| Patent Number |
Title Of Patent |
Date Issued |
| 5676966 |
Feed additive composition for ruminants |
October 14, 1997 |
| A granular additive composition for ruminant feed which stably protects a biologically active substance in the rumen of the ruminant and allows it to be effectively digested and absorbed in the digestive organs after the abomasum. |
| 5674906 |
Stilbene compounds and pharmaceutical compositions containing them |
October 7, 1997 |
| Stilbene compounds of the following formula (I) or their pharmaceutically acceptable salts are effective as carcinostatics and of low toxicity: ##STR1## wherein X represents a hydrogen atom or a nitrile group, and Y represents an amino acid acyl group. |
| 5661012 |
Method for the production of L-threonine by fermentation, using mutated DNA encoding aspartokina |
August 26, 1997 |
| A DNA containing a gene which codes for aspartokinase III originating in Escherichia bacteria and which has in the coding region a mutation which releases the feedback inhibition by lysine on the aspartokinase III, a recombinant DNA wherein the DNA is linked to a vector DNA capable of |
| 5658766 |
Strains of Escherichia coli which produce isoleucine or valine and a method for their production |
August 19, 1997 |
| A method for constructing microorganism strains which produce amino acids comprising: combining in one bacterial genome (a) a mutation affecting the aminoacyl-tRNA synthetase corresponding to the selected amino acid, conferring cells auxotrophy which cannot be fully suppressed by additio |
| 5658605 |
Process for producing bound-formed food |
August 19, 1997 |
| A process for the preparation of bound-formed food comprising adding transglutaminase, a casein and an edible surface active agent, to a raw food material. The resulting bound-formed foods have excellent taste and savor. |
| 5657866 |
Package for preventing caking of powders and granules |
August 19, 1997 |
| The present invention relates to a double packages for preventing caking of powders or granules which comprises an inner container having high water vapor permeability for packaging article, an outer container having no or low water vapor permeability for packing said inner container, an |
| 5650304 |
Process for producing L-lysine by fermentation |
July 22, 1997 |
| The present invention relates to (a) process for producing L-lysine by fermentation which comprises culturing a microorganism having resistance to 4-N-(D-alanyl)-2,4-diamino-2,4-dideoxy-L-arabinose 2,4-dideoxy-L-arabinose or a derivative thereof and belonging to the genus Brevibacter |
| 5643790 |
Plasmid vector and a method for regulation of gene expression using the same |
July 1, 1997 |
| A plasmid vector capable of replicating in a Coryneform bacterial cell bearing a base sequence (a) functioning as an promoter in a Coryneform bacterium, a base sequence (b) functioning as an operator downstream from the base sequence (a), a base sequence (c) functioning as a site for |
| 5639455 |
Immunosuppressant |
June 17, 1997 |
| Peptides which inhibit the binding of human IL-6 to human IL-6 receptor are useful as a treatment for diseases induced or aggravated by IL-6. DNA fragments, vectors, transformants, and methods useful for preparing such peptides are described. |
| 5633366 |
Pyrimidine nucleoside derivatives and methods for producing them |
May 27, 1997 |
| Nucleoside derivatives such as 2'-deoxy-2'-bromo-5'-O-acetyl-5-methyluridine, etc., are important intermediates which can be converted into nucleoside derivatives, such as 3'-azido-3'-deoxythymidine, etc., which are useful as medicines. |
| 5631157 |
Bacterial strain of Escherichia coli VNII genetika 472T23 as the producer of L-threonine |
May 20, 1997 |
| A bacterial strain of Escherichia coli VNII genetika 472T23, a producer of L-threonine, containing the plasmid PYN7 and a plasmid-free variant of E. coli; strain VNII genetika 472T23, deposited at the American Type Culture Collection under Accesion No. ATCC 98081 and 98082, respectively. |
| 5629450 |
Addition salt of acyl-amino acid and .alpha.-aryl amine and process for optical resolution of .a |
May 13, 1997 |
| To produce optically active .alpha.-arylalkylamine from optically impure .alpha.-arylalkylamine.Optically impure .alpha.-arylalkylamine is mixed with optically active N-acyl-aspartic acid or glutamic acid in a solvent and the resulting two types of diastereomer salts are optically resolv |
