| Patent Number |
Title Of Patent |
Date Issued |
| 5370880 |
Pharmaceutical formulations containing acrivastine |
December 6, 1994 |
| The invention relates to a controlled release pharmaceutical formulation for oral administration which comprises discrete units comprising acrivastine or a salt thereof coated with a mixture containing:a) a copolymer or polymer containing repeating monomer units selected from alkyl ester |
| 5364843 |
Agents for potentiating the effects of antitumor agents and combating multiple drug resistance |
November 15, 1994 |
| Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are piperazinyl benzyl compounds such as 1-[.alpha.-(4-Chlorophenyl)-3-methoxybenzyl]-4-allylpiperazine dihydrochloride. |
| 5358970 |
Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
October 25, 1994 |
| This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year. |
| 5346897 |
Agents for potentiating the effects of antitumor agents and combating multiple drug resistance |
September 13, 1994 |
| Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are acrivastine esters and the pharmaceutically acceptable salts thereof. |
| 5322774 |
Procaryotic leader sequence in recombinant baculovirus expression system |
June 21, 1994 |
| A process for the preparation of a protein, which process comprises culturing under such conditions that the protein is obtained cells infected with a recombinant baculovirus having a promoter, capable of directing the expression of a gene in the cells, operably linked to a heterolog |
| 5318974 |
Antiviral compounds |
June 7, 1994 |
| The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment of herpes virus infections. Also provided are pharmaceutical formulations and processes for the preparati |
| 5316938 |
Defined media for serum-free tissue culture |
May 31, 1994 |
| A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, comprising water, an osmolality regulator, a buffer, an energy source, amino acids includ |
| 5310762 |
Medicaments |
May 10, 1994 |
| A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof. |
| 5309903 |
Method for administering surfactant to the lungs while concurrently providing one-lung ventilati |
May 10, 1994 |
| A method of administering a liquid pharmaceutical formulation, particularly a surfactant formulation, to at least one lung of a subject in need of such treatment is disclosed. The method is carried out while the subject has a breathing tube extending through the subject's mouth and laryn |
| 5299566 |
Method of administering phospholipid dispersions |
April 5, 1994 |
| A method of administering a surfactant dispersion to the lungs of a patient in need of such treatment is disclosed. The method comprises heating the dispersion and nebulizing the heated dispersion to produce respirable surfactant particles. The respirable surfactant particles delivered t |
| 5290814 |
Anti-atherosclerotic diaryl compounds |
March 1, 1994 |
| The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1;W is hydrogen, a C.sub.1-16 straight, branched, or cyclic alkyl group, or a C.sub.2-16 straight, branched, or cyclic alkenyl or alkynyl group, or Ph(CH.sub.2).sub.n -- where Ph is phenyl and |
| 5290770 |
Synergistic compositions |
March 1, 1994 |
| A method of controlling veterinary ectoparasites of mammals and birds of the sub-Orders Ixodoidea and Sarcoptiformes comprising the application of a parasiticidally effective, non-toxic amount of a pyrethroid of formula ##STR1## together with at least one parasiticidal organophosphor |
| 5241107 |
Carbocyclic derivatives |
August 31, 1993 |
| The present invention relates to compounds of formula (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 30 carbon atoms in total); ethers, esters, thereof; acid addition salts thereof; wherein Ar is a C.sub.15-18 fu |
| 5240937 |
Pharmaceutically active triazolopyridine compounds |
August 31, 1993 |
| This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals. |
| 5234953 |
Treatment of congestive heart failure |
August 10, 1993 |
| The present invention is concerned with the use of a compound of formula (I) ##STR1## wherein --W-- is ##STR2## wherein Z is --V(CH.sub.2).sub.b CO.sub.2 H where b is 1 or 2 and V is oxygen when b is 1 or methylene when b is 2;X is hydrogen, cyano, or --C.tbd.CH; andthe dotte |
| 5234913 |
Antiviral nucleoside combination |
August 10, 1993 |
| Synergistic combinations of nucleoside derivatives, pharmaceutical formulations containing said combinations and use of the combinations in the treatment of retroviral infections are disclosed. |
| 5229122 |
Pesticidal compositions |
July 20, 1993 |
