| Patent Number |
Title Of Patent |
Date Issued |
| 7419948 |
Treatment of hemophilia with human Factor IX produced in mammary tissue of transgenic mammals |
September 2, 2008 |
| Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into develo |
| 6984772 |
Transgenic non-human mammals producing fibrinogen in their milk |
January 10, 2006 |
| A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glands of the animals |
| 6838281 |
Cells expressing fusion proteins of immunoglobulins |
January 4, 2005 |
| The invention provides methods and compositions for inducing and maintaining tolerance to epitopes or antigens containing the epitopes. The compositions include expression cassettes and vectors including DNA sequences coding for a fusion immunoglobulin operably linked to transcriptio |
| 6344596 |
Expression of active human factor IX in mammary tissue and of milk non human transgenic mammals |
February 5, 2002 |
| Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into develo |
| 6262336 |
Expression of a heterologous protein C in mammary tissue of transgenic animals using a long whey |
July 17, 2001 |
| An isolated DNA sequence which regulates the expression of a heterologous gene composed of a mouse whey acidic protein promoter having a length of greater than about 2.4 kb extending upstream from the unique KpnI site in the mouse whey acidic protein gene is disclosed. Specifically a mou |
| 6191260 |
Brain-associated inhibitor of tissue-type plasminogen activator |
February 20, 2001 |
| The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, |
| 5965789 |
Engineering protein posttranslational modification by PACE/furin in transgenic non-human mammals |
October 12, 1999 |
| The invention relates to transgenic non-human multicellular organisms that contain polynucleotides for expressing proteins that alter posttranslational modification. In particular, the invention provides multiply-transgenic animals in which a first transgene encodes a first protein, |
| 5589604 |
Expression of human protein C in mammary tissue of transgenic mammals |
December 31, 1996 |
| Recombinant protein C characterized by a high percentage of active protein can be obtained in the milk of transgenic mammals that incorporate DNAs according to the present invention. Transgenic mammals of the present invention are produced by introducing into developing embryos DNA that |
| 4961928 |
Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets |
October 9, 1990 |
| The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte |
| 4695460 |
Synthetic, plasma-free, transfusible platelet storage medium |
September 22, 1987 |
| The invention is a sterile, plasma-free platelet storage medium. The platelet storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 7.5 grams of dextrose, between about 3.0 |
