| Patent Number |
Title Of Patent |
Date Issued |
| 4822907 |
Method for recovering .alpha.-L-aspartyl-L-phenylalanine methyl ester |
April 18, 1989 |
| A process for recovering .alpha.-L-aspartyl-L-phenylalanine methyl ester from a solution containing various methyl ester or demethylated derivatives of .alpha.-L-aspartyl-L-phenylalanine methyl ester and chloride ions is disclosed. This process uses a reverse osmosis membrane having |
| 4822738 |
Transducible composite plasmid |
April 18, 1989 |
| A composite vector capable of the transduction of a Coryneform bacterium, which comprises a first DNA segment containing at least the genetic information for replication from a plasmid capable of propagating in a Coryneform bacterium and a second DNA segment containing at least a DNA |
| 4820869 |
Method for the separation of leucine |
April 11, 1989 |
| A method for separating leucine from a mixture of amino acids containing at least leucine and isoleucine, which comprises subjecting an aqueous solution of a mixture of amino acids to centrifugal force, and forcing by the application of pressure a water-saturated organic solvent immiscib |
| 4820861 |
Process for the production of N-formyl-alpha-L-aspartyl-L-phenylalanine methyl ester |
April 11, 1989 |
| N-formyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester is obtained by reacting L-phenylalanine methyl ester with N-formyl-L-aspartic acid anhydride in a reaction solvent containing acetic acid or acetic acid and formic acid in a complete mixing type continuous reaction mode. |
| 4820825 |
Method for purifying tryptophan |
April 11, 1989 |
| A process for purifying tryptophan produced by microbial cells or an enzyme is disclosed. In this process, the microbial cells are separated, the solution containing tryptophan is treated at a pH in the range of 1 to 4 with activated carbon and a non-polar highly porous resin and crystal |
| 4818291 |
Silk-fibroin and human-fibrinogen adhesive composition |
April 4, 1989 |
| The present invention provides a novel adhesive which contains a mixture of human-fibrinogen and silk-fibroin and which is suitable especially for use in surgery. The mixing ratio of silk-fibroin to human-fibrinogen is 5 to 90, preferably 20 to 70% by weight. |
| 4816484 |
Hypoglycemic agent |
March 28, 1989 |
| A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R.sup.1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon atoms, aralkyl of 6 to 12 carbon atoms, ##STR2## --CH.sub.2 CO.sub.2 R.sup.3, --C |
| 4810816 |
Process for the production of n-formyl-aspartyl-phenylalanine or its methyl ester |
March 7, 1989 |
| A process for producing N-formyl-aspartylphenylalanine or its methyl ester, wherein aspartic acid is reacted with formic acid and acetic anhydride in approximately stoichiometric quantities in the presence or absence of a catalyst and phenylalanine or its methyl ester is directly added t |
| 4806376 |
Process for producing a taste-enriching seasoning from beer yeast |
February 21, 1989 |
| A process for producing a taste-enriching seasoning or a food possessing augmented richness in taste, which comprises preparing an extract of beer yeast by first extracting an aqueous suspension of beer yeast cells under conditions where no substantial decomposition of the cells occurs; |
| 4803300 |
Process for separation of N-protected-.alpha.-L-aspartyl-L-phenylalanines |
February 7, 1989 |
| Disclosed herein is a process for separating N-protected-.alpha.-L-aspartyl-L-phenylalanine, more particularly a process for selectively separating N-protected-.alpha.-L-aspartyl-L-phenylalanine from a solution of N-protected-.alpha.-L-aspartyl-L-phenylalanine containing at least |
| 4801204 |
Method and apparatus for measuring the turbidity of liquid media |
January 31, 1989 |
| The method of the present invention which relates to the measurement of the turbidity of a liquid media, is characterized by the following steps.(i) Placing a measuring cell having a sensor having a light-receiving surface in contact with the liquid media, wherein the light-receiving sur |
| 4797493 |
Benzylidene compounds |
January 10, 1989 |
| Disclosed herein are benzylidene compounds represented by the formula (I): ##STR1## wherein A represents ##STR2## (wherein B represents hydrogen atom or an acetyl group, W represents hydrogen atom or --CH.sub.2 --CH.sub.2 --CO--O--R, X.sup.1, X.sup.2 and X.sup.3 represent ind |
