| Patent Number |
Title Of Patent |
Date Issued |
| 4670568 |
Process of producing n-formylaspartic anhydride |
June 2, 1987 |
| A process for producing N-formylaspartic anhydride, which comprises, grinding solid aspartic acid into fine particles; and then reacting said finely ground aspartic acid with formic acid and acetic anhydride. |
| 4670540 |
Novel peptide |
June 2, 1987 |
| Peptides represented by the formula: ##STR1## wherein: X represents Met, Met(O), Nle, or Ile;Y represents a cystine residue or an .alpha.-amino suberic acid residue;Z represents Gly or Ala;m, n, and p each represent 0 or 1;A represents Ser, Ser-Ser, Arg-Ser-Ser, Arg-Arg-Ser-Ser, Leu-Arg- |
| 4670417 |
Hemoglobin combined with a poly(alkylene oxide) |
June 2, 1987 |
| There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure:wherein Hb represents said hemoglobin and n represents a positive |
| 4666838 |
Process for the production of L-aspartyl-L-phenylalanine esters |
May 19, 1987 |
| A process for producing L-aspartyl-L-phenylalanine alkyl or aryl esters wherein L-aspartic acid and L-phenylalanine which is esterified with an alkyl group having at least two carbon atoms, an aryl group or an aralkyl group, are contacted in an aqueous medium with particular microorganis |
| 4663048 |
Method for the separation of a basic amino acid from its fermentation broth |
May 5, 1987 |
| A method for separating a basic amino acid from its fermentation broth, or the liquid resulting from the intermediate treatment of the fermentation broth, containing high-molecular weight contaminants which entails permeating the broth, or liquids resulting from the intermediate treatmen |
| 4658055 |
Method for manufacture of 7-(2,5-dioxocyclopentyl)heptanoic acid derivative |
April 14, 1987 |
| A method for the manufacture of a heptanoic acid derivative represented by the formula ##STR1## wherein R.sup.3 stands for an acyloxy group, a halogen atom, or a hydrogen atom, which comprises reacting a cyclooctene derivative represented by the formula ##STR2## wherein Y |
| 4656194 |
Azulene derivatives and their use as hypocholesterolemics |
April 7, 1987 |
| An azulene derivative capable of exerting a hypocholesterolemic effect on a mammal which is represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.12 alkyl groups and C.sub.2 |
| 4656135 |
Process for producing L-isoleucine by fermentation |
April 7, 1987 |
| A process for producing L-isoleucine, which comprises culturing a microorganism belonging to the genus Brevibacterium or the genus Corynebacterium which has a methyllysine resistance or .alpha.-ketomalonic acid resistance and which is capable of producing L-isoleucine in a liquid med |
| 4642335 |
Anthracycline compounds bound to hydrophilic polypeptides |
February 10, 1987 |
| This invention relates to an antitumor composition of anthracycline compounds bonded to hydrophilic polypeptides having a molecular weight between 10,000 and 15,000. |
| 4642252 |
Body for a pressure-resistant vessel |
February 10, 1987 |
| A body for a pressure-resistant vessel comprising a spirally wound layer formed by a uniaxially stretched film of a crystalline high polymer, e.g., a can. The composite plastic cans according to this invention are useful for holding pressurized carbonated beverages. |
| 4640943 |
Surface modifier for inorganic substances |
February 3, 1987 |
| An inorganic composition of improved characteristics comprising at least one particulate inorganic substance whose surface is modified by an N-acylated basic amino acid. |
| 4634790 |
Process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrohalide |
January 6, 1987 |
| A process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrohalide, which comprises subjecting 3-benzyl-6-carboxymethyl-2,5-diketopiperazine to partial hydrolysis with a strong acid in a solvent mixture of methanol and water. |
| 4623543 |
Low-calorie candies |
November 18, 1986 |
| Low-calorie candies made mainly of reducing maltose syrup having a multi-layer structure comprising a core, a sugar-coating, and a protective coating of high-melting fatty substance are disclosed. These candies have good storage stability, are non-hygroscopic and are easy to mold. A |
| 4618695 |
Method of preparing methyl ester and its hydrochloride |
October 21, 1986 |
