| Patent Number |
Title Of Patent |
Date Issued |
| 5391810 |
Method of crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester |
February 21, 1995 |
| In crystallizing .alpha.-APM from a water solution or a mixed solvent solution of water and a lower alcohol in a crystallizer, the pressure in the crystallizer is held at not higher than atmospheric pressure, a water or water/alcohol mixed solution of .alpha.-APM is fed into the crys |
| 5391809 |
Method for the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride |
February 21, 1995 |
| A method is disclosed for the production of .alpha.-APM.HCl by treating an F-.alpha.-AP derivative with a mixed solvent of methanol, hydrochloric acid and water, wherein the solubility of .alpha.-APM.HCl is lowered to increase the separation yield thereof. |
| 5378616 |
Mutant Escherichia coli capable of enhanced L-glutamic acid production by fermentation |
January 3, 1995 |
| The present invention provides a mutant and a process for producing L-glutamic acid by fermentation using a microorganism belonging to the genus Escherichia. In the present process, L-glutamic acid is produced and accumulated in a culture medium by (A) culturing an Escherichia mutant |
| 5371269 |
Method for production of .alpha.-L-aspartyl-L phenylalanine methyl ester hydrochloride |
December 6, 1994 |
| The methyl ester of .alpha.-L-aspartyl-L-phenylalanine may be obtained in high yields directly from a reaction solution which contains N-protected- or unprotected-.alpha.-L-aspartyl-D-phenylalanine (or its methyl ester derivative), and .alpha.-L-aspartyl-L-phenylalanine methyl ester by |
| 5368981 |
Method for increasing beta-tyrosinase activity in Erwinia herbicola |
November 29, 1994 |
| A method for increasing .beta.-tyrosinase activity in Erwinia herbicola is disclosed. The activity is increased by culturing the microorganism until it reaches stationary phase and maintaining the stationary phase for a period of 6 to 24 hours while maintaining the pH between 7.0 and 8.3 |
| 5367111 |
Hybrid plants of onion and garlic or Chinese chive and method for breeding and propagating the s |
November 22, 1994 |
| Hybrids of onion and garlic or Chinese chive are obtained by culturing the ovule-embryo after fertilization of the male (e.g. garlic pollen) and female (e.g. onion egg cell) gametes. The hybrids have the useful characteristics of both species and can be propagated. |
| 5362903 |
Method for preparing .alpha.-L-aspartyl-L-phenylalanine |
November 8, 1994 |
| This invention is directed to provide a method for obtaining .alpha.-L-aspartyl-L-phenylalanine selectively in high yields. Diffusion dialysis with an ion exchange membrane is used to decrease hydrochloric acid concentration of a mixed solution containing hydrochloric acid and one or |
| 5362636 |
Process for producing L-lysine by fermentation with a bacteria having selenalysine resistance |
November 8, 1994 |
| A process for producing L-lysine, which comprises culturing a mutant L-lysine-producing strain belonging to the genus Brevibacterium or the genus Corynebacterium and having selenalysine resistance in a nutrient medium, producing and accumulating L-lysine in the culture broth and coll |
| 5362635 |
Process for the production of an amino acid using a fermentation apparatus |
November 8, 1994 |
| Amino acid fermentation is conducted by fermenting bacterial cells in a culture medium in a fermentor and separating fermentation solution withdrawn from the fermentor into a solution containing said bacterial cells and a solution not containing bacterial cells by a cell separator. T |
| 5362489 |
Use of recombinant B-cell differentiation factor for augmenting antibody production and stimulat |
November 8, 1994 |
| A purified human B-cell differentiation factor (BCDF) which does not have a natural signal peptide attached to the N-terminal thereof, DNA encoding the BCDF, transformed cells containing such DNA, a process for producing and obtaining the BCDF, compositions containing the BCDF and variou |
| 5358731 |
Process for producing konjak mannan containing processed minced meat foods |
October 25, 1994 |
| A process for producing processed minced meat foods comprising adding from 0.01 to 0.04 parts by weight of an alkaline substance to an aqueous sol containing at least 1 part by weight of konjak mannan, 0.2 to 10 parts by weight of other gel-forming materials and 15 to 50 parts by weight |
| 5358186 |
Method of preparing granules of dipeptide |
October 25, 1994 |
