| Patent Number |
Title Of Patent |
Date Issued |
| RE36268 |
Method and apparatus for amperometric diagnostic analysis |
August 17, 1999 |
| The present invention relates to a novel method and apparatus for the amperometric determination of an analyte, and in particular, to an apparatus for amperometric analysis utilizing a novel disposable electroanalytical cell for the quantitative determination of biologically importan |
| D406895 |
Glucose testing instrument |
March 16, 1999 |
|
| D368967 |
Design for a liquid transfer module for a laboratory analyzer |
April 16, 1996 |
|
| D361129 |
Combined blood coagulation measuring instrument and test strip |
August 8, 1995 |
|
| D342573 |
Lancet actuator |
December 21, 1993 |
|
| D321488 |
Colorimeter |
November 12, 1991 |
|
| D318245 |
Colorimeter |
July 16, 1991 |
|
| 5981199 |
Method for measuring antigen concentration |
November 9, 1999 |
| This invention provides a method for measuring an antigen concentration in a sample, which comprises: preparing VH-domain polypeptide and VL-domain polypeptide of an antibody specific to the antigen; labeling one of the polypeptides with a reporter molecule to form labeled polypeptides, |
| 5976857 |
Cross-linked polypeptide fragments of .beta.-galactosidase |
November 2, 1999 |
| Formation of an intramolecular cross-link in enzyme donor polypeptide fragments of .beta.-galactosidase, thereby forming a cyclic enzyme donor which is hindered from complementation with an enzyme acceptor fragment to form active of .beta.-galactosidase. The cyclic enzyme donor can be |
| 5976783 |
Bis-maleimido cross-linking agents |
November 2, 1999 |
| Formation of an intramolecular cross-link in enzyme donor polypeptide fragments of .beta.-galactosidase, thereby forming a cyclic enzyme donor which is hindered from complementation with an enzyme acceptor fragment to form active of .beta.-galactosidase. The cyclic enzyme donor can be |
| 5935861 |
Diazonium ion assay reagents and methods for their use |
August 10, 1999 |
| Diazonium ions which are useful as reagents for the assay of bilirubin content in a sample, such as a body fluid sample, are provided. In one preferred embodiment, 2-methyl-3-nitroaniline diazonium ion is provided, having the structure: ##STR1## Also provided are reagent composit |
| 5919642 |
Competitive binding assays having improved linearity |
July 6, 1999 |
| Simplified calibration and improved dose-response linearity of the standard curve of competitive assays are obtained by adding a predetermined amount of unlabeled competitive binding compound (usually just the analyte itself) to a first reagent containing anti-analyte antibodies before t |
| 5886252 |
Power supply monitor and control for medical instrument |
March 23, 1999 |
| An instrument for determining a characteristic of a biological fluid or a control comprises a radiation-reflective surface, a first source for irradiating the surface, a first detector for detecting radiation reflected from the surface, and a mechanism for determining the characteris |
| 5846702 |
Reagent including an osmium-containing redox mediator |
December 8, 1998 |
| A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) |
| 5843682 |
N-1-carboxyalkyl derivatives of LSD |
December 1, 1998 |
| Novel derivatives of LSD having the formula ##STR1## wherein R.sub.1 is an alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, preferably an alkyl group having 1 carbon atom;R.sub.2 is a bond or ##STR2## wherein R.sub.3 is alkyl, cycloalkyl or aryl group having 2 to 10 c |
| 5841023 |
Magnet for medical instrument |
November 24, 1998 |
| An instrument monitors the coangulation of coagulable fluid blood, blood fraction or a control by combining the coagulable fluid with particles which are affected by a magnetic field so that the particles become suspended relatively freely in the fluid. A time-varying magnetic field |
| 5832921 |
Analog heater control for medical instrument |
November 10, 1998 |
| An instrument for determining a characteristic of a biological fluid or a control includes a heater and a heater control. The heater comprises a heater element, supported in heat conducting relationship to the biological fluid or control when the instrument is in use. A temperature s |
| 5830741 |
Composition for tissue dissociation containing collagenase I and II from clostridium histolyticu |
November 3, 1998 |
| An enzyme composition for dissociating tissues is disclosed. The composition comprises purified collagenase I and collagenase II from Clostridium histolyticum in a mass ratio of about 0.3 to 0.6 and a neutral protease such that the ratio of total FITC casein units of activity to Wuns |
| 5807752 |
Assay using an unblocked solid phase with immobilized analyte binding partner |
September 15, 1998 |
| The invention relates to a test system useful in carrying out diagnostic assays. One component of the test system is an unblocked solid phase test carrier with a three dimensional configuration, impregnated with a first binding partner for analyte of interest. The second component of a b |
| 5804403 |
Stable aqueous reagent containing NAD |
September 8, 1998 |
| A stable aqueous NAD reagent useful in the measurement of analytes in biological fluids, particularly ethanol and lactate. For the determination of alcohol, the reagent contains alcohol dehydrogenase, pyrazole, NAD, SUTTOCIDE A and an aliphatic, zwitterionic buffer having a secondary or |
| 5795718 |
Detection of complementary nucleotide sequences |
