| Patent Number |
Title Of Patent |
Date Issued |
| 5846490 |
Automated test strip supplying system |
December 8, 1998 |
| Disclosed is an automated supplying system for supplying liquid samples and test strips to an analyzer having a receiving section which receives test strips dipped in liquid samples one by one, a section at which optical characteristics of test pads provided on the received test strips a |
| 5844685 |
Reference laser beam sampling apparatus |
December 1, 1998 |
| Apparatus for sampling a laser beam used in an analytical instrument, e.g., a clinical hematology or flow cytometer instrument, for measuring absorption by particles suspended in a stream moving through a flow cell. The laser beam is typically passed through a mask, e.g., a beam shaping |
| 5844087 |
Method and device for delivering fibrin glue |
December 1, 1998 |
| A method and device for activating and applying a solution of fibrinogen to a desired site. The method includes contacting the solution of fibrinogen with immobilized thrombin resulting in an activated solution of polymerizable fibrin, and delivering the activated solution to the desired |
| 5843930 |
Method of treating otitis with ciprofloxacin-hydrocortisone suspension |
December 1, 1998 |
| The invention is directed to a method of treating otitis which comprises introducing an antibacterially-effective amount of a composition comprising a non-ototoxic, topical, otic pharmaceutic composition comprising (a) ciprofloxacin in aqueous solution in an amount effective for anti |
| 5843761 |
CDNA coding for carcinoembryonic antigen |
December 1, 1998 |
| A nucleic acid comprising a base sequence which codes for a CEA peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or infected with such clonin |
| 5843477 |
Lubricants for use in tabletting |
December 1, 1998 |
| The invention provides a new water soluble lubricant combination which facilitates the production of tablets. The combination of glyceryl behenate and fumaric acid is useful as a lubricant, particularly in tablet compositions containing ingredients where rapid dissolution in an aqueous |
| 5840836 |
Pancreatic islet cell antigens obtained by molecular cloning |
November 24, 1998 |
| Pancreatic islet cell antigens (ICA) that bind with antibodies found in the sera of patients afflicted with insulin-dependent (Type I) diabetes mellitus (IDDM). ICA proteins are expressed by recombinant cloning vehicles comprising DNA inserts isolated from islet cells. Full sequence |
| 5840803 |
Thermoplastic composition containing a grafted copolymeric acrylate rubber |
November 24, 1998 |
| A thermoplastic molding composition which contains (i) a grafted copolymer rubber having a grafted phase of styrene-acrylonitrile phase and a crosslinked (meth)acrylate-acrylonitrile substrate, and (ii) an ungrafted, uncrosslinked SAN having a number average molecular weight of about 20, |
| 5840501 |
Determination of cPSA |
November 24, 1998 |
| A method for determining the complexed forms of immunologically determinable prostate specific antigen (cPSA) in a blood sample, e.g., by two-site immunometric assays, in which the blood sample is treated to render free PSA (fPSA)immunologically nondetectable. A particularly preferre |
| 5840212 |
Rigid foams with improved insulation properties and a process for the production of such foams |
November 24, 1998 |
| Rigid foams having improved insulation properties are made by reacting a polyisocyanate with an isocyanate-reactive material in the presence of a blowing agent mixture composed of from about 1 to about 30% by weight of at least one C.sub.2 -C.sub.5 polyfluoroalkane and from about 70 to a |
| 5837794 |
Toluene diisocyanate residue-based compositions having reduced acid values |
November 17, 1998 |
| TDI residue-based urethane-filled isocyanate compositions are produced by reacting a TDI residue satisfying specified criteria with a monofunctional alcohol in amounts such that the equivalent ratio of isocyanate groups to hydroxyl groups is from about 0.9:1 to about 1:0.9. This reaction |
| 5837519 |
Dry-heat viral inactivation under controlled moisture conditions |
November 17, 1998 |
| A method of rendering a biologically active protein composition substantially free of viruses is disclosed. The method includes the steps of preparing lyophilized samples of the protein composition having a given moisture content, determining a minimum or threshold moisture content w |
| 5834318 |
Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity |
November 10, 1998 |
