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Aventis Pharma S.A. Patents
Assignee:
Aventis Pharma S.A.
Address:
Antony, FR
No. of patents:
299
Patents:


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Patent Number Title Of Patent Date Issued
RE40940 Yeast promoter and use thereof October 20, 2009
The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity. to expression vectors comprising these sequences and to their use for the production of proteins.
RE39743 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and thei July 24, 2007
Novel compounds of the formula ##STR00001## wherein the substituents are defined as in the application having antibiotic properties.
RE38743 Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thro June 14, 2005
Heterogeneous intimate admixtures of sulfated heparinic polysaccharides, well suited for the prophylaxis/treatment of acute thrombotic episodes in a human patient, comprise immixture of sulfated polysaccharides having a weight average molecular weight less than that of heparin and which
RE38556 Recombinant adeno viruses comprising an inserted gene encoding apolipoprotein and their use in g July 13, 2004
The present invention concerns defective recombinant adenoviruses containing an inserted gene encoding apolipoproteins, pharmaceutical compositions comprising the adenovirus, and their use for the treatment or prevention of pathologies linked to dyslipoproteinemias.
RE37952 Grb3-3 cDNA and polypeptides December 31, 2002
The present invention relates to the Grb3-3 protein, nucleotide sequence encoding this protein, and variants thereof, such as antisense sequences. The invention further relates to vectors comprising these sequences and to methods for inducing cell death.
RE37767 Highly stable recombinant yeasts for the production of recombinant proteins June 25, 2002
Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector bearing a functional copy of said gene.
RE37766 K. lactis pyruvate-decarboxylase promoter and use thereof June 25, 2002
The present invention concerns DNA sequences comprising all or part of the K. lactis promoter gene PDC1 or a derivative thereof, and having transcriptional promoter activity. The invention also relates to the use of the sequences for the expression of recombinant genes.
RE37447 Modified Kluyveromyces yeasts, their preparation and use November 13, 2001
The present invention concerns yeasts of the genus Kluyveromyces having one or more genetic modifications of at least one gene coding for a protease, said gene reducing or modifying the proteolytic actively of said yeasts, as well as their use as a cellular host for the secretion of reco
8273548 Nucleic acids encoding a human PAP1 polypeptide September 25, 2012
The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and c
8263395 Recombinant adenoviruses preparation and adenovirus banks September 11, 2012
The invention concerns compositions and methods for preparing recombinant adenoviruses. The resulting adenoviruses can be used for transferring and/or expressing genes in cells, in vitro, ex vivo or in vivo, or also in functional genomics. More particularly, the invention concerns in
8258328 Method and intermediates for preparing 19-norsteroid compounds September 4, 2012
The subject of the invention is a method for preparing compounds of general formula (I): ##STR00001## in which A, Z, R.sub.3 are as defined in the description, and the intermediate compounds for carrying out this method.
8211676 Cholesterol-producing yeast strains and uses thereof July 3, 2012
The invention concerns the production of cholesterol in organisms of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for
8173402 Modified yeasts and uses thereof, in particular for producing steroid derivatives May 8, 2012
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20.alpha.HSD type activity, in parti
8163768 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions con April 24, 2012
This invention relates to compounds of formula (I) ##STR00001## to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.
8124650 Antitumor combinations containing taxane derivatives and epidophyllotoxins February 28, 2012
Antitumor combinations comprising a taxane and at least one epidophllotoxin for treating neoplastic diseases are described.
8119770 Modified soluble FGF receptor Fc fusions with improved biological activity February 21, 2012
The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity inc
8110571 Benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, ph February 7, 2012
This invention relates to benzimidazole and benzothiazole compounds of formula (I) ##STR00001## to methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.
8101652 Antitumour combinations containing taxotere and 5-fluorouracil January 24, 2012
Antitumor combinations comprising a taxane and at least one antimetabolite for treating neoplastic diseases are described.
8071570 Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositi December 6, 2011
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
8058290 7-substituted aza-indazoles, compositions containing same, production method and use thereof November 15, 2011
The disclosure relates to compounds of formula (I): ##STR00001## which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer agents.
8048893 Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal produc November 1, 2011
The present invention relates to the novel derivatives of formula (I) in which ##STR00001## A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl,
8034939 Isoindole derivatives, compositions containing same, preparation thereof and pharmaceutical uses October 11, 2011
This invention relates to isoindole derivates of Formula I ##STR00001## to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising administering of such derivatives.
8008322 Substituted pyrazolopyridines, compositions containing them, method for the production thereof, August 30, 2011
The disclosure relates to substituted pyrazolo-pyridines, compositions containing them, methods for the production thereof, and to their use as medicaments, in particular, as anticancer agents.
8003623 Mixtures of sulfated oligosaccharides August 23, 2011
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
7998667 Mutations of the parkin gene, compositions, methods and uses August 16, 2011
The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene,
7994212 Method of treating cancer with docetaxel and doxorubicin August 9, 2011
Antitumor combinations comprising a taxane and at least one antibiotic for treating neoplastic diseases are described.
