| Patent Number |
Title Of Patent |
Date Issued |
| 4435449 |
Treatment of minimal brain dysfunction (MBD) |
March 6, 1984 |
| A method of Treatment of Minimal Brain Dysfunction (MBD) also known as ATTENTION DEFICIT DISORDER in humans by the administration of the compound of the formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof in a non-toxic, effective therapeutic amount (ca |
| 4431815 |
1-[3-(2,4-Dichlorophenyl)propyl]imidazole and salts thereof |
February 14, 1984 |
| A method for (i) the treatment or prophylaxis of a thrombo-embolic disorder of a mammal or a mammalian tissue (ii) the prevention, treatment or prophylaxis of angina pectoris, or (iii) the prevention or delay of the onset of shock, which comprises the administration to the mammal or |
| 4430435 |
Assay system |
February 7, 1984 |
| The accuracy of assays for monitoring concentrations of basic drugs in biological fluids containing .alpha..sub.1 -acid glycoproteins, such as blood (serum or plasma), is improved by the addition of certain organic phosphate compounds to minimize the "protein effect." Kits containing the |
| 4425363 |
Treatment of tardive dyskinesia in mammals |
January 10, 1984 |
| A method of Treatment of Tardive Dyskinesia (TD) in humans by the administration of the compound of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof in a non-toxic, effective therapeutic amount (calculated as base) to a human in need thereof. |
| 4425354 |
Imidazole derivatives and salts thereof, their synthesis, and intermediates, and pharmaceutical |
January 10, 1984 |
| 1-Substituted-imidazoles of the formula: ##STR1## in which A is selected from the group consisting of straight or branched, saturated or unsaturated, acyclic hydrocarbon radicals of from 1 to 3 carbon atoms and R is ##STR2## wherein n is an integer which is at least 1, and th |
| 4416895 |
Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical fo |
November 22, 1983 |
| Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: ##STR1## wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, ary |
| 4414223 |
Pesticidal anilinomethylimidazolines |
November 8, 1983 |
| 1-Phenoxyalkyl- and 1-anilinoalkyl imidazolines, methods for the preparation thereof, the use thereof as intermediates and pesticides and pesticidal formulations containing such compounds. |
| 4405634 |
Imidazole derivatives for treating myocardial infarction |
September 20, 1983 |
| 1-Substituted-imidazoles of the formula: ##STR1## in which A is selected from the group consisting of straight or branched, saturated or unsaturated, acyclic hydrocarbon radicals of from 1 to 3 carbon atoms and R is ##STR2## wherein n is an integer which is at least 1, and th |
| 4404223 |
Pesticidal formulations |
September 13, 1983 |
| Pyrethroid esters of the formula (I) ##STR1## potentiate the activity of each other against arthropod pests. Values of R.sup.2 and R.sup.3 include halogen and R includes phenoxybenzyl and .alpha.-cyanophenoxybenzyl. Compositions comprise of two or more esters of (I) and formulati |
| 4404212 |
Prostacyclin treatment of thrombosis |
September 13, 1983 |
| Pharmaceutical combinations comprising (a) prostacyclin, dihydroprostacyclin or a pharmaceutically acceptable salt of either of these, and (b) a phosphodiesterase inhibitor. Pharmaceutical formulations comprising a combination as above and a pharmaceutically acceptable carrier. Metho |
| 4400383 |
Treatment of anxiety |
August 23, 1983 |
| This invention is directed to the use of a carbazole compound 9-[3-(3,5-cis-dimethylpiperazino)propyl]carbazole, its salts, especially pharmaceutically acceptable salts, and solvates such as hydrates, alcoholates of the salts thereof as well as pharmaceutical compositions containing |
| 4396771 |
Imidazole derivatives and salts thereof |
August 2, 1983 |
| 1-Substituted-imidazoles of the formula: ##STR1## in which A is selected from the group consisting of straight or branched, saturated or unsaturated, acyclic hydrocarbon radicals of from 1 to 3 carbon atoms and R is ##STR2## wherein n is an integer which is at least 1, and th |
| 4393717 |
Apparatus for testing medicinal tablets |
July 19, 1983 |
| Apparatus for testing medicinal tablets for thickness, diameter and hardness wherein there is a support for receiving and supporting tablets for testing one at a time, a gauge movable relative to the support to measure the thickness, a gauge movable relative to the support to both me |
| 4393078 |
Bupropion and ethanol |
July 12, 1983 |
| This invention relates a method of restoring slowed mental ability in humans caused by ethanol by treatment with the compound of formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof in a non-toxic, effective therapeutic amount to a human in need thereof. |
| 4393063 |
Treatment for gastric lesions |
July 12, 1983 |
| Pharmaceutical combinations comprising (a) prostacyclin, dihydroprostacyclin or a pharmaceutically acceptable salt of either of these, and (b) a phosphodiesterase inhibitor. Pharmaceutical formulations comprising a combination as above and a pharmaceutically acceptable carrier. Metho |