| 4789758 |
Process for the production of an N-protected-L-.alpha.-aspartyl-L-phenylalanine |
December 6, 1988 |
| A process is described for the synthesis of N-protected-L-.alpha.-aspartyl-L-phenylalanine by both (a) the rection of an N-protected-L-aspartic anhydride and a R.sub.1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous medi |
| 4789687 |
Food containing vanillylamine and derivatives useful for accellerating lipid metabolism |
December 6, 1988 |
| A food product comprising a food substance in combination with vanillylamine or a vanillylamide. |
| 4789398 |
Flower-thinning agent for fruit trees |
December 6, 1988 |
| A new flower-thinning agent is now provided, which is comprising cholesterol as the active component and advantageously exerts the flower-thinning effects superior to the known flower-thinning agents. |
| 4786737 |
Aromatic sulfonic acid salts of a proline derivative |
November 22, 1988 |
| A compound which is: ##STR1## wherein R may be 1 to 5 H, Cl, Br, F, C.sub.1 -C.sub.4 straight chain or branched alkyl, OH, or CF.sub.3. |
| 4780528 |
Tripeptides and sweetening agents containing the same |
October 25, 1988 |
| Tripeptide sweeteners represented by formula (I)whereinX is glycine or a D or DL-isomer of alanine, .alpha.-aminobutyric acid, serine, threonine, norvaline, asparagine, B-methyl aspartate, proline or pipecolic acid, andY is a D, L or DL-isomer of alanine, phenylalanine, phenylglycine, serine |
| 4778808 |
Feed additive containing tryptophan |
October 18, 1988 |
| A feed additive produced by concentrating an aqueous solution containing tryptophan and impurities both originating in the culture broth of a tryptophan-producing microorganism, with the pH of the aqueous solution being maintained in the range of 4 to 6 and the temperature thereof being |
| 4777051 |
Process for the production of a composition for animal feed |
October 11, 1988 |
| A process for production of a composition for animal feed, which comprisesspray drying a solution containing 5-95 wt. % based on the solids content of a solution of tryptophan or threonine, or a concentrate thereof, to make sprayed granules in a semi-dry state,depositing said spray granules |
| 4774259 |
Phenylalanine derivatives and uses thereof |
September 27, 1988 |
| The invention provides a phenylalanine derivative having the structural formula: ##STR1## and salts thereof. The derivatives and salts are useful for promoting the absorption of medicaments such as insulin. |
| 4772572 |
Hybridomas and monoclonal antibodies to human IL-2 |
September 20, 1988 |
| Certain hybridomas preparing monoclonal antibodies to human interleukin-2 (IL-2) which do not cross react with rator mouse IL-2 are disclosed. The secreted monoclonal antibody can be used in immunoassays for human IL-2. |
| 4770889 |
Sweetener |
September 13, 1988 |
| Sweetners and sweetened foods are disclosed which comprise aspartame (APM) and sugar alcohols in the following ratio:The sweeteners and sweetened foods can be table sugars, frozen sweets, cookies, fermented milks or beverages, such as soda pops and carbonated cola drinks, and have a swee |
| 4767827 |
Artificial hair comprising poly alpha amino acid having pendant mercapto or disulfide groups |
August 30, 1988 |
| Artificial hair comprising a polyamino acid having a degree of polymerization of 50-10,000, and having pendant mercapto or disulfide groups. |
| 4758553 |
Compositions of nucletic acid components for nutritional replenishment |
July 19, 1988 |
| This invention provides a composition of nucleic acid components for nutritional replenishment characterized in that the composition comprises as effective components at least two nucleic acid compounds selected from the group consisting of (a) nucleic acid bases and pharmaceutically |
| 4758513 |
Human T or B cell lines and a process for producing immunologically active substances using the |
July 19, 1988 |
| This invention relates to a human T or B cell line carrying at least one Ela human adenovirus 12-type gene or fragment thereof; said cell line being capable of spontaneously producing an immmunologically active substance. This invention also relates to a process for producing an immu |