| A method of preparing .alpha.-L-phenylalanine methyl ester and its hydrochloride, which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine .beta.-methyl ester in a methanol/hydrochloric acid mixture solvent which contains, when hydrochloric acid is expressed in terms of concentr |
| 4617155 |
Novel lysine salt crystals and process for production thereof |
October 14, 1986 |
| An equimolar salt of lysine and 2-hydroxy-4-methylthiobutyric acid is disclosed along with a process of preparing this salt. |
| 4610827 |
Amino acid complex and a method for optical resolution of a DL-amino acid |
September 9, 1986 |
| A method for optical resolution of a DL-amino acid comprising reacting the DL-amino acid with an optically active N-acyl aspartic acid in a solvent or mixture of solvents, and separating the resulting two diasteromeric salts by way of the difference between their solubilities in the solv |
| 4606854 |
Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride |
August 19, 1986 |
| A method for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine dimethyl ester in a mixture of 0-10% (v/v) methanol, 8-55% (v/v) of concentrated hydrochloric acid, and water (remainder) to a co |
| 4601983 |
Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production o |
July 22, 1986 |
| A genetic sequence coding for the production of a protein having the activity of homoserine dehydrogenase and having two Pst I cleavage sites in its DNA chain and a molecular weight of 2.24 Md, is incorporated into a vehicle capable of replication in Coryneform bacteria and used to produ |
| 4601829 |
Purification of lysine by reverse-phase osmosis |
July 22, 1986 |
| A process for purifying lysine in a lysine production process, which involves passing a solution containing lysine over a cation exchange resin such that lysine adsorbs onto the resin, eluting adsorbed lysine from the resin with an aqueous solution of ammonia to produce a lysine-containi |
| 4596825 |
Method of treating liver disturbances resulting from alcohol consumption and a composition there |
June 24, 1986 |
| A pharmaceutical composition for preventing or alleviating the effects of acute alcoholism, in particular liver disturbances in mammals, which comprises a mixture of alanine or a pharmaceutically acceptable salt or derivative thereof capable of effectively acting as alanine in vivo or a |
| 4595479 |
Modified electrode |
June 17, 1986 |
| A chemically modified electrode comprising a pyrolytic graphite surface, wherein the basal plane of graphite is exposed on said surface and a redox/adsorption electron mediator is irreversibly absorped directly onto the basal plane of graphite on said surface, is disclosed along with |
| 4591554 |
Rapid method for detecting microorganisms |
May 27, 1986 |
| A small number of microorganisms can be rapidly detected or determined by means of a fluorescence analysis method using specific umbelliferone derivatives such as 4-methylumbelliferyl phosphate and 4-methyl umbelliferyl galactoside, and this detecting method is applicable for a micro |
| 4588818 |
Method for recovery of optically active tryptophane |
May 13, 1986 |
| A method for recovery of optically active tryptophane, which comprises filtering a solution of optically active tryptophane containing impurities through a semi-permeable membrane; adding a lower alcohol or a ketone to the filtrate; maintaining the solution containing the lower alcohol o |
| 4584400 |
Refining phenylalanine |
April 22, 1986 |
| A process for refining phenylalanine, in which a phenylalanine solution containing tyrosine as the main impurity and other impurities is contacted with a non-polar, highly porous synthetic adsorbent, adsorbing phenylalanine on the adsorbent selectively, and eluting and recovering the |
| 4576647 |
Oleophilic composition comprising a powdery or granular substance having a hydrophilic surface a |
March 18, 1986 |
| An oleophilic composition comprising a powdery or granular substance having a hydrophilic surface and a surface modifier comprising an aluminum chelate compound of the formula (I): ##STR1## wherein R.sup.1 is selected from hydrogen and C1-6 alkyl, R.sup.2 is selected from methyl |
| 4564471 |
Method for reductive elimination of protecting groups |
January 14, 1986 |
