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Boehringer Mannheim GmbH Patents
Assignee:
Boehringer Mannheim GmbH
Address:
Mannheim, DE
No. of patents:
987
Patents:


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Patent Number Title Of Patent Date Issued
RE35803 Blood lancet device for and method withdrawing blood for diagnostic purposes May 19, 1998
Blood lancet device for withdrawing blood for diagnostic purposes, in which with the aid of a lancet drive (3) in a housing (1) a lancet holder (6) with a lancet (34) positioned in it and moveable along a predetermined, straight puncture path is moved until the tip (35) of the lancet eme
RE34864 Carrier for coating with immunologically-active material February 21, 1995
The present invention provides a carrier for coating with immunologically-active material, wherein it consists of an injection molded synthetic resin with a content of adjuvant and additional materials of less than 1% by weight. The present invention also provides a carrier coated wi
RE34672 Pharmaceutical composition containing a stable modification of torasemide July 26, 1994
The present invention provides a process for the preparation of cystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, melting point 162.degree. C.) from torasemide of modification II (monoclinic, space group P2/n, melting point 169.degree. C.), wherein a
RE34580 Process for the preparation of a stable modification of torasemide April 5, 1994
The present invention provides a process for the preparation of crystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, .[.melting point 162.degree. C.).]. .Iadd.in prism form) .Iaddend.from torasemide of modification II (monoclinic, space group P2/n, .[.m
RE34312 Process and reagent for the determination of an antibody July 13, 1993
The present invention provides a process for the determination of an antibody by incubation with three different reagents R.sub.1, R.sub.2 and R.sub.3, of which R.sub. and R.sub.3 are present in liquid phase and are bindable with the antibody, R.sub.2 is present bound to a solid phase an
D411621 Blood glucose meter June 29, 1999
D250220 Dispenser for microscope slides November 7, 1978
6689755 Method of stabilizing biologically active substances February 10, 2004
The present invention relates to a rapid and readily reproducible process for stabilizing biologically active substances by combining the biologically active substance witha a stabilizingmixture and drying the resulting mixture into a dry, amorphous product by means of convection dry
6660492 Chimeric serine proteases December 9, 2003
A chimeric serine protease whose protease domain is composed of two domain halves (half-sides) with a .beta.-folded sheet structure, wherein the first domain half corresponds to the first domain half of a first serine protease and the second domain half corresponds to the second domain h
6573374 Nucleotides labelled with an infrared dye and their use in nucleic acid detection June 3, 2003
Nucleoside-5'-triphosphates and phosphoramidites which carry a residue absorbing in the long wavelength region, preferably a carbocyanine group of the general formula (I), on the base portion or on the phosphorus atom ##STR1##in which R.sup.1 and R.sup.2 each denote hydrogen or together
6330063 Low coherence interferometer apparatus December 11, 2001
Low coherence interferometer apparatus for investigation of a sample (15), in particular for multi-dimensional imaging, having an interferometer configuration (2) comprising a low coherence light source, a probe head (9) having a light exit opening (16) for irradiating light into the
6274325 Method for carrying out a homogeneous-immunoassay based on agglutination August 14, 2001
The invention concerns a homogeneous immunoassay based on agglutination using an Fab'-biotin material and agglutinatable particles which carry streptavidin or avidin. The invention also concerns the Fab'-biotin which is bound or linked via linkage groups to a label compound which can
6238664 Process for stabilizing proteins May 29, 2001
An aqueous protein solution buffered with a potassium phosphate buffer, in which the ratio of potassium ions to sodium ions in the solution is at least 10:1, is resistant to the formation of protein aggregates and particles under conditions of freezing, thawing, lyophilization, and r
6235279 Method for treating thromboembolic conditions by inhibiting reocclusion via the use of multiple May 22, 2001
Discussed are therapeutic approaches to the treatment of thrombolic conditions. The therapies use thrombolytically active proteins which inhibit reocclusion in the subject. The proteins are administered in two or more boli.
6184042 Method for reducing hook effect in an immunoassay February 6, 2001
In order to extend the measuring range and to reduce the Hook effect in an immunological method of determination of an antigen based on the principle of a sandwich assay it is preferable to use a method which is characterized in that the labelled detection molecule is an oligomer of a
6180948 Image recording system for evaluating analytical test elements January 30, 2001
Image recording system for the evaluation of analytical test elements with a holding unit (8) into which the test elements are placed or onto which they are placed as well as a lens system (5) which records an image of the test elements on a CCD chip (3) and an evaluation unit that evalu
6171842 Chimeric serine proteases January 9, 2001
A chimeric serine protease whose protease domain is composeD. of two domain halves (half-sides) with a .beta.-folded sheet structure, wherein the first domain half corresponds to the first domain half of a first serine protease and the second domain half corresponds to the second domain
6159722 Chimeric serine proteases December 12, 2000
A chimeric serine protease whose protease domain is composed of two domain halves (half-sides) with a .beta.-folded sheet structure, wherein the first domain half corresponds to the first domain half of a first serine protease and the second domain half corresponds to the second domain h
6153192 Peptides with a characteristic antigenic determinant of .alpha.1-microglobulin November 28, 2000
A peptide according to the present invention is not more than 40 amino acids long and contains a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 144 and 183 of human .alpha.1-microglobulin or/and a sequence which is at least 6
6148666 Method and device for liquid transfer with an analysis apparatus November 21, 2000
A liquid transfer device for an analysis unit includes a transfer needle having a tip, and a capacitive liquid level detector for detecting immersion of the tip of the needle into an analysis liquid by detecting a change in capacitance between a signal electrode and a counter electrode.