| 4757009 |
Recombinant DNA having a phosphoenol pyruvate carboxylase gene inserted therein, bacteria carryi |
July 12, 1988 |
| A recombinant DNA molecule comprising a plasmid vector having operationally inserted therein a gene coding for phosphoenol pyruvate carboxylase is disclosed along with bacteria containing this recombinant DNA molecule and methods of using these bacteria to produce amino acids in large |
| 4755466 |
Process for producing L-phenylalanine |
July 5, 1988 |
| A process for producing L-phenylalanine, which comprises reacting cinnamic acid and an ammonia generator in an aqueous medium in the presence of an enzyme or enzymes from a microorganism belonging to the genus Geotrichum, Moniliella, Syncephalastrum, Endomyces, Aspergillus, Saccharomycop |
| 4753807 |
Oil or fat coated 5'-ribonucleotides and method of making the same |
June 28, 1988 |
| The invention relates to oil or fat coated 5'-ribonucleotides and a method of making the same. |
| 4742164 |
Bacterial cellulose-containing molding material having high dynamic strength |
May 3, 1988 |
| A molding material having high dynamic strength which contains bacterial cellulose having ribbon-shaped microfibrils.Such material is advantageously used as a reinforcing material for composite plastics having high strength, as high quality paper or as acoustic diaphragms for percussion |
| 4741914 |
Flavor enhancing seasoning containing deodorized garlic extract and process |
May 3, 1988 |
| A flavor enhancing seasoning is disclosed, which is prepared by blanching garlic, and extracting the blanched product with water. The extract produced may be deodorized and concentrated, to provide a seasoning additive that dramatically improves flavor fullness, depth and duration, a |
| 4740616 |
Process for the production of an N-protected-L-.alpha.-aspartyl-L-phenylalanine |
April 26, 1988 |
| A process is described for the synthesis of N-protected-L-.alpha.-aspartyl-L-phenylalanine by both (a) the reaction of an N-protected-L-aspartic anhydride and a R.sub.1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous med |
| 4738927 |
Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell |
April 19, 1988 |
| A gene coded for a polypeptide which possesses interleukin-2 activity is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cel |
| 4732699 |
Biphenyl carbonic acid ester compounds and liquid crystal composition containing the same |
March 22, 1988 |
| A liquid crystal compound represented by the following general formula (1), which possess a large spontaneous polarization about room temperature and a liquid crystal composition containing a liquid crystal compound represented by the following general formula (1) ##STR1## wherei |
| 4722844 |
Process of stabilizing aspartame sweetness in water-containing foods |
February 2, 1988 |
| A sweetening agent or sweetened food which comprises .alpha.-L-aspartyl-L-phenylalanine methyl ester (Aspartame) and an aqueous dispersing agent, wherein the Aspartame is present in an amount sufficient to saturate the aqueous dispersing agent and further to provide undissolved Aspar |
| 4720554 |
Aromatic sulfonic acid salts of a proline derivative |
January 19, 1988 |
| A compound which is: ##STR1## wherein R may be 1 to 5 H, Cl, Br, F, C.sub.1 -C.sub.4 straight chain or branched alkyl, OH, or CF.sub.3. |
| 4719200 |
Amino acid derivatives and antihypertensive drugs containing the same |
January 12, 1988 |
| An amino acid derivative having anti-hypertensive activity and having the formula: ##STR1## wherein one of X or Y represents an acyl group RCO--, and wherein R is an amino acid residue selected from the group consisting of glycyl, alanyl, valyl, leucyl, isoleucyl, phenylalanyl, m |
| 4714767 |
Process for the separation of a basic amino acid from a fermentation broth using cation exchange |
December 22, 1987 |
| A process for separating basic amino acids from a liquid containing the same using cation exchange resin towers in series, which comprises effecting repetitive adsorption and elution steps in sequence, wherein the washing water employed in said adsorption and elution steps is obtained by |
| 4714713 |
Phenylalanine derivatives and uses thereof |
December 22, 1987 |
