| Patent Number |
Title Of Patent |
Date Issued |
| RE38796 |
Process for producing 3-amino-2-oxo-1-halogenopropane derivatives |
September 13, 2005 |
| Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-am |
| RE38257 |
Piperdine derivatives and hypotensives containing the same |
September 23, 2003 |
| A piperidine compound of the formula (I): ##STR1##wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH.sub.2).sub.n, which may be substituted, in which n is 0 or an integer of 1 to 10, --CH.ident.CH--, --C.ident.C--, --O--, --S--, --NH--, --N(COCH.sub.3)--, |
| RE37187 |
Aminopeptidase GX, and a method of hydrolyzing a protein with the same |
May 22, 2001 |
| An aminopeptidase is provided which efficiently decomposes a low-molecular-weight peptide containing glutamic acid or aspartic acid in its sequence. A method of hydrolyzing a peptide or protein by use of the aminopeptidase is also provided. Aminopeptidase GX is derived from germinate |
| RE35609 |
Process for purifying 2',3'-dideoxynucleosides |
September 16, 1997 |
| A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin absorbent. |
| RE34878 |
Hypoglycemic agent |
March 14, 1995 |
| A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R.sup.1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon atoms, aralkyl of 6 to 12 carbon atoms, ##STR2## --CH.sub.2 CO.sub.2 R.sup.3, --C |
| 7416740 |
Dry granulated product containing L-lysine as main component |
August 26, 2008 |
| Hydrochloric acid, sulfuric acid or an L-lysine solution having an equivalent ratio of anion/L-lysine higher than 0.95 is added to a raw material L-lysine solution having an equivalent ratio of anion/L-lysine lower than 0.68 to adjust the equivalent ratio of anion/L-lysine of the raw |
| 7414075 |
Composition for lowering internal lipid content |
August 19, 2008 |
| A composition for lowering internal lipid in a subject which contains a capsinoid substance represented by the following formula ##STR00001## wherein n is an integer from 0 to 10. Methods of using the compositions are disclosed and include administering to a subject in need of such t |
| 7411089 |
Nateglinide crystals |
August 12, 2008 |
| New nateglinide crystals, i.e. nateglinide A-type crystals (main peaks in powder X-ray diffraction: 4.4.degree., 5.2.degree., 15.7.degree., 18.5.degree.(2.theta.)), M-type crystals (main peaks in powder X-ray diffraction: 6.0.degree., 14.2.degree., 15.2.degree., 18.8.degree.(2.theta. |
| 7410790 |
Method for producing .gamma.-glutamylcysteine |
August 12, 2008 |
| The yeast which has .gamma.-glutamylcysteine-producing ability and is auxotrophic for pantothenic acid is proliferated in a medium containing a sufficient amount of pantothenic acid, and then it is cultured in a medium containing a limited amount of pantothenic acid to increase the . |
| 7405346 |
Gene capable of imparting salt stress resistance |
July 29, 2008 |
| This invention provides a novel gene that can impart salt stress tolerance to plants for a long period of time and salt stress tolerant transgenic plants to which such gene has been introduced. Such novel gene encodes the following protein (a), (b), or (c), and such salt stress tolerant |
| 7405315 |
Mesoporous silica and process for producing the same |
July 29, 2008 |
| (A) An anionic surfactant, (B) a silicate monomer and (C) a basic silane are mixed in water or a mixed solvent of a water-miscible organic solvent and water to obtain a mesoporous silica complex having mesopores with a uniform size, the anionic surfactant Component (A) is removed by wash |
| 7402696 |
Benzene compounds |
July 22, 2008 |
| The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of obesity, hyperlipemia, fatty liver, hyperglycemia, impaired glucose tolerance, diabetes, |
| 7402412 |
Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives u |
July 22, 2008 |
| A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 244) involved in ef |
| 7399618 |
Method for producing L-histidine using bacteria of Enterobacteriaceae family |
July 15, 2008 |
| A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of the bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talB gene. |
| 7399617 |
Method for producing an L-amino acid in an Escherichia bacterium via altering expression levels |
July 15, 2008 |
| A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the b |
| 7396941 |
Method for producing monatin |
July 8, 2008 |
| By simultaneously carrying out an isomerization reaction at position 2 of monatin in different configurations at positions 2 and 4 in the presence of an aldehyde under a condition of pH 4 to 11 in a mixture solvent of water and an organic solvent, and the crystallization of monatin in th |
| 7396844 |
Benzamidine derivatives |
July 8, 2008 |
| Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood co |
| 7390909 |
Processes of producing glutamic acid compounds and production intermediates therefore and novel |
June 24, 2008 |
| The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. |
| 7388030 |
Suppressors of anemia and appetite suppressors and methods for suppressing anemia and suppressin |
June 17, 2008 |
| The present invention provides a method for suppressing hemolytic anemia by selectively ameliorating reticulocyte increase and iron deposition on spleen caused as the side effects of methionine. The present invention also provides an appetite suppressor with reduced such side effects, |
| 7385080 |
Method for producing optically active .beta.-phenylalanine compounds |
June 10, 2008 |
| Optically active .beta.-phenylalanine compound may be prepared in an industrially advantageous manner by reacting an N-acyl-.beta.-phenylalanine compound with a specific optically resolving agent to effect an optical resolution by formation of diastereomer salts, and removing the opt |
| 7381548 |
Method for producing L-amino acid using bacterium of Enterobacteriaceae family having expression |
June 3, 2008 |
| The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the yafA gene. |
| 7378387 |
Method of suppressing immune response by reducing intracellular content of glutathione in macrop |
May 27, 2008 |
| A method of suppressing immune responses, comprising administering to a patient in need thereof an effective amount of a composition comprising a substance capable of reducing the content of reductive glutathione in macrophages. |
| 7375085 |
Melanocyte-stimulating hormone inhibitors |
May 20, 2008 |
| In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having |
| 7371549 |
Aldolase, and method for producing optically active IHOG and monatin |
May 13, 2008 |
| The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present |
| 7365161 |
Mutant tyrosine repressor which does not require tyrosine to induce expression of the tyrosine p |
April 29, 2008 |
| A mutant tyrosine repressor that does not require tyrosine to induce expression of tyrosine phenol-lyase gene is obtained by introducing a mutation into a tyrosine repressor (tyrR), isolated from Pantoea agglomerans, or a tyrosine repressor (tyrR) which is encoded by SEQ ID NO. 1 and |
| 7361490 |
DNA encoding hydantoinase, DNA encoding N-carbamyl-L-amino acid hydrolase, recombinant DNA, tran |
April 22, 2008 |
| The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene involved in an ability to convert 5-substituted hydantoin or N-carbamylamino acid into optically |
| 7361458 |
Method for producing .alpha.-L-aspartyl-L-phenylalanine-.beta.-ester and method for producing .a |
April 22, 2008 |
| A method for producing an .alpha.-L-aspartyl-L-phenylalanine-.beta.-ester (also named .alpha.-L-(.beta.-o-substituted aspartyl)-L-phenylalanine), which is an intermediate of an .alpha.-L-aspartyl-L-phenylalanine-.alpha.-methyl ester (also named .alpha.-L-aspartyl-L-phenylalanine meth |
| 7358368 |
Azlactone compound and method for preparation thereof |
April 15, 2008 |
| Compounds represented by formula (II): ##STR00001## wherein M is a hydrogen atom, sodium, potassium, or lithium; P is a hydrogen atom, an alkyl group, and the like; and the wavy line indicates a cis form, a trans form, or a mixture thereof for the double bond to which it is attached |
| 7357951 |
Composition for preventing atherosclerosis |
April 15, 2008 |
| The present invention provides a composition obtained by organic solvent extraction of defatted plant seed which is an atherosclerosis preventative agent. The present invention further provides a food and a pharmaceutical composition containing the composition, as well as a method of |
| 7357280 |
Foodstuff feeding apparatus and feeding method |
April 15, 2008 |
| A foodstuff feeding apparatus to convey foodstuff to a metering unit from a hopper without masking or kneading the foodstuff. The apparatus includes a piston pump provided between a lower portion of a hopper and an end of a first pipe to draw foodstuff from the hopper and to press out |
| 7354746 |
Method for producing optically active IHOG and monatin |
April 8, 2008 |
| The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and an aldolase which can be used in these methods. As suc |
| 7354744 |
Process for producing L-glutamic acid |
April 8, 2008 |
| L-glutamic acid is produced by culturing in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source a microorganism that can metabolize a carbon source at a specific pH, and wherein said microorganism has an ability to accumulate L-glutamic acid |
| 7354615 |
Method for producing mixed crystal of disodium 5'-guanylate and disodium 5'-inosinate |
