| Patent Number |
Title Of Patent |
Date Issued |
| 5530155 |
Process for recovering L-phenylalanine |
June 25, 1996 |
| Addition of a reaction mixture obtained by the mineral acid hydrolysis of at least one side flow generated from the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester to a crystallization slurry containing L-phenylalanine while maintaining the pH of the slurry at 3-8 by ad |
| 5529712 |
Detergent composition |
June 25, 1996 |
| A detergent composition which comprises (A) an N-acyl amino acid salt of an amino acid selected from glycine, alanine and .beta.-alanine where the acyl group is a saturated or unsaturated fatty acid residue having 8 to 20 carbon atoms and (B) a higher fatty acid salt at a Component (A)/C |
| 5525335 |
Wound healing agent |
June 11, 1996 |
| Wound healing agents (especially a cicatricial contracture preventing agent, a wound protective or coating agent and a hemostatic agent) containing transglutaminaseas an active ingredient, which are novel and excellent wound healing agents with which cicatricial contracture preventio |
| 5518905 |
Method for producing L-3,4-dihydroxyphenylalanine by precipitation of anhydrous crystals |
May 21, 1996 |
| A method for producing L-3,4-dihydroxyphenylalanine comprising contacting microorganism cells having .beta.-tyrosinase activity with catechol, pyruvic acid and ammonium ion or with catechol and L-serine, at a temperature lower than 25.degree. C. in the presence of anhydrous crystals |
| 5518904 |
Method of producing alpha crystals of L-phenylalanine |
May 21, 1996 |
| A method of producing L-phenylalanine employing a microorganism in which cultivation of the microorganism is continued while precipitating alpha-crystals of L-phenylalanine in the culture by means of seed crystals or a pH shift. |
| 5518742 |
Enzyme preparation for producing bound-formed food |
May 21, 1996 |
| An enzyme preparation for bound-formed food use which comprises transglutaminase, a casein and an edible surface active agent. The enzyme preparation strongly binds raw food materials, and the resulting bound-formed foods have an excellent taste and savor. |
| 5518665 |
Transparent solid detergents |
May 21, 1996 |
| A transparent solid detergent comprising N-acylglutamic acid salts, characterized in that said salts are the potassium and sodium salts, each having a neutralization degree of between 1.5 and 2.0, said potassium and sodium salts being in a molar ratio of 9:1 to 2:8 and being incorporated |
| 5514573 |
Gene encoding transglutaminase derived from fish |
May 7, 1996 |
| The present invention relates to a DNA fragment having a gene derived from fish which codes for a polypeptide possessing transglutaminase activity, a recombinant plasmid comprising a fish-derived DNA fragment which codes for a transglutaminase, a transformant into which a recombinant pla |
| 5512672 |
Curdlan sulfate |
April 30, 1996 |
| A beta-1,3-glucan of sulfated curdlan having a sulfur content of 12.4 to 17% and an average molecular weight of 27,000 to 330,000 daltons. Sulfate curdlan exhibits strong HIV inhibitory activity with little anticoagulant activity and little toxicity. |
| 5510259 |
Human IL-2 receptor .gamma. chain molecule |
April 23, 1996 |
| The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule b |
| 5510137 |
Sweet ice stuffs and jellied foods |
April 23, 1996 |
| Sweet ice stuffs and jellied foods produced in accordance with the present invention using trehalose as one of raw materials are of low calorie and high-grade feeling, and sweet ice stuffs and jellied foods produced by substituting all or part of the cariogenic sugar or a substitute ther |
| 5506321 |
Photosolder resist composition |
April 9, 1996 |
| A photosensitive resin composition or photosensitive heat-curing resin composition comprising a photocurable oligomer containing 2 or more polymerizable double bonds and a carboxyl group and a heat-curing component selected from a compound containing one polymerizable double bond and |
| 5501712 |
Method for crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester |
March 26, 1996 |
| The problems in crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester, namely, problems in crystal slurry properties in solid-liquid separation, scaling at heat transfer surfaces, and the like, are solved by a method for crystallization of .alpha.-L-aspartyl-L-phenylalan |