| Ligands that interact with a target can be more easily identified if false positive interactions (either specific or non-specific) from the detecting system are differentiated from the target-specific interaction. An improved method of identifying peptides which bind with a target protei |
| 5834129 |
Grained and anodized aluminum substrate for lithographic printing plates |
November 10, 1998 |
| The present invention relates to supports for lithographic printing plates and to a process for producing the same. In particular, the invention relates to aluminum plates having an electrochemically grained and anodized surface which is has a smooth, shiny surface and hence greater |
| 5833946 |
Dissemination of fungal infections: animal model and method of prophylaxis |
November 10, 1998 |
| Aspartyl protease inhibitors such as pepstatin A have been found to prevent dissemination of Candida species across an epithelial barrier in mammals. Accordingly, a method for reducing adverse biological effects of dissemination of Candida species in an immunosuppressed mammal comprises |
| 5831112 |
Process for producing stable, low odor S,S,S-tributylphosphorothrithiote |
November 3, 1998 |
| The invention is directed to a process for producing a stable, low odor S,S,S-tributylphosphorotrithioate having a level of dibutyl disulfide of 0.3% by weight or less. The process broadly includes the steps ofa) reacting S,S,S-tributylphosphorotrithioite with an oxidizing agent to produ |
| 5831003 |
Peptides which bind to prothrombin and thrombin |
November 3, 1998 |
| Peptide ligands which bind to thrombin and prothrombin are disclosed. The sequences of these peptides are Gln-Leu-Trp-Gly-Ser-His, Arg-Gln-Leu-Trp-Gly-Ser-His, His-Gln-Leu-Trp-Gly-Ser-His, and Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. The preferred peptides have the sequence Gln-Leu-Trp-Gly-Ser-H |
| 5830764 |
Methods and reagent compositions for the determination of membrane surface area and sphericity o |
November 3, 1998 |
| The invention describes improved methods and reagent compositions employed therein to determine the existence of blood disorders such as hemolytic anemias in a blood sample obtained from an individual. The methods are preferably carried out on an automated flow cytometer and encompass |
| 5827700 |
Process for producing citric acid from an impure process stream |
October 27, 1998 |
| The disclosed invention provides for two improved processes for recovering citric acid and other organic acids. The process for recovering citric acid from an impure process stream includes concentrating the impure process stream to obtain a concentrated solution of citric acid, adding a |
| 5824448 |
Negative working diazo color proofing sheet with adhesive layer having reduced tackiness |
October 20, 1998 |
| This invention relates to color proofing, or more particularly to an improved photographic element and transfer method of color proofing wherein a colored image is prepared by successively producing images of different colors from distinct color separation films onto a single recepto |
| 5822071 |
Spectrometer normalization system |
October 13, 1998 |
| A system for normalizing measurements obtained from spectrometers to correct for measurement biases in individual spectrometers. The normalization system is adapted for use in spectrometers having an optical assembly for obtaining characteristic data from a test sample. A normalizati |
| 5821341 |
Antibodies to sICAM-1 |
October 13, 1998 |
| The present invention relates to a soluble form of intercellular adhesion molecule (sICAM-1) and purified and isolated human sICAM-1, and antibodies thereto. This invention also relates to a purified and isolated DNA sequence encoding sICAM-1. The extracellular domain of sICAM-1 and |
| 5821321 |
Molding composition having improved impact strength |
October 13, 1998 |
| A thermoplastic molding composition having improved impact strength and a process for its preparation are disclosed. The structure of the resinous component of the composition contains carbonate structural units, polyester structural units and lactone-siloxane structural units confor |
| 5821275 |
Flexible foams and flexible molded foams based on liquid isocyanate-terminated allophanate-modif |
October 13, 1998 |
| This invention relates to flexible foams and flexible molded foams prepared from an isocyanate blend comprising an allophanate modified MDI, a polyether polyol, and a polymethylene poly(phenyl isocyanate). The present invention also relates to processes for the production of these flexib |
| 5817955 |
Apparatus for simultaneous aspiration and dispensation of fluids |
October 6, 1998 |
