| Patent Number |
Title Of Patent |
Date Issued |
| RE38796 |
Process for producing 3-amino-2-oxo-1-halogenopropane derivatives |
September 13, 2005 |
| Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-am |
| RE38257 |
Piperdine derivatives and hypotensives containing the same |
September 23, 2003 |
| A piperidine compound of the formula (I): ##STR1##wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH.sub.2).sub.n, which may be substituted, in which n is 0 or an integer of 1 to 10, --CH.ident.CH--, --C.ident.C--, --O--, --S--, --NH--, --N(COCH.sub.3)--, |
| RE37187 |
Aminopeptidase GX, and a method of hydrolyzing a protein with the same |
May 22, 2001 |
| An aminopeptidase is provided which efficiently decomposes a low-molecular-weight peptide containing glutamic acid or aspartic acid in its sequence. A method of hydrolyzing a peptide or protein by use of the aminopeptidase is also provided. Aminopeptidase GX is derived from germinate |
| RE35609 |
Process for purifying 2',3'-dideoxynucleosides |
September 16, 1997 |
| A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin absorbent. |
| RE34878 |
Hypoglycemic agent |
March 14, 1995 |
| A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R.sup.1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon atoms, aralkyl of 6 to 12 carbon atoms, ##STR2## --CH.sub.2 CO.sub.2 R.sup.3, --C |
| 7470524 |
Method for producing L-amino acids using bacteria of the Enterobacteriaceae family |
December 30, 2008 |
| There is disclosed a method for producing an L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity |
| 7468262 |
Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum |
December 23, 2008 |
| The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacterium Corynebacterium glutamicum ssp. lactofermentum and methods of producing substances in organisms having enhanced or attenuated expr |
| 7462630 |
Diarylalkene derivatives and novel diarylalkane derivatives |
December 9, 2008 |
| The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or |
| 7459585 |
Benzene derivatives and pharmaceutical use thereof |
December 2, 2008 |
| The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, |
| 7459582 |
Methods for producing nateglinide crystals |
December 2, 2008 |
| There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalani |
| 7455996 |
Soybean raffinose synthase and a method for producing raffinose |
November 25, 2008 |
| Raffinose is produced by allowing a raffinose synthase having the following properties to act on sucrose and galactinol: (1) action and substrate specificity: produces raffinose from sucrose and galactinol; (2) optimum pH: about 6 to 8; (3) optimum temperature: about 35 to 40.degre |
| 7452905 |
Phenylalanine derivatives |
November 18, 2008 |
| Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the .alpha. 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which .alpha. 4 integrin-depending adhesion process participate |
| 7449452 |
Method for estimating immunostimulant activity of a polysaccharide |
November 11, 2008 |
| The ability of a polysaccharide to act as an immunostimulant may be assessed by comparing the degree of binding of a detection reagent, which contains a fluorescence-labeled version of the polysaccharide, with the binding of a reference reagent, which contains a fluorescence-labeled |
| 7445921 |
Transglycosylation method and protein having transglycosylation activity |
November 4, 2008 |
| The present invention provides a transglycosylation method and a protein catalyzing a transglycosylation reaction. A reaction of transferring a galactosyl.beta.1.fwdarw.3N-acetylgalactosaminyl group from a sugar donor containing a sugar chain having a galactosyl.beta.1.fwdarw.3N-acet |
| 7439038 |
Method for producing L-amino acid using methylotroph |
October 21, 2008 |
| A DNA encoding for a mutant of LysE protein, or a homologous protein thereof, of a coryneform bacterium, wherein the mutant, when introduced into a methanol-assimilating bacterium imparts resistance to L-lysine analogue. The DNA encoding for a mutant of LysE protein, or a homologous |
| 7435560 |
Method for producing purine nucleoside by fermentation |
October 14, 2008 |
| A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide bi |
| 7432100 |
Variant aldolase and processes for producing an optically active IHOG and an optically active mo |
October 7, 2008 |
| The present invention relates to variant aldolase enzymes that are modified so as to produce IHOG (4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid: IHOG), a process for producing an optically active IHOG using the same, and a process for producing an optically active monatin. |
| 7432085 |
Method for producing L-amino acid |
October 7, 2008 |
