| Patent Number |
Title Of Patent |
Date Issued |
| RE36547 |
Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused |
February 1, 2000 |
| This invention relates to a method of selectively enhancing the analgesic potency of morphine and other clinically used bimodally-acting opioid agonists and simultaneously attenuating development of physical dependence, tolerance and other undesirable side effects caused by the chron |
| 7470718 |
Method for treating a demyelinating condition |
December 30, 2008 |
| Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca.sup.2+-channel blocker effective to treat the demyelinating condition. In other aspects, the methods enc |
| 7432246 |
Sir2 products and activities |
October 7, 2008 |
| A novel compound, 2'/3'-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2' and 3' regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2'-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated |
| 7405297 |
Process for preparing inhibitors of nucleoside metabolism |
July 29, 2008 |
| A process of preparing a compound of the formula (I) ##STR00001## wherein B is chosen from OH, NH.sub.2, NHR, H or halogen; D is chosen from OH, NH.sub.2, NHR, H halogen or SCH.sub.3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, h |
| 7402385 |
Radiolabeled antibodies for treatment of tumors |
July 22, 2008 |
| This invention provides methods for imaging and/or treating a tumor in a subject which comprise administering to the subject an amount of a radiolabeled antibody effective to image and/or treat the tumor, where the radiolabeled antibody binds to a cellular component released by dying |
| 7390890 |
Inhibitors of nucleoside metabolism |
June 24, 2008 |
| The present invention provides compounds having the formula: ##STR00001## wherein A is CH or N; B is chosen from OH, NH.sub.2, NHR, H or halogen; D is chosen from OH, NH.sub.2, NHR, H, halogen or SCH.sub.3; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are |
| 7361503 |
Sequences encoding hepatitis C virus glycoproteins |
April 22, 2008 |
| The present invention concerns a modified nucleic acid molecule comprising a nucleotide sequence coding for a full length hepatitis C virus (HCV) glycoprotein selected from the group consisting of E1 glycoprotein and E1/E2 glycoprotein heterodimer, this molecule having at least one n |
| 7326416 |
Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1(INI1)/ |
February 5, 2008 |
| Peptides comprising an Rpt1 domain of an INI1/hSNF5 which inhibit HIV-1 production in a human cell, and vectors encoding those peptides are provided. Also provided are methods of inhibiting HIV-1 production in a cell, or spread of the HIV-1 to another cell, by treating the cells with |
| 7320863 |
Thyroid sodium/iodide symporter and nucleic acid encoding same |
January 22, 2008 |
| The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, an |
| 7314733 |
Saitohin gene and uses of same |
January 1, 2008 |
| The present invention provides an isolated nucleic acid sequence encoding saitohin (STH), an isolated nucleic acid sequence that hybridizes to said sequence, and a purified protein encoded by said nucleic acid sequences. The present invention also provides a purified STH protein, and a m |
| 7314444 |
Memory assessment by retrieval speed and uses thereof |
January 1, 2008 |
| The present invention provides methods for assessing episodic memory in a subject. Also provided are methods for assessing semantic memory in a subject. The present invention further provides methods for screening for an agent directed to treating, slowing down the progress of, attenuati |
| 7303740 |
Methods for the diagnosis and treatment of breast cancer |
December 4, 2007 |
| The present invention provides a method for diagnosing breast cancer in a subject. The present invention also provides a method for treating breast cancer in a subject. Finally, the present invention provides a method for assessing the efficacy of breast cancer therapy in a subject who h |
| 7294465 |
Polycystic kidney disease PKD2 gene and uses thereof |
November 13, 2007 |
| The present invention provides a purified and isolated wild type PKD2 gene, as well as mutated forms of this gene. The present invention also provides one or more single-stranded nucleic acid probes which specifically hybridize to the wild type PKD2 gene or the mutated PKD2 gene, and |
| 7211677 |
Process for preparing inhibitors of nucleoside metabolism |
May 1, 2007 |
| A process of preparing a compound of the formula (I) ##STR00001## wherein B is chosen from OH, NH.sub.2, NHR, H or halogen; D is chosen from OH, NH.sub.2, NHR, H halogen or SCH.sub.3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, h |
| 7211653 |
Inhibitors of nucleoside metabolism |
May 1, 2007 |
| The present invention provides compounds having the formula: ##STR00001## wherein A is CH or N; B is chosen from OH, NH.sub.2, NHR, H or halogen; D is chosen from OH, NH.sub.2, NHR, H, halogen or SCH.sub.3; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are |
| 7211375 |
Methods for identifying compounds which modulate the activity of MSH5 |
May 1, 2007 |
| An animal, e.g., transgenic mouse, in which the MSH5 gene is misexpressed. The animal is useful for screening treatments for a number of conditions. Methods for identifying contraceptive agents are also described. |
| 7169900 |
Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkyl |
January 30, 2007 |
| Novel modified hemoglobins comprising polyalkylene glycols and novel methods for making those hemoglobins are provided. One group of modified hemoglobins comprise polyalkylene glycols bonded to the hemoglobin with an amide linkage at Glu-43(.beta.). Additional polyalkylene glycols can |
| 7161060 |
Transgenic mice comprising a genomic human tau transgene |
January 9, 2007 |
| The invention provides transgenic mice comprising tau transgenes, and methods of preparing and using the transgenic mice. For example, the invention provides a transgenic mouse, the genome of the cells of which stably comprise a DNA molecule which comprises a human genomic DNA sequen |
| 7144989 |
Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof |
December 5, 2006 |
| The present invention provides pegylated hemoglobins comprising a thiocarbamoyl-phenyl-polyethylene glycol (PEG) attached to hemoglobin, and comprising a polyethylene glycol (PEG) attached to hemoglobin by an acyl group. The invention also provides methods of preparing pegylated hemo |
| 7109331 |
5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors |
September 19, 2006 |
| The present invention provides a compound of the formula (I): ##STR00001## wherein A is selected from N, CH and CR, where R is selected from halogen, optionally substituted alkyl, aralkyl and aryl, OH, NH.sub.2, NHR.sup.1, NR.sup.1R.sup.2 and SR.sup.3, where R.sup.1, R.sup.2 and R.s |
| 7109028 |
Methods of isolating hepatic progenitors |
September 19, 2006 |
| This invention relates to methods of isolating hepatoblasts utilizing panning techniques and fluorescence activated cell sorting. This invention further relates to isolated hepatoblasts and to a method of treating liver dysfunction as well as to methods of forming artificial livers. |
| 7098334 |
4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
August 29, 2006 |
| The invention provides a compound of the formula: ##STR00001## wherein A is selected from N, CH and CR; R is selected from halogen, optionally substituted alkyl, aralkyl and aryl, OH, NH.sub.2, NHR.sup.1, NR.sup.1R.sup.2 and SR.sup.3; R.sup.1, R.sup.2 and R.sup.3 are each optionally |
| 7084112 |
Activated polyethylene glycol compounds |
August 1, 2006 |
| Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to amino-groups of biomolecules, for example polypeptides such as antibodies, enzymes, and proteins. |
| 7083915 |
Polycystic kidney disease PKD2 gene and uses thereof |
August 1, 2006 |
| The present invention provides a purified and isolated wild type PKD2 gene, as well as mutated forms of this gene. The present invention also provides one or more single-stranded nucleic acid probes which specifically hybridize to the wild type PKD2 gene or the mutated PKD2 gene, and |
| 7070563 |
Memory tests using item-specific weighted memory measurements and uses thereof |
July 4, 2006 |
| This invention relates to a method for increasing the usefulness, sensitivity and specificity of tests that measure memory and facets of memory, including learning, retention, recall and/or recognition. Specifically, the sensitivity and specificity of such tests are enhanced by selec |
| 7056894 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof |
June 6, 2006 |
| The present invention provides compounds having the formula: ##STR00001## wherein A is chosen from a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group; both B and C are hydrogen, or either B or C is a halogen, amino, or thiol group and the other of B or C |
| 7030096 |
Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K po |
April 18, 2006 |
| The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficie |
| 7026329 |
Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused |
April 11, 2006 |
| This invention relates to a method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist such as morphine and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the ad |
| 7022852 |
Process for preparing inhibitors of nucleoside metabolism |
April 4, 2006 |
| A process of preparing a compound of the formula (I) ##STR00001## wherein B is chosen from OH, NH.sub.2, NHR, H or halogen; D is chosen from OH, NH.sub.2, NHR, H halogen or SCH.sub.3; R is an optionally substituted alkyl, aralkyl or aryl group; and Z is selected from OH, hydrogen, h |
| 7022680 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases |
April 4, 2006 |
| The present invention provides compounds having the formula: ##STR00001## wherein A is a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group, the group being further substituted with an electron contributing moiety; B is hydrogen, or a halogen, amino, or |
| 7019117 |
Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkyl |
March 28, 2006 |
| Novel modified hemoglobins comprising polyalkylene glycols and novel methods for making those hemoglobins are provided. One group of modified hemoglobins comprise polyalkylene glycols bonded to the hemoglobin with an amide linkage at Glu-43(.beta.). Additional polyalkylene glycols can |
| 7001735 |
Glucose transporter/sensor protein and uses thereof |
February 21, 2006 |
| The present invention provides a method for determining whether a subject has a defect in cell proliferation. The present invention further provides a method for assessing the efficacy of therapy to treat a defect in cell proliferation in a subject who has undergone or is undergoing |
| 6989240 |
Method for detecting hemolysis |
January 24, 2006 |
| This invention provides a method for determining the presence of hemolyzed erythrocytes in blood by detecting erythrocyte adenylate kinase in a serum sample from the blood. This invention also provides a method for diagnosing a hemolytic condition in a subject suspected to be suffering |
| 6987091 |
Sir2 products and activities |
January 17, 2006 |
| A novel compound, 2'/3'-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2' and 3' regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2'-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated |
| 6980003 |
Open half volume quadrature transverse electromagnetic coil for high field magnetic resonance im |
December 27, 2005 |
| A half-volume quadrature TEM coil high field (>3 T) imaging applications. This novel coil produces a sufficiently large homogeneous B.sub.1 field region for the use as a volume coil. It provides superior transmission efficiency, resulting in significantly lower power deposition, a |
| 6962954 |
Activated polyethylene glycol compounds |
November 8, 2005 |
| Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to amino-groups of biomolecules, for example polypeptides such as antibodies, enzymes, and proteins. |
| 6932970 |
Peptides for the treatment and diagnosis of systemic lupus erythematosus |
August 23, 2005 |
| The present invention provides a method for identifying a peptide which binds to an anti-double stranded DNA antibody. The present invention also provides a class of peptides identified by the method of the present invention which bind to anti-double stranded DNA antibodies and compo |
| 6897197 |
Method of inhibiting cell proliferation using an anti-oncogene protein |
May 24, 2005 |
| The present invention provides a novel method of inhibiting the growth of tumor cells based upon the discovery that p19.sup.ARF acts as a suppressor of oncogenic transformation by binding to the MDM2 oncoprotein and blocking MDM2's ability to target associated proteins, such as p53 and R |
| 6895396 |
Neural network methods to predict enzyme inhibitor or receptor ligand potency |
May 17, 2005 |
| A new method to analyze and predict the binding energy for enzyme-transition state inhibitor interactions is presented. Computational neural networks are employed to discovery quantum mechanical features of transition states and putative inhibitors necessary for binding. The method i |
| 6881553 |
Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites ther |
April 19, 2005 |
| The present invention provides a method of selecting a compound which inhibits the enzymatic activity of enoyl reductase which comprises: (A) contacting enoyl reductase with the compound linked to an acyl carrier protein; (B) measuring the enzymatic activity of the enoyl reductase of |
| 6875421 |
Method for detecting chitin-containing organisms |
April 5, 2005 |
| The present invention provides a method for detecting chitin-containing organisms on an area of a person or animal by contacting the particular area with a dye that is capable of binding or conjugating to chitin and emitting fluorescence upon exposure to light. If a chitin-containing |
| 6864402 |
Chronic hepatitis virus infection and clonal hepatocellular carcinoma in mouse repopulated liver |
March 8, 2005 |
| A method is provided for repopulating degenerated of immunetolerant mice which lack mature B and T lymphocytes with xenogenic mammalian hepatocytes, particularly primate hepatocytes to generate chimeric mice. In addition, a method of generating a human hepatitis virus-infected chimer |
| 6858716 |
Drosophila recombination-associated protein and methods for use |
February 22, 2005 |
| The invention encompasses Drosophila Recombination Associated Protein (DRAP) isolated from D. melanogaster and a nucleic acid sequence encoding DRAP. The Drosophila Recombination Associated Protein, its homologues from other organisms or active peptides derived therefrom, as well as DNA |
| 6830910 |
Drosophila recombination-associated protein and methods for use |
December 14, 2004 |
| The invention encompasses Drosophila Recombination Associated Protein (DRAP) isolated D. melanogaster and a nucleic acid sequence encoding DRAP. The Drosophila Recombination Associated Protein, its homologues from other organisms or active peptides derived therefrom, as well as DNA encod |
| 6821769 |
IniB, iniA and iniC genes of mycobacteria and methods of use |
November 23, 2004 |
| This invention relates to the identification, cloning, sequencing and characterization of the iniB, iniA and iniC genes of mycobacteria which are induced by a broad class of antibiotics that act by inhibiting cell wall biosynthesis, including the first line antituberculosis agents, i |
| 6821725 |
Methods for the diagnosis and treatment of breast cancer |
November 23, 2004 |
| The present invention provides a method for diagnosing breast cancer in a subject. The present invention also provides a method for treating breast cancer in a subject. Finally, the present invention provides a method for assessing the efficacy of breast cancer therapy in a subject who h |
| 6812239 |
Method of identification of inhibitors of PDE1C and methods of treatment of diabetes |
November 2, 2004 |
| The present invention provides a method of identifying novel agents that increase glucose dependent insulin secretion in pancreatic islet cells as well as methods of treating diabetes using the agents which have an inhibitory effect on the activity of pancreatic islet cell phosphodie |
| 6803455 |
Inhibitors of nucleoside metabolism |
October 12, 2004 |
| The present invention provides compounds having the formula: ##STR1##wherein A is CH or N; B is chosen from OH, NH.sub.2, NHR, H or halogen; D is chosen from OH, NH.sub.2, NHR, H, halogen or SCH.sub.3 ; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are inde |
| 6803199 |
Thyroid sodium/iodide symporter and nucleic acid encoding same |
October 12, 2004 |
| The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, an |
| 6794147 |
Methods for identifying contraceptive compounds |
September 21, 2004 |
| An animal, e.g., transgenic mouse, in which the MSH4 gene is misexpressed. The animal is useful for screening treatments for a number of conditions. Methods for identifying contraceptive agents are also described. |
