| Patent Number |
Title Of Patent |
Date Issued |
| RE40940 |
Yeast promoter and use thereof |
October 20, 2009 |
| The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity. to expression vectors comprising these sequences and to their use for the production of proteins. |
| RE39743 |
2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and thei |
July 24, 2007 |
| Novel compounds of the formula ##STR00001## wherein the substituents are defined as in the application having antibiotic properties. |
| RE38743 |
Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thro |
June 14, 2005 |
| Heterogeneous intimate admixtures of sulfated heparinic polysaccharides, well suited for the prophylaxis/treatment of acute thrombotic episodes in a human patient, comprise immixture of sulfated polysaccharides having a weight average molecular weight less than that of heparin and which |
| RE38556 |
Recombinant adeno viruses comprising an inserted gene encoding apolipoprotein and their use in g |
July 13, 2004 |
| The present invention concerns defective recombinant adenoviruses containing an inserted gene encoding apolipoproteins, pharmaceutical compositions comprising the adenovirus, and their use for the treatment or prevention of pathologies linked to dyslipoproteinemias. |
| RE37952 |
Grb3-3 cDNA and polypeptides |
December 31, 2002 |
| The present invention relates to the Grb3-3 protein, nucleotide sequence encoding this protein, and variants thereof, such as antisense sequences. The invention further relates to vectors comprising these sequences and to methods for inducing cell death. |
| RE37767 |
Highly stable recombinant yeasts for the production of recombinant proteins |
June 25, 2002 |
| Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector bearing a functional copy of said gene. |
| RE37766 |
K. lactis pyruvate-decarboxylase promoter and use thereof |
June 25, 2002 |
| The present invention concerns DNA sequences comprising all or part of the K. lactis promoter gene PDC1 or a derivative thereof, and having transcriptional promoter activity. The invention also relates to the use of the sequences for the expression of recombinant genes. |
| RE37447 |
Modified Kluyveromyces yeasts, their preparation and use |
November 13, 2001 |
| The present invention concerns yeasts of the genus Kluyveromyces having one or more genetic modifications of at least one gene coding for a protease, said gene reducing or modifying the proteolytic actively of said yeasts, as well as their use as a cellular host for the secretion of reco |
| 7618818 |
Method for detecting leptin receptor ligands |
November 17, 2009 |
| The present invention relates to a method for detecting leptin receptor ligands by measuring the energy transfer between fusion proteins comprising a leptin receptor and an energy donor protein or an energy acceptor acceptor protein proteins. The present invention also relates to fus |
| 7604970 |
Variants of the PapM polypeptide of bacteria of the Streptomyces genus |
October 20, 2009 |
| The present invention relates to novel variants of the PapM polypeptide of bacteria of the Streptomyces genus which possess a substrate selectivity and/or an improved effectiveness compared to the wild-type polypeptide. It also relates to the nucleic acids encoding these variants, to the |
| 7595320 |
Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, process for preparing them, compositions containing th |
September 29, 2009 |
| The present invention concerns hydrazinocarbonyl-thieno[2,3-c]pyrazoles of formula (I): ##STR00001## wherein R1, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and their use for the treatment of pathological conditions, in |
| 7592365 |
Substituted pyrroles, compositions containing same, method for making same and use thereof |
September 22, 2009 |
| The disclosure concerns substituted pyrroles of formula (I): ##STR00001## wherein A, L, Ar, R1, R2, R5, and Ra are as defined in the disclosure, compositions containing the same, methods for making the same and uses thereof, in particular as anti-cancer agents. |
| 7585855 |
Bengamides with a substituted caprolactam cycle, method for the preparation thereof, composition |
September 8, 2009 |
| The invention relates to the preparation of substituted caprolactams, a method for the preparation thereof, compositions containing them and the use thereof as a medicament, particularly as anticancer agents. |
| 7582669 |
Aminoindazole derivatives as medicaments and pharmaceutical compositions including them |
September 1, 2009 |
| The present invention relates to novel derivatives of general formula (I) ##STR00001## in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, poly |
| 7575930 |
Method for analyzing oligosaccharides from blood plasma |
August 18, 2009 |
| The present invention relates to a method for analyzing oligosaccharides constituting the heparins of low molecular weight and the heparins of very low molecular weight from blood plasma. |
| 7566736 |