August 18, 1998 |
| The invention relates to a method for detection of a specific nucleic acid sequence which comprises forming a reaction mixture by combining(1) a sample suspected of containing a nucleic acid;(2) a probe/enzyme donor polypeptide conjugate comprising(a) an enzyme donor polypeptide sequence compris |
| 5792944 |
Power supply monitor and control for medical instrument |
August 11, 1998 |
| An instrument for determining a characteristic of a biological fluid or a control comprises a radiation-reflective surface, a first source for irradiating the surface, a first detector for detecting radiation reflected from the surface, and a mechanism for determining the characteris |
| 5789664 |
Fluid dose, flow and coagulation sensor for medical instrument |
August 4, 1998 |
| An instrument and a method for determining a characteristic of a biological fluid or control comprise providing a radiation-reflective surface, a source for irradiating the surface, a detector for detecting radiation reflected from the surface, and a cuvette for holding a sample of the |
| 5763196 |
Assays using cross-linked polypeptide fragments of .beta.-galactosidase |
June 9, 1998 |
| Formation of an intramolecular cross-link in enzyme donor polypeptide fragments of .beta.-galactosidase, thereby forming a cyclic enzyme donor which is hindered from complementation with an enzyme acceptor fragment to form active of .beta.-galactosidase. The cyclic enzyme donor can be |
| 5762770 |
Electrochemical biosensor test strip |
June 9, 1998 |
| An electrochemical biosensor test strip that has a minimum volume blood sample requirement of about 9 microliters. The test strip has working and counter electrodes that are substantially the same size and made of the same electrically conducting material placed on a first insulating |
| 5753485 |
Purified mixture of collagenase I, collagenase II and two other proteases |
May 19, 1998 |
| A purified enzyme mixture useful for isolating cells or cell clusters from tissue is disclosed. The mixture includes at least two collagenase enzymes, at least two other proteases, and additional non-protease components. The mixture is purified by removing at least some of the non-pr |
| 5724066 |
Method and apparatus for automatic control of instruments through video |
March 3, 1998 |
| A system and method provide for distinguishing among characters of a character set. The characters are represented by a data stream of pixel information to a display port. A subset of the pixel information in the data stream contains sufficient information for unique identification of |
| 5719063 |
Multiplex immunoassay system |
February 17, 1998 |
| Disclosed is a method of assaying and apparatus for assaying, in assay apparatus, for an analyte in a sample by specifically binding the analyte to a binding molecule having a detectable tag to form a complex, the presence of which can be determined quantitatively by measuring the amount |
| 5710622 |
Fluid dose, flow and coagulation sensor for medical instrument |
January 20, 1998 |
| A method of immunizing the operation of an instrument which determines a characteristic of a biological fluid or a control against noise. The instrument includes a surface upon which a user deposits a sample of biological fluid or control the characteristic of which is to be determin |
| 5707820 |
Reagent and assay methods including a phenazine-containing indicator |
January 13, 1998 |
| A new reagent and methods for measuring the concentration of (or detecting the presence of) an analyte in a sample. The reagent includes a phenazine-containing compound and an enzyme. The phenazine-containing compound must be of sufficient type to form a semiquinoid (the color indica |
| 5686659 |
Fluid dose flow and coagulation sensor for medical instrument |
November 11, 1997 |
| A method of determining whether a sample or a control has been applied to an instrument for measuring coagulation of a fluid by optically detecting when the fluid that has been applied to the instrument has passed a first and a second points, determining the flow time for the fluid betwe |
| 5652755 |
Printer interface system |
July 29, 1997 |
| Monitor (11) includes a microcontroller (51) programmed in a first mode of operation to drive various loads (59), (69) which operate to perform tests on patient samples. The results of the tests are sensed by sensors (61), (75) and digitally stored in storage (67) for display on display |
| 5639668 |
Optical apparatus for performing an immunoassay |
June 17, 1997 |
| An optical system which may be a component of apparatus for assaying a fluid sample with radiation is capable of exciting fluorescence in fluorescent material and includes a totally internally reflecting, unitary elongated substrate transmissive to both the excitation radiation and to |
| 5639631 |
Stable reagent for ferric ion complex indicator systems |
June 17, 1997 |
| The invention is a stable reagent used in assay systems that form a colored ferric ion complex, such as Prussian Blue. Such reagents are useful for the detection or measurement of an analyte from a fluid sample. Surprisingly, it has been found that the inclusion of certain ferric ion |
| 5627075 |
Stable diagnostic reagent |
May 6, 1997 |
| The inclusion of succinic acid or a salt thereof to stabilize compositions that include glucose oxidase and/or ferricyanide. Typically, the succinic acid or succinic acid salt is included in a diagnostic reagent utilized in test strips or test solutions useful for the analysis of glucose |
