| Patent Number |
Title Of Patent |
Date Issued |
| D370978 |
Impression coping for use in oral implantology |
June 18, 1996 |
|
| D362720 |
Abutment for use in oral implantology |
September 26, 1995 |
|
| D356869 |
Abutment replica for use in oral implantology |
March 28, 1995 |
|
| D356868 |
Single tooth fixture for use in oral implantology |
March 28, 1995 |
|
| D355972 |
Adapter for mounting abutment parts for use in oral implantology |
February 28, 1995 |
|
| D355487 |
Drill extension for use in oral implantology |
February 14, 1995 |
|
| 5908833 |
Colon or ileum-specific steroid derivatives |
June 1, 1999 |
| Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formulafor colon- or ileum-specific delivery of the GCS to inflamed bowel mucosa, as well as processes for their preparation, pharmaceutical preparations containing the compounds and the |
| 5686428 |
Pharmaceutical composition |
November 11, 1997 |
| Combinations of 3'-azido-3'deoxythymidine and phsphonoformate have been found to produce a synergistic inhibitory effect against human immunodeficiency virus (HIV). |
| 5616483 |
Genomic DNA sequences encoding human BSSL/CEL |
April 1, 1997 |
| The present invention relates to a DNA molecule containing intron sequences and encoding a human protein which is, depending on the site of action, called Bile Salt-Stimulated Lipase (BSSL) or Carboxyl Ester Lipase (CEL). The DNA molecule is advantageously used in the production of recom |
| 5614514 |
Steroid esters |
March 25, 1997 |
| Compounds of the general formula (I), ##STR1## in which formula the 1,2-position is saturated or is a double bond, R.sub.1 is hydrogen or a straight or branched hydrocarbon chain, R.sub.2 is hydrogen or a straight or branched hydrocarbon chain, R.sub.3 is acyl, X.sub.1 is hydroge |
| 5602253 |
Peptides derivatives |
February 11, 1997 |
| The invention concerns the compound of the formula: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing serine protease inhibitors. The invention further concerns an improved method for synthesizing serine proteas |
| 5602099 |
.delta. opioid receptor antagonists |
February 11, 1997 |
| The invention concerns compounds of the formula 1 ##STR1## and pharmaceutical compositions containing the compounds as active ingredients. The peptides of the invention are .delta. opioid receptor antagonists and are useful as analgesics and immunosuppressants. |
| 5599794 |
Synergistic combination of a substance with gastric acid secretion inhibiting effect and an acid |
February 4, 1997 |
| The invention consists of a combination of a substance that increases the intragastric pH and an acid degradable antibacterial compound. By this combined product regimen it will be possible to obtain maximal local antibacterial effect of acid degradable antibiotics as well as enhanced |
| 5591889 |
Method for the synthesis of trisodium phosphonoformate hexahydrate |
January 7, 1997 |
| The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50.degree. C., adding triethyl phosphonoformate to said so |
| 5585378 |
Composition containing an oxoindole compound |
December 17, 1996 |
| The present invention relates to an oxindole compound having the formula 5-cyclohexyl-1,3-dihydro-1-[2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-2H-in dol-2-one for the prevention or treatment of cognitive dysfunctions. |
| 5576296 |
Galanin antagonist |
November 19, 1996 |
| A galanin antagonist which is a galanin receptor ligand is described. New peptides, Galanin (1-12)-Pro-Substance P(5-11), Galanin (1-12)-Pro-Bradykinin(2-9), Galanin (1-12)-Pro-Pro-Pro- (Leu.sup.5 -Enkephalin (5-1), Galanin (1-12)-Pro-Lys(.epsilon.-NH-)Pro-(Leu5-Enkephalin (5-1) and |
| 5562923 |
Process for conditioning of water-soluble substances |
October 8, 1996 |
| A process for providing water-soluble micronized pharmaceutically acceptable inhalable substances, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation of the pharmaceutically acceptable substances. This process is carried out by |
| 5556964 |
Process for the manufacture of budesonide |
September 17, 1996 |
| The present invention relates to a novel process for the manufacture of (22 R,S)-16.alpha., 17.alpha.-butylidenedioxy-11.beta., 21-dihydroxypregna-1,4-diene-3,20 dione (I) by reacting 11.beta., 16.alpha., 17.alpha. 21-tetrahydroxypregna-1,4-diene (II) with butanal, CH.sub.3-- CH.sub. |
| 5534644 |
Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof |
July 9, 1996 |
| The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichlor |
| 5523475 |
New compounds |
June 4, 1996 |
| The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alk |
| 5500425 |
Chroman derivatives and a method of treating 5-HT mediated disorders |
March 19, 1996 |
| Compounds of the formula I ##STR1## processes for their preparation, pharmaceutical preparations, use of and method of treatment of disorders in CNS by using compounds of formula I. |
| 5498724 |
Pyrazoleamidine compounds |
March 12, 1996 |
| A process for the production of guanidino protected .omega.-aminoalkyl guanidines comprising reacting a diamine selectively at one amino group with an alkoxycarbonyl or aralkoxycarbonyl protected electrophilic guanylation reagent. The process of the invention is general and may be pe |
| 5484286 |
Method for the preparation of implants made of titanium or alloys thereof |
January 16, 1996 |
| The invention relates to a method for treating the surface of surgical implants made of titanium or a titanium alloy, for instance dental implants, before implantation in bone tissue. The method results in a roughened exterior implant surface and at the same time a cleaning action is |
| 5468876 |
Intermediates for the stereoconservative synthesis of 1-substituted (S)-and (R)-2-aminomethylpyr |
November 21, 1995 |
| Disclosed are (R)- and (S)-isomers of the compounds of the Formulas II and III with at least 95% optical purity ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent a hydrogen atom, a lower alkyl, lower alkenyl or lower alkynyl group, a cycloalkyl group or |
| 5455230 |
Delta opioid receptor antagonists and their use as analgesic agents |
October 3, 1995 |
| Compounds of the formula I as well as a process for their preparation, their pharmaceutical preparations and their usewherein X is--Phe--OH,--Phe--NH.sub.2,--Phe--Phe--OH,--Phe--Phe--NH.sub.2,--Trp--Phe--NH.sub.2,--Trp--Phe--OH,--Phe--Phe(p-NO.sub.2)--OH,--Trp--Phe(p-NO.sub.2)--H or--Phe--Trp--N |
| 5441976 |
Pharmacological use of certain cystine derivatives |
August 15, 1995 |
| A pharmaceutical preparation and method for the treatment of diseases due to defects in the immune system using cystine derivatives. |
| 5439917 |
Active compounds |
August 8, 1995 |
| Therapeutically active compounds of the formula: ##STR1## wherein the variables are defined in the specification are provided. |
| 5434304 |
Process for preparing formoterol and related compounds |
July 18, 1995 |
| The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to certain formoterol related compounds |
| 5430042 |
Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceut |
July 4, 1995 |
| The novel compounds of the formula I ##STR1## and physiologically acceptable salts thereof, wherein R.sup.1 and R.sup.2, which are different is each H alkyl containing 1-4 carbon atoms or --C(O)--R.sup.5 ;whereinR.sup.5 is alkyl containing 1-4 carbon atoms or alkoxy containing 1-4 |
| 5420151 |
Chroman derivatives |
May 30, 1995 |
| 3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans, as well as enantiomers and salts thereof, are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the treatment of 5-hydroxytryptami |
| 5419918 |
Method for the manufacture of a controlled release solid unit dosage form |
May 30, 1995 |
| A method for the manufacture of oral controlled release dosage units containing hydroxypropyl methylcellulose wherein the aqueous granulation is performed in the presence of one or more solutes, which inhibit gel formation during the granulation but allows the formation of a gel when |
| 5399572 |
Chlormethiazole in the treatment of neurodegeneration |
March 21, 1995 |
| A thiazole of the following formula is disclosed ##STR1## for the treatment of neurodegeneration involving loss of neuronal structure. |
| 5395323 |
Dissolution system |
March 7, 1995 |
| The invention provides a device for mixing a pharmaceutical from a solid supply into a parenterally acceptable liquid flowing through a set for parenteral administration of the liquid to a patient, said device comprising a first compartment defining a mixing space through which the l |
| 5386032 |
Method of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl-1H-ben |
January 31, 1995 |
| The present invention relates to an improved method for the synthesis of omeprazole, comprising the steps of reacting 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-1H-benzimida zole with m-chloroperoxybenzoic acid in a methylene chloride solution at a substantially con |
| 5385921 |
Pharmaceutical formulations |
January 31, 1995 |
| New pharmaceutical formulations comprising 5-(2-chloro-1-hydroxyethyl)-4-methylthiazole or optical isomers or a pharmaceutically acceptable salt or solvate thereof. |
| 5385904 |
Organic salts of N,N'-diacetyl cystine |
January 31, 1995 |
| New crystalline organic salts of N,N'-diacetyl cystine with immunomodulating effect, processes for their preparation, pharmaceutical compositions containing them and methods of their pharmacological use. |
| 5380648 |
Method for the diagnosis of virulent bacteria |
January 10, 1995 |
| Induction of virulence related proteins in virulent pathogenic E. coli and Shigella by growing such bacteria in the presence of Congo Red as induction triggering factor, and the application of the induction for purposes of diagnosing virulent pathogens and their antibiotic sensitivit |
| 5376687 |
Bicyclic amino-substituted compounds |
December 27, 1994 |
| A compound of formula (I), wherein X is O, CH.sub.2, S, SO or SO.sub.2 ; R is F or Cl; R.sub.1 is H, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl; R.sub.2 is H, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl; R.sub.3 is H, C.sub.1 -C.sub.6, alkyl, a pharmaceutically acceptable |
| 5360805 |
Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect a |
November 1, 1994 |
| Compounds of the formula IV for use as local anaesthetica and analgetica, as well as a method for their preparation, their pharmaceutical preparations and their use. ##STR1## |
| 5354773 |
Use of bafilomycine and derivatives to treat bone diseases |
October 11, 1994 |
| A method for the treatment of diseases related to loss of bone mass such as osteoporosis, Paget's disease of bone, hyperparathyroidism, parodontal diseases and implant-related bone loss comprising administration to a patient suffering therefrom an amount of a compound of formula (I), or |
| 5331013 |
Method for the treatment of ulcerative proctitis and colitis |
July 19, 1994 |
| A method for treatment of ulcerative colitis (and sequelae to surgically treated colitis, for instance ileal pouchiris) and ulcerative proctitis comprising administration to a patient suffering therefrom of a therapeutically effective amount of a local anaesthetic or a pharmaceutical |
| 5250411 |
Nucleic acid probes specific for Plasmodium vivax and methods of using the same |
October 5, 1993 |
| Disclosed are the DNA sequences of probes specific for Plasmodium vivax and the methods by which they were obtained. These nucleic acid sequences proved useful in detection of malaria in man caused by P. vivax by nucleic acid hybridization assays. The high sensitivity of these assays and |
| 5227389 |
Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect a |
July 13, 1993 |
| Compounds of the formula IV for use as local anesthesia and analgesia, as well as a method for their preparation, their pharmaceutical preparations and their use. ##STR1## |
| 5200551 |
Method of preparing an intermediate for the manufacture of bambuterol |
April 6, 1993 |
| The present invention relates to an improved method for the preparation of an intermediate for bambuterol, i.e. for the preparation of 2'-bromo-3,5-di[N,N-dimethylcarbamoyloxy]acetophenone (1), by reacting 3,5-dihydroxyacetophenone with N,N-dimethylcarbamoylchloride in ethyl acetate, |
| 4990534 |
Aralkyl esters and processes for their preparation |
February 5, 1991 |
| Aralkyl esters are used to provide a potentiating effect on cholinergic responses. |
| 4263273 |
Pharmaceutical preparation comprising a cardiac glycoside with a polymer coating |
April 21, 1981 |
| A solid pharmaceutical preparation for administration in dosage unit form comprising a therapeutically effective cardiac glycoside, whereby each dosage unit is to comprise a plurality of bodies, each of said bodies having a pharmaceutically indifferent core, a first layer thereon con |
| 3959311 |
Oxotremorine antagonists |
May 25, 1976 |
| A new class of amino-imide compounds is disclosed in which a 2-oxo-cycloalkylimide group and an amino group are joined by a chain containing acetylenic unsaturation. The compounds are effective to antagonize the tremorogenic effect of oxotremorine and possess valuable pharmaceutical |
| 3953601 |
Dibenzothiophene derivatives as serum lipid lowering agents |
April 27, 1976 |
| A compound of the general formula ##SPC1##And pharmaceutically acceptable salts thereof, in which formula R.sup.0 is H, F, Cl, Br or OCH.sub.3 ; R.sup.1 and R.sup.2 are the same or different and selected from the group consisting of H and alkyl groups having 1-3 carbon atoms; R.sup.3 |
| 3948920 |
New anti-malarial agents |
April 6, 1976 |
| Compounds of the formula ##SPC1##Wherein A designates that the fused six-membered ring could be either unreduced, partially reduced or totally reduced and wherein R.sup.1 is --N(CH.sub.3).sub.2, --N(C.sub.2 H.sub.5).sub.2, ##EQU1## or --N(CH.sub.2 CH.sub.2 Cl).sub.2 and R.sup.2 i |
