| Patent Number |
Title Of Patent |
Date Issued |
| 4957924 |
Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof |
September 18, 1990 |
| The present invention relates to certain amino acid exters of the purine nucleoside acyclovir, pharmaceutically acceptable salts thereof and their use in the treatment of herpes virus infections. The invention also includes pharmaceutical formulations and processes for the preparation of |
| 4954350 |
Pharmaceutical formulations containing acrivastine |
September 4, 1990 |
| The invention relates to a controlled release pharmaceutical formulation for oral administration which comprises discrete units comprising acrivastine or a salt thereof coated with a mixture containing:(a) a copolymer or polymer containing repeating monomer units selected from alkyl este |
| 4952597 |
Benzo[c]curbazole derivatives, compositions and use |
August 28, 1990 |
| The present invention related to anti tumor compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused |
| 4940729 |
Pesticidal formulations |
July 10, 1990 |
| Pyrethroid esters of the formula (I) ##STR1## potentiate the activity of each other against arthropod pests. Values of R.sup.2 and R.sup.3 include halogen and R includes phenoxybenzyl and .alpha.-cyanophenoxybenzyl. Compositions comprise of two or more esters of (I) and formulati |
| 4940713 |
Substituted glutamic acids |
July 10, 1990 |
| The present invention provides a compound of formula (I): ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, acetyl or formyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen or C.sub.1-4 alkyl; R.sup.4 is NR.sup.11 R.sup.12 ; R.sup.11, R.sup.12, R.sup.5 and R.sup. |
| 4937248 |
6-piperidyl carbostyril compounds and compositions containing them |
June 26, 1990 |
| The present invention is concerned with the compound of formula (I) ##STR1## and its acid addition salts. The invention is also directed to the use of the compound of formula (I) and its pharmaceutically acceptable acid addition salts as positive conotropic agents in mammals. |
| 4931469 |
Novel pesticides, preparation and use |
June 5, 1990 |
| The specification describes and claims methods of controlling acarine pests by application of a compound of Formula (I), methods of controlling arthropod pests by application of a compound of Formula (IA), compounds of Formula (IA) per se, pesticidal compositions comprising a compound of |
| 4929444 |
Low pH pharmaceutical formulation containing t-PA |
May 29, 1990 |
| A lyophilized pharmaceutical formulation of tissue plasminogen activator and a process for its preparation by vaccum drying a frozen aqueous solution of thereof, in which the pH is from 2 to 5. |
| 4923892 |
Tricyclic aromatic compounds |
May 8, 1990 |
| The present invention relates to compounds of formula I ##STR1## or a salt, ester or amide thereof; wherein R.sup.1 is --CH.sub.2 --CH.sub.2 --, CH.sub.2 --O-- or --O--CH.sub.2 --; R.sup.2 and R.sup.3 are the same or different and are each hydrogen, C.sub.1-4 alkyl or taken toget |
| 4921950 |
Preparation of 3'azido-3-'-deoxythymidine |
May 1, 1990 |
| This invention relates to a new synthetic process for the manufacture of zidovudine from the starting material D-xylose involving:(i) Conversion of D-xylose to a 1-(.beta.-D-xylofuranosyl)thymine derivative:(ii) 2'-Deoxygenation of the thymaine derivative; and(iii) 3'-Azidation of the 2'-deo |
| 4921836 |
Substituted glutamic acids |
May 1, 1990 |
| The present invention provides a compound of formula (I): ##STR1## wherein Y is sulfur; R.sup.2 and R.sup.3 are the same or different and are hydrogen or C.sub.1-4 alkyl; R.sup.4 is NR.sup.11 R.sup.12 ; R.sup.11, R.sup.12, R.sup.5 and R.sup.6 are the same or different and are hydroge |
| 4921835 |
Method of treating asthma |
May 1, 1990 |
| The peptides of the formula ##STR1## together with their pharmacologically acceptable salts, which have been described as exhibiting analgesic, antidiarrhoeal and antitussive activity, are effective in reversing neuronally-mediated bronchoconstriction in mammals. The said compoun |
| 4920210 |
2,6-diaminopurine-9-.beta.-D-2',3'-dideoxyribofuranoside |
April 24, 1990 |
| The present invention relates to certain 2',3'-dideoxynucleosides and pharmaceutically acceptable derivatives thereof, methods for preparing them, their use in the treatment and prophylaxis of viral, especially retroviral, infections, and pharmaceutical formulations containing them. |
| 4918101 |
Tetracyclic phenanthro furan heterocyclic derivatives compositions and use |
April 17, 1990 |
