| Patent Number |
Title Of Patent |
Date Issued |
| RE39267 |
Thienopyrimidine-based inhibitors of the SRC family |
September 5, 2006 |
| Various thienopyrimidine-based analog compounds that selectively inhibit the Src family of tyrosine kinases. These compounds are thienopyrimidines and contain a hydrozone bridge created by heating a thienopyrimidine hydrazine with an aldehyde in ethanol at reflux. Such compounds are |
| RE38972 |
Intravascular device |
February 7, 2006 |
| A multi-element occlusion device (10, 20, 30, 40) provides an improvement over existing systems by increasing the occupation of a vascular lumen. The device (10, 20, 30) comprises an anchoring element (12, 22, 32), a lead element (14, 24, 34) and at least one fiber (16, 26, 36) attaching |
| 7626693 |
Illumination sources and customizable spectral profiles |
December 1, 2009 |
| Methods for generating a customized spectral profile, which can be used to generate a corresponding filter, lamp or other type of illuminant. A trial spectrum is generated. A reference spectrum is determined or otherwise obtained. A SOURCE spectrum is determined or otherwise obtained |
| 7625724 |
MAVS in the prevention and treatment of viral diseases |
December 1, 2009 |
| The present invention includes compositions and methods for the identification, characterization and use of a novel anti-viral protein that includes a mitochondrial anti-viral signaling protein. |
| 7625674 |
Switchable holographic gratings |
December 1, 2009 |
| The present invention includes systems and compositions of holographic grating structures devices and methods for fabricating such holographic grating structures. The method comprises the steps of preparing a composite mixture comprising a polymerizable matrix, a liquid crystal, and |
| 7625563 |
Cancer treatment methods using selected immunoconjugates for binding to aminophospholipids |
December 1, 2009 |
| Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are a |
| 7622306 |
Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy |
November 24, 2009 |
| The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma |
| 7622289 |
Ornithine aminotransferase (OAT): a target for anticancer drugs |
November 24, 2009 |
| Ornithine .delta.-aminotransferase (OAT) facilitates microtubule assembly in addition to its aminotransferase activity in mitochondria. An N-terminal proteolysis of the first 17 amino acids of OAT block its transport to the mitochondria. The resultant truncated protein (OATC) forms s |
| 7622118 |
Cancer treatment methods using selected antibodies to aminophospholipids |
November 24, 2009 |
| Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are a |
| 7622106 |
Necrosis assay |
November 24, 2009 |
| A necrosis assays is performed with a cell expressing RIPK1 and RIP3 by (a) culturing the cell with a smac mimetic, caspase-8 inhibitor and TNF-.alpha.; and (b) detecting a resultant necrosis of the cell. |
| 7619000 |
S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutat |
November 17, 2009 |
| Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been consi |
| 7618630 |
Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagoni |
November 17, 2009 |
| Antagonists of .alpha.4 integrin/.alpha.4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of mult |
| 7615223 |
Selected immunoconjugates for binding to aminophospholipids |
November 10, 2009 |
| Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are a |
| 7615208 |
Metal ion-labeled bis-aminoethanethiol-targeting ligand conjugates, compositions, and methods fo |
November 10, 2009 |
| The invention provides, in a general sense, a new labeling strategy employing .sup.99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to .sup.99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the i |
| 7611866 |
Selection of bacterial inner-membrane anchor polypeptides |
November 3, 2009 |
| The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating polypeptides capable of anchoring heterologous polypeptides to a bacterial inner membrane. In the technique, libraries of candidate anchor polypeptides are expressed as fusions with |
| 7611704 |
Compositions and methods for treating viral infections using antibodies and immunoconjugates to |
November 3, 2009 |
| Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are a |
| 7611465 |
Rapid and accurate detection of bone quality using ultrasound critical angle reflectometry |
November 3, 2009 |
| The present invention is an apparatus, method and system for determining the coefficient of elasticity of a target by detecting determining simultaneously two or more critical-angle reflections of an ultrasound wave from the target using an ultrasound transducer that includes a trans |
| 7608158 |
Method of maintaining particle size |
October 27, 2009 |
| The present invention includes particle compositions and methods of fabrication that prevent agglomeration, thereby maintaining particle size and/or shape. Particles of the present invention were prepared after embedding chemically disordered metal-containing particles in at least on |
| 7601731 |
Antimicrobial flush solutions |
October 13, 2009 |
| The present invention provides antimicrobial solutions that comprise at least one alcohol, at least one antimicrobial agent and at least one chelator and/or anticoagulant. Also provided are methods for rapidly reducing a microbe or a virus from surfaces including surfaces of indwelli |
| 7601490 |
Development of influenza A antivirals |
October 13, 2009 |
| The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein and an Influenza A NS1A protein; and determining whether the binding between the CPSF30 |
| 7598344 |
Composition, method and use of bi-functional biomaterials |
October 6, 2009 |
| The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The |
| 7592909 |
Location and tracking system using wireless technology |
September 22, 2009 |
| A system for locating one or more objects. The system includes one or more objects having an unknown location. Each object comprises at least one mobility sensor for providing sensory information about the object, a wireless communications package for providing received signal strength |
| 7587282 |
Statistical methods for analyzing biological sequences |
September 8, 2009 |
| Statistical algorithms that are useful to aid in the identification of evolutionarily conserved amino acid positions within a family of proteins, and in the identification of interacting amino acid positions within a protein sequence are disclosed. The algorithms may also be useful i |
| 7586102 |
Automated system for formulating radiopharmaceuticals |
September 8, 2009 |
| The present invention provides automated systems for the purification of radioisotopes, the formulation of radiopharmaceuticals or both. In preferred embodiments the radioisotopes are produced by a generator. In further preferred embodiments the automated systems comprise replaceable |
| 7585817 |
Compositions and methods for improving the productivity of hydrocarbon producing wells using a n |
September 8, 2009 |
| Compositions comprise nonionic fluorinated polymeric surfactants and solvent. The solvent comprises: at least one of a polyol or polyol ether, wherein the polyol and polyol ether have from 2 to 25 carbon atoms; and at least one monohydroxy alcohol, ether, or ketone having from 1 to 4 |
| 7582281 |
Ethylenedicysteine (EC)-drug conjugates compositions and methods for tissue specific disease ima |
September 1, 2009 |
| The invention provides, in a general sense, a new labeling strategy employing .sup.99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to .sup.99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the i |
| 7579152 |
SENP1 as a marker of cancer development and target for cancer therapy |
August 25, 2009 |
| The present invention relates to compositions and methods for the use of SENP1 as a marker for cancer diagnosis, specifically prostate cancer. Still further, it relates to the use of inhibitors of SENP1 to inhibit cell proliferation of a neoplasm or tumor cell and to treat a hyperpro |
| 7579014 |
Mesoporous compositions for use in drug delivery |
August 25, 2009 |
| The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have applications as drug-delivery vehicles. |
| 7576194 |
UspA2 nucleic acid of moraxella catarrhalis |
August 18, 2009 |
| The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than |
| 7572448 |
Combined cancer treatment methods using selected antibodies to aminophospholipids |
August 11, 2009 |
| Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are a |
| 7572442 |
Selected antibody compositions for binding to aminophospholipids |
August 11, 2009 |
| Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are a |
| 7569683 |
UspA2 nucleic acid of Moraxella catarrhalis |
August 4, 2009 |
| The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than |
| 7563446 |
Methods and compositions for inducing autoimmunity in the treatment of cancers |
July 21, 2009 |
| Disclosed are methods and compositions for the prevention and treatment of cancers using lipid-carrier protein conjugate compositions for generating lipid-specific immune responses in an animal. Also disclosed are methods for making phosphatidylserine conjugate compositions and their |
| 7559843 |
Method and apparatus for providing real-time machine learning to computer-controlled agents used |
July 14, 2009 |
| A method for providing real-time machine learning to agents used in video games is disclosed. Initially, adjusted fitnesses of a set of agents within a population are determined. An agent having a relatively low adjusted fitness is then removed from the population. Subsequently, a pa |
| 7556942 |
Tumor suppressor designated Hippo |
July 7, 2009 |