| The apparatus for simultaneous aspiration and dispensation of fluids is in the form of a syringe with two chambers located end to end along the length of the syringe. Each syringe chamber includes a port. A piston inside the syringe includes a median section that is movable in both of |
| 5817734 |
Prepolymers with low TDI content |
October 6, 1998 |
| This invention relates to novel liquid toluene diisocyanate/polyether/polymethylene poly(phenylisocyanate) prepolymers having an NCO content of from about 2 to 20%, a viscosity or about 10,000 mPa.s or less at 25.degree. C., and which contains about 1.0% or less of monomeric TDI. Thi |
| 5817519 |
Automated method and device for identifying and quantifying platelets and for determining platel |
October 6, 1998 |
| The present invention provides a highly sensitive and accurate method and system for the discrimination and quantification of platelets in a whole blood sample using automated hematology instruments. The method and system of the invention provide the accurate measurements of platelet dry |
| 5814521 |
Metal ion determination by sandwich aggregation assay |
September 29, 1998 |
| The present invention relates to a method for the determination of polyvalent metal ions using a sandwich aggregation assay. One or more chelating agents capable of forming at least 2:1 or higher ratio stoichiometry complexes with polyvalent metal ions are attached to a suitable carr |
| 5811224 |
Process for rejuvenating developer in printing plate development |
September 22, 1998 |
| This invention pertains to an ultrafiltration process which maintains a constant developer strength in a printing plate developing operation. Such a process enables development of more plates than conventional processes while using less developer and generating less liquid waste. The |
| 5810199 |
Dispensing instrument for fluid monitoring sensor |
September 22, 1998 |
| A sensor dispensing instrument is adapted to receive a generally circular sensor pack containing a plurality of blood glucose sensors. Each of the sensors are disposed in sensor cavities, each of which is in fluid communication with a corresponding desiccant cavity and has a support wall |
| 5808152 |
Synthesis of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide using sodium formate |
September 15, 1998 |
| The present invention relates to a process for making N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide. The process includes the steps of (a) reacting 2-chloro-N-(4-fluorophenyl)-N-(1-methylethyl)acetamide with sodium formate to form a reaction mixture that contains N-(4-f |
| 5804648 |
Toluene diisocyanate residue-based compositions and the use of such compositions as fillers for |
September 8, 1998 |
| A TDI residue generated from the phosgenation of toluene diamine having an ortho-isomer content of less than 0.5% is used to produce a urethane-filled hydroxyl compound. The TDI residues useful in this invention must contain at least 10% monomeric TDI and have a total NCO content of |
| 5804581 |
Inhibition of matrix metalloproteases by substituted phenalkyl compounds |
September 8, 1998 |
| Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the generalized formula: ##STR1## wherein T is a substituent and R.sup.24 is a substituted amide |
| 5804420 |
Preparation of recombinant Factor VIII in a protein free medium |
September 8, 1998 |
| Recombinant Factor VIII can be produced in relatively large quantities on a continuous basis from mammalian cells in the absence of any animal-derived proteins such as albumin by culturing the cells in a protein free medium supplemented with polyol copolymers, preferably in the presence |
| 5803673 |
Portable pneumatic precision metering device |
September 8, 1998 |
| The present invention is a device and method for the transportation and metering of precise amounts of particulate matter. The device provides an environmentally and operator safe means of transporting and dispensing precise amounts of particulate matter from the point of manufacture |
| 5801210 |
Method and apparatus for the production of essentially void free foams |
September 1, 1998 |
| A process for the manufacture of polyurethane foam comprising the steps of (i) mixing at a reaction index of 40 to 400: (a) a polyisocyanate blend comprising at least one polyisocyanate and optionally, additives and fillers; (b) a polyol blend comprising isocyanate reactive components an |
| 5798031 |
Electrochemical biosensor |
August 25, 1998 |
| The present invention concerns an electrochemical sensor made up of an insulating base having an electrode layer on its surface and a lid of deformable material which comprises a concave area in the central portion thereof, so that when it is mated with the base, the lid and base form a |
| 5792872 |