Substituted indoles, compositions containing them, method for the production thereof and their u |
July 28, 2009 |
| Compounds of formula (I): ##STR00001## wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as anticancer agents. |
| 7560571 |
Substituted pyrroles and imidazoles, compositions containing same, manufacturing process therefo |
July 14, 2009 |
| The disclosure concerns substituted imidazoles and pyrroles, compositions containing the same, the preparation thereof, and the use thereof as medicaments, particularly as anti-cancer agents. |
| 7550453 |
2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use |
June 23, 2009 |
| The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents. |
| 7537887 |
Net, a transcription factor of the TCF family, as regulator of angiogenic factor expression |
May 26, 2009 |
| The present invention relates to the regulation of the activity of NET (ERP/SAP-2) protein and to compounds which modify or regulate NET protein activity. The invention further relates to methods of screening for agonists or antagonists of NET in order to identify new pro-angiogenic or |
| 7528147 |
Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the f |
May 5, 2009 |
| Novel compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors. |
| 7524838 |
Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal produc |
April 28, 2009 |
| The present invention relates to the novel derivatives of formula (I) in which ##STR00001## A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, ( |
| 7517902 |
Substituted indazoles, compositions containing the same, and the preparation and use thereof |
April 14, 2009 |
| Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds. |
| 7517881 |
Triazine derivatives, their preparation and therapeutic application thereof |
April 14, 2009 |
| The invention relates to triazine derivatives of general formula (I): ##STR00001## Wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein. The invention also relates to a method for preparing these triazine derivatives and to the therapeutic application thereof. |
| 7507734 |
Pyridazinone derivatives |
March 24, 2009 |
| Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R.sup.1 and R.sup.2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharma |
| 7491710 |
Organophosphorus derivatives of indazoles and use thereof as medicinal products |
February 17, 2009 |
| The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers. |
| 7482352 |
Chemical derivatives and their application as antitelomerase agents |
January 27, 2009 |
| The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans. |
| 7476670 |
Purine derivatives, method for preparing, pharmaceutical compositions and novel use |
January 13, 2009 |
| The invention relates to novel products of formula (I): ##STR00001## in which: Y represents N, O, S, CHR3 or .dbd.CR3 the dashed line representing a single or double bond, R and R1 represent in particular H, Hal, OH, alkyl, alkoxy, cyano, NO.sub.2, NR4R5, trifluoromethyl, trifluorom |
| 7473701 |
Substituted indazoles, compositions containing them, method of production and use |
January 6, 2009 |
| Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particular in oncology. |
| 7470781 |
Formulation of stabilized cationic transfection agent(s)/nucleic acid particles |
December 30, 2008 |
| The invention concerns a composition containing stabilised particles of cationic transfection agent(s)/nucleic acid complexes characterised in that it includes besides said transfection agent and nucleic acid at least a non-ionic surfactant in sufficient amount for preventing the agg |
| 7470689 |
4-benzimidazol-2-ylpyridazin-3-one derivatives |
December 30, 2008 |
| Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R.sup.1 and R.sup.2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals |
| 7449572 |
Process and intermediates for preparing 17-halogenated 19-norsteroid compounds |
November 11, 2008 |
| The invention relates to a process for preparing compounds of formula (I): ##STR00001## in which R.sub.1, R.sub.2, R.sub.3, n and X are as defined in the description, and to the intermediate compounds for implementing this process. |
| 7435820 |
Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use |
October 14, 2008 |
| Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology. ##STR00001## |
| 7407981 |
Aminoindazole derivatives as medicaments and pharmaceutical compositions including them |
August 5, 2008 |
| The present invention relates to the use of novel derivatives of general formula (I) ##STR00001## in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adam |
| 7381718 |
Method for preparing oestrogen derivatives |
June 3, 2008 |
| A process for the preparation of compounds of formula (I) ##STR00001## in which R.sub.1, R.sub.2, R.sub.3 and n are defined as indicated in the description, use of said compounds as intermediates for the preparation of estrogen derivatives as well as the intermediates of this process. |
| 7378274 |
Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses |
May 27, 2008 |
| The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucle |
| 7364871 |
MEKK1-interacting FHA protein 1 (MIF1) |
April 29, 2008 |
| The present invention relates to a novel protein of the MEKK signal transduction pathway, and the gene encoding it. The invention further relates to diagnostic and therapeutic uses of the protein or the gene, and to methods of screening for agonists or antagonists of the protein, par |
| 7354933 |
Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
April 8, 2008 |
| The present invention relates to a cyclic urea compound of formula I: ##STR00001## as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use, as an inhibitor on a protein kinase. Thus, it is |
| 7348333 |
Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists |
March 25, 2008 |
| There are described cycloalkyl derivatives of the formula (I) R.sup.1--Y-A-B-D-E-F-G (I) in which R.sup.1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin re |
| 7294712 |
Nucleotide sequences coding for variable regions of .beta. chains of human T lymphocyte receptor |
November 13, 2007 |
| The present invention relates to new nucleotide sequences coding for variable regions of .beta. chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses. |
| 7288549 |
Heterocyclic compounds, method for preparing same and use thereof as medicines, in particular as |
October 30, 2007 |
| The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: ##STR00001## The invention also relates to a process for the preparation of these compounds, as well as their use as medicaments, in particular as anti-bacterial agents. |
| 7285619 |
Echinocandin derivatives, their method of preparation and their application as anti-fungal agent |
October 23, 2007 |
| Compounds of the formula ##STR00001## wherein the substituents are as defined in the application useful as antifungal agents. |
| 7279480 |
Hexahydropyridazine-3-carboxylic acid hydrazide and hydrazone derivatives, combinatorial librari |
October 9, 2007 |
| The present invention discloses and claims hexahydropyridazine-3-carboxylic acid hydrazides and hydrazones of formula (I) ##STR00001## as inhibitors of proteases and kinases, and methods of using said compounds of formula (I) for the prevention or treatment of certain cardiovascular |
| 7255989 |
Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use i |
August 14, 2007 |
| The invention concerns a method for preparing nucleic acids from an environment sample, more particularly a method for obtaining a library of nucleic acids from a sample. The invention also concerns nucleic acids of nucleic acid libraries obtained by said method their use in the synthesi |
| 7241907 |
Acetone solvate of dimethoxy docetaxel and its process of preparation |
July 10, 2007 |
| This invention discloses and claims an acetone solvate of dimethoxydocetaxel or 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1-hydroxy-7.beta.,10.beta.- -dimethoxy-9-oxotax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate and its preparation by |
| 7241601 |
Process for the preparation of Fexofenadine |
July 10, 2007 |
| A process for the preparation of a compound of the formula ##STR00001## by means of bioconversion with a microorganism culture of a compound of the formula ##STR00002## |
| 7241591 |
Adenovirus comprising a gene coding for glutathione peroxidase |
July 10, 2007 |
| The present invention relates to a defective adenovirus comprising at least a DNA sequence coding for all or an active part of glutathione peroxidase or a derivative thereof. It also relates to their utilization in therapy and to the corresponding pharmaceutical compositions. |
| 7232799 |
Streptogramin derivatives and compositions thereof |
June 19, 2007 |
| The present invention discloses and claims pharmaceutical compositions comprising Group A streptogramin derivatives of formula (I) and salts thereof in combination with at least one natural group B streptogramin derivative ##STR00001## |
| 7227022 |
Use of 2-amino-thiazoline derivatives as inhibitors of inducible no-synthase |
June 5, 2007 |
| The present invention relates to a process for preparing 2-amino-thiazoline derivatives of formula (II): ##STR00001## in which either Y is a methylene (CH.sub.2) and X is chosen from the following groups: O, NH, (C1 C4) N-Alkyl, N-Bn, N-Ph, N-(2-Py), N-(3-Py), N-(4-Py), N-2-pyrimidy |
| 7226905 |
Process for the preparation of cyclosporin derivatives |
June 5, 2007 |
| The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or several free hydroxy |
| 7217705 |
Combination of a CB1 receptor antagonist and of a product which activates dopaminergic neurotran |
May 15, 2007 |
| The present invention relates to the combination of one or more CB1 antagonist azetidine derivatives and of one or more products which activate dopaminergic neurotransmission in the brain, to the pharmaceutical compositions comprising them and to their use in the treatment of Parkins |