| 5496824 |
Cyclopropane derivatives and anti-viral agent containing the same |
March 5, 1996 |
| The present invention provides a pharmaceutical agent having a high pharmaceutical potency against varicella-zoster viruses and herpes simplex viruses, compositions containing the same, and methods for treating varicella-zoster viruses using the same. |
| 5492818 |
Method of producing L-glutamic acid by fermentation |
February 20, 1996 |
| The present invention provides a method of producing L-glutamic acid by fermentation, comprising the steps ofculturing a mutant of an L-glutamic acid-producing microorganism of the genus Brevibacterium or Corynebacterium which has lower .alpha.-ketoglutaric acid dehydrogenase activity co |
| 5491150 |
Supplementary therpeutic agents for the treatment of immunodeficiency syndrome |
February 13, 1996 |
| A supplementary therapeutic agent for the treatment of immunodeficiency syndrome with reduced NK (natural killer) activity and an immunopotentiator preparation containing it are provided.A supplementary therapeutic agent for immunopotentiation which comprises L-cysteine, L-cystine, or L- |
| 5488150 |
Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalanine and methods for preparing the |
January 30, 1996 |
| Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be forme |
| 5484714 |
Method of producing trehalose by microorganisms which can produce tremalose with sucrose or malt |
January 16, 1996 |
| A method of producing trehalose, in which a microorganism belonging to the genus Brevibacterium, Corynebacterium, Microbacterium or Arthrobacter and having the ability to produce trehalose is incubated in a liquid medium containing sucrose or maltose as an essential carbon source and the |
| 5476573 |
Apparatus for defoaming and controlling aerobic culture fermentation |
December 19, 1995 |
| An apparatus and method for defoaming aerobic fermentation cultures is provided, where the amount of liquid culture medium used is greater than that in conventional aerobic cultures (70% or more of the total capacity of the culture tank) without lowering the productivity of the intended, |
| 5474778 |
Cosmetic and an external preparation containing an oil-soluble n-long chained acyl acidic amino |
December 12, 1995 |
| Herein is disclosed a cosmetic or an external preparation containing, as an oleo-phase component, an oil-soluble N-long chained acyl acidic amino acid mono- or di-ester having at least one sterol ester in the molecule, which is a novel compound of excellent emulsifying and hydrating perf |
| 5470419 |
Easily tearable film and pouch made therefrom |
November 28, 1995 |
| An easily tearable plastic film and a pouch made therefrom comprises a thin-wall part for easy tearing. The thin-wall part being made by incorporating strings in the plastic film when it is made by melt extrusion. A method for producing the film and pouch is also shown. |
| 5466864 |
Method for recovering L-phenylalanine |
November 14, 1995 |
| The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalani |
| 5466864 |
Method for recovering L-phenylalanine |
November 14, 1995 |
| The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalani |
| 5466793 |
Process for preparing 2', 3'- dideoxyinosine |
November 14, 1995 |
| A process for preparing 2',3'-dideoxyinosine comprising reducing a nucleoside of the formula IIIa or IIIb ##STR1## wherein R.sup.2 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl or a silyl protecting group; X is Cl, Br, or I; R.sub.5 is C.sub.1-12 acyl; H.sub.x |
| 5466793 |
Process for preparing 2', 3'- dideoxyinosine |
November 14, 1995 |
| A process for preparing 2',3'-dideoxyinosine comprising reducing a nucleoside of the formula IIIa or IIIb ##STR1## wherein R.sup.2 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl or a silyl protecting group; X is Cl, Br, or I; R.sub.5 is C.sub.1-12 acyl; H.sub.x |
| 5464819 |
Physiologically active peptide having immunoregulatory activities |
November 7, 1995 |
| A novel, substantially pure, physiologically active peptide is disclosed, comprising an amino acid sequence selected from Gly-Glu (SEQ ID NO. 5), Pro-Val-Val (SEQ ID NO. 6), Glu-Pro-Val-Val (SEQ ID NO. 7), Glu-Glu-Pro-Val-Val (SEQ ID NO. 8), Ala-Glu-Glu-Pro-Val-Val (SEQ ID NO. 9), an |