| The invention provides a novel and efficient method for the elimination of protecting groups, e.g. benzyloxycarbonyl group, from a protected amino acid, peptide or derivative thereof having at least one functional group protected by a protecting group, e.g. a lower alkyl ester of N-b |
| 4560652 |
Process for producing L-tryptophan by fermentation |
December 24, 1985 |
| A process for economically producing L-tryptophan which involves culturing aerobically in a culture medium a mutant of the genus Bacillus which is resistant to azaserine and a tryptophan analogue and recovering the L-tryptophan produced which accumulates in the culture medium. |
| 4550180 |
Method for manufacture of N-formylaspartic anhydride |
October 29, 1985 |
| In a method for the manufacture of N-formylaspartic acid anhydride which comprises reacting a mixture of aspartic acid, formic acid and acetic anhydride in the presence of an entraining organic solvent, the improvement comprising adding to the mixture, prior to or during the course o |
| 4546155 |
Latent curing agents for epoxy resins |
October 8, 1985 |
| A latent curing agent for epoxy resin, characterized in that the latent curing agent is an adduct obtained by reacting (a) a polyfunctional epoxy compound, (b) a compound having at least one OH, NH.sub.2, NH or SH group together with a tertiary amino group in the molecule and (c) a carbo |
| 4544733 |
Latent curing agents for epoxy resins |
October 1, 1985 |
| A latent curing agent for epoxy resin, characterized in that the latent curing agent is the hydrazides of the formula (I) or (II). ##STR1## The present curing agent is useful in formulating storable, one-package, heat-curable epoxy resin-based compositions. |
| 4543330 |
Process for the production of a fermentation starting material |
September 24, 1985 |
| A process for the production of a fermentation starting material from cane molasses which comprises: inverting most of the sugar contained in cane molasses either enzymatically with invertase or with a mineral acid, passing the cane molasses containing invert sugar through a column c |
| 4542202 |
Latent curing agents for epoxy resins |
September 17, 1985 |
| An addition product obtained by reacting (a) a polyfunctional epoxy compound and (b) a compound having at least one functional group of OH group, SH group, COOH group and CONHNH.sub.2 group together with a tertiary amino group in the molecule, and an addition product obtained (a), (b |
| 4539056 |
Release sheet and a method for making thereof |
September 3, 1985 |
| This invention relates to a release sheet which comprises a backing sheet, a release resin layer and a pattern layer, the pattern layer being positioned directly or indirectly on the reverse side of the release resin layer in relation to a peeling surface thereof. The release sheet is |
| 4536395 |
Amino acid derivatives and antihypertensive drugs containing them |
August 20, 1985 |
| N-terminal phosphorus dipeptides having antihypertensive properties are disclosed. |
| 4533637 |
Culture medium |
August 6, 1985 |
| On the new findings that cyclodextrin shows no cytotoxicity or only slight cytotoxicity on cell growth and that lipophilic substances such as unsaturated fatty acids and lipophilic vitamins when present together with, or included in, cyclodextrin show such effects as cell growth prom |
| 4530991 |
Latent curing agents for epoxy resins |
July 23, 1985 |
| Hydrazides of the formula (I) or (II)are good latent curing agents for epoxy resin, in the formula (II) R is divalent hydrocarbon residue having 2-24 carbon atoms. The curing agents are useful in formulating novel storable one-package, heat-curable epoxy resin-based compositions. |
| 4529697 |
Process for producing L-glutamic acid by fermentation |
July 16, 1985 |
| A process for producing L-glutamic acid by fermentation is disclosed, which process comprises culturing aerobically in a culture medium a mutant of the genus Brevibacterium or Corynebacterium which has an increased superoxide dismutase activity and is capable of producing L-glutamic acid |
| 4529555 |
Surface modifier for powdery or granular substance having hydrophilic surface comprising an alum |
July 16, 1985 |
| A surface modifier for a powdery or granular substance having a hydrophilic surface is provided. The surface modifier comprises an aluminum chelate compound of the formula (I): ##STR1## wherein R.sup.1 is selected from hydrogen and C1-6 alkyl, R.sup.2 is selected from methyl and |