| 5625057 |
Process for preparing 2',3'-Dideoxy-2',3'-dehydronucleosides |
April 29, 1997 |
| A process for preparing a 2', 3'-dideoxy-2',3'-didehydropyrimidine nucleoside comprising reacting the pyrimidine ribofuranoside with a trialkyl orthoester to yield the 2',3'-O-alkoxyethylidene derivative; which is reacted with hydrogen bromide in acetic acid or acetyl bromide to yiel |
| 5624686 |
Feed additives for fattening pigs, feed for fattening pigs, and method of fattening pigs |
April 29, 1997 |
| Feeding fattening pigs a feed additive which contains as an active ingredient active folic acid (in the form of leucovorin, H.sub.2 -folic acid, a liver powder, disrupted cells of a microorganism or a cell extract of a microorganism), or a feed for fattening pigs and lactating sows which |
| 5623079 |
Method of preparing N-formyl-L-aspartic anhydride |
April 22, 1997 |
| The present invention provides an industrial method of producing N-formyl-L-aspartic anhydride from N-formyl-L-aspartic acid, formic acid and acetic anhydride with less residual formic acid than conventional methods. |
| 5621137 |
Method of dissolving crystals of L-.alpha.-aspartyl-L-phenylalanine methyl ester |
April 15, 1997 |
| A method for dissolving crystalline L-alpha-aspartyl-L-phenyl-alanine methyl ester product is disclosed. The product is obtained by crystallizing the ester from an aqueous solution, by cooling. The initial concentration of ester in the aqueous solution used provides at least 10 grams |
| 5620868 |
Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell |
April 15, 1997 |
| A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is |
| 5616791 |
Method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic acid-(S)-N-.alpha.-alkylbenzylam |
April 1, 1997 |
| The present invention provides a method of preparing L-aspartyl-D-.alpha.-aminoalkane carboxylic acid-(S)-N-.alpha.-alkylbenzylamide which is less expensive and more efficient than previous methods using N-protected-L-aspartic anhydride. |
| 5616786 |
Method of obtaining anhydrous phenylalanine crystals |
April 1, 1997 |
| A method of obtaining optically active anhydrous phenylalanine crystals from an aqueous solution containing optically active phenylalanine, which involves crystallizing and precipitating optically active phenylalanine from an optically active phenylalanine super-saturated solution at a |
| 5616766 |
Method for recovering L-phenylalanine |
April 1, 1997 |
| The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalani |
| 5616552 |
Detergent composition comprising N-acylthreonine salt |
April 1, 1997 |
| The present invention provides a novel detergent composition containing an N-acylthreonine salt which exhibits little irritation to the skin and hair as well as an improved foam maintenance, foam quality and feel upon use.A detergent composition containing (A) N-acylthreonine salt in which t |
| 5616480 |
Temperature sensitive plasmid |
April 1, 1997 |
| A plasmid having a temperature-sensitive replication origin which has the following properties:a) capable of autonomous replication in Corynebacterium and being retained in Corynebacterium; and,b) when a cell containing said plasmid is cultured at 31.degree. to 37.degree. C., replication |
| 5610284 |
Method of purification of human BCDF |
March 11, 1997 |
| There are disclosed (i) a purification process for obtaining a human BCDF having the intramolecular disulfide linkage and the stereostructure of natural type human BCDF which comprises subjecting to an oxidation reaction and a refolding treatment a reduced type human BCDF obtained by |
| 5607849 |
Gene encoding transglutaminase derived from fish |
March 4, 1997 |
| The present invention relates to a DNA fragment having a gene derived from fish which codes for a polypeptide possessing transglutaminase activity, a recombinant plasmid comprising a fish-derived DNA fragment which codes for a transglutaminase, a transformant into which a recombinant pla |
| 5594012 |
Amino acid derivatives and anti-active oxygen agents |
January 14, 1997 |
| A novel anti-active oxygen agent which comprises as active ingredient an amino acid derivative represented by the following general formula (I): ##STR1## wherein Ar represents a 2-hydroxyphenyl, 2-hydroxy-1-naphthyl or pyridyl group, and one or more of the hydrogen atoms attached to |
