| Patent Number |
Title Of Patent |
Date Issued |
| RE39087 |
Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
May 2, 2006 |
| A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of di |
| 7410985 |
Cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
August 12, 2008 |
| The present invention provides an cycloalkyl derivative of 3-hydroxy-4-pyridinone which is useful for the chelation of metal ions such as iron. Its preparation and use is described. In particular, the invention concerns the removal of iron in chemical and biological systems including |
| 7049328 |
Use for deferiprone |
May 23, 2006 |
| A method of treating iron induced cardiac disease in a patient with iron overload, such as in thalassemia or the like comprising administering to the patient a therapeutically effective amount of deferiprone or a physiologically acceptable salt thereof sufficient to treat iron induced |
| 6531486 |
Pharmaceutical compositions comprising quinapril magnesium |
March 11, 2003 |
| Solid pharmaceutical compositions comprising quinapril magnesium can be made by reacting a quinapril or an acid addition salt thereof with an alkaline magnesium compound in the presence of a solvent so as to convert the quinapril or quinapril acid addition salt to quinapril magnesium. |
| 6506929 |
Process to manufacture simvastatin and intermediates |
January 14, 2003 |
| A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure. |
| 6476229 |
Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxam |
November 5, 2002 |
| The present invention relates to a novel process for the preparation of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide of formula I: ##STR1##The method comprises of the TEMPO oxidation of a primary alcohol of 3-O-protected-2-hydroxymethyl-6-alkyl-4H-pyran-4-one of f |
| 6472532 |
Processes for the manufacturing of 3-hydroxy-n,1,6-trialkyl-4-OXO-1,4-dihydropyridine-2-carboxam |
October 29, 2002 |
| The present invention relates to a novel process for the preparation of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide of formula I: ##STR1##The method comprises of the TEMPO oxidation of a primary alcohol of 3-O-protected-2-hydroxymethyl-6-alkyl-4H-pyran-4-one of f |
| 6468977 |
Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
October 22, 2002 |
| Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase, common cold by inhibition of human rhinovirus |
| 6426418 |
Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxam |
July 30, 2002 |
| The present invention relates to a novel process for the preparation of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide of formula I: ##STR1##The method comprises of the TEMPO oxidation of a primary alcohol of 3-O-protected-2-hydroxymethyl-6-alkyl-4H-pyran-4-one of f |
| 6245903 |
Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
June 12, 2001 |
| A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of di |
| 6162791 |
Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
December 19, 2000 |
| Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase, common cold by inhibition of human rhinovirus |
| 6114537 |
Process for scavenging thiols |
September 5, 2000 |
| Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologica |
| 6060472 |
Thiadiazole compounds useful as inhibitors of H.sup.+ /K.sup.+ atpase |
May 9, 2000 |
| Novel 3,5-disubstituted 1,2,4-thiadiazole compounds are provided, which are effective in treating peptic ulcers by the inhibition of H.sup.+ /K.sup.+ -ATPase. The compounds of the present invention are 3,5-disubstituted 1,2,4-thiadiazole corresponding to the general formula (I): ##ST |
| 6024247 |
Deblistering machine |
February 15, 2000 |
| Solid dosage forms of pharmaceuticals, e.g. tablets, may be removed from blister packs with a deblistering machine. The machine has a roller and a stationary plate. The roller has a longitudinal axis of rotation and means for rotating the roller about the axis. The roller has an inner co |
| 5914401 |
Methods for the manufacture of quinolone carboxylic acids derivatives and intermediates thereof |
June 22, 1999 |
| Novel process for the preparation of quinolone carboxylic acid derivatives of general formula I, and intermediates thereof as illustrated in Scheme 1 wherein the key intermediate is a compound of formula IX. ##STR1## |
| 5908959 |
Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereo |
June 1, 1999 |
| A process is provided for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises of:a) reacting 4-aminobutyric acid with phosphorous acid and phosphorus trichloride in the presence of a polyalkylene(glycol); andb) recovering said 4-amino-1- |
| 5900485 |
Methods for the manufacture of neofazodone |
May 4, 1999 |
| Process for the manufacture of triazolone compounds and in particular nefazodone and intermediates useful in the manufacture thereof. |
| 5847118 |
Methods for the manufacture of amorphous cefuroxime axetil |
December 8, 1998 |
| A process for preparing pure amorphous cefuroxime axetil comprising the steps of dissolving crystalline cefuroxime axetil in a highly polar organic solvent and adding the resulting solution to water, or alternatively, dissolving crystalline cefuroxime axetil in a highly polar solvent |
| 5723618 |
1,4-dihydropyridines, N-substituted bicyclic 4-hydropyridines, and bicyclic N-substituted 4,5-di |
March 3, 1998 |
| The invention relates to a novel process to prepare 1,4-dihydropyridines and in particular amlopidine and in novel intermediates obtained during the synthesis of the 1,4-dihydropyridines which have potential activity as antihypertensive agents. |
| 5691173 |
Fermentation process for preparation of compactin |
November 25, 1997 |
| A novel microorganism, Penicillium adametzioides and a process of using the microorganism to produce compactin, the process consisting of fermentation in a nutrient medium. |
| 5677302 |
Thiadiazole compounds useful as proton pump inhibitors |
October 14, 1997 |
| Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H.sup.+ /K.sup.+ -ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5-.alpha.]benzimidazole and 3-substituted |
| 5433256 |
Pill guide and dispenser tray |
July 18, 1995 |
| A pill guide for use in combination with pill, capsule and caplet dispensing trays has a tapered guide channel for removable attachment to the pill return outlet of the tray. The guide combines with adjacent wall portions of the tray return outlet to form a convergent funnel, through |
| 5409820 |
Process for the production of lovastatin using Coniothyrium fuckelii |
April 25, 1995 |
| A novel microorganism, Coniothyrium fuckelii ATCC 74227, and a process of using the microorganism for the production of lovastatin comprising fermenting Coniothyrium fuckelii ATCC 74227 or a lovastatin-producing mutant thereof in a nutrient medium containing assimilable sources of ca |
| 5393893 |
Process for producing simvastatin and analogs thereof |
February 28, 1995 |
| A process is disclosed for the preparation of simvastatin and its analogs through a novel intermediate (III), which enables a selective .alpha. carbon alkylation of the C-8 acyl side chain. |