| The present invention relates to antitumor compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused |
| 4917900 |
Controlled release formulations containing zidovudine |
April 17, 1990 |
| The invention relates to pharmaceutical formulations comprising discrete units of zidovudine provided with a controlled release coating in which the said units are preferably in the form of spheroids. |
| 4910218 |
Phenanthro[2,3-6]thiophene derivatives, pharmaceutical compositions and use |
March 20, 1990 |
| The present invention relates to anti tumor compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused |
| 4897395 |
Treatment with dialkoxy pyridopyrimidines |
January 30, 1990 |
| Potent antiproliferative activity in combination with low inhibition of histamine N-methyltransferase has been found in a class of 2,4-diamino-6-(2,5-dialkoxybenzyl)-5-methylpyrido[2,3-d]pyrimidines. |
| 4897394 |
Antiviral combinations |
January 30, 1990 |
| This invention relates to synergistic combinations of nucleoside analogues, which are converted to viral DNA polymerase inhibitors through the action of at least one virus-induced enzyme, and nucleoside transport inhibitors. These combinations are especially useful in combatting herpes v |
| 4897386 |
Synergistic compositions |
January 30, 1990 |
| A method of controlling veterinary ectoparasites of mammals and birds of the sub-Orders Ixodoidea and Sarcoptiformes comprising the application of a parasiticidally effective, non-toxic amount of a pyrethroid of formula ##STR1## together with at least one parasiticidal organophosphor |
| 4883812 |
Treatment of hypertension using prostacyclin |
November 28, 1989 |
| Prostacyclin, its salts biosynthesis and synthesis thereof, pharmaceutical formulations containing them, and their use in medicine. |
| 4883810 |
Ethers |
November 28, 1989 |
| Prostacyclin, its salts, biosynthesis and synthesis thereof, pharmaceutical formulations containing them, and their use in medicine. |
| 4882358 |
Carbocyclic derivatives |
November 21, 1989 |
| The present invention relates to compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters, thereof; acid addition salts thereof; wherein Ar is a C.sub.15-18 fu |
| 4880812 |
Pyrimidine compounds |
November 14, 1989 |
| The present invention provides a compound of formula (I): ##STR1## wherein R.sup.1 is hydrogen , C.sub.1-4 alkyl, acetyl or formyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen or C.sub.1-4 alkyl; R.sup.4 is NR.sup.11 R.sup.12 ; R.sup.11, R.sup.12, R.sup.5 and R.sup |
| 4879296 |
Xanthine derivatives |
November 7, 1989 |
| The present invention relates to certain novel 8-phenylxanthines substituted in the 3 or 4 position of the phenyl group by an alkenylene, alkenyleneoxy, alkynylene or alkynyleneoxy bearing a terminal acidic grouping, and to their use in human and veterinary therapy, particularly for |
| 4874751 |
Antibacterial treatment |
October 17, 1989 |
| Treatment of susceptible gram-negative infections in animals is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically |
| 4874609 |
Treatment of human viral infections |
October 17, 1989 |
| Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5'-mono-, di- and triphosphate of |
| 4873258 |
Benzo[c] carbazole propanediol containing anti tumor compositions and use |
October 10, 1989 |
| The present invention relates to antitumor compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused |
| 4871865 |
Tricyclic aromatic compounds |
October 3, 1989 |
| The present invention relates to compounds of formula I ##STR1## or a salt, ester or amide thereof; wherein R.sup.1 is --CH.sub.2 --CH.sub.2 --, CH.sub.2 --O-- or --O--CH.sub.2 --; R.sup.2 and R.sup.3 are the same or different and are each hydrogen, C.sub.1-4 alkyl or taken toget |
| 4866073 |
Acridinylmethylamino derivatives and pharmaceutical compositions containing them |
September 12, 1989 |
| The present invention relates to compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a C.sub.8-13 fuse |
| 4866070 |
Acenaphtho[1,2b]quinolinylmethylamino derivatives and pharmaceutical compositions containing the |
September 12, 1989 |
| The present invention relates to compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused tricyclic |
| 4863966 |
Pesticidal amines |
September 5, 1989 |
| Compounds of formula (I) are pesticides having activity against arthropods: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are H, alkyl, alkoxy, halo, cyano or trifluoromethyl, or two of R.sup.1, R.sup.2 and R.sup.3 are linked to form a 3 or 4 carbon atom group;X is O or NA where A is |
