| Patent Number |
Title Of Patent |
Date Issued |
| RE39743 |
2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and thei |
July 24, 2007 |
| Novel compounds of the formula ##STR00001## wherein the substituents are defined as in the application having antibiotic properties. |
| RE38743 |
Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thro |
June 14, 2005 |
| Heterogeneous intimate admixtures of sulfated heparinic polysaccharides, well suited for the prophylaxis/treatment of acute thrombotic episodes in a human patient, comprise immixture of sulfated polysaccharides having a weight average molecular weight less than that of heparin and which |
| RE38556 |
Recombinant adeno viruses comprising an inserted gene encoding apolipoprotein and their use in g |
July 13, 2004 |
| The present invention concerns defective recombinant adenoviruses containing an inserted gene encoding apolipoproteins, pharmaceutical compositions comprising the adenovirus, and their use for the treatment or prevention of pathologies linked to dyslipoproteinemias. |
| RE37952 |
Grb3-3 cDNA and polypeptides |
December 31, 2002 |
| The present invention relates to the Grb3-3 protein, nucleotide sequence encoding this protein, and variants thereof, such as antisense sequences. The invention further relates to vectors comprising these sequences and to methods for inducing cell death. |
| RE37767 |
Highly stable recombinant yeasts for the production of recombinant proteins |
June 25, 2002 |
| Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector bearing a functional copy of said gene. |
| RE37766 |
K. lactis pyruvate-decarboxylase promoter and use thereof |
June 25, 2002 |
| The present invention concerns DNA sequences comprising all or part of the K. lactis promoter gene PDC1 or a derivative thereof, and having transcriptional promoter activity. The invention also relates to the use of the sequences for the expression of recombinant genes. |
| RE37447 |
Modified Kluyveromyces yeasts, their preparation and use |
November 13, 2001 |
| The present invention concerns yeasts of the genus Kluyveromyces having one or more genetic modifications of at least one gene coding for a protease, said gene reducing or modifying the proteolytic actively of said yeasts, as well as their use as a cellular host for the secretion of reco |
| 7407981 |
Aminoindazole derivatives as medicaments and pharmaceutical compositions including them |
August 5, 2008 |
| The present invention relates to the use of novel derivatives of general formula (I) ##STR00001## in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adam |
| 7381718 |
Method for preparing oestrogen derivatives |
June 3, 2008 |
| A process for the preparation of compounds of formula (I) ##STR00001## in which R.sub.1, R.sub.2, R.sub.3 and n are defined as indicated in the description, use of said compounds as intermediates for the preparation of estrogen derivatives as well as the intermediates of this process. |
| 7378274 |
Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses |
May 27, 2008 |
| The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucle |
| 7364871 |
MEKK1-interacting FHA protein 1 (MIF1) |
April 29, 2008 |
| The present invention relates to a novel protein of the MEKK signal transduction pathway, and the gene encoding it. The invention further relates to diagnostic and therapeutic uses of the protein or the gene, and to methods of screening for agonists or antagonists of the protein, par |
| 7354933 |
Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
April 8, 2008 |
| The present invention relates to a cyclic urea compound of formula I: ##STR00001## as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use, as an inhibitor on a protein kinase. Thus, it is |
| 7348333 |
Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists |
March 25, 2008 |
| There are described cycloalkyl derivatives of the formula (I) R.sup.1--Y-A-B-D-E-F-G (I) in which R.sup.1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin re |
| 7294712 |
Nucleotide sequences coding for variable regions of .beta. chains of human T lymphocyte receptor |
November 13, 2007 |
| The present invention relates to new nucleotide sequences coding for variable regions of .beta. chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses. |
| 7288549 |
Heterocyclic compounds, method for preparing same and use thereof as medicines, in particular as |
October 30, 2007 |
| The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: ##STR00001## The invention also relates to a process for the preparation of these compounds, as well as their use as medicaments, in particular as anti-bacterial agents. |
| 7285619 |
Echinocandin derivatives, their method of preparation and their application as anti-fungal agent |
October 23, 2007 |
| Compounds of the formula ##STR00001## wherein the substituents are as defined in the application useful as antifungal agents. |
| 7279480 |
Hexahydropyridazine-3-carboxylic acid hydrazide and hydrazone derivatives, combinatorial librari |
October 9, 2007 |
| The present invention discloses and claims hexahydropyridazine-3-carboxylic acid hydrazides and hydrazones of formula (I) ##STR00001## as inhibitors of proteases and kinases, and methods of using said compounds of formula (I) for the prevention or treatment of certain cardiovascular |
| 7255989 |
Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use i |
August 14, 2007 |
