| Patent Number |
Title Of Patent |
Date Issued |
| RE39608 |
Substituted benzimidazoles and their use as PARP inhibitors |
May 1, 2007 |
| Compounds of the formula Ia or IB ##STR00001## where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiolo |
| 7601730 |
Carboxylic acid derivatives, their preparation and use |
October 13, 2009 |
| Carboxylic acid derivatives ##STR00001## where R--R.sup.6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. |
| 7582647 |
Carboxylic acid derivatives, their preparation and use |
September 1, 2009 |
| Carboxylic acid derivatives ##STR00001## where R--R.sup.6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. |
| 7504485 |
Human antibodies that bind human IL-12 |
March 17, 2009 |
| Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length |
| 7501519 |
Method for producing biperiden IV |
March 10, 2009 |
| The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting |
| 7491729 |
3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof |
February 17, 2009 |
| 3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof. The invention relates to 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical |
| 7465744 |
Triazole compounds and the therapeutic use thereof |
December 16, 2008 |
| The invention relates to triazole compounds of general formula (I), wherein A, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meaning cited in claim 1. The invention also relates to a pharmaceutical agent containing at least one compound of general formula (I) in addition to the u |
| 7369946 |
Method of identifying inhibitors of Tie-2 |
May 6, 2008 |
| The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The invention also relates to |
| 7332497 |
Pyrazolopyrimidines as therapeutic agents |
February 19, 2008 |
| The present invention provides compounds of Formula I, ##STR00001## including pharmaceutically acceptable salts and/or prodrugs thereof, where G, R.sub.a, R.sub.2, and R.sub.3 are defined as described herein. |
| 7320979 |
N-[(piperazinyl)hetaryl]arylsulfonamide compounds |
January 22, 2008 |
| The invention relates to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula I ##STR00001## in which Q is a bivalent, 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents R.sup.a wh |
| 7279468 |
Integrin ligands |
October 9, 2007 |
| The invention relates to novel compounds which bind to integrin receptors, their use as ligands of integrin receptors, in particular as ligands of the .alpha..sub.v.beta..sub.3 integrin receptor, their use, and pharmaceutical preparations comprising these compounds. |
| 7276500 |
Substituted amides, their preparation and use |
October 2, 2007 |
| An amide of the formula I ##STR00001## and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: A --(CH.sub.2).sub.p--R.sup.1, where R.sup.1 can be pyrro |
| 7273624 |
Stable dosage forms containing ubiquinones |
September 25, 2007 |
| The invention relates to stable solid dosage forms for peroral administration containing, in addition to an ubiquinone, at least one thermoplastically processible matrix-forming auxiliary agent. |
| 7144902 |
Prodrugs of thrombin inhibitors |
December 5, 2006 |
| The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the p |
| 7125883 |
Integrin receptor ligands |
October 24, 2006 |
| The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one |
| 7119097 |
Carboxylic acid derivatives, their preparation and their use |
October 10, 2006 |
| A compound of the formula ##STR00001## pharmaceutically acceptable salts and enantiomers thereof and pharmaceutical compositions containing this compound, its pharmaceutically acceptable salts and enantiomers are claimed. |
| 7109205 |
Carboxylic acid derivatives, their preparation and use |
September 19, 2006 |
| Carboxylic acid derivatives ##STR00001## where R R.sup.6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. |
| 7105508 |
Integrin receptors antagonists |
September 12, 2006 |
| The invention relates to novel compounds which bind to integrin receptors, and to the preparation thereof and the use thereof as drugs. |
| 7098214 |
Dopamine D.sub.3 receptor ligands or antagonists for use in the treatment of renal function diso |
August 29, 2006 |
| Dopamine D.sub.3 receptor ligands or antagonists are disclosed for use in the treatment of renal function disorders, such as diabetic nephropathy. |
| 7091227 |
Benzothiazole derivatives |
August 15, 2006 |
