| Patent Number |
Title Of Patent |
Date Issued |
| 5824534 |
Aminopeptidase GX, and a method of hydrolyzing a protein with the same |
October 20, 1998 |
| An aminopeptidase is provided which efficiently decomposes a low-molecular-weight peptide containing glutamic acid or aspartic acid in its sequence. A method of hydrolyzing a peptide or protein by use of the aminopeptidase is also provided. Aminopeptidase GX is derived from germinate |
| 5824449 |
Process for producing D-malic acid |
October 20, 1998 |
| A process for producing D-malic acid selectively without producing L-malic acid, using inexpensive maleic acid as a starting material, may be carried out using a microorganism belonging to the genus Erwinia, Mycoplana, Sporosarcina, Vibrio, Geotrichum or Torulaspora. The microorganism ma |
| 5817859 |
.alpha.-acyloxy-.beta.-amino-thiocarboxylic acid esters |
October 6, 1998 |
| The present invention provides a simple and inexpensive method for producing a-hydroxy-.beta.-aminocarboxylic acids and their esters. An ester of an N-protected .alpha.-amino acid ester is converted into a .beta.-ketosulfoxide, which is then processed with an acid to give an .alpha.- |
| 5814513 |
Method of removing cells from fermentation broth through membrane |
September 29, 1998 |
| A method for removing cells from a fermentation broth obtained by culturing a microorganism belonging to the genus Escherichia through a membrane to separate the cells, comprising adding polyethyleneimine to the fermentation broth to form a mixture, and then filtering the mixture thr |
| 5814333 |
Feed additive for sows |
September 29, 1998 |
| A feed additive for sows containing, as an active ingredient, a reduced form of folic acid. Included are 7,8-dihydrofolic acid, leucovorin, liver powder, disrupted cells or cell extract of a microorganism, etc. |
| 5811278 |
Dipeptidyl peptidase IV from Xanthomonas maltophilia and process for producing the same |
September 22, 1998 |
| Dipeptidyl peptidase IV obtainable from a microorganism of the species Xanthomonas maltophilia is described, which hydrolyzes specifically a peptide and derivatives thereof having proline at the second position from the amino terminus to release a dipeptide having proline at the carboxyl |
| 5811086 |
Hair care products |
September 22, 1998 |
| A hair care product which exhibits an excellent setting power, an excellent use feeling, and improved solubility comprising the following ingredients (A), (B) and (C),(A) a polyacidic amino acid or its salt,(B) cationic cellulose, and(C) an ampholytic surfactant. |
| 5804414 |
Method of amplifying genes using artificial transposons in coryneform bacteria |
September 8, 1998 |
| A method of amplifying a desired gene in a chromosome of a coryneform bacterium, which comprises forming an artificial transposon in which a drug resistance gene and the desired gene are inserted into an insertion sequence of the coryneform bacterium, and introducing said artificial |
| 5801003 |
Method and reagent detecting human disorders |
September 1, 1998 |
| The invention provides a method for detecting (1) leukemia, (2) cancer, (3) autoimmune disorder, (4) inflammatory disorder, (5) allergic disorder or (6) viral infection, characterized by measuring soluble, human interleukin-2 receptor .gamma.-chain molecules existing in a human body |
| 5795979 |
Water-insoluble glucan purification method |
August 18, 1998 |
| The present invention relates to a water-insoluble glucan purification method characterized in that a culture solution of a microbe that produces water-insoluble glucan or a microbial cell-containing solution comprising water-insoluble glucan as a component is treated with both an oxide |
| 5795777 |
Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the said gene, a living cell |
August 18, 1998 |
| A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is |
| 5795769 |
Gene encoding interleukin-2 polypeptide, recombinant DNA carrying the gene, a living cell line p |
August 18, 1998 |
| A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is |
| 5795612 |
Aspartyldipeptideamine derivatives and sweetner |
August 18, 1998 |