| 5591577 |
Mobile genetic element originated from brevibacterium strain |
January 7, 1997 |
| A DNA fragment which contains a mobile genetic element originated from a strain of the genus Brevibacterium is obtained, and a gene is transferred into the chromosomal DNA of the strain making use of the DNA fragment.This invention provides a DNA fragment which contains a mobile genetic |
| 5582854 |
Cooking with the use of microwave |
December 10, 1996 |
| A method and apparatus of preparing heat-gelled foods, dried instant foods together with water added thereto, and liquid food, using microwaves, wherein the food to be prepared by microwave heating is placed in a vessel and at least one protrusion is arranged in the vessel. The protrusio |
| 5582826 |
Monoclonal antibodies which bind the gamma chain of human interleukin-2 receptor |
December 10, 1996 |
| A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human |
| 5582818 |
Ultraviolet screening powder and cosmetics |
December 10, 1996 |
| Herein disclosed are cosmetics having spherical silica containing an ultraviolet reflecting meterial surface-treated with platy N-lauroyl-L-lysine incorporated therein. According to the present invention, those cosmetics having spherical silica containing a conventional ultraviolet r |
| 5581009 |
Process for crystallization of L-phenylalanine monomethyl sulfate using added salt |
December 3, 1996 |
| A process for improving the yield of crystallization of L-phenylalanine monomethyl sulfate from an aqueous solution containing L-phenylalanine and monomethyl sulfate, by adding an effective crystallization improving amount of a salt of an inorganic or organic acid with an alkali metal, a |
| 5580903 |
Liver regeneration accelerator |
December 3, 1996 |
| A method of treating a patient in need of stimulation of hepatocyte mitosis which comprises administering to said patient an effective amount of alanine and/or glutamine. |
| 5573945 |
Mutant and method for producing L-glutamic acid by fermentation |
November 12, 1996 |
| A mutant of the genus Escherichia is described, the .alpha.-ketoglutarate dehydrogenase activity of which is deficient or reduced, and/or the phosphoenol pyruvate carboxylase and/or glutamate dehydrogenase activities of which are amplified. The mutant is useful in the fermentative pr |
| 5573670 |
Method for treatment of waste water by activated sludge process |
November 12, 1996 |
| Waste water is treated by an activated sludge process, the equipment for which is provided with an aeration tank unit comprised of three tanks of a first tank, a second tank and a third tank, said waste water and microorganisms being fed into the first tank while the ratio of aeration |
| 5565575 |
Method for the production of 5-cyclohexylmethylhydantoin derivatives |
October 15, 1996 |
| 5-Cyclohexylmethylhydantoin derivatives may be conveniently prepared by reducing, in the presence of a metal catalyst, a 5-(3-cyclohexene-1-yl)melthylenehydantoin derivative which is obtained by the condensation of a hydantoin derivative and a 3-cyclohexene-1-carbaldehyde derivative |
| 5558861 |
Modified microbially-produced cellulose gel with human epidermal cells adsorbed thereon for use |
September 24, 1996 |
| Disclosed is a gel of microbially-produced cellulose, characterized in that the microbially-produced cellulose is modified by (1) physically or chemically bonding an animal cell adhesive protein to the cellulose, and/or (2) substituting hydrogen atoms of at least parts of hydroxyl gr |
| 5556994 |
Cyclopropane derivatives and method of preparing the same |
September 17, 1996 |
| A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. In addition another aspect of the invention provides (3-oxa-2-oxobicyclo[3,1,0]hexan-1-yl)methanol and a method of preparing a cyclopropane derivative of formula (I |
| 5556776 |
Sucrase gene derived from coryneform bacteria |
September 17, 1996 |
| The present invention provides a DNA fragment derived from Coryneform bacteria and containing a gene coding for a protein having sucrase activity and a recombinant DNA vector containing said DNA fragment and capable of expression in Coryneform bacteria, The recombinant DNA is introdu |
| 5552145 |
Feed composition and a method for decreasing piglet mortality in piglets |
September 3, 1996 |