| 5463116 |
Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing t |
October 31, 1995 |
| Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be forme |
| 5463078 |
Anisomycin derivatives and anticancer agents, antifungal agents and antiprotozoan agents contain |
October 31, 1995 |
| Anisomycin derivatives represented by the following formula: ##STR1## and salts thereof, wherein R is hydrogen or an acyl group of 1-18 carbon atoms, and X is either a carbamoyl group represented by the formula --CONR.sup.1 R.sup.2 or an alkyl group represented by the formula --C |
| 5451671 |
Method of purifying 2',3'-dideoxynucleosides |
September 19, 1995 |
| A crude 2',3'-dideoxynucleoside compound is purified by extracting with an organic solvent, or crystallizing, the 2',3'-dideoxynucleoside compound from a basic aqueous solution having a pH of not less than 12 containing the same. In another embodiment of purification a basic aqueous solu |
| 5449840 |
Cyclopropane derivative |
September 12, 1995 |
| A cyclopropane derivative of formula (I) ##STR1## wherein B.sup.1 is a purine or pyrimidine residue, R.sup.1 and R.sup.2 are, independently, hydrogen or a protecting group for hydroxyl and each of k, m and n represents, independently, an integer of 1 or 2 is useful for its antivi |
| 5447732 |
High-absorption mineral-containing composition and foods |
September 5, 1995 |
| To provide a composition containing a mineral absorption accelerator which accelerates the absorption of minerals. It contains minerals and degradated products of poly-.gamma.-glutamic acid as a mineral absorption accelerator and may be used in foods in a variety of forms, including a |
| 5441644 |
Method of isolation and purification of trehalose |
August 15, 1995 |
| A method for isolating and purifying trehalose from trehalose-containing solutions is described. Using ultrafiltration and selective concentration, highly pure crystals of trehalose dihydrate are obtained from aqueous solution. |
| 5439977 |
Acid anhydride-containing one package of epoxy resin composition |
August 8, 1995 |
| An acid anhydride-containing one package epoxy resin composition consisting indispensably of (1) an epoxy resin having two or more epoxy groups in one molecule, (2) an acid anhydride, (3) at least one of (a) a liquid latent curing accelerator, (b) a latent curing accelerator soluble in a |
| 5432262 |
Method of purifying .alpha.-L-aspartyl-L-phenylalanine methyl ester |
July 11, 1995 |
| Mixture containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and 3-benzyl-6-carboxymethyl-2,5-dioxopiperazine are brought into contact with hydrochloric acid in an aqueous solvent to precipitate .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride and 3-benzyl-6-carbox |
| 5430112 |
Epoxy resin and polythiol composition |
July 4, 1995 |
| Epoxy resin compositions which contain (1) an epoxy resin which has two or more epoxy groups in its molecule, (2) a polythiol compound which has two or more thiol groups in its molecule and (3) an accelerator which is (i) a solid dispersion-type amine adduct latent curing accelerator or |
| 5429832 |
Feed additive composition for ruminants |
July 4, 1995 |
| The present invention provides a feed additive composition for ruminants containing a biologically active substance therein. When administered to ruminants, the composition containing the active substance is stably protected in the rumen while efficient release of the active substance is |
| 5426050 |
Plasmid vectors for expression of genes in coryneform bacteria |
June 20, 1995 |
| A recombinant plasmid vector is provided which is capable of replicating and expressing in a Coryneform bacterial cell, which plasmid vector is pEC 701, pEC 702, pEC 801, pEC 830 or pEC 901. |
| 5425787 |
Method for crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester |
June 20, 1995 |
| The problems in crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester, namely, problems in crystal slurry properties in solid-liquid separation, scaling at heat transfer surfaces, and the like, are solved by a method for crystallization of .alpha.-L-aspartyl-L-phenylalan |
| 5421864 |
Agent for filler surface treatment in water |
June 6, 1995 |