| Novel aspartyldipeptideamide derivatives of formula (I):and salts thereof, wherein X is a D-.alpha.-amino acid residue or a DL-.alpha.-amino acid residue selected from the group consisting of D-alanine, D-.alpha.-aminobutyric acid, D-norvaline, D-valine, D-norleucine, D-leucine, D-isoleu |
| 5795585 |
Ruminant feed additive composition containing novel phosphoric acid-amino acid composite salt an |
August 18, 1998 |
| A ruminant feed additive composition comprises a phosphoric acid-amino acid composite salt and a water-insoluble salt of a polyvalent-metal-sensitive water-soluble high-molecular weight substance. The composite salt contains a basic amino acid, an alkaline-earth metal and phosphoric acid |
| 5795071 |
Standing pouch |
August 18, 1998 |
| A standing pouch having a recess formed on the upper part of a side of the body of the pouch and spaced from the upper side of the body, and a relief connecting with the inside of the pouch surrounded by an end of the upper side, the upper part of the side and the upper part of the reces |
| 5792868 |
Process for producing acyclic nucleosides and process for separating purine nucleosides |
August 11, 1998 |
| Herein is disclosed a novel and industrially advantageous process for synthesizing acyclic nucleosides such as acyclovir and ganciclovir from ribonucleosides, which process comprises adding an acid catalyst and an acid anhydride to a solution of a ribonucleoside such as guanosine and an |
| 5780452 |
Antimalarial drug |
July 14, 1998 |
| A novel antimalarial drug having high therapeutic effect, which comprises a sulfated polysaccharide or a pharmaceutically acceptable salt thereof as an active ingredient or both of a sulfated polysaccharide or a pharmaceutically acceptable salt thereof and quinine as active ingredien |
| 5777116 |
Cyclopropane derivatives and method of preparing the same |
July 7, 1998 |
| A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. Another aspect of the invention provides (3-oxa-2-oxobicyclo[3,1,0]hexan-1-yl)methanol and a method of preparing a cyclopropane derivative of formula (I) from this |
| 5767316 |
Process for producing 3-amino-2-oxo-1-halogenopropane derivatives |
June 16, 1998 |
| Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-am |
| 5766925 |
Method of producing L-lysine |
June 16, 1998 |
| A coryneform bacterium having high L-lysine productivity is provided by integrating a gene coding for aspartokinase originating from coryneform bacteria with desensitized feedback inhibition by L-lysine and L-threonine, into chromosomal DNA of a coryneform bacterium harboring leaky t |
| 5763657 |
Phosphoric acid-amino acid-polyvalent metal composite salt and ruminant feed additive compositio |
June 9, 1998 |
| The present specification discloses a ruminant feed additive composition which contains as an active ingredient a phosphoric acid-amino acid-polyvalent metal composite salt (final composite salt) which is insoluble in neutral or alkaline water and is soluble in acidic water and which |
| 5763231 |
Process for producing L-leucine |
June 9, 1998 |
| A process for producing L-leucine, which includes incubating an L-leucine-productive microorganism belonging to the genus Corynebacterium, Escherichia, Brevibacterium, or Microbacterium in a culture medium and reacting the resulting cells with saccharides and acetic acid or its salt |
| 5763028 |
Doubly-packaged easily oxidizable article |
June 9, 1998 |
| A doubly-packaged easily oxidizable article and a process for packaging the article are provided, wherein the deterioration of the easily oxidizable article during heat sterilization or storage is prevented. A hermetically sealed plastic vessel filled with an easily oxidizable article is |
| 5760257 |
Pigment dispersant |
June 2, 1998 |
| A pigment-dispersible polyallylamine derivative represented by formula (I), and a pigment dispersant containing the same as an active ingredient exhibit excellent compatibility with a wide variety of resins and excellent pigment dispersibility. ##STR1## In formula (I), R.sup.1 re |
| 5756666 |
Peptides capable of inducing immune response to HIV |
May 26, 1998 |