| The invention provides a phenylalanine derivative having the structural formula: ##STR1## and salts thereof. The derivatives and salts are useful for promoting the absorption of medicaments such as insulin. |
| 4711722 |
Method for preventing fouling of electrodialysis membrane |
December 8, 1987 |
| A method for preventing fouling of an electrodialysis membrane when conducting desalting of an inorganic salt-containing aqueous solution containing electrodialysis membrane-fouling substances, which is characterized by adjusting the pH of the solution to the isoelectric points of th |
| 4708881 |
Method for producing frozen foods |
November 24, 1987 |
| An improved method of producing frozen food including at least two steps of freezing. Food is frozen at a temperature in the neighborhood of a temperature at which the maximum crystallization of ice takes place. Then, the food is processed, and frozen again at a temperature which is not |
| 4699793 |
Method of producing a seasoning from cheese whey |
October 13, 1987 |
| A method for producing a seasoning from whey is disclosed wherein lactic acid bacteria are inoculated into whey and cultured at a temperature of 30.degree.-50.degree. C. while adjusting the pH to from 6-7. The fermented solution is centrifuged to produce a precipitate phase which contain |
| 4695651 |
Biphenyl-based diester compounds and liquid crystal compositions containing same |
September 22, 1987 |
| A liquid crystal compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represent C.sub.1-18 alkyl group, alkyl halide group or aralkyl halide, R.sup.1 may be the same as or different from R.sup.2, X is selected from --COOCH.sub.2 -- or --OCO--. |
| 4691054 |
Method for separating a basic amino acid |
September 1, 1987 |
| A method for separating a basic amino acid from a liquor containing the same, which entails (a) contacting the basic amino containing liquor with a strongly acidic cation exchange resin at a pH at which the basic amino acid exists in the form of a divalent cation, thereby adsorbing at le |
| 4691028 |
Tetra-substituted fulvalene derivatives |
September 1, 1987 |
| A fulvalene derivative represented by formula (1) below. ##STR1## where A.sup.1 -A.sup.8 are at least one atom or a combination of two or more atoms selected from S atom, Se atom, and Te atom; and R.sup.1 -R.sup.4 are alkyl or alkene having 3 to 22 carbon atoms.The fulvalene derivati |
| 4689388 |
One pack type alicyclic epoxy resin compositions |
August 25, 1987 |
| A curable epoxy resin composition, comprising (1) an alicyclic epoxy resin having an average of more than one epoxy group per molecule, (2) a polybasic acid hydrazide, and (3) a latent curing agent for said epoxy resin which comprises an addition product obtained by reacting (a) a po |
| 4684553 |
Transparent plastic can |
August 4, 1987 |
| A transparent plastic can which comprises a transparent body formed of a laminated plastic structure, the inner surface of which is coated with a thin layer of silicon oxide. |
| 4680403 |
Process for producing N-protected-.alpha.-L-aspartyl-L-phenylalanine methyl ester |
July 14, 1987 |
| The invention relates to a process for producing N-protected-.alpha.L-aspartyl-L-phenylalanine methyl ester, which comprises esterifying L-phenylalanine with methanol in the presence of a strong acid catalyst, adding, to the resulting solution, an aqueous alkaline solution to neutral |
| 4680313 |
Acceleration of lipid metabolism using vanillylamine derivatives |
July 14, 1987 |
| A food product comprising a food substance in combination with vanillylamine or a vanillylamide. |
| 4676976 |
Konjak mannan-containing reversible gel |
June 30, 1987 |
| A konjak mannan-containing reversible gel comprising konjak mannan and xanthane gum and free of any alkali agent for solidifying konjak mannan and a process for producing the reversible gel and a foodstuff containing the reversible gel. |
| 4673744 |
Method for conversion of .beta.-aspartylphenylalanine derivatives to .alpha . |
June 16, 1987 |
| A method for converting .beta.-aspartylphenylalanine derivative (1) to .alpha.-aspartylphenylalanine derivatives (2) and (3), said derivatives having the following structures: ##STR1## which comprises: reacting said .beta.-aspartylphenylalanine derivative (1) at a temperature of |