| A microencapsulated pesticide formulation comprises non-encapsulated pesticide as well as encapsulated pesticide. The two pesticides may be the same or different, and typically a formulation of 25% permethrin has 20% permethrin inside the capsules and 5% outside. |
| 5225431 |
Therapeutic substituted indole compounds and compositions thereof |
July 6, 1993 |
| The present invention is concerned with compounds of formula (I) ##STR1## wherein R, R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1-4 alkyl;R.sup.3 and R.sup.4 are independently selected from hydrogen, C.sub.1-6 alkyl (including cycloalkyl) and aryl (wherein |
| 5225184 |
Medicaments |
July 6, 1993 |
| The present invention relates to the treatment and prophylaxis of Pneumocystis carinii infections with 2-[4-(4-chlorophenyl)cyclohexyl-3-hydroxy-1,4-naphthoquinone. |
| 5217995 |
Pesticidal compositions |
June 8, 1993 |
| Compositions for treating timber, especially timber to be exposed to the ground, comprising creosote and a compound of formula I: ##STR1## wherein Z and Z.sup.1 are the same or different and are each halo, halophenyl or haloalkyl, X is hydrogen or cyano, and Y is hydrogen or a fl |
| 5216028 |
Therapeutic uses of a diphenylsulfide compound to treat depression and effect serotonin uptake |
June 1, 1993 |
| A halogen-substituted diphenylsufide compound is disclosed which produce a large selective inhibition of serotonin uptake in brain. This compound is useful in the treatment of depression as well as anxiety, obsessive compulsive disorders and alcoholism. |
| 5207220 |
Method for administering pharmaceuticals, including liquid surfactant, to the lungs |
May 4, 1993 |
| A method of administering a liquid pharmaceutical formulation, particularly a surfactant formulation, to at least one lung of a subject in need of such treatment is disclosed. The method is carried out while the subject has a breathing tube extending through the subject's mouth and laryn |
| 5206435 |
4-amino-2-cyclopentene-1-methanol |
April 27, 1993 |
| The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to |
| 5206268 |
Medicaments |
April 27, 1993 |
| A method for treating or preventing a Pneumocystis carinii infection in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof. |
| 5198539 |
5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine |
March 30, 1993 |
| The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations. |
| 5194450 |
Anti-hypertensive sulfonanilides |
March 16, 1993 |
| The present invention is concerned with compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-4 alkoxy;R.sub.2 is carbonyl, hydroxymethylene, or methylene; andR.sub.3 is hydrogen or hydroxy;and salts thereof, provided that when R.sub.1 is hydrogen and R.sub.2 is carbon |
| 5185437 |
Therapeutic nucleosides |
February 9, 1993 |
| This invention relates to certain 6-substituted 2',3'-dideoxypurine nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. Also provided are pharmaceutical formulations a |
| 5175319 |
Naphthoquinone derivatives |
December 29, 1992 |
| Novel antiprotozoal naphthoquinones having the general formula ##STR1## (wherein either R.sup.1 is hydrogen and R.sup.2 is selected from C.sub.1-6 alkoxy, aralkoxy, C.sub.1-6 alkyl-C.sub.1-6 alkoxy, phenyl substituted by one or two groups selected from halogen and C.sub.1-6 alkyl, ha |
| 5175274 |
Therapeutic nucleosides |
December 29, 1992 |
| This invention relates to certain 2'-fluoro nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the production of the compounds according to the invention. |
| 5175165 |
Antiviral combinations and compounds therefor |
December 29, 1992 |
| The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, espectially viruses o |
| 5166209 |
Pharmacologically active compounds |
November 24, 1992 |
| This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals. |
| 5166160 |
Quinoline compound |
November 24, 1992 |
| The present invention is concerned with the compound of formula (I) ##STR1## and its acid addition salts. The invention is also directed to the use of the compound of formula (I) and its pharmaceutically acceptable acid addition salts as positive conotropic agents in mammals. |
| 5164395 |
Antiviral acetyl pyridine derivative or said acetyl pyridine derivative in combination with acyc |
November 17, 1992 |
| The present invention relates to a novel ribonucleotide reductase inhibitor and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, especiallly viruses |
| 5157114 |
2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
October 20, 1992 |
| The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations. |