| A surface modifying agent for surface treating a filler in water which comprises 100 parts by weight of a zirconate base or/and aluminate base coupling agent(s) whose unhydrolyzable side chains have a solubility parameter (x) of 6.5-12, and 3 to 30 parts by weight of a nonionic surface |
| 5420338 |
Method for the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride |
May 30, 1995 |
| A method is disclosed for the production of .alpha.-APM HCl by treating an F-.alpha.-AP derivative with a mixed solvent of methanol, hydrochloric acid and water, wherein the solubility of .alpha.-APM HCl is lowered to increase the separation yield thereof. |
| 5420025 |
Recombinant transglutaminase |
May 30, 1995 |
| A DNA gene which encodes transglutaminase, a plasmid in which the DNA gene is incorporated, a transformant transformed with the plasmid and a process for the production of transglutaminase that comprises culturing the transformant. |
| 5413991 |
Allosamidin compounds |
May 9, 1995 |
| Novel allosamidin compounds, AJI9463A, AJI9463B and AJI9463C, represented by the following structural formula (1): ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen and R.sub.3 is hydroxy (AJI9463A); R.sub.1 and R.sub.3 are hydrogen and R.sub.2 is hydroxy (AJI9463B); and R.sub.1 |
| 5405777 |
Acetic acid assimilating gene and a method for preventing accumulation of acetic acid in culture |
April 11, 1995 |
| The gene responsible for the capability of E. coli to assimilate acetic acid has been isolated and characterized. Transforming bacteria with this gene enhances the bacteria's ability to assimilate acetic acid and results in a bacteria having improved growth characteristics, particularly |
| 5405628 |
Feed additive composition for ruminants |
April 11, 1995 |
| A feed additive composition is provided having a core which contains a biologically active substance and which is coated with a coating composition which contains components a) and b):a) at least one substance selected from the group consisting of linear or branched saturated or unsatura |
| 5399669 |
Interleukin-2 polypeptides |
March 21, 1995 |
| Recombinantly produced interleukin-2 exhibits human IL-2 activity, has a molecular weight of about 15,000 daltons, is activity stable at a pH of 2-9 and is resistant to elevated temperatures. The recombinant IL-2 has the principal biological activity of human IL-2, promotion of proli |
| 5399554 |
Readily soluble 2',3'-dideoxyinosine compositions |
March 21, 1995 |
| A readily soluble 2',3'-dideoxyinosine composition is prepared by combining 80 to 1 parts by weight of a basic amino acid and 20 to 99 parts by weight of 2',3'-dideoxyinosine. The greater solution velocity of this composition improves solubility for therapeutic uses. |
| 5393915 |
Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride salt |
February 28, 1995 |
| A method for the solid-liquid separation of a suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester (.alpha.-APM) or its hydrochloride salt (.alpha.-APM.HCl), wherein an aqueous suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride salt is subject |
| 5393890 |
Piperidine derivatives and hypotensives containing the same |
February 28, 1995 |
| A piperidine compound of the formula (I): ##STR1## wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH.sub.2).sub.n, which may be substituted, in which n is 0 or an integer of 1 to 10, --CH.dbd.CH--, --C.dbd.C--, --O--, --S--, --NH--, --N(COCH.sub.3)--, |
| 5393671 |
Mutant Escherichia coli capable of enhanced L-glutamic acid production |
February 28, 1995 |
| The present invention provides a mutant and discloses a process for producing L-glutamic acid by fermentation using a microorganism belonging to the genus Escherichia. The L-glutamic acid is produced and accumulated in a culture medium by culturing a mutant designated as FERM P-12379 whi |
| 5393664 |
Method of preparing (S)-1-phenyl-1,3-propanediol or derivatives thereof from their respective ke |
February 28, 1995 |
| (S)-1phenyl-1,3-propanediol or a derivative thereof having high optical purity can be produced simply in high yield, by contacting 1-phenylpropan-3-ol-1-one with a culture of microorganisms, microorganism cells isolated from the culture, or a product obtained by processing the microo |