Process for producing N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-trifluoromethyl-1,3,4-thiadia |
August 11, 1998 |
| The present invention relates to a process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadia zol-2-yl)oxy]acetamide, which process includes the steps of reacting 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4,-thiadiazole with N-(4-fluorophenyl)-2-hyd |
| 5792588 |
Negative working, peel developable, single sheet color proofing system |
August 11, 1998 |
| This invention relates to negative working color proofing sheet constructions which, upon exposure to an actinic radiation source through a screened image, can accurately reproduce said image. The construction is useful as a color proofing film which can be employed to accurately pre |
| 5789519 |
High viscosity, high equivalent weight polyisocyanate mixtures containing allophanate and isocya |
August 4, 1998 |
| The present invention is directed to a polyisocyanate mixture whichi) is prepared from a monomeric starting material containinga) 95 to 100% by weight, based on the weight of a) and b), of an aliphatic diisocyanate having 4 to 18 carbons in the hydrocarbon chain andb) 0 to 5% by weight, based on |
| 5789497 |
Hexamethylene diisocyanate residue-based compositions as fillers for polyether polyols |
August 4, 1998 |
| Urethane-filled, polyether polyols are prepared by reacting (1) a hexamethylene diisocyanate residue from the phosgenation of hexamethylene diamine with contains less than 10% by weight monomeric hexamethylene diisocyanate and has a total isocyanate group content of at least 25% with |
| 5789434 |
Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
August 4, 1998 |
| Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula ##STR1## in which each T represents a substituent group; |
| 5788927 |
Unified fluid circuit assembly for a clinical hematology instrument |
August 4, 1998 |
| A unified fluid cell circuit assembly for an analytical instrument, such as a clinical hematology, immunoassy or chemistry or a flow cytometry instrument. The assembly includes a unified fluid circuit, a shear valve, a fluid pump assembly, and a plurality of solenoid valves. The unified |
| 5786458 |
Selective stabilization of protein during viral inactivation |
July 28, 1998 |
| A process for viral inactivation of a solution containing a biologically active protein, wherein the process comprises the steps of 1) contacting the solution with an immobilized ligand under conditions which allow protein to bind to the ligand, 2) subjecting the bound protein to a viral |
| 5786440 |
Mixtures of cyclic oligocarbonates and their manufacture |
July 28, 1998 |
| A process for the manufacture of cyclic oligocarbonate is disclosed. The process comprises a reaction of a bis-chlorocarbonic acid ester with isatinbisphenol or with a bis-chlorocarbonic ester thereof. The mixture of cyclic oligocarbonates thus prepared is useful as a precursor in the |
| 5786405 |
Amine-initiated polyether polyols and a process for their production |
July 28, 1998 |
| Clear, amine-initiated polyether polyols are made by epoxidizing an amine in the presence of an alkali metal hydroxide catalyst. After the desired degree of epoxidation has been achieved, a hydroxy-carboxylic acid is added to the epoxidized mixture in an amount sufficient to neutralize a |
| 5786180 |
Monoclonal antibody 369.2B specific for .beta. A4 peptide |
July 28, 1998 |
| The instant invention provides for monoclonal antibody which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention f |
| 5783663 |
Peptide ligands for affinity purification of fibrinogen |
July 21, 1998 |
| Peptides which bind to fibrinogen are disclosed. These peptides have available fibrinogen binding domains having a Trp-Gln-Glu-His-Tyr-Asn, Trp-Gln-Glu-Thr-TyrGln,or Tyr-Glu-Asn-Tyr-Gly-Tyr sequence. Peptides containing at least one of these fibrinogen binding domains are immobilized |
| 5783652 |
Reactivity improvement of urethane prepolymers of allophanate-modified diphenylmethane diisocyan |
July 21, 1998 |
| This invention relates to mixtures of urethane prepolymers of allophanate-modified diphenylmethane diisocyanates with epoxides. The addition of the epoxide increases the reactivity of these prepolymers. It is now possible to form polyurethanes from these mixtures based on prepolymers |
| 5783056 |
Electrochemical enzyme biosensor |
July 21, 1998 |
| In the case of the electrochemical enzyme biosensor comprising noble metal electrodes, an electrochemical oxidation of pyridine nucleotides takes place, in particular of NADH. The noble metal electrodes have a microtexture rich in surface pores and having catalytic properties, as a r |