| 5606164 |
Method and apparatus for biological fluid analyte concentration measurement using generalized di |
February 25, 1997 |
| A method and apparatus for measuring the concentration of an analyte present in a biological fluid is disclosed. The method includes the steps of applying NIR radiation to calibration samples to produce calibration data, analyzing the calibration data to identify and remove outliers, |
| 5594906 |
Zero power receive detector for serial data interface |
January 14, 1997 |
| A serial data interface includes a receive data terminal, a received serial data out terminal and an operating power supply terminal. A zero-power receive detector for the serial data interface includes a source for furnishing operating power to the interface. The supply of power from th |
| 5589326 |
Osmium-containing redox mediator |
December 31, 1996 |
| A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) |
| 5583006 |
Stabilizing tetrazolium salts in a reagent |
December 10, 1996 |
| A stable reagent for assaying an analyte from a fluid sample which includes an enzyme, a mediator, a tetrazolium salt and an oxidizing agent selected from the group consisting of sodium chlorate, 2,5-dimethylhexane-2,5-dihydroperoxide, benzoyl peroxide, t-butyl peroxide, sodium iodat |
| 5543299 |
Extender containing polymer compositions and uses thereof |
August 6, 1996 |
| The invention relates to polymeric compositions useful in analyte determination. The compositions contain a polymer, a reagent system for analyte determination, and an extender. The last component alleviates tackiness in the composition, and thus reduces damage in preparation of test |
| 5538870 |
Method for preparing nucleic acids for analysis and kits useful therefor |
July 23, 1996 |
| Methods useful in purifying nucleic acids from whole cell samples are described. This is accomplished by adding one or both of a non-phenyl group containing non-ionic detergent or a cross-linked, polycarboxylic acid. Kits which can be used in the methods are also described. |
| 5538870 |
Method for preparing nucleic acids for analysis and kits useful therefor |
July 23, 1996 |
| Methods useful in purifying nucleic acids from whole cell samples are described. This is accomplished by adding one or both of a non-phenyl group containing non-ionic detergent or a cross-linked, polycarboxylic acid. Kits which can be used in the methods are also described. |
| 5526111 |
Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood f |
June 11, 1996 |
| A method for calculating a coagulation characteristic of a sample of blood, a blood fraction, or a control comprises generating an output signal indicative of coagulation of the sample, sampling the output signal at a sampling rate for a predetermined time to provide a plurality of sampl |
| 5525474 |
Piperidine analogs and conjugates of procainamide and NAPA |
June 11, 1996 |
| Novel derivatives of procainamide and N-acetylprocainamide (NAPA) are disclosed having the following formula: ##STR1## wherein: X=hydrogen or acetyl;n=1 to p where p=MW of Z/1000;Z=a poly(amino acid) or polysaccharide; andR3=a bond or ##STR2## wherein R2=an alkyl, cycloalkyl or a |
| 5522255 |
Fluid dose, flow and coagulation sensor for medical instrument |
June 4, 1996 |
| An instrument and a method for determining a coagulation characteristic of blood, a blood fraction or a control comprise a radiation-reflective surface, a first source for irradiating the surface, and a first detector for detecting radiation reflected from the surface. A cuvette holds a |
| 5514560 |
Substrates for .beta.galactosidase |
May 7, 1996 |
| Galactopyranoside derivative compounds for use as substrates for hydrolysis by enzymes with .beta.-galactosidase activity are provided. The concentration of the reaction products can be measured by spectroscopy. The compounds find particular use in diagnostic assays for detection of |
| 5508171 |
Assay method with enzyme electrode system |
April 16, 1996 |
| A new electrochemical biosensor and method of its use. The electrochemical biosensor has a pair of electrodes consisting of a working electrode and a counter electrode made of the same electrically conducting materials. The counter electrode may be the same size or smaller than the worki |
| 5492813 |
Muteins of .beta.-galactosidase fragments having increased activity |
February 20, 1996 |
| Muteins of enzyme acceptor polypeptide fragments of .beta.-galactosidase are provided which exhibit substantially increased kinetic complementation activity with no significant loss in stability. A preferred enzyme acceptor fragment has an amino acid other than cysteine located at po |
| 5492674 |
Evanescent wave immunoassay system |
February 20, 1996 |
| Apparatus for assaying a fluid sample with radiation capable of exciting fluorescence in fluorescent material comprises a totally internally reflecting, unitary elongated substrate transmissive to both the excitation radiation and to the fluorescence. The fluorescent material include |
| 5488816 |
Method and apparatus for manufacturing a coagulation assay device in a continuous manner |
February 6, 1996 |
| A ribbon-like flat web having a plurality of side by side depressions is fed through a horizontal slot having a downward facing surface having an aperture communicating with a reservoir of reagent containing solution. The web is urged against the downward facing surface to provide sealin |
