| Patent Number |
Title Of Patent |
Date Issued |
| RE38981 |
DNA sequence coding for protein C |
February 14, 2006 |
| Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed. |
| RE37958 |
DNA sequence coding for protein C |
January 7, 2003 |
| Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed. |
| 6161031 |
Optical imaging methods |
December 12, 2000 |
| There is disclosed an apparatus for real-time imaging of cortical intrinsic signals or imaging tumor tissue or the margins, dimensions and grade of tumor tissue, comprising, a means for obtaining analog video images and a means for processing the analog video signals into either an avera |
| 6043225 |
Diagnosis and treatment of arterial chlamydial granuloma |
March 28, 2000 |
| Method of diagnosing arterial chlamydial granuloma by detecting in a biological sample both a first marker associated with Chlamydia pneumoniae and a second marker associated with arterial granuloma. Therapeutic composition for treating arterial chlamydial granulomatous disease, incl |
| 6037119 |
Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
March 14, 2000 |
| The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and m |
| 6022736 |
Nucleic acid vectors comprising DNase I hypersensitive sites |
February 8, 2000 |
| The present invention provides novel recombinant nucleic acid vectors which may be used to produce .alpha.-globin as well as other proteins of interest in quantity in the red blood cells of transgenic animals or cell cultures of erythroid lineage. The present invention also provides for |
| 6008781 |
Virtual retinal display |
December 28, 1999 |
| A virtual retinal display utilizes photon generation and manipulation to create a panoramic, high resolution, color virtual image that is projected directly onto the retina of the eye without creating a real or an aerial image that is viewed via a mirror or optics. The virtual retinal di |
| 5955583 |
Antibodies to cGMP-binding, cGMP-specific phospodiesterase |
September 21, 1999 |
| The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Antibodies to the cGMP-binding, cGMP-stimulated phosphodiesterase are disclosed. Also provided by the invention are methods a |
| 5919911 |
Monoclonal antibodies to stem cell factor receptors |
July 6, 1999 |
| The present invention relates to monoclonal antibodies specific for a cell receptor specific for human stem cell factor (hSCF) as well as pharmaceutical compositions containing such monoclonal antibodies and uses of such monoclonal antibodies. |
| 5906938 |
Method of reconstituting hematopoietic cells using monoclonal antibodies to the stem cell factor |
May 25, 1999 |
| The present invention relates to monoclonal antibodies specific for a cell receptor specific for human stem cell factor (hSCF) as well as pharmaceutical compositions containing such monoclonal antibodies and uses of such monoclonal antibodies for the isolation and reconstitution of h |
| 5854070 |
Murine and humanizer 23F2G antibodies and cell lines expressing said antibodies |
December 29, 1998 |
| Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory processes associated with the multiple sclerosis disease, by administering a pharmaceutically effective amount of antibody substance |
| 5845639 |
Optical imaging methods |
December 8, 1998 |
| Methods for optically imaging blood flow changes, blood flow characteristics and changes in the oxygenation of blood in an area of interest are disclosed. The area of interest is illuminated with electromagnetic radiation(emr) in the visible or infrared regions of the spectrum, and a |
| 5830874 |
Compositions and methods for the treatment of arterial chlamydial granuloma |
November 3, 1998 |
| Method of diagnosing arterial chlamydial granuloma by detecting in a biological sample both a first marker associated with Chlamydia pneumoniae and a second marker associated with arterial granuloma. Therapeutic composition for treating arterial chlamydial granulomatous disease, incl |
| 5714146 |
IL-4 bone therapy |
February 3, 1998 |
| An in vivo assay for selecting a candidate therapeutic for treating osteoporosis. A candidate reagent is administered to an IL-4 transgenic mammal whose cells contain a recombinant IL-4 coding sequence operably lined to a promoter sequence which is transcriptionally active in bone ma |
| 5702936 |
Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
December 30, 1997 |
| The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and m |
| 5659327 |
Virtual retinal display |
August 19, 1997 |
| A virtual retinal display utilizes photon generation and manipulation to create a panoramic, high resolution, color virtual image that is projected directly onto the retina of the eye without creating a real or an aerial image that is viewed via a mirror or optics. The virtual retinal di |
| 5652131 |
Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
July 29, 1997 |