| Herein disclosed is a peptide which is a fragment of the whole protein of HIV, the fragment being a peptide having a sequence of successive 8 to 11 amino acid residues, which corresponds to an HLA-binding motif, which actually binds to HLA and which can induce killer cells capable of |
| 5756347 |
Temperature-sensitive plasmid |
May 26, 1998 |
| A plasmid having a temperature-sensitive replication origin which has the following properties:a) capable of autonomous replication in Corynebacterium and being retained in Corynebacterium; and,b) when a cell containing said plasmid is cultured at 31.degree. to 37.degree. C., replication |
| 5753223 |
Granular feed additives for ruminants containing lipase, bile powder and pancreatin |
May 19, 1998 |
| The invention relates to biologically active substances coated with a coating composition containing at least one substance selected from the group consisting of hardened vegetable fats and oils, hardened animal fats and oils, fatty acid esters and phospholipids and an enzyme and/or enzy |
| 5750498 |
Transparent gelatin gel type air freshener |
May 12, 1998 |
| Objects of the invention is to provide an air freshner composition which has both excellent functional properties such as shrinkage with the passage of time, clear end point and the like and excellent visual decorativeness due to transparency and is used in a space where an offensive |
| 5744178 |
Ruminant feed additive composition containing novel phosphoric acid-amino acid-polyvalent metal |
April 28, 1998 |
| A ruminant feed additive composition in the form of a powder or granules comprises as active ingredients a gastric antacid, a phosphoric acid-amino acid-polyvalent metal composite salt and optionally a water-insoluble salt of a polyvalent metal-sensitive water-soluble high-molecular weig |
| 5736356 |
Transglutaminase originating from Crassostrea gigas |
April 7, 1998 |
| The present invention relates to a transglutaminase originating from Crassostrea gigas, a gene coding for the transglutaminase, a plasmid carrying the gene, a microorganism transformed with the plasmid, a method for producing an intended transglutaminase by cultivating the microorgan |
| 5731353 |
Stilbene derivatives and pharmaceutical compositions containing them |
March 24, 1998 |
| A stilbene derivative of the following general formula (I) or a pharmaceutically acceptable acid addition salt thereof have low toxicity, but are water soluble and effective as carcinostatics: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each |
| 5731183 |
Bacillus-derived transglutaminase |
March 24, 1998 |
| The present invention relates to (1) a transglutaminase (hereinafter referred to as TG) isolated from a Bacilli such as those of Bacillus subtilis, (2) a fraction having transglutaminase activity, and (3) a method for producing a protein, a non-proteinaceous amino acid polymer, a pep |
| 5728398 |
Feed additive for sows |
March 17, 1998 |
| A feed additive for sows containing, as an active ingredient, a reduced form of folic acid. Included are 7,8-dihydrofolic acid, leucovorin, liver powder, disrupted cells or cell extract of a microorganism, etc. |
| 5723651 |
Process for producing .alpha.-l-aspartyldipeptide amide derivatives |
March 3, 1998 |
| An economical process for producing .alpha.-L-aspartyldipeptide amide derivatives useful as sweeteners, by using amino protecting groups which can be removed by hydrolysis under acidic conditions, resulting in conversion of a .beta.-carboxyl acid ester to a carboxylic acid. |
| 5723262 |
Resin composition |
March 3, 1998 |
| An alkali soluble resin and a resin composition thereof useful as a solder resist, having good adhesive properties, solder heat resistance, and plating resistance are provided. Particular resistance to plating under alkaline conditions is provided by the invention. |
| 5723165 |
Aspartyldipeptide derivatives and sweetener compositions containing the same |
March 3, 1998 |
| Aspartyldipeptide compounds of the formula (I)where R.sub.1 is alkyl or alkoxymethyl, R.sub.2 is phenyl, benzyl, cyclohexyl or cyclohexylmethyl, C* has an (S) configuration when R.sub.1 is alkyl and an (R) configuration when R.sub.1 is alkoxymethyl and X is a residue of a D-.alpha.-amino |