| The invention concerns a method for preparing nucleic acids from an environment sample, more particularly a method for obtaining a library of nucleic acids from a sample. The invention also concerns nucleic acids of nucleic acid libraries obtained by said method their use in the synthesi |
| 7241907 |
Acetone solvate of dimethoxy docetaxel and its process of preparation |
July 10, 2007 |
| This invention discloses and claims an acetone solvate of dimethoxydocetaxel or 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1-hydroxy-7.beta.,10.beta.- -dimethoxy-9-oxotax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and its preparation by |
| 7241601 |
Process for the preparation of Fexofenadine |
July 10, 2007 |
| A process for the preparation of a compound of the formula ##STR00001## by means of bioconversion with a microorganism culture of a compound of the formula ##STR00002## |
| 7241591 |
Adenovirus comprising a gene coding for glutathione peroxidase |
July 10, 2007 |
| The present invention relates to a defective adenovirus comprising at least a DNA sequence coding for all or an active part of glutathione peroxidase or a derivative thereof. It also relates to their utilization in therapy and to the corresponding pharmaceutical compositions. |
| 7232799 |
Streptogramin derivatives and compositions thereof |
June 19, 2007 |
| The present invention discloses and claims pharmaceutical compositions comprising Group A streptogramin derivatives of formula (I) and salts thereof in combination with at least one natural group B streptogramin derivative ##STR00001## |
| 7227022 |
Use of 2-amino-thiazoline derivatives as inhibitors of inducible no-synthase |
June 5, 2007 |
| The present invention relates to a process for preparing 2-amino-thiazoline derivatives of formula (II): ##STR00001## in which either Y is a methylene (CH.sub.2) and X is chosen from the following groups: O, NH, (C1 C4) N-Alkyl, N-Bn, N-Ph, N-(2-Py), N-(3-Py), N-(4-Py), N-2-pyrimidy |
| 7226905 |
Process for the preparation of cyclosporin derivatives |
June 5, 2007 |
| The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or several free hydroxy |
| 7217705 |
Combination of a CB1 receptor antagonist and of a product which activates dopaminergic neurotran |
May 15, 2007 |
| The present invention relates to the combination of one or more CB1 antagonist azetidine derivatives and of one or more products which activate dopaminergic neurotransmission in the brain, to the pharmaceutical compositions comprising them and to their use in the treatment of Parkins |
| 7211399 |
Method for detecting leptin receptor ligands |
May 1, 2007 |
| The present invention relates to a method for detecting leptin receptor ligands using resonance energy transfer between fusion proteins comprising a leptin receptor and energy donor protein and a leptin receptor and energy acceptor protein. The present invention also relates to the f |
| 7196109 |
Aminoindazole derivatives as medicaments and pharmaceutical compositions including them |
March 27, 2007 |
| The present invention relates to the use of novel derivatives of general formula (I) ##STR00001## in which R3 is a (1 6C)alkyl, aryl, aryl(1 6C)alkyl, heteroaryl, heteroaryl(1 6C)alkyl, aryl or heteroaryl fused to a (1 10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, ad |
| 7179909 |
Process for the manufacture of a product of the thiazolo [3,4,5-de] [4,1]benzothiazepine type |
February 20, 2007 |
| Novel processes for the preparation of a compound of the thiazolo[3,4,5-de] [4,1]benzothiazepine type and in particular of 2-imino-9-trifluoromethyl-4,5-dihydro-2H,7H-thiazolo[3,4,5-de] [4,1]benzothiazepine 6,6-dioxide methanesulfonate and (R,S)-2-imino-9-trifluoromethyl-4,5-dihydro- |
| 7179816 |
Chemical derivatives and their application as antitelomerase agents |
February 20, 2007 |
| The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which inhibits telomerase. It also relates to novel chemical compounds as well as their therapeutic application in humans. |
| 7169913 |
Engineered secreted alkaline phosphatase (SEAP) reporter genes and polypeptides |
January 30, 2007 |
| The invention provides a novel reporter gene (mSEAP) capable of being expressed in a mammal for extended periods of time. Nucleic acids encoding the reporter gene, cells and vectors comprising the nucleic acids, and methods of using the reporter gene to identify expression vectors an |
| 7166629 |
Aminoindazole derivatives as medicaments and pharmaceutical compositions including them |
January 23, 2007 |
| The present invention relates to novel derivatives of general formula (I) ##STR00001## in which R3 is a (1 6C)alkyl, aryl, aryl(1 6C)alkyl, heteroaryl, heteroaryl(1 6C)alkyl, aryl or heteroaryl fused to a (1 10C)cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, pol |
| 7166594 |
Streptogramin derivatives, their preparation and compositions containing them |
January 23, 2007 |
| Group A streptogramin derivatives of general formula (I) in which: R.sub.1 represents a halogen atom or an azido or thiocyanato radical, R.sub.2 represents a hydrogen atom or a methyl or ethyl radical, R.sub.3 represents a hydrogen atom, or the residue of an aliphatic, cycloaliphatic |
| 7157445 |
Administration of enoxaparin sodium to patients with severe renal impairment |
January 2, 2007 |
| Methods having novel enoxaparin sodium dosing regimens for patients with severe renal impairment are disclosed. The methods may be used for one or more of preventing thrombotic episodes, treating thrombotic episodes, preventing postoperative venous thrombosis, controlling thrombosis and/ |
