| Patent Number |
Title Of Patent |
Date Issued |
| 7351571 |
Process for the production of .beta.-amino acids using acylase |
April 1, 2008 |
| The present invention relates to a Variovorax sp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl .beta.-amino acid to selectively produce an R-.beta.-amino acid, and a Burkholderia sp. which produces both an acylase having an asymmetric hydrolysis a |
| 7351569 |
Aldolase and production process of substituted .alpha.-keto acids |
April 1, 2008 |
| 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or |
| 7345164 |
Production method of 5'-acyloxynucleoside compound |
March 18, 2008 |
| A production method for conveniently producing a 5'-acyloxynucleoside compound shown by the formula [A] in a good yield while suppressing formation of by-products, including subjecting a 2',3',5'-triacyloxynucleoside compound represented by the formula [I] to selective deacylation in |
| 7345049 |
Phenylalanine derivatives |
March 18, 2008 |
| Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to .alpha.4 integrin. They are used as therapeutic agents for various diseases concerning .alpha.4 integrin. |
| 7344874 |
L-glutamic acid-producing microorganism and a method for producing L-glutamic acid |
March 18, 2008 |
| L-Glutamic acid is produced by culturing a microorganism in which an expression of L-glutamic acid-export gene, a yhfK gene, is enhanced or overexpressed, in a medium to produce and cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid from the medium. |
| 7342053 |
Resin composition, adhesive film using the same and multilayer printed circuit board |
March 11, 2008 |
| Producing a printed circuit board, by coating a resin composition comprising an aromatic cyanate compound having two or more cyanato groups in a molecule and a radical-polymerizable resin on a circuit substrate, photo-curing the resin composition, and thermally curing the photo-cured |
| 7338780 |
Method for producing tripeptides and/or peptides longer than tripeptides |
March 4, 2008 |
| A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empe |
| 7335506 |
Method for producing L-lysine or L-arginine by using methanol-assimilating bacterium |
February 26, 2008 |
| A DNA encoding a variant of a protein, the protein having a loop region and six hydrophobic helices and involved in secretion of L-lysine to the outside of a cell, wherein the DNA encodes a variant of a protein not containing the loop region and facilitates secretion of L-lysine, L-a |
| 7335496 |
Method for producing target substance |
February 26, 2008 |
| A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting the target substance from the medium, wherein the bacterium is modified so that a syst |
| 7329523 |
Phosphoserine phosphatase of coryneform bacteria and variants thereof |
February 12, 2008 |
| The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that complicates serB deficiency of Escherichia coli as a open reading frame in the DNA fragment. (A) A |
| 7329427 |
Process for producing .gamma.-hydroxyamino acid derivatives and monatins |
February 12, 2008 |
| Dihydroisoxazole derivatives are conveniently converted to .gamma.-hydroxyamino acid derivatives which are important as various synthetic intermediates by a catalytic hydrogenation reaction. High-purity monatins which may be used as sweeteners or ingredients thereof can be obtained b |
| 7326701 |
Lactam compounds and pharmaceutical use thereof |
February 5, 2008 |
| An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound |
| 7326546 |
Purine-derived substance-producing bacterium and a method for producing purine-derived substance |
February 5, 2008 |
| A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial |
| 7321055 |
Production method of optically active dephenylalanine compounds |
January 22, 2008 |
| Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric |
| 7320973 |
Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same |
January 22, 2008 |
| The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal tracts ##STR00001# |
| 7320794 |
Transporter protein |
January 22, 2008 |
| A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin comp |
| 7319025 |
Method for producing L-glutamic acid |
January 15, 2008 |
| A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability in a liquid medium of which pH is adjusted to a condition under which L-glutamic acid produced by the microorganism is allowed to be precipitated |
| 7316984 |
Textile product |
January 8, 2008 |
| A textile product having arginine impared thereto; a process for producing the product; and a method for the pretreatment of a textile product. The textile product compensates for the water-retaining function of the horny layer and enhances metabolism. It hence has the effect of keeping |
| 7316916 |
DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, re |
