| Patent Number |
Title Of Patent |
Date Issued |
| RE38796 |
Process for producing 3-amino-2-oxo-1-halogenopropane derivatives |
September 13, 2005 |
| Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-am |
| RE38257 |
Piperdine derivatives and hypotensives containing the same |
September 23, 2003 |
| A piperidine compound of the formula (I): ##STR1##wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH.sub.2).sub.n, which may be substituted, in which n is 0 or an integer of 1 to 10, --CH.ident.CH--, --C.ident.C--, --O--, --S--, --NH--, --N(COCH.sub.3)--, |
| RE37187 |
Aminopeptidase GX, and a method of hydrolyzing a protein with the same |
May 22, 2001 |
| An aminopeptidase is provided which efficiently decomposes a low-molecular-weight peptide containing glutamic acid or aspartic acid in its sequence. A method of hydrolyzing a peptide or protein by use of the aminopeptidase is also provided. Aminopeptidase GX is derived from germinate |
| RE35609 |
Process for purifying 2',3'-dideoxynucleosides |
September 16, 1997 |
| A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin absorbent. |
| RE34878 |
Hypoglycemic agent |
March 14, 1995 |
| A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R.sup.1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon atoms, aralkyl of 6 to 12 carbon atoms, ##STR2## --CH.sub.2 CO.sub.2 R.sup.3, --C |
| 7618804 |
Method for producing L-amino acid using bacteria belonging to the genus Escherichia |
November 17, 2009 |
| There is provided a method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine using a bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of the bacterium is enhanced by enhancing the activities of the proteins coded by t |
| 7618803 |
Method for producing L-amino acid using bacteria belonging to the genus Escherichia |
November 17, 2009 |
| A method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine is provided using Escherichia bacteria wherein the L-amino acid productivity of the bacteria is enhanced by increasing the activity of proteins encoded by the b2682 and b2683 genes, or pro |
| 7618796 |
Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method |
November 17, 2009 |
| The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produ |
| 7615244 |
Glycopeptide and peptide having a kokumi taste imparting function, and method of imparting the k |
November 10, 2009 |
| Glycopeptides and peptides having the formula: ##STR00001## where X represents a hydrogen atom or a sugar chain, provide a taste improving function, particularly a kokumi taste imparting function. Such glycopeptides and peptides may be used to impart the kokumi taste to foods or sea |
| 7612214 |
Organic amine salts of glutamic acid derivatives and their application |
November 3, 2009 |
| The present invention provides an organic amine salt of monatin, or crystal form thereof, and its application as well as a method for resolving the stereoisomers of monatin by forming its salt. The present invention further provides a salt form of monatin that is useful as a sweeteni |
| 7611873 |
Method for producing L-methionine by fermentation |
November 3, 2009 |
| L-Methionine is produced by culturing a microorganism which is deficient in repressor of L-methionine biosynthesis system and/or enhanced intracellular homoserine transsuccinylase activity is cultured in a medium so that L-methionine should be produced and accumulated in the medium, |
| 7608695 |
Substance with antithrombotic activity and method for detecting glycokallidin |
October 27, 2009 |
| A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric protein constructed by |
| 7608437 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino aci |
October 27, 2009 |
| A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium so that it is close to |
| 7608432 |
Method for producing purine nucleoside by fermentation |
October 27, 2009 |
| A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide bi |
| 7608250 |
Cosmetic composition |
October 27, 2009 |
| A cosmetic composition for skin and/or hair, which comprises at least one kind of substance selected from the group consisting of an N.sup..alpha.,N.sup.G-di-acylarginine, for example, a compound represented by the following general formula (I): ##STR00001## wherein R.sup.1 and R.su |
| 7605180 |
Nateglinide-containing preparation |
October 20, 2009 |
| The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the nateglinide is amorphous. |
| 7605165 |
Phenylalanine derivatives |
October 20, 2009 |
| The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to .alpha.4 integrin and therapeutic agents for various diseases concerning .alpha.4 integrin. ##STR00001## |
| 7604979 |
Method for producing an L-amino acid using a bacterium with an optimized level of gene expressio |
October 20, 2009 |
| A method is provided for obtaining an L-amino acid or nucleic acid-producing bacterium belonging to the genus Escherichia with an optimized level of expression of the gene which influences the distribution of carbon flow, such as the sucAB genes, comprising introducing into the chrom |
| 7601519 |
Method for producing purine nucleoside by fermentation |