6144449 Low coherence interferometric device November 7, 2000
Low coherence interferometer apparatus for investigation of a sample (15), in particular for multidimensional imaging, having an interferometer configuration (2) comprising a low coherence light source, a probe head (9) having a light exit opening (16) for irradiating light into the
6121322 Azulene derivatives September 19, 2000
The invention provides novel azulene derivatives of general formula I ##STR1## wherein R.sub.1 to R.sub.6 have the significance given in the description, as well as their tautomers, enantiomers, diastereomers, racemates and physiologically compatible salts or esters and substances wh
6074836 Method of marking eukaryotic cells June 13, 2000
A method of marking a eukaryotic (mammalian) cell by expressing in this cell a nucleic acid, said nucleic acid encoding a cell surface receptor, and by subsequently presenting said receptor at the cell surface, characterized by using a nucleic acid in which the region encoding the in
6074360 Electromagnetic transdermal injection device and methods related thereto June 13, 2000
Featured is a method for injection of a payload into the tissues of an organism or a body, including the steps of generating forces by electromagnetic repulsion and accelerating the payload to be injected, using the generated electromagnetic forces. The payload is thereby accelerated
6060455 Cationic and polycationic amphiphiles, reactives containing the same and their use May 9, 2000
The invention concerns new cationic or polycationic amphiphiles which are capable of forming aggregates with macromolecules, in particular with DNA or RNA, and it concerns their delivery into prokaryotic or eukaryotic cells. Compounds with spermyl-dioleoyloxypropyl structure have proven
6055060 Analytical system with means for detecting too small sample volumes April 25, 2000
Analytical system for evaluating test elements having means of determining whether a sufficient amount of sample liquid was evenly applied to an application zone comprising in a first embodiment of the invention at least two sources of light which illuminate separate or at least not full
6033876 Anti-CD30 antibodies preventing proteolytic cleavage and release of membrane-bound CD30 antigen March 7, 2000
An antibody which binds to the CD30 antigen and a) inhibits the release of sCD30 from Hodgkin's disease cells, and b) does not bind to B cell non-Hodgkin's lymphomas or plasma cells. An example of such antibodies are the antibodies secreted from hybridoma cell line DSM ACC 2204. The
6025142 Hydrophobic u-PAR binding site February 15, 2000
The invention relates to an antibody which inhibits the binding between u-PA and u-PAR to an extent of at least 90% in an assay as defined in the specification, or an active fragment or immunological equivalent of said antibody. Examples of such antibodies are deposited Jul. 7, 1994 at
6013467 Blood substitute suppression by peroxides January 11, 2000
The invention concerns a method for the elimination or/and reduction of interferences which are caused by the presence of free haemoglobin in the determination of an analyte in a sample by optical measurement, wherein one or several peroxidic compounds are added to the analytical reagent
5989812 Transcription method November 23, 1999
An improved method of transcribing nucleic acids wherein the amount of abortive transcripts formed is reduced wherein the improvement comprises an effector sequence in the transcription reaction.
5985555 Method and apparatus for processing nucleic acids using a small temperature-changing zone November 16, 1999
Method and device for processing nucleic acids in a reaction mixture on a surface that can be temperature-controlled and its immediate vicinity wherein the main space of the reaction mixture remains essentially isothermal. The method has the advantage of a very short processing time.
5965424 Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases October 12, 1999
The present invention concerns a process for the isolation of recombinant IgA protease from inclusion bodies. In addition a recombinant DNA is claimed which codes for an IgA protease whose C-terminal helper sequence and preferably also its N-terminal signal sequence is no longer active.