| In producing granules of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a particle size of falling within a determined particle size range by compaction granulation, formation of fine powdery .alpha.-APM is prevented by breaking the compacted .alpha.-APM so that the one-pass yiel |
| 5344564 |
Method for removing extraction solvent from extraction residue trapped in an oil-and-fat extract |
September 6, 1994 |
| A method for removing an organic extraction solvent from an extraction residue, which is characterized in that an oil or fat is allowed to contact an extraction residue remaining in an oil-and-fat extractor which contains an organic solvent, and the oil or fat is then drawn out of said |
| 5342963 |
Optically active pyrrolidine derivative |
August 30, 1994 |
| Optically active pyrrolidine derivative represented by the following formula (XI): ##STR1## wherein R.sup.1 represents a benzyl group R.sup.2 represents an alkyl group having 1 to 6 carbon atoms, R.sup.3 represents an alkyl group having 1 to 6 carbon atoms, a benzyl group or an a |
| 5342840 |
Cyclopropane derivative |
August 30, 1994 |
| A cyclopropane derivative of formula (I) ##STR1## wherein B.sup.1 is a purine or pyrimidine residue, R.sup.1 and R.sup.2 are, independently, hydrogen or a protecting group for hydroxyl and each of k, m and n represents, independently, an integer of 1 or 2 is useful for its antivi |
| 5340718 |
Method for assaying a human muscular dystrophy protein |
August 23, 1994 |
| Methods and polypeptides for assaying human proteins associated with Duchenne muscular dystrophy, are disclosed. |
| 5340599 |
Method of manufacturing three-dimensionally formed foods |
August 23, 1994 |
| In a method of manufacturing three-dimensionally formed foods which comprises the step of continuously processing food material into a three-dimensional form by using a drum-type forming machine in which the forming surface of the forming blocks is release treated, the method compris |
| 5338672 |
Method for producing L-3, 4-dihydroxyphenyalanine by Erwinia having tyrosinase activity |
August 16, 1994 |
| The present invention relates to improved methods for producing L-3, 4-dihydroxyphenylalanine from catechol, pyruvic acid and ammonium ion, or catechol and L-serine, by utilizing .beta.-tyrosinase activity of a microorganism which belongs to the genus Erwinia. According to the method |
| 5336770 |
Transglycosilation process for producing acyclic nucleosides |
August 9, 1994 |
| Herein is disclosed a novel and industrially advantageous process for synthesizing acyclic nucleosides such as acyclovir and ganciclovir from ribonucleosides, which process comprises adding an acid catalyst and an acid anhydride to a solution of a ribonucleoside such as guanosine and an |
| 5334713 |
N-long chain acyl neutral amino acid esters |
August 2, 1994 |
| The present invention relates to N-long chain acyl neutral amino acid esters of the general formula (I): ##STR1## wherein X represents an ester-forming residue of a sterol; COR represents a long chain acyl group having 8 to 22 carbon atoms; R.sub.1 and R.sub.2 are identical or di |
| 5334510 |
Process for producing riboflavin by fermentation |
August 2, 1994 |
| The present invention provides a process for producing riboflavin by fermentation, a method for providing microorganisms having an improved riboflavin-producing capability, and strains of microorganisms having improved riboflavin-producing ability. The strains of the present inventio |
| 5329014 |
Method for recovering optically active tryptophan |
July 12, 1994 |
| Optically active tryptophan of high purity can be obtained in high yields from a tryptophan fermentation broth, using crystallization of optically active tryptophan hydrochloride in combination with concurrent neutralization crystallization. According to the present invention, optica |
| 5326693 |
Method for concurrent fermentation of basic amino acid and acidic amino acid |
July 5, 1994 |
| A basic L-amino acid and an acidic L-amino acid may be concurrently produced by either culturing a basic L-amino acid-producing bacteria under conditions for producing an acidic L-amino acid or mix-culturing a basic L-amino acid-producing bacteria and an acidic L-amino acid-producing |
| 5324645 |
Highly retrovirus-producing DNA construct and cell line |
June 28, 1994 |
| A highly retrovirus-producing DNA construct, which comprises a gene encoding retrovirus which is incorporated into a vector for gene amplification. |
| 5310895 |
Method for production of nucleoside derivatives by selective hydrolysis |