| The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and m |
| 5602306 |
Synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic a |
February 11, 1997 |
| The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the .beta.-globin locus are sufficie |
| 5571110 |
Orthopedic saw guide for use in a robot-aided system for surgery |
November 5, 1996 |
| An orthopedic saw guide for confining the blade of a surgical saw to movement in a single plane while allowing translational and rotational movement of the blade within the plane. A pair of elongated guideplates are secured together at either end to form a partially enclosed space. The |
| 5469403 |
Digital sonar system |
November 21, 1995 |
| A transponder of an active digital sonar system identifies a multifrequency underwater activating sonar signal received from a remote sonar transmitter. The transponder includes a transducer that receives acoustic waves, including the activating sonar signal, and generates an analog |
| 5467459 |
Imaging and graphics processing system |
November 14, 1995 |
| The present invention provides a unified image and graphics processing system that provides both image and graphics processing at high speeds. The system includes a parallel vector processing unit, a graphics subsystem, a shared memory and a set of high-speed data buses for connectin |
| 5467104 |
Virtual retinal display |
November 14, 1995 |
| A virtual retinal display utilizes photon generation and manipulation to create a panoramic, high resolution, color virtual image that is projected directly onto the retina of the eye without creating a real or an aerial image that is viewed via a mirror or optics. The virtual retinal di |
| 5459677 |
Calibration transfer for analytical instruments |
October 17, 1995 |
| A technique for transferring a multivariant calibration model from a reference analytical instrument to a target analytical instrument that may be a different instrument, or the same instrument at a later time. In a "direct" approach, a plurality of transfer samples are selected, and a |
| 5424187 |
Method of screening for arterial chlamydial granuloma |
June 13, 1995 |
| Method of diagnosing arterial chlamydial granuloma by detecting in a biological sample both a first marker associated with Chlamydia pneumoniae and a second marker associated with arterial granuloma. Therapeutic composition for treating arterial chlamydial granulomatous disease, incl |
| 5409010 |
Vector doppler medical devices for blood velocity studies |
April 25, 1995 |
| An ultrasonic pulse-echo medical device for determining the angular heading and magnitude of the velocity of blood flowing through a blood vessel by transmitting a pulsed ultrasonic beam from a single transmitting transducer and receiving echoes from sample volumes along such beam by a |
| 5403319 |
Bone imobilization device |
April 4, 1995 |
| A system and method for positioning a tool relative to a patient's bone to facilitate the performance of a surgical bone alteration task. The system comprises a bone immobilization device for supporting the bone in a fixed position with respect to a reference structure, and a robot that |
| 5361184 |
Adaptive sequential controller |
November 1, 1994 |
| An adaptive sequential controller (50/50') for controlling a circuit breaker (52) or other switching device to substantially eliminate transients on a distribution line caused by closing and opening the circuit breaker. The device adaptively compensates for changes in the response ti |
| 5311131 |
Magnetic resonance imaging using pattern recognition |
May 10, 1994 |
| An MRI technique in which the similarity of samples from different portions of a body is determined and displayed. In one embodiment, the method can be used to track the spread of a known primary tumor to other portions of a patient's body. The MRI apparatus is used to produce a training |
| 5300216 |
Method for initiating pyrolysis using a shock wave |
April 5, 1994 |
| Apparatus and method for initiating pyrolysis of a feedstock by establishing a continuous, standing shock wave. Several embodiments of a shock wave reactor (10, 100, 150) are disclosed; each is connected to receive an ethane feedstock and a carrier fluid comprising superheated steam. |
| 5236432 |
Robot-aided system for surgery |
August 17, 1993 |
| A system and method for positioning a tool relative to a patient's bone to facilitate the performance of a surgical bone alteration task. The system comprises a bone immobilization device for supporting the bone in a fixed position with respect to the reference structure, and a robot tha |
| 5220825 |
Apparatus for collecting particulate samples |
June 22, 1993 |
| Multi-chamber devices of collecting particles in aquatic environments including an upper chamber serving as a particle interceptor chamber, a lower chamber serving as a particle accumulator chamber, and a valve assembly interposed between the upper and lower chambers are disclosed. U |