| In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and collecting the L-amino acid from the medium, a Gram-negative bacterium having the Entner-Doudoroff |
| 7427688 |
Production method of optically active diphenylalanine compounds |
September 23, 2008 |
| The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-methyl-2-pyrrolidone, |
| 7423019 |
Agent for inducing conversion of intestinal cells into insulin-producing cells and antidiabetic |
September 9, 2008 |
| A partial peptide of a preproglucagon peptide comprising at least the amino acid sequence at positions 92-97 of a preproglucagon peptide is used as an effective ingredient of an antidiabetic drug. |
| 7422880 |
Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having a |
September 9, 2008 |
| There is provided a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, having the glycogen biosynthesis pathway disrupted. |
| 7419810 |
Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine |
September 2, 2008 |
| L-Arginine is produced by culturing a coryneform bacterium in which an arginine repressor involved in L-arginine biosynthesis is deleted by disrupting a gene coding for the repressor, and which has L-arginine producing ability in a medium to produce and accumulate L-arginine in the m |
| 7416740 |
Dry granulated product containing L-lysine as main component |
August 26, 2008 |
| Hydrochloric acid, sulfuric acid or an L-lysine solution having an equivalent ratio of anion/L-lysine higher than 0.95 is added to a raw material L-lysine solution having an equivalent ratio of anion/L-lysine lower than 0.68 to adjust the equivalent ratio of anion/L-lysine of the raw |
| 7414075 |
Composition for lowering internal lipid content |
August 19, 2008 |
| A composition for lowering internal lipid in a subject which contains a capsinoid substance represented by the following formula ##STR00001## wherein n is an integer from 0 to 10. Methods of using the compositions are disclosed and include administering to a subject in need of such t |
| 7411089 |
Nateglinide crystals |
August 12, 2008 |
| New nateglinide crystals, i.e. nateglinide A-type crystals (main peaks in powder X-ray diffraction: 4.4.degree., 5.2.degree., 15.7.degree., 18.5.degree.(2.theta.)), M-type crystals (main peaks in powder X-ray diffraction: 6.0.degree., 14.2.degree., 15.2.degree., 18.8.degree.(2.theta. |
| 7410790 |
Method for producing .gamma.-glutamylcysteine |
August 12, 2008 |
| The yeast which has .gamma.-glutamylcysteine-producing ability and is auxotrophic for pantothenic acid is proliferated in a medium containing a sufficient amount of pantothenic acid, and then it is cultured in a medium containing a limited amount of pantothenic acid to increase the . |
| 7405346 |
Gene capable of imparting salt stress resistance |
July 29, 2008 |
| This invention provides a novel gene that can impart salt stress tolerance to plants for a long period of time and salt stress tolerant transgenic plants to which such gene has been introduced. Such novel gene encodes the following protein (a), (b), or (c), and such salt stress tolerant |
| 7405315 |
Mesoporous silica and process for producing the same |
July 29, 2008 |
| (A) An anionic surfactant, (B) a silicate monomer and (C) a basic silane are mixed in water or a mixed solvent of a water-miscible organic solvent and water to obtain a mesoporous silica complex having mesopores with a uniform size, the anionic surfactant Component (A) is removed by wash |
| 7402696 |
Benzene compounds |
July 22, 2008 |
| The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of obesity, hyperlipemia, fatty liver, hyperglycemia, impaired glucose tolerance, diabetes, |
| 7402412 |
Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives u |
July 22, 2008 |
| A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 244) involved in ef |
| 7399618 |
Method for producing L-histidine using bacteria of Enterobacteriaceae family |
July 15, 2008 |
| A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of the bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talB gene. |
| 7399617 |
Method for producing an L-amino acid in an Escherichia bacterium via altering expression levels |
July 15, 2008 |
| A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the b |
| 7396941 |
Method for producing monatin |
July 8, 2008 |
| By simultaneously carrying out an isomerization reaction at position 2 of monatin in different configurations at positions 2 and 4 in the presence of an aldehyde under a condition of pH 4 to 11 in a mixture solvent of water and an organic solvent, and the crystallization of monatin in th |
| 7396844 |
Benzamidine derivatives |
July 8, 2008 |
| Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood co |
| 7390909 |
Processes of producing glutamic acid compounds and production intermediates therefore and novel |
June 24, 2008 |