| 5153222 |
Method of treating pulmonary hypertension with benzidine prostaglandins |
October 6, 1992 |
| The present invention is concerned with methods for the prophylaxis, treatment and diagnosis of pulmonary hypertension which comprise the administrative of an effective amount of a compound of formula (I) ##STR1## wherein a is an integer of from 1 to 3; X and Y, which may be the same |
| 5147885 |
N-amino bicyclic compounds |
September 15, 1992 |
| N-amino hexahydrocyclopenta imidazole-2(1H)-one derivatives useful for treating or preventing thrombo-embolic disorders and ocular diseases characterized by increased ocular pressure. |
| 5147788 |
Baculovirus vectors and methods of use |
September 15, 1992 |
| A baculovirus transfer vector incorporates a restriction site into which a foreign gene may be cloned a short distance downstream of the N-terminus of the polyhedrin gene body and the natural ATG translation start codon for the polyhedrin gene is not provided such that the N-terminal |
| 5145840 |
Treatment of idiopathic thrombocytopaenic purpura |
September 8, 1992 |
| A method of treating idiopathic thrombocytopaenia purpura with 2',3'-dideoxy-3'-azidonucleosides, in particular 3'-azido-3'-deoxythymidine, is disclosed. |
| 5136080 |
Nitrile compounds |
August 4, 1992 |
| A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy. |
| 5124348 |
Pesticidal amides |
June 23, 1992 |
| A compound of Formula (I):where R.sup.1 is alkyl optionally substituted by a group selected from alkoxy, alkenyl, alkynyl, alkenyloxy, alkynyloxy, aryl, aryloxy, arylalkoxy and cycloalkyl fused to an aryl ring; x=1 or 2; X=O or S; each A and A.sup.1 is independently hydrogen, alkyl or ha |
| 5112609 |
Acidic formulations of t-PA |
May 12, 1992 |
| An aqueous parenteral solution of tissue-plasminogen activator, in which the pH is from 2 to 5. |
| 5104897 |
Medical uses of halogen substituted diphenylsulfides |
April 14, 1992 |
| A class of halogen-substituted diphenylsulfide compounds are disclosed which produce a large selective inhibition of serotonin uptake in brain. Such compounds are useful in the treatment of depression, anxiety, obsessive compulsive disorders and substance abuse disorders such as alco |
| 5104870 |
Heterocyclic pharmaceutical compounds and use |
April 14, 1992 |
| Novel (2S, 3S, 5R) morpholinols of formula (I) ##STR1## together with the (+-)-(2R*,3R*,5S*) racemates thereof, and their salts, whereinX is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or a group --CH.sub.2 --X.sup.1 where X.sup.1 is cycloalkyl of 3 to |
| 5102914 |
Antihypertensive sulfonanilides |
April 7, 1992 |
| The present invention is concerned with compounds of formula (I) ##STR1## wherein R.sub.1 is hydrogen;R.sub.2 is carbonyl; andR.sub.3 is hydroxy;and salts thereof, with processes for preparing same and with their use in medicine for the treatment of hypertension. |
| 5101071 |
Pesticidal compounds |
March 31, 1992 |
| Pesticidal compositions for use against insects and acarines comprising a compound of Formula (I):whereinR.sup.1 is: C.sub.1-14 alkyl optionally substituted by C.sub.1-6 alkoxy, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.2-6 alkenyloxy, C.sub.2-6 alkynyloxy, aryl, aryloxy or aryl (C.sub |
| 5098715 |
Flavored film-coated tablet |
March 24, 1992 |
| The invention comprises a flavored thin film coating on solid oral dosage pharmaceutical tablets containing unpleasant tasting ingredients such as triprolidine hydrochloride and pseudoephedrine hydrochloride. The flavored coating of the invention is comprised of a film-forming substance |
| 5096895 |
Novel synergistic compositions |
March 17, 1992 |
| A method of controlling veterinary ectoparasites of mammals and birds of the sub-orders Ixodoidea and Sarcoptiformes comprising the application of a parasiticidally effective, non-toxic amount of a pyrethroid of formula ##STR1## together with at least one parasiticidal organophosphor |
| 5095039 |
Diphenylsulfide compound and use |
March 10, 1992 |
| A halogen-substituted diphenylsulfide compound is disclosed which produce a large selective inhibition of serotonin uptake in brain. This compound is useful in the treatment of depression as well as anxiety, obsessive compulsive disorders and alcoholism. |
| 5095018 |
3-benzyl-1,2,4-triazolo[4,3-.alpha.] pyrazines |
March 10, 1992 |
| 3-benzyl-1,2,4-triazolo [4,3-.alpha.] pyrazines are prepared. They are useful as anticonvulsants. |
| 5093114 |
Treatment of human viral infections |
March 3, 1992 |
| Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5'-mono-, di- and triphosphate of |