| 7148258 |
Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions com |
December 12, 2006 |
| The present invention relates to the combination of a CB1 receptor antagonist and of sibutramine, to the pharmaceutical compositions comprising them and to their use in the treatment of obesity. |
| 7148215 |
Chemical compounds |
December 12, 2006 |
| The present invention concerns compounds of general formula (I): ##STR00001## in which the substituents are as described herein. |
| 7138138 |
Pharmaceutical formulation having a masked taste and method for the production thereof |
November 21, 2006 |
| The invention relates to a pharmaceutical formulation in the form of a powder which is administered orally in an aqueous suspension, having a masked taste, and comprising at least one cellulose polymer, a methacrylic polymer and an active ingredient which is distributed in a homogene |
| 7132414 |
Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their |
November 7, 2006 |
| The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: ##STR00001## in which R.sub.1 represents a radical --NHCOR.sub.4 or --N(R.sub.5)--Y--R.sub.6, Y is CO or SO.sub.2, R.sub.4 represents a radical -alk-SO.sub.2--R.sub.11, |
| 7132396 |
Compositions which can be used for regulating the activity of parkin |
November 7, 2006 |
| The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and c |
| 7119180 |
2-halogenated derivatives of 5-O-desosaminyl-erythronolide A, their preparation process and thei |
October 10, 2006 |
| A subject of the invention is a process for the preparation of the compounds of formula (I): ##STR00001## Wherein the substituents are defined as in the application. The compounds of this invention exhibit antibiotic properties. |
| 7119115 |
Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncol |
October 10, 2006 |
| The present invention relates to novel compounds derived from indazoles or indoles of formula (1) or formula (2), to methods for treating tumors or cancerous cells with compounds of formula (1) or formula (2) and to pharmacaetutical compositions comprising a pharmaceutically acceptable |
| 7109340 |
Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use |
September 19, 2006 |
| Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology. ##STR00001## |
| 7105504 |
Combination of a CB1 receptor antagonist and of a product which activates dopaminergic neurotran |
September 12, 2006 |
| The present invention relates to the combination of one or more CB1 antagonist azetidine derivatives and of one or more products which activate dopaminergic neurotransmission in the brain, to the pharmaceutical compositions comprising them and to their use in the treatment of Parkins |
| 7091360 |
Process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents and uses the |
August 15, 2006 |
| The present invention is directed to a novel process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents that are useful in the synthesis of a variety of pharmaceuticals, in particular certain cysteine protease inhibitors. |
| 7084118 |
Combination treatment with t-PA variant and low molecular weight heparin |
August 1, 2006 |
| The invention concerns an improved therapeutic regimen for the treatment of thrombolytic disorders, such as acute myocardial infarction (AMI). In particular, the present invention concerns the treatment of thrombolytic disorders, e.g. AMI, with a combination of a tissue plasminogen activ |
| 7074821 |
Taxoids, their preparation and pharmaceutical composition containing them |
July 11, 2006 |
| New taxoids of general formula (I), their preparation and pharmaceutical compositions containing them.In general formula (I), Ar represents an aryl radical, R represents a hydrogen atom or an acetyl, alkoxyacetyl or alkyl radical, R.sub.1 represents a benzoyl radical or a radical of |
| 7070940 |
Method for determining the ability of a compound to modify the interaction between parkin and th |
July 4, 2006 |
| The present invention relates to a method for determining the ability of a compound to modify the interaction between parkin and the p38 protein, and in particular to a method for screening for or detecting compounds intended for the prevention and/or treatment of neurodegenerative p |
| 7067133 |
Methods and compositions for diseases associated with amyloidosis |
June 27, 2006 |
| The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods an |
| 7041824 |
Purine derivatives, preparation method and use as medicines |
May 9, 2006 |
| The use of purine derivatives of formula (I): ##STR00001## in which: Rx is --(Z).sub.n--R.sub.1 wherein Z is a divalent radical selected from --CH.sub.2--, --SO.sub.2--, --CO--, --COO--, --CONH-- and --(CH.sub.2).sub.2--NR.sub.6--, n is the an integer selected from 0 and 1, R.sub. |
| 7041668 |
Substituted benzimidazole compounds and their use for the treatment of cancer |
May 9, 2006 |
| The present invention discloses and claims benzimidazole compounds of formula (I): ##STR00001## in which A is aryl or heteroaryl; R.sub.1 is selected from optionally substituted alkyl, alkoxy, aryl or heteroaryl, NH-lower alkyl or NH-cycloalkyl, or halogen, NH.sub.2; 1-imidazolyl or |
| 7037944 |
Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions com |
May 2, 2006 |
| The present invention relates to the combination of a CB1 receptor antagonist and of sibutramine, to the pharmaceutical compositions comprising them and to their use in the treatment of obesity. |