7989489 Method of treating leukemia with docetaxel and vinca alkaloids August 2, 2011
Antitumor combinations comprising a taxane and at least one therapeutically useful substance for treating neoplastic diseases are described.
7977065 Yeast strains autonomously producing steroids July 12, 2011
The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains.
7968566 Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the f June 28, 2011
Novel compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
7956046 Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositio June 7, 2011
Oligosaccharide mixtures comprising anti-Xa activities of from 190 IU/mg to 450 IU/mg and anti-IIa activities of less than 0.2 IU/mg; and having constituent oligosaccharides with an average molecular weight of from 1800 to 2400 Daltons, constituent oligosaccharides comprise from 2 to 16
7935819 Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors May 3, 2011
Compounds of formula (I): ##STR00001## wherein Ra, Rb, R, X.sub.1 and X.sub.2 are as defined in the disclosure, pharmaceutical compositions comprising said compounds, processes for making and methods of using the same are provided.
7884123 Substituted thieno[2,3-c]pyrazoles, process for preparing them, compositions containing them, an February 8, 2011
Compounds of formula (I), ##STR00001## wherein R1 and R3 have the meanings given in the description, said compounds being in all isomeric forms; and salts thereof; processes for the preparation of the compounds and intermediates; compositions containing them, and the use thereof as
7884084 Oligonucleotides which inhibit expression of the OB-RGRP protein February 8, 2011
The present application relates to antisense oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions.It also relates to a method for detecting compounds which modify the interaction bet
7884082 Combined therapeutical treatment of hyperproliferative diseases February 8, 2011
A medicinal combination of one or more nucleic acids that at least partially inhibit oncogenic cell signalling pathways, and a therapeutic anticancer agent, for use simultaneous, separate or over a period of time to treat hyperproliferative diseases.
7879592 Modified yeasts and uses thereof, in particular for producing steroid derivatives February 1, 2011
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20.alpha.HSD type activity, in parti
7851443 Combination comprising combretastatin and anticancer agents December 14, 2010
This invention relates to therapeutic combinations comprising VEGF Trap and a stilbene derivative, and to methods for treatment of cancer comprising administration of such combinations.
7837991 Method of cancer treatment by p53 protein control November 23, 2010
Method of cancer treatment by controlling cellular p53 protein levels. The invention concerns, in particular, the use of a compound capable of modulating calpaine activity.
7825115 Cyclic urea compounds, preparation thereof and pharmaceutical use thereof as kinase inhibitors November 2, 2010
The disclosure relates to a cyclic urea compound of formula I: ##STR00001## as defined herein, to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use as an inhibitor on a protein kinase. Thus, the compound of formula I is useful for p
7812007 Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compo October 12, 2010
Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
7803538 Method for detecting Alzheimer's disease September 28, 2010
The present invention relates to a method for diagnosing an individual for early onset Alzheimer's disease by measuring the presence or absence of the minor allele of the rs908832 polymorphism of the ABCA2 gene. The presence of the minor allele of the rs908832 polymorphism of the ABCA2
7786114 Bis-azaindole derivatives, preparation and pharmaceutical use thereof as kinase inhibitors August 31, 2010
Compounds of formula (I): ##STR00001## wherein R1, R2, R3, R4, and R5 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and the use thereof as protein kinase inhibitors.
7759379 Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors July 20, 2010
The invention relates to compounds of formula (I): ##STR00001## in which R1, R2, L.sub.1, X, R3, A, R4, R.sub.4', R.sub.4'', R.sub.4''', R5, Y and L.sub.2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases
7754713 4-benzimidazol-2-ylpyridazin-3-one derivatives July 13, 2010
Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R.sup.1 and R.sup.2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals
7741316 Pharmacological uses of azetidine derivatives June 22, 2010
A method of treating or preventing Alzheimer's disease, Parkinson's Disease and/or schizophrenia, this method comprising administering to a patient in need of such treatment a compound of formula: ##STR00001## in which R, R.sub.3 and R.sub.4 are as defined in the specification.
7732610 Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-ba June 8, 2010
The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: ##STR00001## The invention also relates to a process for the preparation of these compounds as well as their use as medicaments, in particular as anti-bacterial agents.
7732431 Pharmaceutical compositions comprising trimegestone June 8, 2010
The invention concerns a pharmaceutical composition comprises trimegestone optionally associated with an oestrogen, characterized in that it comprises a buffer solution whereof the pH, when it is introduced in the composition, ranging essentially between 2 and 5.5. The invention also
7700823 Transgenic animals exhibiting major disorders related to Alzheimer's disease April 20, 2010
The present invention relates to nonhuman transgenic animals exhibiting major disorders related to Alzheimer's disease. The animals can be used for demonstrating compounds intended for the treatment of Alzheimer's disease.
7687493 Product, method and intermediates for the preparation of azetidine derivatives March 30, 2010
The present invention relates to a novel method for the preparation of azetidine derivatives such as N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-quinol-6-ylmethylsulfona- mide and the dihydrochloride thereof and N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl
7687274 Method for determining specific groups constituting heparins or low molecular weight heparins March 30, 2010
The invention provides methods for analyzing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention
7678766 Process for the preparation of cyclosporin derivatives March 16, 2010
The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or several free hydroxy
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