October 13, 2009 |
| A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide bi |
| 7597691 |
Liquid storage bag |
October 6, 2009 |
| A liquid storage bag having a partition wall allowed to be peeled easily and not peeled by an accidental drop, etc. The liquid storage bag is one wherein the upper part thereof is closed with a freely and closable zipper, the bottom thereof is provided with a liquid outlet, and an ea |
| 7592480 |
Process for producing optically active carboxylic acid |
September 22, 2009 |
| The invention provides a process for producing optically active 2,2-dimethylcyclopropanecarboxylic acid by reacting an optical isomer mixture of 2,2-dimethylcyclopropanecarboxylic acid with an optically inactive amine to form (precipitate, crystallize or the like) an ammonium salt of |
| 7592465 |
Fertilizer/plant vitalizer |
September 22, 2009 |
| Contamination by microorganism of an aqueous proline solution is prevented by adjusting a proline concentration of the solution to 20% (W/W/) or more. Such solutions are useful as fertilizers and/or plan vitalizers. Preservation of the novel solutions are possible over a significant |
| 7586001 |
Nateglinide crystals |
September 8, 2009 |
| New nateglinide crystals, i. e. nateglinide A-type crystals (main peaks in powder X-ray diffraction: 4.4.degree., 5.2.degree., 15.7.degree., 18.5.degree. (2.theta.)), M-type crystals (main peaks in powder X-ray diffraction: 6.0.degree., 14.2.degree., 15.2.degree., 18.8.degree. (2.the |
| 7582454 |
5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optic |
September 1, 2009 |
| The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the racemase, and processes for producing optically active amino acids. |
| 7575910 |
Method for producing L-fuculose and method for producing L-fucose |
August 18, 2009 |
| The present invention provides a method for producing L-fuculose and L-fucose which is suitable as an industrial method. L-Fuculose is synthesized from L-fucitol in the presence of a microorganism-derived protein having a dehydrogenase activity which results in production of L-fuculo |
| 7575901 |
Method for producing nucleotide by fermentation |
August 18, 2009 |
| Nucleoside 5'-phosphate ester is produced by culturing a bacterium belonging to the genus Escherichia having an ability to produce nucleoside 5'-phosphate ester, in which ushA gene and aphA gene do not function normally, in a medium to produce and accumulate nucleoside 5'-phosphate e |
| 7572815 |
Amide derivative |
August 11, 2009 |
| Amide derivatives represented by the formula (I): ##STR00001## wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is --NRa--, --(CRbRb')m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen |
| 7569548 |
Method of preparing peptide |
August 4, 2009 |
| The present invention provides a method of preparing an intermediate for LHRH antagonists, which requires fewer steps than conventional methods and provides the intermediate in high yield and high purity. |
| 7569388 |
Plants having an enhanced amino acid content, plants having an enhanced nitrogen content, plants |
August 4, 2009 |
| The object of the present invention is to provide a transformed plant having an enhanced amino acid content, a progeny of the plant, seeds of the plant and a method for producing the plant. The present invention provides a transformed plant having a gene encoding DNA binding protein |
| 7569360 |
.gamma.-glutamylcysteine producing yeast |
August 4, 2009 |
| A yeast which harbors a mutant glutathione synthetase having one or both of mutations selected from the group consisting of a mutation to replace a threonine residue at the position 47 with an isoleucine residue and a mutation to replace a glycine residue at the 387-position with an |
| 7563606 |
Method for producing non-amino organic acid |
July 21, 2009 |
| Non-amino organic acids such as succinic acid, malic acid and fumaric acid are produced by reacting bacterial cells or treated bacterial cells of a coryneform bacterium with an organic raw material in an aqueous medium containing magnesium carbonate and/or magnesium hydroxide, and a cert |
| 7556947 |
Method for producing .beta.-hydroxy amino acid and enzyme used therefor |
July 7, 2009 |
| A method for producing .beta.-hydroxy amino acid and its optically-active isomer is provided. The .beta.-hydroxy amino acid is produced by reacting a predetermined D-.alpha.-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belon |
| 7555392 |
Method for determining metabolic flux |
June 30, 2009 |
| A method for determining metabolic flux distribution of a cell, which comprises the steps of: 1) creating a stoichiometric matrix based on formulas of biochemical reactions from a substrate to a product, 2) computing a set of vectors of solutions existing in a solution space which th |
| 7553974 |
Crystal of (2R,4R)-monatin potassium salt and sweetener composition containing same |
June 30, 2009 |
| Crystals of (2R,4R)-monatin potassium salt which exhibit an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2.theta. of 5.5.degree., 7.2.degree., 8.1.degree., 8.9.degree., and 16.3.degree., by powder X-ray diffraction (Cu--K.alpha. radiation), are s |
