| Patent Number |
Title Of Patent |
Date Issued |
| 5976843 |
Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine |
November 2, 1999 |
| A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867. |
| 5968581 |
Dipeptide derivatives and sweetening agents |
October 19, 1999 |
| Novel dipeptide derivatives, such as N-3,3-dimethylbutyl-.alpha.-L-aspartyl-.alpha.-methyl-L-phenylalanine methyl ester and N-3,3-dimethylbutyl-.alpha.-L-aspartyl-.alpha.-methyl-L-tyrosine methyl ester, and sweetening agents comprising, as the active ingredient, anyone of the der |
| 5968568 |
Enzyme preparation for use in the binding of food materials and process for producing bound food |
October 19, 1999 |
| An composition containing transglutaminase and collagen. The composition can be used to prepare bound food, preferably without the use of allergy-causing casein proteins. |
| 5968492 |
Hair care products |
October 19, 1999 |
| A composition suitable for hair care which has excellent hair conditioning effects and provides a pleasant sensory feeling during use. The composition contains basic amino acids and high alcohols, and is preferably free of non-polymeric alkyl quaternary ammonium salts, which are irri |
| 5959139 |
Process for producing optically active 2-hydroxy-4-arylbutyric acid or its ester |
September 28, 1999 |
| Provided is an industrially useful process for producing an optically active 2-hydroxy-4-arylbutyric acid or its ester. An optically active acyloxysuccinic anhydride is reacted with an aromatic compound in the presence of a Lewis acid to produce an optically active 2-acyloxy-4-oxo-4- |
| 5958977 |
Phosphoric acid-amino acid complex salt and additive composition containing the salt and used in |
September 28, 1999 |
| A novel phosphoric acid-amino acid complex salt is provided which manifests insolubility in a neutral or alkaline aqueous solution and solubility in an acidic aqueous solution and has a basic amino acid, an alkaline earth metal, and phosphoric acid as main components thereof. An additive |
| 5958869 |
Surfactant, and toiletry or detergent composition containing the same |
September 28, 1999 |
| Provided is a novel surfactant which is less irritating to the skin or the mucous membrane than prior art surfactants, which exhibits excellent conditioning effects and fabric softening effects, and which can be widely used in a toiletry or detergent composition. Basic amino-acid derivat |
| 5958496 |
Aspartyl dipeptide amide derivatives and sweeteners |
September 28, 1999 |
| Novel aspartyldipeptidoamides and salts thereof. The apartyldipeptides are useful as a low-calorie sweetener for food and beverage products and have excellent taste and chemical stability. |
| 5955124 |
Process for producing a condiment |
September 21, 1999 |
| The present invention provides a method for producing a condiment with decreased animal smell and which has increased beefwise taste and greater body flavor and complex flavor. The condiment is produced by blending therein denatured meat and/or the extract thereof, wherein the denatured |
| 5955047 |
Process for producing alkali metal polyphosphates |
September 21, 1999 |
| A process for producing an alkali metal polyphosphate, comprising heating a solution comprising a solvent, alkali metal ions, phosphate ions, and 3 to 50% by weight of organic matter, wherein the solution contains, in total, 5 to 65% by weight of the alkali metal ions and the phosphate i |
| 5948662 |
Bacillus-derived transglutaminase |
September 7, 1999 |
| A method for processing a protein, a non-proteinaceous amino acid polymer, or a non-proteinaceous amino acid polymer, or a peptide or derivatives thereof having a crosslinked structure, which entails contacting glutamine and lysine residues in a protein, a non-proteinaceous amino acid po |
| 5946820 |
Apparatus and method for continuously granulating powder material |
September 7, 1999 |
| An apparatus for continuously granulating powder material has a feeder for continuously supplying powder material, and a granulation vessel. The granulation vessel includes a granulation zone and a drying zone. The apparatus also has a spray nozzle disposed so as to be declined above the |
| 5942617 |
Process for producing purine derivatives |
August 24, 1999 |
| A process for preparing 7-benzylpurine derivatives is provided. An acetylpurine nucleoside is reacted with a benzyl halide to benzylate the 7-position of the purine base, and an acid is then added to the reaction mixture to hydrolyze the glycoside bond. The 7-benzylpurines may be used |
| 5939111 |
Process for the production of highly concentrated extracts for food use |
August 17, 1999 |
| A process for producing a highly concentrated extract for food use which includes effecting molecular weight reduction (viscosity reduction) of a raw material extract using a proteolytic enzyme prior to its concentration, or effecting viscosity reduction of the extract by keeping it |
| 5935635 |
Feed additive containing granules and caking preventive agent |
August 10, 1999 |
| A feed additive comprising granules containing amino acids and other fermentation products and a caking preventive agent. The feed additive has excellent flowability, exhibits less caking following moisture absorption, and is convenient to use. and store. |
| 5932267 |
Seasoning material |
August 3, 1999 |
| Compounds of the formula (1) ##STR1## wherein X and Y are each N or NH, Z is O or OH, (1) when X=N and Y=NH, Z=O, and *1 and *3 are double bonds, (2) when X=NH and Y=N, Z=O, and *2 and *3 are double bonds, (3) when X=N and Y=N, Z=OH, and *2 and *4 are double bonds, and R is a sid |
| 5929221 |
Gene derived from coryneform bacteria and use thereof |
July 27, 1999 |
| The L-lysine productivity of an L-lysine producing Coryneform bacterium is enhanced by amplifying a novel gene derived from a Coryneform bacterium and participating in L-glutamic acid production, while the L-glutamic acid productivity of an L-glutamic acid-producing Coryneform bacterium |
| 5925756 |
Cyclopropane derivatives and method of preparing the same |
July 20, 1999 |
| A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. Another aspect of the invention provides (3-oxa-2-oxobicyclo[3,1,0]hexan-1-yl)methanol and a method of preparing a cyclopropane derivative of formula (I) from this |
| 5919748 |
Surfactant, and toiletry or detergent composition containing the same |
July 6, 1999 |
| Provided is a novel surfactant which is less irritating to the skin or the mucous membrane than prior art surfactants, which exhibits excellent conditioning effects and fabric softening effects, and which can be widely used in a toiletry or detergent composition. Basic amino-acid derivat |
| 5919694 |
Mutant phosphoenolpyruvate carboxylase, its gene, and production method of amino acid |
July 6, 1999 |
| A phosphoenolpyruvate carboxylase gene, which has mutation such as mutation to replace 625th glutamic acid from the N-terminus of phosphoenolpyruvate carboxylase with lysine, mutation to replace 438th arginine from the N-terminus with cysteine and the like, is introduced into Escherichia |
| 5916805 |
Antithrombotic agent and anti-von Willebrand factor monoclonal antibody |
June 29, 1999 |
| A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which |
| 5912113 |
Method and apparatus for controlling carbon source concentration in aerobic cultivation of a mic |
June 15, 1999 |
| The present invention is a method for aerobically cultivating yeast or bacteria in a culture medium of fed-batch, continuous or cell-recycling continuous cultures, wherein the carbon source concentration in the culture medium is maintained at a constant low level of under g/l. The ca |
| 5908768 |
Process for producing L-glutamic acid by fermentation with E. coli resistant to aspartic acid an |
June 1, 1999 |
| A fermentative process for producing L-glutamic acid efficiently and at low cost is disclosed. Also disclosed are microorganisms having improved ability to produce L-glutamic acid. These microorganisms belong to the genus Escherichia, have resistance to an aspartic acid antimetabolite, a |
| 5907031 |
Milk whey protein-containing powder and process food obtained by using the same |
May 25, 1999 |
| A process is described in which a solution of milk whey protein is reacted with a transglutaminase, heated, and then dried. The resulting milk whey protein composition, and food products containing the resulting milk whey protein composition are also described. The milk whey protein comp |
| 5906842 |
Diet for stabilizing high milk yield of dairy cow and feeding method for obtaining stable high m |
May 25, 1999 |
| A corn-based mixed diet comprises rumen-protected lysine, rumen-protected methionine and an appetizer preferred by the dairy cows, which makes it possible to obtain a stable and high milk production from dairy cows. A method for stably producing a high yield of milk comprises the step of |