| The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. |
| 7388030 |
Suppressors of anemia and appetite suppressors and methods for suppressing anemia and suppressin |
June 17, 2008 |
| The present invention provides a method for suppressing hemolytic anemia by selectively ameliorating reticulocyte increase and iron deposition on spleen caused as the side effects of methionine. The present invention also provides an appetite suppressor with reduced such side effects, |
| 7385080 |
Method for producing optically active .beta.-phenylalanine compounds |
June 10, 2008 |
| Optically active .beta.-phenylalanine compound may be prepared in an industrially advantageous manner by reacting an N-acyl-.beta.-phenylalanine compound with a specific optically resolving agent to effect an optical resolution by formation of diastereomer salts, and removing the opt |
| 7381548 |
Method for producing L-amino acid using bacterium of Enterobacteriaceae family having expression |
June 3, 2008 |
| The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the yafA gene. |
| 7378387 |
Method of suppressing immune response by reducing intracellular content of glutathione in macrop |
May 27, 2008 |
| A method of suppressing immune responses, comprising administering to a patient in need thereof an effective amount of a composition comprising a substance capable of reducing the content of reductive glutathione in macrophages. |
| 7375085 |
Melanocyte-stimulating hormone inhibitors |
May 20, 2008 |
| In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having |
| 7371549 |
Aldolase, and method for producing optically active IHOG and monatin |
May 13, 2008 |
| The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present |
| 7365161 |
Mutant tyrosine repressor which does not require tyrosine to induce expression of the tyrosine p |
April 29, 2008 |
| A mutant tyrosine repressor that does not require tyrosine to induce expression of tyrosine phenol-lyase gene is obtained by introducing a mutation into a tyrosine repressor (tyrR), isolated from Pantoea agglomerans, or a tyrosine repressor (tyrR) which is encoded by SEQ ID NO. 1 and |
| 7361490 |
DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, tran |
April 22, 2008 |
| The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene involved in an ability to convert 5-substituted hydantoin or N-carbamylamino acid into optically |
| 7361458 |
Method for producing .alpha.-L-aspartyl-L-phenylalanine-.beta.-ester and method for producing .a |
April 22, 2008 |
| A method for producing an .alpha.-L-aspartyl-L-phenylalanine-.beta.-ester (also named .alpha.-L-(.beta.-o-substituted aspartyl)-L-phenylalanine), which is an intermediate of an .alpha.-L-aspartyl-L-phenylalanine-.alpha.-methyl ester (also named .alpha.-L-aspartyl-L-phenylalanine meth |
| 7358368 |
Azlactone compound and method for preparation thereof |
April 15, 2008 |
| Compounds represented by formula (II): ##STR00001## wherein M is a hydrogen atom, sodium, potassium, or lithium; P is a hydrogen atom, an alkyl group, and the like; and the wavy line indicates a cis form, a trans form, or a mixture thereof for the double bond to which it is attached |
| 7357951 |
Composition for preventing atherosclerosis |
April 15, 2008 |
| The present invention provides a composition obtained by organic solvent extraction of defatted plant seed which is an atherosclerosis preventative agent. The present invention further provides a food and a pharmaceutical composition containing the composition, as well as a method of |
| 7357280 |
Foodstuff feeding apparatus and feeding method |
April 15, 2008 |
| A foodstuff feeding apparatus to convey foodstuff to a metering unit from a hopper without masking or kneading the foodstuff. The apparatus includes a piston pump provided between a lower portion of a hopper and an end of a first pipe to draw foodstuff from the hopper and to press out |
| 7354746 |
Method for producing optically active IHOG and monatin |
April 8, 2008 |
| The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and an aldolase which can be used in these methods. As suc |
| 7354744 |
Process for producing L-glutamic acid |
April 8, 2008 |
| L-glutamic acid is produced by culturing in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source a microorganism that can metabolize a carbon source at a specific pH, and wherein said microorganism has an ability to accumulate L-glutamic acid |
| 7354615 |
Method for producing mixed crystal of disodium 5'-guanylate and disodium 5'-inosinate |
April 8, 2008 |
| Disclosed herein are a process for producing mixed crystals of disodium 5'-guanylate and disodium 5'-inosinate which comprises precipitating mixed crystals of disodium 5'-guanylate and disodium 5'-inosinate (I+G mixed crystals) by adding an aqueous mixed solution of disodium 5'-guany |