| 7553824 |
Kit for determining polysaccharide-binding activity of mononuclear cells present in peripheral b |
June 30, 2009 |
| A kit for the determination of the ability of a peripheral blood mononuclear cell to bind to a polysaccharide herein provided comprises a detection reagent comprising a fluorescence-labeled immunostimulant polysaccharide; and a reference reagent comprising a fluorescence-labeled mate |
| 7553650 |
Polynucleotide encoding a mutant transglutaminase |
June 30, 2009 |
| The present invention relates to a method for designing and preparing mutant transglutaminases on the basis of the three-dimensional structure of MTG derived from Streptoverticillium mobaraense (MTG), and the mutant MTG thus prepared. The present invention provides a method for modifying |
| 7553638 |
Candida utilis containing .gamma.-glutamylcysteine |
June 30, 2009 |
| Food containing .gamma.-glutamylcysteine or cysteine is produced by culturing Candida utilis containing 1% by weight or more of .gamma.-glutamylcysteine per dry cells in logarithmic growth phase when cultured in a minimal medium, for example, Candida utilis in which a gene encoding g |
| 7553367 |
Method of making a diL-lysine monosulfate trihydrate crystal |
June 30, 2009 |
| A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor is described. The crystal is obtained by a novel process wherein crystallization is conducted at a lower temperature. |
| 7550696 |
Thawing method and apparatus for articles to be thawed |
June 23, 2009 |
| This invention relates to a method of and an apparatus for thawing an object to be thawed. The method of thawing an object to be thawed according to the present invention comprises a step of generating a first stream (F1) inside of a reservoir (8) containing liquid by supplying addit |
| 7547531 |
L-amino acid producing microorganism which has been modified to inactive the fimH gene, and a me |
June 16, 2009 |
| An L-amino acid producing bacterium of the Enterobacteriaceae family is described, wherein the bacterium has been modified so as to not produce type I fimbrial adhesin protein is cultured in a medium to produce and excrete said L-amino acid in the medium, and collecting said L-amino acid |
| 7544834 |
Methods for producing nateglinide B-type crystals |
June 9, 2009 |
| A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no solvent remains and making a crystal conversion thereof. According to this method, B-type |
| 7534898 |
Process for producing monatin or salt thereof |
May 19, 2009 |
| To provide a process for producing monatin where steric configuration of 2-position is in an R configuration or a salt thereof by isomerization of 2-position of monatin where steric configuration of 2-position is in an S configuration.A process for producing monatin where steric configur |
| 7534590 |
Method for producing monatin |
May 19, 2009 |
| A solution to be treated containing monatin and impurities is treated with a nonpolar resin having aromatic rings, whereby monatin is separated from the solution. Treatment with the nonpolar resin having aromatic rings results in efficient separation of monatin under a mild pH condition. |
| 7531340 |
Peptide-forming enzyme gene |
May 12, 2009 |
| DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an amine component by us |
| 7531332 |
Method for producing a lower alkyl ester of .alpha.-L-aspartyl-L-phenylalanine using Escherichia |
May 12, 2009 |
| A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing the activity of the protein encoded by the yedA gene. A further method is prov |
| 7527950 |
Method for producing an L-amino acid by enhancing expression of the yfiK gene in an Escherichia |
May 5, 2009 |
| A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of the yfiK gene is described. A method for producing the L-amino acid using the bacterium is also des |
| 7524822 |
Crystalline form of 1'-(1-methylethyl)-4'-[(2-fluoro-4-methoxyphenyl)methyl]-5'-methyl-1H-pyr- |
April 28, 2009 |
| The invention relates to a crystalline form of 1'-(1-methylethyl)-4'-[(2-fluoro-4-methoxyphenyl)methyl]-5'-methyl-1H-pyr- azol-3'-O-.beta.-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments. |
| 7524656 |
Method for producing an L-amino acid by enhancing expression of the yggA gene in an Escherichia |
April 28, 2009 |
| A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of the yggA gene is described. A method for producing the L-amino acid using the bacterium is also des |
| 7521426 |
HIV-specific CTL inducing peptides and medicaments for preventing or treating AIDS comprising th |
April 21, 2009 |
| Peptides which can induce specific CTLs for HIV, DNAs encoding for the peptides and medicaments for preventing and/or treating HIV comprising the peptides are provided. According to the present invention, peptides carrying novel CTL epitopes derived from HIV Pol or Env proteins are p |
| 7517996 |
Azole compound |
April 14, 2009 |
| Azole compounds represented by formula I: ##STR00001## wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically |
