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Canji, Inc. Patents
Assignee:
Canji, Inc.
Address:
Palo Alto, CA
No. of patents:
39
Patents:












Patent Number Title Of Patent Date Issued
8133481 Selectively replicating viral vectors March 13, 2012
The present invention provides recombinant viruses which replicate the viral genome selectively in response to the intracellular conditions of the target cell through the use a pathway-responsive promoter which substantially inhibits viral replication in the host cell based on the ph
8022044 Compositions and methods for therapeutic use September 20, 2011
A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: ##STR00001## wherein: n is an integer from 2-8; X.sub.1 is a cholic acid group or de
7691822 Methods and compositions for treatment of interferon-resistant tumors April 6, 2010
The present invention provides a method for the treatment of interferon resistant tumors through the use of recombinant vectors encoding interferon species. In particular it is noted that interferon species provided by recombinant vectors possesses properties not associated with the
7691370 Selectivity replicating viral vector April 6, 2010
The present invention provides recombinant viruses which replicate the viral genome selectively in response to the intracellular conditions of the target cell through the use a pathway-responsive promoter which substantially inhibits viral replication in the host cell based on the ph
7538093 Compositions and methods for therapeutic use May 26, 2009
A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: ##STR00001## wherein: n is an integer from 2-8; X.sub.1 is a cholic acid group or deoxyc
7534769 Compositions and methods for enhancing delivery of therapeutic agents to cells May 19, 2009
This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulat
7465442 Reduction of dermal scarring December 16, 2008
Methods and compositions for reducing or inhibiting dermal scarring by expressing p21.sup.WAF1/Cip1 in a wound site are provided.
7462351 Nucleic acid delivery December 9, 2008
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced
7355056 Transfection agents April 8, 2008
The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating ag
7307146 DNAXCCR10 December 11, 2007
Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are disclosed. Methods of using the chemokines, receptors, reagents and diagnostic kits are
7157261 Rat secreted embryonic alkaline phosphatase January 2, 2007
Rat secreted embryonic alkaline phosphatase and methods for it use are provided.
7157079 Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms January 2, 2007
In one embodiment, this invention provides methods of treating mammalian cancer or hyperproliferative cells, said method comprising contacting said cells with a tumor suppressor protein or tumor suppressor nucleic acid and also contacting said cell with at least one adjunctive anti-c
7105156 Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferati September 12, 2006
Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56.sup.RB protein, a fragment of the p56.sup.RB protein, and the gene encoding p56.sup.RB protein to alter the cell cycle progr
7094583 Nucleic acid delivery August 22, 2006
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced
7041284 Recombinant adenoviral vector and method of use May 9, 2006
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing
7002027 Compositions and methods for therapeutic use February 21, 2006
The present invention is directed to compositions and methods of treating cancer by gene therapy using a therapeutic gene formulated in a buffer comprising a delivery-enhancing agent. The delivery-enhancing agents of the invention can be used to formulate therapeutic or diagnostic agents
7001770 Calpain inhibitors and their applications February 21, 2006
The present invention provides a method to enhance apoptosis in a cell by the administration of p53 in combination with a calpain inhibitor. The present invention provides a method of increasing the infectivity of a cell to a viral vector by treatment of the cell with a calpain inhibitor
6989268 Recombinant adenoviral vector and methods of use January 24, 2006
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing
6949379 Aptamer-mediated regulation of gene expression September 27, 2005
This invention provides methods of regulating gene expression. An aptamer is positioned in a nucleic acid molecule along with a sequence encoding a transcriptional regulatory polypeptide. The aptamer disrupts translation of the transcriptional regulatory polypeptide when contacted with a
6902731 Methods of treating hyperproliferative disorders using retinoblastoma fusion proteins June 7, 2005
Fusions of the transcription factor E2F and the retinoblastoma protein RB are provided, along with methods of treatment of hyperproliferative diseases.
6737252 7 transmembrane receptor family member BLRX May 18, 2004
Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are disclosed. Methods of using the chemokines, receptors, reagents and diagnostic kits are als
6649158 Methods and compositions to induce antitumor response November 18, 2003
The present invention provides compositions which are engineered to induce killing of tumor cells and concomitantly mobilize differentiate, activate and attract dendritic cells through the expression of cytokines and dendritic cell chemoattractants. The present invention invention is
6635476 Targeted vectors October 21, 2003
This invention provides therapeutic and diagnostic agent delivery vehicles, including viral vectors, that are complexed to a targeting moiety by coordinate covalent linkages mediated by a transition metal ion. The complex is typically formed with a transition metal ion that is in a k
6489305 Methods and compositions for the treatment of ocular diseases December 3, 2002
Methods and composition for the treatment of ocular disease with a cyclin dependent kinase inhibitor are provided.
6475481 Purging of stem cell products November 5, 2002
Methods for purging stem cell products of tumor cells and for treating an individual having a disease which is treated by myeloablative therapy and stem cell rescue using a purged product are provided.
6464976 Methods and compositions for reducing immune response October 15, 2002
The present invention provides an apparatus and method to diminish the pre-existing immune response to the administration of a therapeutic virus by the selective elimination of antiviral antibodies from the serum. The present invention provides a chromatographic material for the eliminat
6392069 Compositions for enhancing delivery of nucleic acids to cells May 21, 2002
This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a
6379927 Retinoblastoma fusion proteins April 30, 2002
Fusions of the transcription factor E2F and the retinoblastoma protein RB are provided, along with methods of treatment of hyperproliferative diseases.
6248514 Methods for measuring viral infectivity June 19, 2001
The instant invention addresses the need for a more accurate method of quantitating infectious viral particles in a population. The methods of the instant invention are based on the unexpected and surprising result that flow cytometry analysis of cells infected using specified ranges of
6210939 Recombinant adenoviral vector and methods of use April 3, 2001
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing
6165779 Compositions and methods for therapeutic use December 26, 2000
A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer compris
6074850 Retinoblastoma fusion polypeptides June 13, 2000
Fusions of the transcription factor E2F and the retinoblastoma protein RB are provided, along with methods of treatment of hyperproliferative diseases.
6043088 Prostate/colon tumor suppressor gene located on human chromosome 8 March 28, 2000
This invention provides a novel nucleic acid molecule encoding a prostate/colon tumor suppressor gene product. The means and methods for detecting mutations and/or loss of prostate/colon tumor suppressor gene are provided. Also included within the scope of this invention are methods
5994134 Viral production process November 30, 1999
The present invention is directed to a method of producing recombinant viral vectors at high titers incorporating a variety of important advancements over the art. The method of the present invention incorporates multiple features which provide enhanced production of viruses, particu
5932210 Recombinant adenoviral vector and methods of use August 3, 1999
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing
5851991 Therapeutic use of the retinoblastoma susceptibility gene product December 22, 1998
This invention provides a method of preventing or inhibiting the proliferation of a pathologically proliferating cell, wherein the pathological proliferation of the cell is the result of the absence of a functional retinoblastoma protein or polypeptide in the cell. The method require
5837520 Method of purification of viral vectors November 17, 1998
The invention provides a method for purifying viral vectors containing therapeutic genes for use in gene therapy. The invention comprises a method of purification from a cell lysate of a recombinant viral vector containing a therapeutic gene, which comprises: a) treating said lysate
5789244 Compositions and methods for the treatment of cancer using recombinant viral vector delivery sys August 4, 1998
A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol.
5710255 Characterization of a novel anti-p110.sup.RB monoclonal antibody January 20, 1998
This invention provides a family of monoclonal antibodies specific for epitopes of p110.sup.RB protein present in the nucleus. These antibodies have superior properties that prove useful for the detection of p110.sup.RB or its complexes with other cellular regulatory proteins in cell

 
 
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