May 10, 1994 |
| A method for selective hydrolysis of nucleoside derivatives using cyclodextrin in basic solution is disclosed. |
| 5310550 |
Method of treating thrombocytopenia using human BCDF in combination with IL-3 |
May 10, 1994 |
| Thrombocytopenia is treated by administering a subject suffering from thrombocytopenia a composition containing human B cell differentiation activity in combination with IL-3. |
| 5305650 |
Automatic preparation apparatus |
April 26, 1994 |
| An automatic preparation apparatus comprising turntable means for mounting thereon a plurality of containers including sample containers, rack means, provided at a stationary position separate from the turntable means, for mounting thereon a plurality of sample containers, robot means fo |
| 5304671 |
Method for recovery of .alpha.-L-aspartyl-L-phenylalanine methyl ester, L-phenylalanine and L-as |
April 19, 1994 |
| A method for the recovery of .alpha.-L-aspartyl-L-phenylalanine methyl ester, L-phenylalanine and L-aspartic acid from the mother liquor obtained by the solid-liquid separation of a suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester crystals is disclosed. |
| 5304476 |
Process for producing l-lysine by fermentation employing a microorganism resistant to acyl-lysin |
April 19, 1994 |
| The present invention relates to a fermentation process using a L-lysine-producing microorganism having a resistance to an acyl-lysine, a methylated acyl-lysine or both an acyl-lysine and a methylated acyl-lysine. By the process of the present invention, L-lysine may be produced in h |
| 5300297 |
Feed additive for ruminants |
April 5, 1994 |
| The present invention relates to a biologically active substance that is stable in the rumen of ruminants and released in the abomasum and its subsequent digestive tract. The biologically active substance has the additional properties of being digested and absorbed with good efficiency. |
| 5298648 |
Method of crystallizing aspartame |
March 29, 1994 |
| Aspartame, crystallized in the presence of a crystal growth inhibitor comprising one or more of dipeptides, amino acids, saccharides, organic acids and inorganic salts, has a thick and firm crystal habit. The crystals may be easily separated by solid-liquid separation, and the drying |
| 5294714 |
2,5-dioxopiperazine compounds and method for preparing .alpha.-aspartyl-L-phenylalanine methyl e |
March 15, 1994 |
| A method of preparing .alpha.-APM derivatives without using an expensive L-phenylalanine is provided, wherein 2,5-dioxopiperazine-3-acetamide is reacted with acetic anhydride to give N,N'-diacetyl-6-cyanomethyl-2,5-dioxopiperazine, which is then reacted with benzaldehyde in the prese |
| 5292925 |
N-t-butyloxycarbonyl-3-cyclohexyl-L-alanine methyl ester in crystalline form |
March 8, 1994 |
| N-t-butyloxycarbonyl-3-cyclohexyl-L-alanine methyl ester, previously known only as an oil, is provided in crystalline form. By addition of an organic solvent, such as methanol and/or n-hexane, to the ester in the form of an oil and cooling, crystals may be obtained. Alternatively, the es |
| 5292923 |
Method of preparing .alpha.-l-aspartyl-l-phenylalanine methyl ester hydrochloride |
March 8, 1994 |
| A method of preparing .varies.-L-aspartyl-L-phenylalanine methyl ester hydrochloride (.varies.-APM.HCL) from a reaction mixture of N-formyl-L-aspartic acid anhydride and L-phenylalanine methyl ester (PM), wherein .alpha.-APM.HCl is produced without isolating an intermediate by solid- |
| 5290927 |
Process for preparing 2',3'-dideoxyadenosine |
March 1, 1994 |
| A process for preparing 2',3'-dideoxyadenosine of the formula ##STR1## wherein B is adenine, wherein R.sup.1 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl, or silyl, said process comprising:reducing a nucleoside of the formula IIIa or IIIb ##STR2## wherein R. |
| 5286897 |
N-t-butyloxycarbonyl-3-cyclohexyl-L-alanine methyl ester in crystalline form |
February 15, 1994 |
| N-t-butyloxycarbonyl-3-cyclohexyl-L-alanine methyl ester, previously known only as an oil, is provided in crystalline form. By addition of an organic solvent, such as methanol and/or n-hexane, to the ester in the form of an oil and cooling, crystals may be obtained. Alternatively, the es |
| 5281415 |
Sustained release composition for application to the oral cavity |
January 25, 1994 |
| There is provided a novel composition for oral cavity application to which a sustained release property is imparted so as to effectively exhibit the effects of a component for preventing bad odor from the oral cavity and/or a flavor component and/or an anti-dental caries component in the |
