| Patent Number |
Title Of Patent |
Date Issued |
| 6761922 |
Sweetener compositions containing aspartyl dipeptide ester compounds |
July 13, 2004 |
| The present invention provides solid and liquid sweetening compositions with a high intensity sweetness containing aspartyl dipeptide ester compounds, processing of making the aspartyl dipeptide ester compounds, as well as food and beverages containing the compositions. |
| 6761767 |
Production method of famciclovir and production and crystallization method of intermediate there |
July 13, 2004 |
| An N-9-position alkylated form is selectively precipitated by subjecting a mixture containing the N-9-position alkylated form and an N-7-position alkylated form of 2-amino-6-halopurine to a crystallization step using a mixed solvent of an organic solvent and water. Then, this N-9-positio |
| 6759075 |
Brown broth |
July 6, 2004 |
| A fond de veau is produced by boiling baked meats for extraction independently, separating a boiled extract therefrom, and reacting a protease with at least a residue of the meats to produce a protein decomposition solution, and then using said protein decomposition solution and said |
| 6756482 |
Purified human activin and process for producing the same |
June 29, 2004 |
| The present invention provides a process for purifying human activin by cation exchange chromatography and chaotropic ion concentration gradient elution. |
| 6753461 |
Method for increasing stress-resistance to a plant |
June 22, 2004 |
| The present invention enables production of a plant resistant to environmental stresses including drought and high salt concentration. The invention increases stress resistance to a plant by increasing galactinol content in the plant. |
| 6749873 |
Cheese yield enhancing method |
June 15, 2004 |
| Herein is disclosed a cheese yield enhancing method in a cheese manufacturing method including a process of separating a cheese curd from a whey after a milk coagulating treatment of a material milk by a milk coagulating enzyme, said cheese yield enhancing method comprising steps of: |
| 6739040 |
Method of manufacturing multilayered printed wiring board using adhesive film |
May 25, 2004 |
| The present invention relates to a method of manufacturing a multilayered printed wiring board by a buildup system in which a conductive circuit layer and an insulating layer are alternately piled up. This method also involves using an adhesive film to facilitate manufacturing the mu |
| 6737255 |
Mutant ilvH gene and method for producing L-valine |
May 18, 2004 |
| The present invention provides an isolated DNA molecule encoding a small subunit of acetohydroxy acid synthase isozyme III originating from Escherichia coli and mutants of Escherichia coli acetohydroxy acid synthase isozyme III, which are free from inhibition by L-valine an can catal |
| 6727411 |
Method of producing transgenic plants having improved amino acid composition |
April 27, 2004 |
| Transgenic plants containing free amino acids, particularly at least one amino acid selected from among glutamic acid, asparagine, aspartic acid, serine, threonine, alanine and histidine accumulated in a large amount, in edible parts thereof, and a method of producing them are provided.I |
| 6716461 |
Method for modifying raw material milk and dairy product prepared by using the modified raw mate |
April 6, 2004 |
| Herein is disclosed a method for modifying raw material milk, wherein a reducing agent such as a thiol compound is added when transglutaminase is caused to act upon raw material milk for a dairy product, whereby the reactivity of the transglutaminase to the raw material milk such as raw |
| 6710056 |
Amidinophenylpyruvic acid derivatives |
March 23, 2004 |
| An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII. ##STR1## |
| 6710031 |
Protein having antithrombotic activity and method for producing the same |
March 23, 2004 |
| A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not less than 30% to the amino acid sequence of SEQ ID NO: 1 and forms a higher order structure composed of a first .beta. stra |
| 6708468 |
Apparatus for counting and packing solid foods |
March 23, 2004 |
| An apparatus for counting and packing solid foods comprising a table device for holding the solid foods to be counted and packed, plural vacuum nozzles, a flexible vacuum pad, and adsorption confirmation sensors. The apparatus also includes an arm holding the vacuum nozzles. The vacuum |
| 6706304 |
Granular sweetener |
March 16, 2004 |
| Herein is disclosed a granulated sweetener comprising Aspartame and Acesulfame-K as active ingredients, wherein the amount of the Acesulfame-K is 5 to 90% by weight based on the total amount of both the components and wherein the maximum particle size of the granules is about 1,400 .mu.m |
| 6703517 |
Method for preparing N-long chain acyl neutral amino acid |
March 9, 2004 |
| A method for preparing a highly purified N-long chain acyl neutral amino acid for use of a detergent and the like in a simple and convenient manner and in a high yield by reacting a neutral amino acid such as glycine, .gamma.-aminobutyric acid, and alanine, with a saturated or unsaturate |
| 6703379 |
Benzene derivatives and pharmaceutical use thereof |
March 9, 2004 |
| The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, |
| 6703031 |
Cysteine derivatives |
March 9, 2004 |
| Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feel |
| 6696571 |
Process for producing .alpha.-aminoketones |
February 24, 2004 |
| A process for producing .alpha.-aminohalomethyl ketones or N-protected .alpha.-aminohalomethyl ketones from specified 3-oxazolidin-5-one derivatives via 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. By this process, .alpha.-aminohalomethyl ketones and compounds relating to them c |
| 6693214 |
Intermediate for sweetener with high sweetness and process for producing the same |
February 17, 2004 |
| The present invention relates to a 3-substituted-phenyl-3-merthylbutyric acid and 3-substituted-phenyl-3-merthylaldehyde derivatives, which are useful in the production of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-.alpha.-aspartyl]-L-p henylalanine 1-methyl ester, which is |
| 6689902 |
Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same |
February 10, 2004 |
| 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-.alpha.-aspartyl]-L-ph enylalanine 1-methyl ester, which |
| 6683214 |
Process for producing .alpha.-aminoketones |
January 27, 2004 |
| An amino group of an .alpha.-amino acid ester is protected as an imine, and it is then reacted with a halomethyllithium to obtain an N-protected-.alpha.-aminohalomethylketone. Further, this N-protected-.alpha.-aminohalomethylketone is treated with an acid to obtain an .alpha.-aminoha |
| 6682912 |
L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
January 27, 2004 |
| A method for producing L-glutamic acid which comprises culturing a microorganism belonging to the genus Klebsiella, Erwinia or Pantoea and having an ability to produce L-glutamic acid in a culture medium, and collecting produced L-glutamic acid from the culture medium. The microbial |
| 6673576 |
Process for producing nucleic acids |
January 6, 2004 |
| The present invention relates to a process for producing 5'-inosinic acid or 5'-guanylic acid for use in seasonings or the like from inosine or guanosine or a precursor thereof using an adenosine triphosphate (ATP)-regenerating microorganism containing a DNA encoding a protein that h |
| 6664412 |
Method for producing lysine derivative |
December 16, 2003 |
| The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl g |
| 6656982 |
Woody thermoplastic resin composition |
December 2, 2003 |
| There is disclosed a woody thermoplastic resin composition which prevents the occurrence of rust on the metal surface in a molding machine and suppresses the generation of a volatile substance as encountered when a woody thermoplastic resin composed of a thermoplastic resin and wood flou |
| 6656892 |
Detergent composition |
December 2, 2003 |
| A detergent composition comprising (A) 5 to 30% by weight of at least one kind of surfactant selected from the group consisting of an anionic surfactant, an amphoteric surfactant, and a nonionic surfactant based on the total weight of the composition; (B) 0.1 to 5% by weight of a sub |
| 6653111 |
Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine |
November 25, 2003 |
| The present invention provides a method for deriving an E. coli strain which produces L-theronine from E.coli strain VNIIgenetika 472T23 by transducing with bacteriophage P1 which bears a transposon. |
| 6653110 |
Method for producing L-glutamic acid |
November 25, 2003 |
| A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability in a medium having pH of 5.0 or less, wherein a total content of an organic acid that inhibits growth of the microorganism at the pH is one at which |
| 6652901 |
Sweetener compositions and uses thereof |
November 25, 2003 |
| The present invention provides compositions containing one or more aspartyl dipeptide derivatives represented by formulas (1) and/or (2) mixed with another high intensity sweetner, such Aspartame, sugar, sugar alcohol, and oligosaccharide; food, beverages, and/or medicinal products conta |
| 6649784 |
Aspartyl dipeptide ester derivatives and sweeteners |
November 18, 2003 |
| Aspartyl dipeptide ester derivatives, such as a N-[N-[3-(3,4-dihydroxyphenyl)-3-methylbutyl]-L-.alpha.-aspartyl]-L-phenyla lanine 1-methyl ester, or salts thereof, having a high degree of sweetness compared to conventional sweeteners. These derivatives are excellent in sweetening pote |
| 6641841 |
Tablet composition |
November 4, 2003 |
| A tablet composition containing N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine and low substituted hydroxypropylcellulose is disclosed. This tablet composition is rapidly disintegrated in the stomach after the administration and absorbed without being influenced by meals to |
| 6639094 |
Process for producing .alpha.-aminoketone derivatives |
October 28, 2003 |
| A process for producing .alpha.-amino-dihalogenated methyl ketone derivatives by reacting an N-protected .alpha.-amino acid ester with a dihalomethyl lithium is provided. This process is suitable for the production on an industrial scale and by this process, .alpha.-amino-dihalogenat |
| 6630341 |
Phosphohexuloisomerase and gene therefor |
October 7, 2003 |
| There are provided a DNA coding for phosphohexuloisomerase, which is a protein defined in the following (A) or (B), and a method for producing the enzyme: (A) a protein having the amino acid sequence of SEQ ID NO: 3 shown in Sequence Listing, (B) a protein having the amino acid seq |
| 6630191 |