| 4523999 |
Ultrafiltration method |
June 18, 1985 |
| A method for removing impurities including humic substances, gums, polysaccharides, proteins or a mixture thereof from an amino acid fermented liquor obtained from cane, beet molasses, or a mixture thereof, said amino acid being selected from the group consisting of glutamic acid, ly |
| 4521514 |
Process for producing an addition compound of a dipeptide ester and an amino acid ester |
June 4, 1985 |
| A process for producing an addition compound of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester and phenylalanine methyl ester. Benzyloxycarbonylation of the amino group of L-aspartic acid by benzyloxycarbonylchloride in the presence of a base and esterification o |
| 4514502 |
Composite plasmid |
April 30, 1985 |
| A composite plasmid which comprises (A) a drive-unit region derived from a plasmid a capable of propagating in a Coryneform glutamic acid-producing bacterium, and (B) a gene fragment derived from a plasmid b capable of propagating in Escherichia coli or Bacillus subtilis and having at le |
| 4507282 |
High molecular weight antitumor antibiotic AN-7D |
March 26, 1985 |
| A high molecular weight peptide antibiotic designated as AN-7D which is effective as an agent. |
| 4472447 |
Mixed seasoning on basis of monosodium glutamate |
September 18, 1984 |
| A mixed seasoning consisting of 100 parts by weight of monosodium glutamate, 0.05 to 25 parts by weight of a flavor inducing 5' nucleotide, and 0.5 to 10.0 parts by weight of at least one alkali salt of an organic acid selected from the group consisting of sodium fumarate, sodium cit |
| 4469790 |
Continuous and spontaneous interferon producing lymphoblastoid cell lines, process for preparing |
September 4, 1984 |
| Process for preparing a continuous and spontaneous human-interferon-producing lymphoblastoid cell line which involves (a) transforming human lymphocytes isolated from a human infant from birth up to about 2 years or an aborted human fetus, the transforming being carried out with Epst |
| 4458016 |
Production of 1-.beta.-D-ribofuranosyl-1,2,4-triazole |
July 3, 1984 |
| The production of a 1-.beta.-D-ribofuranosyl-1,2,4-triazole of the formula ##STR1## wherein R is hydroxy, amino, or alkoxy, is carried out by reacting a 1,2,4 triazole of formula ##STR2## wherein R is hydroxy, amino, or alkoxy group, with a greater than equimolar amount of a |
| 4442208 |
Method for producing L-isoleucine by fermentation |
April 10, 1984 |
| L-isoleucine is produced by a fermentation process comprising aerobically culturing in an aqueous culture medium an L-isoleucine producing microorganism obtained by isolating a transformed strain resistant to .alpha.-amino-.beta.-hydroxy valeric acid prepared by incorporating into a |
| 4442034 |
Process for producing corn oil |
April 10, 1984 |
| Corn oil is produced by several process modifications in which maize is initially milled, the higher oil-content germ is separated from the lower oil-content germ, and then the lower oil content germ is pelletized. Thereafter, the processes vary with regard to mixing, heating and flaking |
| 4430500 |
Process for purifying cephalosporin compounds |
February 7, 1984 |
| A cephalosporin compound of the formula: ##STR1## wherein X is hydrogen, halogen, hydroxy, alkyloxy, aralkyloxy, aryloxy, mercapto, alkylthio, aralkylthio, arylthio, alkylsulfonyl, aralkylsulfonyl, arylsulfonyl, alkylsulfinyl, aralkylsulfinyl, arylsulfinyl, amino, mono-or di-alky |
| 4430430 |
Method for producing L-arginine by fermentation |
February 7, 1984 |
| An L-arginine producing microorganism which is constructed by transforming into a recipient strain of the genus Escherichia of a vector having inserted therein an arg A gene derived from a chromosomal DNA of the genus Escherichia, is useful for the production of high levels of L-arginine |
| 4397840 |
Novel erythropoietin product and method for the preparation thereof |
August 9, 1983 |
| The invention provides a novel erythropoietin product prepared from the urine of healthy human but exhibiting no inhibitory effect against erythropoiesis as is the most disadvantageous problem in the product prepared from the urine of healthy human. The method for the preparation of |