| 4381344 |
Process for producing deoxyribosides using bacterial phosphorylase |
April 26, 1983 |
| The novel compounds 3-deaza-2'-deoxyadenosine and certain of its derivatives and their pharmaceutically acceptable salts have anti-inflammatory activity as well as immune response suppression activity. 3-Deaza-2'-deoxyadenosine and certain of its intermediates are synthesized by the |
| 4379160 |
Carbazole compounds and medicinal use thereof |
April 5, 1983 |
| This invention is directed to a carbazole compound 9-[3-(3,5-cis-dimethylpiperazino)propyl]carbazole, its salts, especially pharmaceutically acceptable salts, and solvates such as hydrates, alcoholates of the salts thereof as well as pharmaceutical compositions containing same which |
| 4379156 |
Heterocyclic chemicals, their preparation and use |
April 5, 1983 |
| Compounds of formula (III): ##STR1## wherein R.sup.5 is a single substituent in position 2 or 3 of the phenyl ring and when in the 2-position R.sup.5 is a chlorine atom, a methyl group or a nitro group; and R.sup.6 is a hydrogen atom or a CO.CH.sub.3 group may be prepared by meth |
| 4374146 |
Topical inflammatory pharmaceutical formulations |
February 15, 1983 |
| A compound of the formula (I) may be prepared by known methods and may be used in the treatment of pain, inflammation or pyresis in mammals, by administration of the compound alone or in a pharmaceutical formulation suitable for administration to a mammal in need thereof. ##STR1## |
| 4372957 |
Treatment with dialkoxy pyridopyrimidines |
February 8, 1983 |
| Potent psoriasis activity in combination with low inhibition of histamine N-methyltransferase has been found in a class of 2,4-diamino-6-(2,5-dialkoxybenzyl)-5-methylpyrido[2,3-d]pyrimidines. |
| 4366158 |
1-(8-Quinolyl)-2-pyrrolidone and its pharmaceutical compositions |
December 28, 1982 |
| The compound of formula (I) ##STR1## and acid addition salts thereof are of value in medicine in the treatment or prophylaxis of pain, inflammation or fever. The compound and its salts may be administered alone or as a pharmaceutical formulation. The compound may be prepared by m |
| 4364263 |
High pressure liquid chromatographic system |
December 21, 1982 |
| A high pressure liquid chromatograph system which includes a plurality of columns and a plurality of solvent containers (reservoirs) and which are selectable by use of a select or subsystem to permit the desired measurement (analysis) to be made by the system. With this system one may |
| 4363800 |
Biologically active amides |
December 14, 1982 |
| Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met.Gly.Phe (4NO.sub.2).ProNH.sub.2 and Tyr.D-Met(O). Gly. Phe(4NO.sub.2). ProNH.sub.2 as anti-diarrhoeals and anti-tussives. |
| 4362717 |
Biologically active amides |
December 7, 1982 |
| Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met. Gly.Phe(4NO.sub.2).ProNH.sub.2 and Tyr.D-Met(O).Gly.Phe(4NO.sub.2).ProNH.sub.2 as anti-diarrhoeals and anti-tussives. |
| 4360522 |
Purine derivatives |
November 23, 1982 |
| 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention, a |
| 4357340 |
Imidazole derivatives and angina pectoris |
November 2, 1982 |
| 1-Substituted-imidazoles of the formula: ##STR1## in which A is selected from the group consisting of straight or branched, saturated or unsaturated, acyclic hydrocarbon radicals of from 1 to 3 carbon atoms and R is ##STR2## wherein n is an integer which is at least 1, and th |
| 4356165 |
Bupropion radioimmunoassay, and kit |
October 26, 1982 |
| A radioimmunoassay proceedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n --O--(CO).sub.m -- |
| 4355179 |
Radioactive nuclide labeled propiophenone compounds |
October 19, 1982 |
| A radioimmunoassay procedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n --O--(CO).sub.m --( |
| 4355025 |
Biologically active amides |
October 19, 1982 |
| A polypeptide, designated Pancreatic Hormone III, together with pharmaceutically acceptable salts or metal complexes thereof; pharmaceutical formulations of the said polypeptide or its salts or complexes and the preparation of such formulations; and the use of the said polypeptide, s |
| 4347382 |
3.sup.H Labeled compounds |
August 31, 1982 |
| A radioimmunoassay procedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n -0-(CO).sub.m -(CH. |
| 4347315 |
Synthesis of ribosides using bacterial phosphorylase |
August 31, 1982 |
| 4-Substituted-3-deazapurine ribosides are prepared by the enzymatically catalyzed reaction of 4-substituted-3-deazapurine with a ribose donor. |
| 4347257 |
Prolactin suppression in mammals |
August 31, 1982 |
| A method of suppressing prolactin secretion in humans by the administration of the compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof in a non-toxic, effective prolactin suppression amount (calculated as base) to a human in need thereof. |
| 4347178 |
Compounds and methods of making |
August 31, 1982 |
| A radioimmunoassay procedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n -O-(CO).sub.m -(CH. |
| 4347177 |
Compounds and methods of making them |
August 31, 1982 |
| A radioimmunoassay procedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n --O--(CO).sub.m --( |
| 4347176 |
Compounds and methods of making same |
August 31, 1982 |
| A radioimmunoassay procedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n --0--(CO).sub.m --( |
| 4346083 |
Biologically active amides |
August 24, 1982 |
| Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met.Gly.Phe(4NO.sub.2).ProNH.sub.2 and Tyr.D-Met(O).Gly.Phe(4NO.sub.2).ProNH.sub.2 as anti-diarrhoeals and anti-tussives. |
| 4343795 |
Biologically active amides |
August 10, 1982 |
| Peptides, acid addition salts, salts, and pharmaceutical compositions thereof, and their use as morphine agonists, and especially Tyr.D.Met. Gly.Phe (4NO.sub.2). ProNH.sub.2 and Tyr. D-Met(O). Gly. Phe(4NO.sub.2). ProNH.sub.2 as anti-diarrhoeals and anti-tussives. |
| 4341760 |
Synergistic compositions |
July 27, 1982 |
| Acaricidal compositions comprising a pyrethroid of formula ##STR1## wherein Z and Z.sup.1 are the same or different and each is halo and wherein X is hydrogen or cyano, provided that when Z and Z.sup.1 are both chloro, X must be cyano together with at least one organophosphorus c |
| 4341697 |
Antigenic material |
July 27, 1982 |
| A novel, glycoprotein antigen obtained from T. cruzi organisms can be used in vaccines for inducing immunity in humans to Chagas' disease. The glycoprotein is extracted by treating trypanosomes with a detergent and separating it from the cell debris and other proteinaceous material by |
| 4337274 |
Flukicidal compounds |
June 29, 1982 |
| Diphenylethers of the formula: ##STR1## their synthesis, formulations containing them, methods of making such formulations, and their use in the treatment of liver fluke infections in mammals. |
| 4337262 |
Hydantoin derivatives, pharmaceutical compounds and methods of use |
June 29, 1982 |
| Hydantoins of formula (I) ##STR1## have biological properties related to those of naturally occurring prostaglandins and may be used in medicine, for example in the treatment of thrombosis. |
| 4337254 |
Pharmaceutical compositions |
June 29, 1982 |
| Pharmaceutical combinations comprising (a) prostacyclin, dihydroprostacyclin or a pharmaceutically acceptable salt of either of these, and (b) a phosphodiesterase inhibitor. Pharmaceutical formulations comprising a combination as above and a pharmaceutically acceptable carrier. Metho |
| 4335139 |
Pharmaceutical formulations containing prostacyclin compounds |
June 15, 1982 |
| Stabilized pharmaceutical formulations of prostacyclin or certain analogues thereof comprising an amino acid buffer, optionally containing a base, and the preparation of such formulations. |
| 4331649 |
Immune complex assay |
May 25, 1982 |
| Method for the estimation of immune complex and analysis of a constituent thereof. Method comprises a latex particle agglutination test in which a reagent comprising low affinity latex particles is contacted with a sample containing immune complex. The low affinity coated latex particles |
| 4330070 |
Relating to dose determining means of paste dispenser |
May 18, 1982 |
| A paste dose dispenser is provided which incorporates a housing (1) through which passes a drive rod (3) connected to a plunger (4). A lever (14) is pivotally mounted on a pin (15) for movement towards a handle (2), such action causing a plate (9) to tilt and thus grip the rod (3) and dr |
| 4329365 |
Flukicidal compounds |
May 11, 1982 |
| Diphenylethers of the formula: ##STR1## their synthesis, formulations containing them, methods of making such formulations, and their use in the treatment of liver fluke infections in mammals. |
| 4329362 |
2-Amino-4-(substituted hydrazino)-6-oxo pyrimidines |
May 11, 1982 |
| The present invention provides pyrimido (4,5-c) pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido (4,5-c)pyridazines of this invention are useful due to their act |
| 4328234 |
Imidazole derivatives and salts thereof and pharmaceutical formulations useful in thrombo-emboli |
May 4, 1982 |
| Imidazoles of formula (I) ##STR1## wherein A is a chemical bond or a straight or branched, saturated or unsaturated, aliphatic residue having from 1 to 6 carbon atoms wherein 1, 2 or 3 of such carbon atoms may be replaced by a corresponding number of heteroatoms selected from oxy |
| 4323679 |
Pyrimido(4,5-c)pyridazines |
April 6, 1982 |
| The present invention provides pyrimido(4,5-c)pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido(4,5-c)pyridazines of this invention are useful due to their ac |
| 4323573 |
Adenine derivatives |
April 6, 1982 |
| Novel 2-amino substituted adenine compounds and their use as antiviral compounds are disclosed. In particular the compound 2-amino-9-(2-hydroxyethoxymethyl) adenine is particularly advantageous as an antiviral in that it has high oral absorption and that upon metabolism in mammals, i |