| 5720970 |
Method for supplementing amino acid levels in ruminant animals |
February 24, 1998 |
| A method for supplementing the amino acid levels in ruminants is provided where rumen-protected amino acids, particularly lysine and/or methionine, are used to supplement ruminant feed. |
| 5705671 |
Method for producing .alpha.-hydroxy-.beta.-aminocarboxylic acids |
January 6, 1998 |
| The present invention provides a simple and inexpensive method for producing .alpha.-hydroxy-.beta.-aminocarboxylic acids and their esters. An ester of an N-protected .alpha.-amino acid ester is converted into a .beta.-ketosulfoxide, which is then processed with an acid to give an .a |
| 5705608 |
Human IL-2 receptor .gamma. chain molecule |
January 6, 1998 |
| The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule b |
| 5705371 |
Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine |
January 6, 1998 |
| A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867. |
| 5700913 |
Unglycosylated human interleukin-2 polypeptides |
December 23, 1997 |
| Recombinant human Interleukin-2 (IL-2) polypeptides are provided. The polypeptides are produced by expression of suitable nucleic acid molecules in transformed host cells such as E. coli. |
| 5693614 |
Drug for the treatment of senile dementia of the ischemic and hypoglycemic types |
December 2, 1997 |
| A subject suffering from ischemic shock is treated by administering to the subject a therapeutically effective amount of aFGF as the active ingredient of a pharmaceutical composition further containing a pharmaceutically acceptable carrier. |
| 5690981 |
Low calorie foodstuff, aqueous paste composition, as well as production process thereof |
November 25, 1997 |
| The invention relates to (a) a low calorie foodstuff containing, as a substitute for protein, carbohydrate and/or oil and fat, from 0.7 to 10% by weight, based on the dry weight, of dietary fibers with a size of not greater than 80 .mu.m and a retained water amount of 9 or greater, (b) a |
| 5689001 |
Process for purifying valine |
November 18, 1997 |
| A process is provided for obtaining high-purity valine in high yield by a simple method using an inexpensive precipitant of p-isopropylbenzene sulfonic acid or a water-soluble salt thereof. |
| 5688948 |
Process for isomerizing acyclic nucleosides and process for separating purine nucleosides |
November 18, 1997 |
| Herein is disclosed a novel and industrially advantageous process for synthesizing acyclic nucleosides such as acyclovir and ganciclovir from ribonucleosides, which process comprises adding an acid catalyst and an acid anhydride to a solution of a ribonucleoside such as guanosine and an |
| 5688671 |
Mutant aspartokinase gene |
November 18, 1997 |
| Recombinant DNA replicable in microorganisms belonging to the genus Corynebacterium, which contains a DNA fragment coding for an aspartokinase .alpha.-subunit protein originating from a bacterium belonging to the genus Corynebacterium, in which synergistic feedback inhibition by L-ly |
| 5688546 |
Seasoning material |
November 18, 1997 |
| A seasoning composition containing food and an amino acid derivative that imparts a "thick, sour taste" to the food. |
| 5681717 |
DNA encoding novel cell surface protein |
October 28, 1997 |
| A DNA fragment containing a gene coding for a novel cell surface layer protein derived from Brevibacterium lactofermentum and having two sequences of: ##STR1## in the molecule, and having a molecular weight of about 63,000 dalton is introduced into Coryneform bacteria to obtain a |
| 5681598 |
Process for producing cheese using transglutaminase |
October 28, 1997 |
| The present invention relates to a process for producing natural cheese, characterized in that a transglutaminase is included therein for a reaction. The process can provide a large amount of cheese curd compared to conventional methods, making it possible to efficiently use the star |
| 5679857 |
Method of preparing D-amino acid-N-(S)-.alpha.-alkylbenzylamide |
October 21, 1997 |
| L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)-.alpha.-alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, which is racemized at the amino |