January 8, 2008 |
| DNA for encoding a protein having D-hydantoinase activity which has a base sequence represented by Sequence ID No. 1 in the Sequence Listing. DNA for encoding a protein having D-carbamylase activity which has a base sequence represented by Sequence ID No. 3 in the Sequence Listing. |
| 7314738 |
DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, re |
January 1, 2008 |
| DNA for encoding a protein having D-hydantoinase activity which has a base sequence represented by Sequence ID No. 1 in the Sequence Listing. DNA for encoding a protein having D-carbamylase activity which has a base sequence represented by Sequence ID No. 3 in the Sequence Listing. |
| 7311913 |
Methods of treating thrombotic diseases with von Willebrand factor specific antibodies |
December 25, 2007 |
| Anti-thrombotic agents containing humanized antibodies which bind to von Willebrand factor. |
| 7311836 |
Process for producing amino acid or salt thereof by column technique and production apparatus th |
December 25, 2007 |
| According to the process for producing amino acid or salt thereof in the present invention, in the adsorption step, an amino acid-containing aqueous solution is fed into a pressure tight column so that a free amino acid is adsorbed on a carbonate-type anion exchange resin packed in the |
| 7307160 |
OtsA gene encoding trehalose-6-phosphate synthase from a coryneform bacterium |
December 11, 2007 |
| L-Glutamic acid is produced by culturing a coryneform bacterium having L-glutamic acid producing ability, in which trehalose synthesis ability is decreased or deleted by, for example, disrupting the otsA gene derived from a coryneform bacterium source, coding for trehalose-6-phosphate |
| 7306933 |
Method for producing L-lysine or L-threonine |
December 11, 2007 |
| A bacterium belonging to the genus Escherichia which has an ability to produce L-lysine or L-threonine and which is modified so that a malic enzyme does not function normally in a cell, and a method for producing L-lysine or L-threonine, comprising culturing the bacterium in a medium |
| 7300786 |
Bacteria of the Enterobacteriaceae family having enhanced transaldolase activity |
November 27, 2007 |
| A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talb gene. |
| 7300776 |
L-amino acid-producing bacterium and a method for producing L-amino acid |
November 27, 2007 |
| An L-amino acid-producing strain of Escherichia coli is bred by modifying an Escherichia coli K12 strain or a derivative thereof so as to become resistant to L-valine and have an ability to produce one or more L-amino acids selected from the group consisting of L-tryptophan, L-phenyl |
| 7297800 |
Process of producing glutamate derivatives |
November 20, 2007 |
| The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted .alpha.-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing |
| 7297521 |
Carbamoyl-phosphate synthetase gene of coryneform bacteria and method for producing L-arginine |
November 20, 2007 |
| A DNA fragment which encodes a polypeptide defined in the following (a) or (b), and a polypeptide defined in the following (c) or (d): (a) a polypeptide which has at least the amino acid sequence of the amino acid numbers 50 to 393 in SEQ ID NO: 2 shown in Sequence Listing, (b) a pol |
| 7297513 |
Gene encoding glutathione synthetase from Candida utilis |
November 20, 2007 |
| A gene encoding glutathione synthetase from Candida utilis is provided and food containing .gamma.-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by means of a gene encoding glutathione synthetase under a suitable condition and mixing the |
| 7294491 |
Method for producing L-glutamic acid |
November 13, 2007 |
| The present invention provides a method for producing L-glutamic acid by fermentation, by culturing in a liquid medium a microorganism that can metabolize a carbon source at a specific pH, and wherein said medium contains a carbon source and L-glutamic acid at a saturation concentrat |
| 7291752 |
Production method of .beta.-amino acid |
November 6, 2007 |
| A production method of an optically active .beta.-amino acid represented by the formula (I) ##STR00001## wherein each symbol is as defined in the specification, which includes reacting a compound represented by the formula (II) with a lithium amide represented by the formula (III) in th |
| 7288544 |
Pyrimidine compounds useful as N-type calcium channel antagonists |
October 30, 2007 |
| Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseas |
| 7288389 |
Peptide-forming enzyme gene |
October 30, 2007 |
| DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an amine component by us |
| 7288388 |
Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method |
October 30, 2007 |
| The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produ |
| 7282257 |