| 4863906 |
2'-deoxy-5-ethynyluridine-3',5'-diestens for treatment of VZV and CMV infections |
September 5, 1989 |
| The present invention relates to the use of 2'-deoxy-5-ethynyluridine and its pharmaceutically acceptable derivatives in the treatment and prophylaxis of varicella zoster virus and cytomegalovirus infections. Also provided are pharmaceutical formulations and processes for the preparation |
| 4857511 |
Treatment of human viral infections |
August 15, 1989 |
| Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5'-mono-, di- and triphosphate of |
| 4855453 |
Tetracyclic thiophene derivatives |
August 8, 1989 |
| The present invention relates to anti tumor compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused |
| 4855086 |
Novel pesticides, preparation and use |
August 8, 1989 |
| The specification describes and claims methods of controlling acarine pests by application of a compound of Formula (I), methods of controlling arthropod pests by application of a compound of Formula (IA), compounds of Formula (IA) per se, pesticidal compositions comprising a compound of |
| 4847244 |
Treatment of human viral infections |
July 11, 1989 |
| Treatments of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5'-mono-, di- and triphosphate of |
| 4839169 |
Synergistic combination of t-PA and prostacyclin |
June 13, 1989 |
| A combination of t-PA and a prostaglandin of use in removing or inhibiting the formation of a blood clot in a mammal. |
| 4837208 |
Treatment of human viral infections |
June 6, 1989 |
| Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5'-mono-, di- and triphosphate of |
| 4837203 |
Pharmacologically active compounds and use |
June 6, 1989 |
| The peptides of the formulawherein X is hydrogen or an amidino group and X.sup.2 is D-S-methylmethionyl or D-arginyl, together with their pharmacologically acceptable salts, which have been described as exhibiting analgesic, antidiarrhoeal and antitussive activity, are effective in rever |
| 4837016 |
Protozoal antigen |
June 6, 1989 |
| Protection inducing antigens or parasites of the genus Plasmodium are described. The antigens have an apparent molecular weight of 1.8 to 2.5.times.10.sup.5 and are associated with the membranes of the erythrocytic schizont forms of the parasite. The antigens may be incorporated into |
| 4833130 |
Treatment of human viral infections |
May 23, 1989 |
| Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5'-mono, di- and triphosphate of |
| 4833126 |
Pharmacologically active compounds and use |
May 23, 1989 |
| The peptides of the formula ##STR1## together with their pharmacologically acceptable salts, which have been described as exhibiting analgesic, antidiarrhoeal and antitussive activity, are effective in reversing neuronally-mediated bronchoconstriction in mammals. The said compoun |
| 4831021 |
Ganglioside derivatives |
May 16, 1989 |
| A novel mono-sialo ganglioside derivative substantially identical chemically and physically with a product prepared by(a) concentration of an aqueous solution of a mono-sialo ganglioside and calcium ions under sub-atmospheric pressure at 40.degree.-80.degree. C. for 18-240 hours,(b) adju |
| 4829090 |
Chrysene derivatives |
May 9, 1989 |
| The present invention relates to compounds of formula (I)or a monomethyl or a monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a chrysene or s |
| 4828838 |
Treatment of human viral infection |
May 9, 1989 |
| Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of 5'-mono-, di- and triphosphate of 3' |
| 4827034 |
Carbocyclic derivatives |
May 2, 1989 |
| The present invention relates to compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters, thereof; acid addition salts thereof; wherein Ar is a C.sub.15-18 fu |
| 4820873 |
Pyrene derivatives |
April 11, 1989 |
| The present invention relates to compounds of formula (I)or a monomethyl or a monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a pyrene or sub |
| 4818750 |
Treatment of human viral infections |
April 4, 1989 |
| Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically basic salt thereof.Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-d |
| 4818538 |
Treatment of human viral infections |
April 4, 1989 |
| Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5.dbd.-mono-, di- and triphosphate o |
| 4818443 |
Carbocyclic derivatives |
April 4, 1989 |
| The present invention relates to compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters, thereof; acid addition salts thereof; wherein Ar is a C.sub.15-18 fu |