5959078 Isolated polysialyl transferases September 28, 1999
Isolated nucleic acid molecules encoding polysialyl transferases, and the polysialyl transferases themselves are disclosed. SEQ ID NOS: 1, 2, 7 and 8 present examples of these. The nucleic acid molecules and the proteins can be used diagnostically or therapeutically. Additionally, antise
5958722 Use of recombinant inhibitor from Erythrina caffra for purifying serine proteases September 28, 1999
Process for purifying serine proteases from a protein mixture by binding the serine protease to an immobilized polypeptide with the activity of an inhibitor DE-3 from Erythrina caffra, removing unbound components from the protein mixture, detaching the serine protease from the inhibitor
5957822 Lid for closing vessels September 28, 1999
A lid for closing an opening of a vessel includes a lid body configured to engage the opening, with the vessel having a defined shape. The lid body includes an engagement part which engages a corresponding surface of the vessel, thereby closing the opening. A handling element is disposed
5952185 Photo-activatable biotin derivatives and their use to reduce interference in immunoassays September 14, 1999
The invention addresses new photo-activatable biotin derivatives having the formula I ##STR1## wherein R=[(CH.sub.2).sub.n --O.sub.m ].sub.q --[(CH.sub.2).sub.r --O.sub.s ].sub.t --(CH.sub.2).sub.pwith n,r=2,3; m,s=0,1; q+t=1-4; p=1-4,wherein the sum of all CH.sub.2 groups does not e
5939470 Dry polymer bead preparation August 17, 1999
The invention addresses a method of preparing a dry polymer bead preparation. To achieve this, the polymer beads are coated with a layer of an easily soluble substance which dissolves again in a liquid when the polymer beads are resuspended. The resuspension is thus largely free of a
5935780 Method for the qualitative or/and quantitative detection of an analyte August 10, 1999
For the qualitative or/and quantitative detection of a substance to be determined in a test sample with the aid of an immunoassay or nucleic acid hybridization assay the following components are used:a) a capture reagent which enables a specific detection of the substance to be determine
5935778 Method for serological typing using type-specific antigens August 10, 1999
The invention concerns a method for typing antibodies in a sample liquid by means of type-specific antigens and in particular a method for typing antibodies to the hepatitis C virus and peptide antigens suitable for this.
5932296 Process for producing a surface coated with amino groups August 3, 1999
A surface coated with amino groups is produced by applying a polymerizable amine to a surface by means of a pulsed plasma. The coated surfaces obtained thereby have a high density of amino groups so that a specific binding phase can be obtained by covalently binding a partner of a sp
5919757 Aqueous pharmaceutical preparations of G-CSF with a long shelf life July 6, 1999
Aqueous pharmaceutical preparations of G-CSF are disclosed that are stable on storage and a buffer selected from the group consisting of a salt of citrate, maleate, a combination of phosphate and citrate, and arginine; and at least one surfactant.
5919622 System for the temperature adjustment treatment of liquid samples July 6, 1999
A system for the temperature adjustment treatment of liquids, especially during the isolation and amplification of nucleic acids with a reusable thermostat element and a disposable heating element has the advantage of a particularly simple means of conducting temperature adjustment treat
5916759 Cholesterol oxidase from Brevibacterium sterolicum June 29, 1999
The invention concerns a cholesterol oxidase, a process for the production of a recombinant cholesterol oxidase, a DNA sequence suitable for this process which causes a cytoplasmatic expression of the recombinant cholesterol oxidase in a host bacterium as well as the recombinant chol
5914336 Method of controlling the serum solubility of orally administered torasemide and composition rel June 22, 1999
A method of controlling the serum solubility of orally administered torasemide is disclosed. A new crystallin modification of torasemide, called modification III which has significantly higher rates of solubilization than the known crystallin form of torasemide, modification I, is bl
5910246 Device for isolating nucleic acids June 8, 1999
Device for the isolation of nucleic acids from a liquid sample by introducing the liquid into the device through an inlet opening and passage of the sample through a nucleic acid binding material and discharging of the resulting liquid through an outlet opening, wherein the nucleic a
5908625 Use of the protease domain of human plasminogen activator for the treatment of thromboembolic di June 1, 1999
The invention relates to the use of thromboembolic proteins. These contain, as their only structural portion effecting thrombolytic activity, the protease domain of human tissue type plasminogen activator. These derivatives show reduced side effects, such as a reduction in bleeding w
5907047 Papyracillic acid, method for preparation and its use as synthon for bioactive substances May 25, 1999
This invention relates to a new biologically active compound as shown in formula (I) and its biologically active derivatives; whereas derivatives are produced by the reaction of formula (I) with nucleophiles. ##STR1##
5906947 Method for the repeated transfer of liquids May 25, 1999
A method for the repeated transfer of liquids from one of several storage containers into a transfer container wherein protective tips are placed onto a tip of a pipette in order to avoid contamination.
5902878 Modified phosphoramidite process for the production of modified nucleic acids May 11, 1999
The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.
5893364 Apparatus for light reflection measurements April 13, 1999
An apparatus for light transport measurements on a test object with a measuring head which includes a contact surface for placing against an interface of the test object, light irradiation device with a light transmitter for irradiating light through the contact surface and an interf
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