| 5902887 |
Process for producing 3-amino-2-oxo-1-halogenopropane derivatives |
May 11, 1999 |
| Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-am |
| 5900492 |
Method of producing optically active cyclopropane derivatives |
May 4, 1999 |
| A method for resolving optically impure 3-oxa-2-oxobicyclo[3.1.0]hexane-1-carboxylic acid esters. A method is provided for producing a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid.N-benzyl-.alpha.-phenylethylamine diastereomer salt. An enantiomer of N-benzyl-.al |
| 5891848 |
Peptide fragments |
April 6, 1999 |
| Peptide fragments and their pharmaceutically acceptable salts, and therapeutic agents containing one or more of them as an effective component possess excellent therapeutic activity for improving cerebral function and protecting cerebral neurons and are useful as pharmaceutical agent |
| 5889160 |
Human IL-2 receptor .gamma.-chain molecule antibody |
March 30, 1999 |
| The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule b |
| 5888783 |
Methods for producing L-valine and L-leucine |
March 30, 1999 |
| L-valine is produced by culturing a microorganism belonging to the genus Escherichia with the capability of producing L-valine or L-leucine wherein it requires lipoic acid for growth, a microorganism belonging to the genus Escherichia with the capability of producing L-valine or L-leucin |
| 5885580 |
Anti-AIDS secretory recombinant BCG vaccine |
March 23, 1999 |
| A vaccine containing Mycobacterium bovis BCG which secretes a fusion protein to be obtained by inserting a foreign antigen peptide into the molecular surface of a secretory protein, a carrier, having a signal peptide. BCG constituting the present invention secretes a fusion protein t |
| 5883284 |
Method for producing .alpha.-hydroxy-.beta.-aminocarboxylic acids |
March 16, 1999 |
| The present invention provides a simple and inexpensive method for producing .alpha.-hydroxy-.beta.-aminocarboxylic acids and their esters.An ester of an N-protected .alpha.-amino acid ester is converted into a .beta.-ketosulfoxide, which is then processed with an acid to give an .alpha. |
| 5876983 |
Mutant phosphoenolpyruvate carboxylase, its gene, and production method of amino acid |
March 2, 1999 |
| A phosphoenolpyruvate carboxylase gene, which has mutation such as mutation to replace 625th glutamic acid from the N-terminus of phosphoenolpyruvate carboxylase with lysine, mutation to replace 438th arginine from the N-terminus with cysteine and the like, is introduced into Escherichia |
| 5876717 |
Polypeptides capable of binding to heavy chains of IL-2 receptors |
March 2, 1999 |
| The present invention relates to (1) polypeptide capable of binding to .beta. chain of IL-2 receptor and having the inhibitory activity of the binding between IL-2 and .beta. chain of IL-2 receptor, and (2) the process of producing the polypeptide, especially in E. coli as a host. THe |
| 5871773 |
Method for supplementing amino acid levels in ruminant animals |
February 16, 1999 |
| A method for supplementing the amino acid levels in ruminants is provided where rumen-protected amino acids, particularly lysine and/or methionine, are used to supplement ruminant feed. |
| 5869300 |
Method for producing L-glutamic acid by continuous fermentation |
February 9, 1999 |
| A method for producing L-glutamic acid, comprising inoculating a microorganism having an ability to produce L-glutamic acid, in a liquid medium containing a carbon source and a nitrogen source, conducting continuous L-glutamic acid fermentation in which both a carbon source and a nut |
| 5861100 |
Method of waste water treatment by flocculating sedimentation |
January 19, 1999 |
| The method of the invention is characterized by adding comprises adding an inorganic flocculant to waste water treated with activated sludge process, adjusting the waste water between pH 4.0 and 5.0, waste water in this state for at least 1 minute, adjusting the waste water between pH 5. |
| 5858369 |
Anti-acids secretory recombinant BCG vaccine |
January 12, 1999 |
| A vaccine containing Mycobacterium bovis BCG which secretes a fusion protein to be obtained by inserting a foreign antigen peptide into the molecular surface of a secretory protein, a carrier, having a signal peptide. BCG constituting the present invention secretes a fusion protein t |
| 5856579 |