| The present invention is directed to a compound of formula (I), ##STR00001## racemic-diastereomeric mixtures thereof, optical isomers thereof, prodrugs thereof, isotopes thereof or pharmaceutically-acceptable salts of said compound, isomers, prodrugs and isotopes, wherein the variab |
| 7084110 |
Dolastatin 15 derivatives |
August 1, 2006 |
| Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G).sub.r-(K).sub.s-L, (I) and acid salts thereof, wherein A, B, D, E, F, G and K are .alpha.-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent |
| 7060822 |
2-pyrazolin-5-ones |
June 13, 2006 |
| Chemical compounds having structural formula I ##STR00001## and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiog |
| 7049312 |
Benzothiazinone and benzoxazinone compounds |
May 23, 2006 |
| ##STR00001## Q is --N=or CR.sup.2 X is S, O or NOR.sup.3 Y is --O--, --S--, --SO-- or --SO.sub.2-- R and R.sup.1 are each, independently, H, a substituted or unsubstituted aliphatic, aromatic, heteroaromatic or aralkyl group R.sup.2 is H or a substituent R.sup.3 is H, or --C(O)R |
| 7041675 |
Heterocyclic compounds and their use as PARP inhibitors |
May 9, 2006 |
| The invention relates to compounds of the formula I ##STR00001## and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors. |
| 7034158 |
Method of producing biperiden I |
April 25, 2006 |
| The invention relates to a method for producing biperiden which is characterized in that an exo/endo mixture of 1-(bicyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is reacted with an isomer ratio of the exo form to the endo form of at least 2.5:1 with diphenyl magnesium, an iso |
| 7026311 |
Dibenzodiazepine derivatives, their preparation and use |
April 11, 2006 |
| The invention relates to compounds of the formula I ##STR00001## and their tautomeric forms, possible enantiomeric and diastereomeric forms and their prodrugs, and to their preparation and use, where A, B, R.sup.1 and X.sup.1 have the meanings given in the description. |
| 7014810 |
Method of producing solid shape forms containing an active ingredient |
March 21, 2006 |
| The present invention relates to an apparatus for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one polymeric binder. The apparatus according to the invention has at least one extruder 1 for continuous pla |
| 6992216 |
Crystallization of amino acids using ultrasonic agitation |
January 31, 2006 |
| A method for reducing the particle size of amino acid crystals using ultrasound is discussed. |
| 6919342 |
Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 |
July 19, 2005 |
| The invention relates to triazole compounds of the general formula I ##STR1##wherein R.sup.1 is hydrogen or methyl, and R.sup.2 is C.sub.3 -C.sub.4 alkyl or C.sub.1 -C.sub.2 fluoroalkyl,as well as the physiologically tolerated acid addition salts of these compounds.The invention also r |
| 6914128 |
Human antibodies that bind human IL-12 and methods for producing |
July 5, 2005 |
| Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length |
| 6900319 |
Thrombin inhibitors |
May 31, 2005 |
| The invention relates to a compound of the formula I: ##STR1##or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R.sup.1, R.sup.2, A, B, C and D have the meanings described in the specification. |
| 6835839 |
Method for the production of biperiden II |
December 28, 2004 |
| The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicylo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is |
| 6803387 |
Treatment of neuropathic pain or fibromyalgia |
October 12, 2004 |
| A compound of formula I ##STR1##or a pharmaceutically acceptable salt thereof in which R.sub.1 and R.sub.2 are independently H or methyl (for example N,N-dimethyl-1-[1-(4-chlorophenyl) cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used fo |
| 6783756 |
Methods for regulating gene expression |
August 31, 2004 |
| A method for regulating expression of a tet operator-linked gene in a cell of a subject is disclosed. In one embodiment, the method involves introducing into the cell a nucleic acid molecule encoding a tetracycline-controllable transactivator (tTA), the tTA comprising a Tet repressor |
| 6753327 |
Substituted amides, their preparation and use |
June 22, 2004 |
| An amide of the formula I ##STR1##and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: A --(CH.sub.2).sub.p --R.sup.1, where R.sup.1 can be pyrrolidine |
| 6740647 |
Thrombin inhibitors |
May 25, 2004 |
| Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the com |
| 6737421 |
Cyclo-alkyl substituted benzimidazoles and their use as PARP inhibitors |
May 18, 2004 |