| 5279821 |
Pyrogen adsorbent containing amide groups |
January 18, 1994 |
| Here is disclosed a water-insoluble pyrogen adsorbent composed of a polymer possessing amide groups optionally modified, said polymer being, e.g., a poly amino acid, a nylon, on a polyacrylamide. |
| 5279744 |
Method for purification of an amino acid using ion exchange resin |
January 18, 1994 |
| A method for purification of an amino acid which comprises contacting an amino acid solution containing impurities with an ion exchange resin to selectively adsorb the amino acid onto the resin, eluting and recovering the adsorbed amino acid whereby the resin is contacted with the amino |
| 5275702 |
Distillation method of separating organic solvents |
January 4, 1994 |
| The present invention discloses a method to separate each component from a mixed solution of organic solvents obtained during the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester, which is useful as a sweetener, namely, a mixed solution of acetic acid and toluene or a mixed |
| 5272067 |
Process for producing L-glutamic acid |
December 21, 1993 |
| A process for the production of L-glutamic acid comprising growing microorganisms belonging to the genera Brevibacterium and Corynebacterium that are resisted to prumycin. |
| 5266719 |
Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester |
November 30, 1993 |
| In neutralizing an acid addition salt of .alpha.-APM in an aqueous medium, the .alpha.-APM concentration in the neutralized liquid is controlled to fall within the range of from 3 to 10 wt. % at the finish of neutralization. Then, the liquid is heated to 50.degree. to 80.degree. C. a |
| 5260486 |
Process for producing a beta-ketoalcohol |
November 9, 1993 |
| Herein is disclosed a process for producing a .beta.-ketoalcohol by the oxidative ring-opening reaction of a 1,3-dioxane derivative, said .beta.-ketoalcohol being able to be a substrate for asymmetric reaction. |
| 5260216 |
Apparatus for amino acid fermentation |
November 9, 1993 |
| Amino acid fermentation is conducted by fermenting using bacterial cells in a culture medium in a fermentor and separating fermentation solution withdrawn from the fermentor into a solution containing the bacterial cells and a solution not containing bacterial cells by a cell separator, |
| 5250681 |
Piperidine derivatives and hypotensives containing the same |
October 5, 1993 |
| A piperidine compound of the formula (I): ##STR1## wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH.sub.2).sub.n, which may be substituted, in which n is 0 or an integer of 1 to 10, --CH.dbd.CH--, --C.dbd.C--, --O--, --S--, --NH--, --N(COCH.sub.3)--, |
| 5250434 |
Microorganisms for production of glutamic acid |
October 5, 1993 |
| Novel bacteria identified as effective in glutamic acid production through fermentation chemistry conducted at temperatures above 42.degree. C. |
| 5250423 |
Method for the production of L-lysine employing thermophilic corynebacterium thermoaminogenes |
October 5, 1993 |
| L-lysine is produced by culturing, in a medium, an L-lysine-producing mutant which belongs to the genus Corynebacterium thermoaminogenes which is capable of growing at 40.degree. C. or higher and which has resistance to S-(2-aminoethyl)-L-cysteine thereby producing and accumulating L-lys |
| 5248806 |
Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester |
September 28, 1993 |
| An acid addition salt of .alpha.-APM is dissolved or suspended in an aqueous medium at 50.degree. C. or lower at a pH of 3 or less and a concentration of the salt of 3 wt.% or more (solution A). A liquid having a pH of 3 or more and containing or not containing .alpha.-APM is prepared |
| 5244669 |
Feed additives for ruminants |
September 14, 1993 |
| A feed additive granule for ruminants comprising a granulated physiologically active substance as the core, a first coating layer placed on the surface of said core, said first coating layer containing a high molecular substance which dissolves or swells in water in an acidic pH regi |
| 5240911 |
Method of reducing blood sugar levels using a hypoglycemic agent |
August 31, 1993 |
| Pharmaceutical compositions containing the polypeptides BUF-3, BUF-4 and BUF-5 have hypoglycemic activity. BUF-3 is a homodimer of monomer A shown in FIG. 1. The monomer has a molecular weight of 16.+-.1 kd. BUF-4 is a heterodimer of monomer A and monomer B (FIG. 2). These products can b |