Adduct salts of novel substituted benzylamines and a process for optically resolving them |
January 5, 1999 |
| A process for optical resolution of a racemic substituted benzylamine is provided that involves reacting the racemic substituted benzylamine in a solvent with an optically active N-acyl-phenylalanine, -aspartic acid, or -glutamic acid, and separating the diastereomers formed by making us |
| 5856140 |
.gamma.-chain humaninterleukin-2 receptor polypeptide and method of making |
January 5, 1999 |
| A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human |
| 5856126 |
Peptide having anti-thrombus activity and method of producing the same |
January 5, 1999 |
| A multimer peptide from a snake venom has an activity to inhibit binding between von Willebrand factor and platelets. The multimer peptide is used to obtain a single strand peptide which does not substantially cause decrease in platelets at a minimum dose for exhibiting the activity in |
| 5854199 |
Cleaning compositions containing acylated dipeptides and acylated amino acids |
December 29, 1998 |
| A cleansing composition containing a N-long-chain-acylated dipeptide and an N-long-chain-acylated acidic amino acid. The cleansing composition exhibits low skin irritation, excellent resistance to hard water, is free from turbidity and the unpleasant odor associated with some natural |
| 5846790 |
Methods of producing L-lysine and L-glutamic acid by fermentation |
December 8, 1998 |
| A mutant strain having an ability to produce L-glutamic acid in the absence of any biotin action-suppressing agent in a medium containing an excessive amount of biotin is obtained by giving temperature sensitivity with respect to a biotin action-suppressing agent to a coryneform L-glutam |
| 5843755 |
Group of antitumor compounds and method for producing the same |
December 1, 1998 |
| A mold belonging to the genus Ascochyta is cultivated with a medium to obtain a culture. A compound having a structure represented by the following formula and having an antitumor activity, which is capable of forming a tautomeric equilibrium mixture composed of tautomers, is collect |
| 5843514 |
Seasoning material |
December 1, 1998 |
| A novel seasoning material mainly composed of a turbid material obtained from an extract or liquid of livestock meat, fish or shellfish, vegetables, fungi or the like by reducing the ionic strength or electroconductivity thereof, when added to the prior art processed versions of natu |
| 5837248 |
Peptide capable of inducing immune response to human gastric cancer and agent for preventing or |
November 17, 1998 |
| A peptide that induces CTL against human gastric cancer cells is provided. A peptide having a specific amino-acid sequence and induces cytotoxic T cells that targets gastric cancer cells may be used as an agent for preventing or treating gastric cancer. |
| 5831092 |
Process for producing purine derivatives |
November 3, 1998 |
| Purine derivatives in which a desired substituent is introduced into the 9-position only are synthesized by first introducing an easily-removable substituent in the 7-position of a purine base of natural purine nucleosides obtained through fermentation or derivatives thereof, then hy |
| 5830716 |
Increased amounts of substances by modifying a microorganism to increase production of NADPH fro |
November 3, 1998 |
| A method of producing a target substance by microbial fermentation, where the natural ability of the microorganism to produce NADPH from NADH is increased. The present method is useful for producing a wide variety of materials, such as amino acids, antibiotics, vitamins, growth factors a |
| 5827712 |
Process for efficiently producing transglutaminase through DNA recombination |
October 27, 1998 |
| The present invention relates to a process for producing a transglutaminase, which comprises incubating Escherichia coli expressing genes encoding a heat shock protein (DnaJ) and a transglutaminase. The transglutaminase is produced in large quantities, at low cost and has the appropr |
| 5827698 |
Lysine decarboxylase gene and method of producing l-lysine |
October 27, 1998 |
| L-lysine is produced efficiently by cultivating, in a liquid medium, a microorganism belonging to the genus Escherichia with decreased or disappeared lysine decarboxylase activity relevant to decomposition of L-lysine, for example, a bacterium belonging to the genus Escherichia with |