April 8, 2008 |
| Disclosed herein are a process for producing mixed crystals of disodium 5'-guanylate and disodium 5'-inosinate which comprises precipitating mixed crystals of disodium 5'-guanylate and disodium 5'-inosinate (I+G mixed crystals) by adding an aqueous mixed solution of disodium 5'-guany |
| 7351571 |
Process for the production of .beta.-amino acids using acylase |
April 1, 2008 |
| The present invention relates to a Variovorax sp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl .beta.-amino acid to selectively produce an R-.beta.-amino acid, and a Burkholderia sp. which produces both an acylase having an asymmetric hydrolysis a |
| 7351569 |
Aldolase and production process of substituted .alpha.-keto acids |
April 1, 2008 |
| 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or |
| 7345164 |
Production method of 5'-acyloxynucleoside compound |
March 18, 2008 |
| A production method for conveniently producing a 5'-acyloxynucleoside compound shown by the formula [A] in a good yield while suppressing formation of by-products, including subjecting a 2',3',5'-triacyloxynucleoside compound represented by the formula [I] to selective deacylation in |
| 7345049 |
Phenylalanine derivatives |
March 18, 2008 |
| Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to .alpha.4 integrin. They are used as therapeutic agents for various diseases concerning .alpha.4 integrin. |
| 7344874 |
L-glutamic acid-producing microorganism and a method for producing L-glutamic acid |
March 18, 2008 |
| L-Glutamic acid is produced by culturing a microorganism in which an expression of L-glutamic acid-export gene, a yhfK gene, is enhanced or overexpressed, in a medium to produce and cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid from the medium. |
| 7342053 |
Resin composition, adhesive film using the same and multilayer printed circuit board |
March 11, 2008 |
| Producing a printed circuit board, by coating a resin composition comprising an aromatic cyanate compound having two or more cyanato groups in a molecule and a radical-polymerizable resin on a circuit substrate, photo-curing the resin composition, and thermally curing the photo-cured |
| 7338780 |
Method for producing tripeptides and/or peptides longer than tripeptides |
March 4, 2008 |
| A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empe |
| 7335506 |
Method for producing L-lysine or L-arginine by using methanol-assimilating bacterium |
February 26, 2008 |
| A DNA encoding a variant of a protein, the protein having a loop region and six hydrophobic helices and involved in secretion of L-lysine to the outside of a cell, wherein the DNA encodes a variant of a protein not containing the loop region and facilitates secretion of L-lysine, L-a |
| 7335496 |
Method for producing target substance |
February 26, 2008 |
| A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting the target substance from the medium, wherein the bacterium is modified so that a syst |
| 7329523 |
Phosphoserine phosphatase of coryneform bacteria and variants thereof |
February 12, 2008 |
| The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that complicates serB deficiency of Escherichia coli as a open reading frame in the DNA fragment. (A) A |
| 7329427 |
Process for producing .gamma.-hydroxyamino acid derivatives and monatins |
February 12, 2008 |
| Dihydroisoxazole derivatives are conveniently converted to .gamma.-hydroxyamino acid derivatives which are important as various synthetic intermediates by a catalytic hydrogenation reaction. High-purity monatins which may be used as sweeteners or ingredients thereof can be obtained b |
| 7326701 |
Lactam compounds and pharmaceutical use thereof |
February 5, 2008 |
| An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound |
| 7326546 |
Purine-derived substance-producing bacterium and a method for producing purine-derived substance |
February 5, 2008 |
| A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial |
| 7321055 |
Production method of optically active dephenylalanine compounds |
January 22, 2008 |
| Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric |
| 7320973 |
Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same |
January 22, 2008 |
| The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal tracts ##STR00001# |
| 7320794 |
Transporter protein |
January 22, 2008 |
| A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin comp |
| 7319025 |
Method for producing L-glutamic acid |
January 15, 2008 |
| A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability in a liquid medium of which pH is adjusted to a condition under which L-glutamic acid produced by the microorganism is allowed to be precipitated |