| Tumor suppressor genes (TSGs) play a major role in the pathogenesis of human cancers. Here, a new TSG designated hippo (hpo) is described, and the human homolog mst2 is identified as an additional TSG. hpo as a gene that regulates both cell proliferation and cell death in Drosophila, and |
| 7556596 |
Adaptive intracavitary brachytherapy applicator |
July 7, 2009 |
| The invention is a novel adaptive CT-compatible brachytherapy applicator with remotely-controlled radial and longitudinal motion radioactive source lumen shields that can be manipulated by the radiation oncologist to optimize the dose distribution to the target and normal tissue stru |
| 7556490 |
Multi-material stereolithography |
July 7, 2009 |
| Methods and systems of stereolithography for building cost-efficient and time-saving multi-material, multi-functional and multi-colored prototypes, models and devices configured for intermediate washing and curing/drying is disclosed including: laser(s), liquid and/or platform level |
| 7555507 |
Apparatus for solving differential equations |
June 30, 2009 |
| An apparatus for solving time-continuous differential equations is disclosed. The apparatus includes a group of hybrid integrators interconnected to each other. Each one of the hybrid integrators includes an analog integrator, a conversion logic and multiple digital registers. The an |
| 7550617 |
Compositions and methods for the treatment of renal and cardiovascular disease |
June 23, 2009 |
| Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such composit |
| 7550141 |
Methods for imaging tumor vasculature using conjugates that bind to aminophospholipids |
June 23, 2009 |
| Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and |
| 7547759 |
Induction of tumor immunity by variants of folate binding protein |
June 16, 2009 |
| The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic T-lymphocytes but preferably not to the extent tha |
| 7544466 |
Ghrelin o-acyltransferase (GOAT) biochemical assay |
June 9, 2009 |
| Ghrelin is acylated by ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a resultant decrease in acylation of the ghrelin by the acyltransferase. |
| 7543010 |
Modular pipeline fast Fourier transform |
June 2, 2009 |
| A modular pipeline algorithm and architecture for computing discrete Fourier transforms is described. For an N point transform, two pipeline {square root over (N)} point fast Fourier transform (FFT) modules are combined with a center element. The center element contains memories, mul |
| 7541398 |
Method for transformation of conventional and commercially important polymers into durable and r |
June 2, 2009 |
| The present invention includes compositions and methods of making an antimicrobial polymer by mixing sterically hindered N-halo-amines with polymeric materials with a source of halides selected from sodium di-X-isocyanurate, sodium hypohalite, N--X-succinimide, and calcium hypohalite |
| 7538538 |
Method of using a four terminal hybrid silicon/organic field effect sensor device |
May 26, 2009 |
| A four terminal field effect device comprises a silicon field effect device with a silicon N-type semiconductor channel and an N+ source and drain region. An insulator is deposited over the N-type semiconductor channel. An organic semiconductor material is deposited over the insulato |
| 7538129 |
Diazonamide A analog |
May 26, 2009 |
| A specific diazonamide A analog and its salts and conjugates are effective in treating proliferative diseases. |
| 7537903 |
FGF21 upregulates expression of GLUT-1 in a .beta.klotho-dependent manner |
May 26, 2009 |
| A method is provided to identify a modulator of .beta.Klotho-dependant glucose transporter-1 (GLUT-1) upregulation that specifically modulates interaction of .beta.Klotho and an FGFR. |
| 7534926 |
Soil remediation using heated vapors |
May 19, 2009 |
| Methods are provided for remediating contaminated soil. The methods may include collecting contaminated soil at a plurality of treatment sites. The contaminated soil at one or more of the plurality of treatment sites may be at least partially contained. Vapors produced from heating soil |
| 7534729 |
Modification of semiconductor surfaces in a liquid |
May 19, 2009 |
| Compositions and methods are provided herein that include modifications to at least one surface of a silicon-based semiconductor material. Modifications occur in a liquid and comprise alterations of surface states, passivation, cleaning and/or etching of the surface, thereby providin |
| 7534202 |
System and method for high dose rate radiation intracavitary brachytherapy |
May 19, 2009 |
| The apparatus, method and system for performing a high dose rate brachytherapy procedure in a body cavity may include an at least partially indwelling multi-lumen catheter with a plurality of inflatable balloons coupled thereto. A lumen may be adapted to receive radiation seeds. The |
