diamond and for making thermal contact with a side surface of the diamond adjacent to an edge of a growth surface of the diamond, a noncontact temperature measurement device posit
7157067 Tough diamonds and method of making thereof January 2, 2007
A single crystal diamond grown by microwave plasma chemical vapor deposition has a hardness of 50 90 GPa and a fracture toughness of 11 20 MPa m.sup.1/2. A method for growing a single crystal diamond includes placing a seed diamond in a holder; and growing single crystal diamond at a
7115241 Ultrahard diamonds and method of making thereof October 3, 2006
A single crystal diamond grown by microwave plasma chemical vapor deposition annealed at pressures in excess of 4.0 GPa and heated to temperature in excess of 1500 degrees C. that has a hardness of greater than 120 GPa. A method for manufacture a hard single crystal diamond includes
6984495 Human hairless gene and protein January 10, 2006
The novel nucleotide sequence and deduced amino acid sequence of the human Hairless gene and protein, respectively, are disclosed. A Hairless expression construct may be used in transcription assays. Moreover, processes of making and using the aforementioned products in screening ass
6936728 Production of hydroxylated fatty acids in genetically modified plants August 30, 2005
This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty
6864404 Engineering disease resistance with pectate lyase-like genes March 8, 2005
A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obta
6858078 Apparatus and method for diamond production February 22, 2005
An apparatus for producing diamond in a deposition chamber including a heat-sinking holder for holding a diamond and for making thermal contact with a side surface of the diamond adjacent to an edge of a growth surface of the diamond, a noncontact temperature measurement device positione
6800790 Method for maintenance and propagation of germline stem cells using members of the TFG-.beta. fa October 5, 2004
The TGF-.beta. family of growth factors, particularly the bone morphogenetic protein (BMP)-2/4 homolog decapentaplegic (dpp), are specifically required to maintain germline stem cells and promote their division. Overexpression of dpp blocks germline stem cell differentiation. Mutatio
6774279 Use of FLP recombinase in mice August 10, 2004
A method is disclosed for producing site-specific recombination of DNA in a transgenic non-human mammal at chromosomal regions containing Flp-recognition sites (e.g., a DNA sequence containing an FRT site). The invention in particular discloses the use of site-specific recombinases s
6735960 Composition and method for hydrogen storage May 18, 2004
A method for hydrogen storage includes providing water and hydrogen gas to a containment volume, reducing the temperature of the water and hydrogen gas to form a hydrogen clathrate at a first cryogenic temperature and a first pressure and maintaining the hydrogen clathrate at second cryo
6543295 High pressure anvil and optical window April 8, 2003
The present invention is generally related to high pressure cells used for high pressure and spectroscopic studies. More particularly, the present invention is directed to the use of moissanite in a high pressure cell or a high pressure press as the anvil and/or gasket material. Addition
6437220 Strong early seed-specific gene regulatory region August 20, 2002
Nucleic acid sequences and methods for their use are described which provide for early seed-specific transcription, in order to modulate or modify expression of foreign or endogenous genes in seeds, particularly embryo cells. The method finds particular use in conjunction with modify
6433250 Use of plant fatty acyl hydroxylases to produce hydroxylated fatty acids and derivatives in plan August 13, 2002
The present invention relates to the identification of nucleic acid sequences and constructs, and methods related thereto, and the use of these sequences and constructs to produce genetically modified plants for the purpose of altering the composition of plant oils, waxes and related
6310194 Plant fatty acid hydroxylases October 30, 2001
This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty
6291742 Production of hydroxylated fatty acids in genetically modified plants September 18, 2001
This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty
6207382 Production of lampbrush chromosome March 27, 2001
A process for inducing a transcriptionally active chromosome (i.e., a "lampbrush" chromosome) from condensed chromatin or nucleus is disclosed. The condensed chromosome is contacted with the contents of a germinal vesicle. Preferably, the nuclear envelope is disrupted or removed. Mor
6028248 Plant fatty acid hydroxylase February 22, 2000
The present invention relates to the identification of nucleic acid sequences and constructs, and methods related thereto, and the use of these sequences and constructs to produce genetically modified plants for the purpose of altering the composition of plant oils, waxes and related
6027900 Methods and tools for transformation of eukaryotic algae February 22, 2000
Genetic fusions for use in genetic engineering of eukaryotic algae employ a promoter from a light harvesting protein fused to a protein of interest. The fusions can be introduced and selected using an antibiotic resistance determinant. One gene useful for such selection is the sh ble gen
5965793 Strong early seed-specific gene regulatory region October 12, 1999
Nucleic acid sequences and methods for their use are described which provide for early seed-specific transcription, in order to modulate or modify expression of foreign or endogenous genes in seeds, particularly embryo cells. The method finds particular use in conjunction with modify
5900545 Strain monitoring system May 4, 1999
A apparatus is provided for detecting deformation in solids in deep holes having a resilient vessel pre-stressed into a rock formation. The vessel is filled with fluid and is sealed except for an outlet tube of small diameter which extends all the way to, or close to, the surface. There
5801026 Use of plant fatty acyl hydroxylases to produce hydroxylated fatty acids and derivatives in plan September 1, 1998
The present invention relates to the identification of nucleic acid sequences and constructs, and methods related thereto, and the use of these sequences and constructs to produce genetically modified plants for the purpose of altering the composition of plant oils, waxes and related
5739435 Two-stage strain-sensing device and method April 14, 1998
A device for detecting deformations in solids includes a casing constructed and arranged to be insertable in a solid. The casing has walls defining a substantially closed container. The container has an inner dividing wall separating the container into an upper enclosed section and a low
5668292 Use of plant fatty acyl hydroxylases to produce hydroxylated fatty acids and derivatives in plan September 16, 1997
The present invention relates to the identification of nucleic acid sequences and constructs, and methods related thereto, and the use of these sequences and constructs to produce genetically modified plants for the purpose of altering the composition of plant oils, waxes and related
5648245 Method for constructing an oligonucleotide concatamer library by rolling circle replication July 15, 1997
An in vitro method for constructing an oligonucleotide concatamer library is revealed. The method has four steps. The first step involves the generation of a primer-bridged circular template oligonucleotide. In the second step, the primer-bridged circular template is used to generate a
5633152 Method of controlling viral growth May 27, 1997
The present invention relates to a method of specifically inhibiting the growth of a virus, particularly an animal virus, in a permissive host cell comprising introducing into the host cell a virus-related gene encoding a product capable of interacting with the genome of the infecting vi
5220167 Multiple ion multiplier detector for use in a mass spectrometer June 15, 1993
A mass spectrometer for ion ratio detection. The ions are produced and initially focussed in the conventional way. After focusing, the ion beams are refocused by a magnifying focusing assembly which is located past the focal plane. The magnifying lens magnifies the beam spacing, and the
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