| 5219530 |
Apparatus for initiating pyrolysis using a shock wave |
June 15, 1993 |
| Apparatus for initiating pyrolysis of a feedstock by establishing a continuous, standing shock wave. Several embodiments of a shock wave reactor (10, 100, 150) are disclosed; each is connected to receive an ethane feedstock and a carrier fluid comprising superheated steam. The feedst |
| 5186046 |
Surface pressure measurement by oxygen quenching of luminescence |
February 16, 1993 |
| Methods and compositions for measuring the pressure of an oxygen-containing gas on an aerodynamic surface, by oxygen-quenching of luminescence of molecular sensors is disclosed. Objects are coated with luminescent films containing a first sensor and at least one of two additional sensors |
| 5183046 |
Ultrasonic plethysmograph |
February 2, 1993 |
| Quadrature phase signals (I and Q) from a pulsed Doppler medical instrument are analyzed to detect phase changes of consecutive echoes from tissue at a depth of interest. Such phase changes are analyzed to determine tissue displacement. Relative displacements at different depths are exam |
| 5182307 |
Polyethylene terephthalate foams with integral crystalline skins |
January 26, 1993 |
| Polyethylene terephthalate composite structures having integral crystalline skins on a foam of polyethylene terephthalate are described. The structures exhibit enhanced physical properties compared to polyethylene terephthalate foams. The structures are produced by a method that crys |
| 5180963 |
Optically triggered high voltage switch network and method for switching a high voltage |
January 19, 1993 |
| An optically triggered solid state switch and method for switching a high voltage electrical current. A plurality of solid state switches (350) are connected in series for controlling electrical current flow between a compensation capacitor (112) and ground in a reactive power compensato |
| 5169944 |
Methods and compositions for the enteral administration of hepatobiliary MRI contrast agents |
December 8, 1992 |
| Hepatobiliary magnetic resonance imaging of a human or animal subject is enhanced by enterally administering to the subject an effective amount of a lipophilic contrast enhancing agent. Representative contrast enhancing agents include manganese mesoporphyrin, manganese deuteroporphyrin, |
| 5151697 |
Data structure management tagging system |
September 29, 1992 |
| An adaptive data compression and decompression system having a fixed dictionary size is disclosed. The compression system builds a data dictionary tree such that each path in the tree represents a string .omega., which was, along with its prefixes, in the input character stream being |
| 5134356 |
Reactive power compensator |
July 28, 1992 |
| A system and method for determining and providing reactive power compensation for an inductive load. A reactive power compensator (50,50') monitors the voltage and current flowing through each of three distribution lines (52a, 52b, 52c), which are supplying three-phase power to one o |
| 5034428 |
Immobilized biomolecules and method of making same |
July 23, 1991 |
| A method of biomolecule immobilization is described in which the biomolecule itself or, alternatively, a monomer-conjugated biomolecule, is grafted with free monomer onto a hydrophilic, solid-phase, polymeric substrate which has been pre-irradiated with ionizing radiation. The pre-ir |
| 5009102 |
Method of monitoring solidification of a liquid composition |
April 23, 1991 |
| Reference materials of differing indices of refraction or acoustic impedances are incorporated into liquid compositions to monitor the solidification process of these liquid compositions. Light or acoustic waves are used to indirectly measure the difference between the index of refra |
| 4847066 |
Method of treating a consumable product and packaging for consumable products to indicate the pr |
July 11, 1989 |
| A method is described for treating consumable products, such as foods, drugs or dietary supplements, for example drugs enclosed in capsules, to detect contamination. A colorimetric indicator, which can react with a contaminating substance such as cyanide, is incorporated into the con |
| 4834024 |
Inducing polyploidy in oysters |
May 30, 1989 |
| A method of inducing polyploidy in oysters through the use of hydrostatic pressure is disclosed. The method includes separating oysters from one another such that male oysters are separated from female oysters, inducing the oysters to spawn, controlling the temperature of eggs from the |
| 4358535 |
Specific DNA probes in diagnostic microbiology |
November 9, 1982 |
| Method and compositions for infectious disease diagnosis and epidemiology involving labeled nucleotide probes complementary to nucleic acid coding for a characteristic pathogen product. Clinical isolates are cultivated, expanding the number of microorganisms, the resulting colonies lysed |