| Administering a feed composition, containing at least one member selected from the group consisting of sterilized bacterial cells; disrupted cell fragments obtained by mechanical disruption or enzymatic decomposition of the cells and cell wall component-containing fractions obtained by |
| 5547864 |
Coryneform bacteria deficient in a cell surface protein |
August 20, 1996 |
| A DNA fragment containing a gene coding for a novel cell surface layer protein derived from Brevibacterium lactofermentum and having two sequences of:(1)Thr-Leu-Arg-Gln-His-Tyr-Ser-Ser-Leu-Ile-Pro-Asn-Leu-Phe-Ile-Ala-Ala-Val- Gly-Asn-Ile-Asn-Glu-Leu-Asn-Asn-Ala-Asp-Gln-Ala-Ala-Arg-Glu-Leu |
| 5547858 |
Method for purification of amino acids, nucleic acids using a hydrocyclone |
August 20, 1996 |
| Crystals of an amino acid, a nucleic acid or a derivative thereof can be efficiently isolated and purified at low cost from a solution containing the crystals, bacterial cells and medium components by using a liquid cyclone. |
| 5547857 |
Process for producing 5-methyluridine and purification by sedimentation velocity |
August 20, 1996 |
| The present provides a process for obtaining high-purity 5-methyluridine crystals from nucleic acid ingredients as starting materials using a microorganism. The process comprises culturing a microorganism, removing part or the whole of the culture medium ingredients, conducting the enzym |
| 5543554 |
Process for preparing dry crystals of the methyl ester of .alpha.-L-aspartyl-L-phenylalanine, ha |
August 6, 1996 |
| A process for obtaining dry crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a water content of about 2 wt. % to about 6 wt. % based on the weight of the wet crystals is disclosed. This process comprises exposing wet crystals of .alpha.-L-aspartyl-L-phenylalanine me |
| 5543486 |
Epoxy-resin composition containing titanium and/or zirconium alkoxide and latent hardener |
August 6, 1996 |
| An epoxy-resin composition containing, as essential components, (1) an epoxy resin having two or more epoxy groups in one molecule, (2) a solid-dispersing, amine adduct-type latent hardener, and (3) a titanium and/or zirconium alkoxide(s). |
| 5541088 |
Recombinant process of producing non-glycosylated B-cell defferentiation factor |
July 30, 1996 |
| A purified human B-cell differentiation factor (BCDF) which does not have a natural signal peptide attached to the N-terminal thereof, DNA encoding the BCDF, transformed cells containing such DNA, a process for producing and obtaining the BCDF, and compositions containing the BCDF are |
| 5538873 |
Bacterial strain of escherichia coli BKIIM B-3996 as the producer of l-threonine |
July 23, 1996 |
| A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867. |
| 5538873 |
Bacterial strain of escherichia coli BKIIM B-3996 as the producer of l-threonine |
July 23, 1996 |
| A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867. |
| 5534508 |
Cephem compounds and antimicrobial agents |
July 9, 1996 |
| Herein disclosed are novel cephem compounds represented by the following general formula (I), and novel antimicrobial, and especially anti-MRSA, agents which contain as an active ingredient at least one of the novel cephem compounds and the physiologically acceptable salts thereof. # |
| 5534421 |
Production of isoleucine by escherichia coli having isoleucine auxotrophy and no negative feedba |
July 9, 1996 |
| The present invention provides strains of Escherichia coli which have an isoleucine-tRNA synthetase with an increased Km and no negative feedback inhibition of isoleucine production. These strains are effective for the production of isoleucine in high amounts. |
| 5532407 |
Process for recovering L-phenylalanine |
July 2, 1996 |
| An industrial process for recovering L-phenylalanine in high yield from a side stream obtained from .alpha.-APM is disclosed. L-aspartic acid or an aqueous solution thereof is added to such a side stream when hydrolysis of the side stream is performed under acidic conditions with a miner |
| 5532015 |
Process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester |
July 2, 1996 |
| A process for quickly and reproducibly obtaining .alpha.-L-aspartyl-L-phenylalanine methyl ester with controlled water content is disclosed. Wet crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester obtained by crystallization are subjected to a drying step to adjust the water |