Resin composition and adhesive film for multi-layered printing wiring board |
October 16, 2007 |
| The present invention relates to resin compositions that are useful for preparing adhesive films, which are, in turn, useful for forming interlayer insulation layers for multi-layered printed wiring boards having an excellent mechanical strength and capable of being roughened by an o |
| 7279484 |
Heterocyclic compounds |
October 9, 2007 |
| The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) ##STR00001## wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituen |
| 7272894 |
Drum dryer |
September 25, 2007 |
| A drum dryer provided with a liquid splash and scatter preventing equipment, which enables continuous operation by preventing a scattering liquid from making dry powder in the case in which the equipment is provided above a neighborhood of a liquid concentration section. A double dru |
| 7271257 |
Glutamate receptors and utilization thereof |
September 18, 2007 |
| An isolated DNA molecule which encodes a novel glutamate receptor and a transformed cell expressing the receptor are provided. |
| 7270972 |
Process for producing subunit peptide originating in polymer protein |
September 18, 2007 |
| It is provided a method for producing a subunit peptide originating from an oligomeric protein having disulfide bonds within a subunit and between subunits. The method comprises producing a subunit originating from an oligomeric protein having disulfide bonds within a subunit and between |
| 7262035 |
Method for producing L-glutamine by fermentation and L-glutamine producing bacterium |
August 28, 2007 |
| L-Glutamine is produced by culturing a coryneform bacterium which has L-glutamine producing ability and has been modified so that its intracellular glutamine synthetase activity should be enhanced, preferably which has been further modified so that its intracellular glutamate dehydro |
| 7259003 |
Escherichia bacteria transformed with a yedA homolog to enhance L-amino acid producing activity, |
August 21, 2007 |
| A method for producing an L-amino acid, such as L-phenylalanine or L-threonine, is provided using a bacterium belonging to the genus Escherichia, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the protein encoded by the yedA gene. |
| 7256209 |
Pyrazole derivatives and diabetic medicine containing them |
August 14, 2007 |
| The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine ##STR00001## |
| 7255888 |
Method of improving taste and/or flavour of foods and beverages |
August 14, 2007 |
| The present invention discloses a method for producing foods and/or beverage having improved taste and/or flavour, comprising reacting a microbial aminopeptidase on a protein material optionally under the co-existence of a protease, wherein said aminopeptidase has the properties of: |
| 7252978 |
Method for producing L-arginine |
August 7, 2007 |
| L-Arginine is produced by culturing a microorganism which has L-arginine producing ability and has been modified so that expression of lysE gene should be enhanced, such a microorganism further modified so that an arginine repressor should not function normally, or such a microorganism |
| 7252972 |
Methods for secretory production of proteins |
August 7, 2007 |
| The object of the present invention is to provide a method of producing a heterologous protein by making a coryneform bacterium to produce and efficiently extracellularly secrete (secreto-production) an industrially useful heterologous protein. According to the present invention, a g |
| 7250516 |
Phenylalanine derivatives |
July 31, 2007 |
| Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to .alpha.4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning .alpha.4 integrin in which |
| 7250277 |
Soybean raffinose synthase and a method for producing raffinose |
July 31, 2007 |
| Raffinose is produced by allowing a raffinose synthase having the following properties to act on sucrose and galactinol: (1) action and substrate specificity: produces raffinose from sucrose and galactinol; (2) optimum pH: about 6 to 8; (3) optimum temperature: about 35 to 40.degre |
| 7247645 |
Dihydropyridine derivatives |
July 24, 2007 |
| Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: ##STR00001## analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of |
| 7247616 |
Pyrazole derivatives and diabetic medicine containing them |
July 24, 2007 |
| The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine ##STR00001## |
| 7247459 |
L-glutamic acid producing bacterium and process for producing L-glutamic acid |
July 24, 2007 |
| L-glutamic acid is produced by culturing in a medium a microorganism belonging to enterobacteria and having L-glutamic acid productivity, into which a citrate synthase gene derived from a coryneform bacterium is introduced to produce and accumulate L-glutamic acid in the medium and c |