| Compounds of the formula I or II ##STR1##and their tautomeric forms, possible enantiomeric and diastereomeric forms, possible cistrans isomers on the rings in A and prodrugs thereof, pharmaceutical compositions containing these compounds and methods of treating neurodegenerative dise |
| 6713474 |
Pyrrolopyrimidines as therapeutic agents |
March 30, 2004 |
| Chemical compounds having structural formula I ##STR1##and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immun |
| 6706255 |
Liquid pharmaceutical compositions comprising thyroid hormones |
March 16, 2004 |
| Liquid pharmaceutical compositions comprising at least one thyroid hormone, ethanol, a pH adjusting agent, and water are disclosed. The compositions may be delivered by a metered dosage delivery system such as an aerosol or pump-action spray, and are useful in the treatment of disorders |
| 6696437 |
Heterocyclically substituted benzimidazoles, the production and application thereof |
February 24, 2004 |
| The present invention relates to novel benzimidazoles, their preparation and their use as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30) for producing drugs. |
| 6693120 |
Spray drying of thrombin inhibitors |
February 17, 2004 |
| The invention relates to a process for preparing constant-weight thrombin inhibitors of the formula I ##STR1##where n is 0, 1, 2, and tautomers thereof,wherein an aqueous solution of the active substance is spray dried. |
| 6692765 |
Exactly divisible tablet |
February 17, 2004 |
| The invention describes a tablet with two end faces and a circumferential face, in which the mutually opposite end faces of the tablet a) overall are nonplanar and are arranged at least approximately parallel to one another, and b) are each provided with a score on the top and bottom s |
| 6686369 |
.alpha.-hydrdroxylic acid derivatives, their production and use |
February 3, 2004 |
| The present invention relates to carboxylic acid derivatives of the formula ##STR1##where the radicals have the meanings stated in the description, to the preparation of these compounds and to their use as drugs. |
| 6677465 |
Method for the enantioselective preparation of 3,3-diphenyl-2,3-epoxy propionic acid esters |
January 13, 2004 |
| The invention relates to a process for the enantioselective preparation of glycide ester (I) by (a) dihydroxylation of a corresponding 3-phenyl cinnamate (II) by osmium (VIII) oxide catalysis in the presence of a Sharpless ligand and an oxidizing agent to form the dihydroxy ester (III |
| 6670367 |
Azinyloxy, and phenoxy-diaryl-carboxylic acid derivatives, their preparation and use as mixed ET |
December 30, 2003 |
| The invention relates to carboxylic acid derivatives of the formula I ##STR1##where the radicals have the meanings stated in the description, and to their use as drugs. |
| 6669236 |
Multipart label for blister packs, and the production and use thereof |
December 30, 2003 |
| A multipart label for providing information on blister packs, having a text-carrying surface which is larger than the pack surfaces, comprises a sheet-like base element which, without obstructing the removal of the packed objects to any significant extent, is suitable for fixing the labe |
| 6660744 |
Pyrazolopyrimidines as therapeutic agents |
December 9, 2003 |
| The present invention is directed to pyrazolopyrimidine derivatives which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis. |
| 6642388 |
Method for producing 2-aminomethyl-4-cyano-thiazol |
November 4, 2003 |
| The invention relates to processes for preparing 2-aminomethyl-4-cyanothiazole and its salts of the formulae Ia and Ib ##STR1##in which n=1 or 2 and, for n=1, X is chloride, bromide, triflate and hydrogen sulfate and for n=2, X is sulfate, comprising the process step where the thioa |
| 6599931 |
Test system for characterizing the compatibility of bioactive substances and polyvinylpyrrolidon |
July 29, 2003 |
| A test system for characterizing the compatibility of bioactive substances with polyvinylpyrrolidones in a solid dispersion consisting of one or more bioactive substances and 1,3-bis(1-pyrrolidonyl)butane. |
| 6599528 |
Mechanically stable pharmaceutical presentations form containing liquid or semisolid surface-act |
July 29, 2003 |
| The present invention relates to mechanically stable pharmaceutical presentations for oral administration, comprising in addition to one or more active ingredients and at least one melt-processable matrix-forming excipient more than 10 and up to 40% by weight of a surface-active subs |