Aspartyl dipeptide ester derivatives and sweeteners |
October 7, 2003 |
| The present invention relates to novel, aspartyl dipeptide ester derivatives and salts thereof, such as N-[N-(3-(3-hydroxy-4-methoxyphenyl)propyl]-L-.alpha.-aspartyl]-L-(.alpha.- methyl)phenylalanine 1-methyl ester which provide high degrees of sweetness in comparison to conventional |
| 6627419 |
Modified bacterial cellulose |
September 30, 2003 |
| This invention provides a bacterial cellulose comprising ribbon-shaped microfibrils having a thickness of 10 to 100 nm and a width of 160 to 1000 nm or a bacterial cellulose comprising ribbon-shaped microfibrils having a thickness of 10 to 100 nm and a width of 50 to 70 nm. The former ba |
| 6620967 |
Ketosis-treating agent |
September 16, 2003 |
| A ketosis-treating agent comprising, as an active ingredient, at least one amino acid selected from valine, isoleucine, serine, glutamine and glutamic acid, or a peptide or protein comprising at least one amino acid selected from valine, isoleucine, serine, glutamine and glutamic acid; a |
| 6620916 |
Modified physiologically active proteins and medicinal compositions containing the same |
September 16, 2003 |
| The present invention relates to a modified physiologically active protein, modified physiologically active proteins produced by the process and pharmaceutical compositions containing the same. |
| 6613987 |
Insulating resin composition for multilayer printed-wiring board |
September 2, 2003 |
| Herein is disclosed an insulating resin composition for a multilayer printed-wiring board, comprising two or more kinds of resins which are different in etching rate by plasma treatment and which are not compatible with each other, so that the surface of the resulting insulating layer ca |
| 6613933 |
Process for separating and purifying aspartame and a derivative thereof |
September 2, 2003 |
| A process for easily and efficiently separating aspartame (APM) from N-[N-(3,3-dimethylbutyl)-L-(.alpha.-aspartyl]-L-phenylalanine methyl ester (APM derivative), and thus separating and purifying the APM and the above-mentioned APM derivative, more specifically the N-(3,3-dimethylbut |
| 6613574 |
Method to identify interface residue in biomolecular complex |
September 2, 2003 |
| A method of identifying interface residues in a biomolecular complex are identified by selecting one molecule with residues to be identified, and the nonexchangeable hydrogens (protons) and not less than 70% of exchangeable hydrogens (protons) in the one molecule are exchanged to deu |
| 6613328 |
Methods of treating thrombotic diseases with von Willebrand factor specific antibodies |
September 2, 2003 |
| Anti-thrombotic agents containing humanized antibodies which bind to von Willebrand factor. |
| 6610717 |
Dihydropyridine derivatives |
August 26, 2003 |
| Dihydropyridine derivatives represented by the following formula: ##STR1##analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating t |
| 6610710 |
Phenylalanine derivatives |
August 26, 2003 |
| Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to .alpha.4.beta.7 integrin and a selectivity toward .alpha.4.beta.1 integrin. They are used as therapeutic agents for various diseases to which .alpha.4.beta.7 integrin relates. ## |
| 6605575 |
Cutting fluid composition |
August 12, 2003 |
| The object of the present invention is to provide a cutting oil composition excellent in solubility, lubricity, cutting properties, antirust ability, safety, and washing ability and reduced in foaming, and for that purpose, an N-acylamino acid having a long chain acyl group and/or a salt |
| 6602492 |
Cysteine derivatives |
August 5, 2003 |
| Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feel |
| 6599876 |
Medicament and method for treating renal disease |
July 29, 2003 |
| A medicament for treating a renal disease, comprising a therapeutically effective amount of an activin inhibitor as an active ingredient. Also, a method for treating a renal disease, comprising administering a therapeutically effective amount of an activin inhibitor to a patient suff |
| 6596517 |
Method for producing L-glutamic acid |
July 22, 2003 |
| A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability at a first pH that is suitable for growth of the microorganism, and then culturing the microorganism at a second pH that is suitable for L-glutamic |
| 6593117 |
GMP synthetase and gene coding for the same |
July 15, 2003 |
| A protein which has a GMP synthetase activity, a DNA which codes for the protein and a transformant which is introduced with the DNA in a form that allows expression of the protein encoded by the DNA. |
| 6592916 |
Edible microcapsule and food containing the same |
July 15, 2003 |
| An edible microcapsule comprising a core and a capsule wall, wherein the core is an edible hydrophobic substance, the capsule wall is formed by salting-out of a combination of a protein and an edible salt, and transglutaminase is used as a crosslinking agent for hardening (solidifyin |
| 6579976 |
Process for producing 2',3'-diethyl substituted nucleoside derivatives |
June 17, 2003 |
| There can be provided an excellent industrial process for producing compounds having sugar-moiety hydroxyl groups or halogen atoms reduced in nucleic acids or in derivatives thereof by allowing O-thiocarbonyl derivatives of sugar-moiety hydroxyl groups or allowing halogenated derivat |
