| Patent Number |
Title Of Patent |
Date Issued |
| RE39588 |
Transdermal drug delivery device |
April 24, 2007 |
| A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at a |
| RE35601 |
Delivery device providing beneficial agent stability |
September 2, 1997 |
| The present invention is directed to an improved fluid-imbibing dispensing device for delivering a beneficial agent to a biological environment of use, the dispensing device being of the type having a housing which includes a fluid-impermeable first wall section with an open end and a |
| D402757 |
Implanter |
December 15, 1998 |
|
| D384745 |
Electrotransport drug delivery system |
October 7, 1997 |
|
| D372098 |
Electrotransport drug delivery system |
July 23, 1996 |
|
| D372097 |
Electrotransport drug delivery system |
July 23, 1996 |
|
| D362912 |
Electrotransport drug delivery system |
October 3, 1995 |
|
| D357743 |
Electrotransport drug delivery system |
April 25, 1995 |
|
| D357742 |
Electrotransport drug delivery system |
April 25, 1995 |
|
| D349960 |
Electrotransport drug delivery patch |
August 23, 1994 |
|
| D281528 |
Body mounted pump for dispensing medication |
November 26, 1985 |
|
| D278363 |
Bandage |
April 9, 1985 |
|
| 7438926 |
Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure |
October 21, 2008 |
| This invention relates to a method for inhibiting a decrease in the transdermal flux of an agent that is being transdermally delivered or sampled over a prolonged period of time wherein the delivery or sampling involves disrupting at least the stratum corneum layer of the skin to for |
| 7435299 |
Method and apparatus for coating skin piercing microprojections |
October 14, 2008 |
| An apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections (10). The coating solution is applied to the skin piercing microprojections (10) using a coating technique which selectively coats only th |
| 7419481 |
Apparatus and method for piercing skin with microprotrusions |
September 2, 2008 |
| A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicat |
| 7407500 |
Osmotic delivery system flow modulator apparatus and method |
August 5, 2008 |
| An osmotic delivery system flow modulator assembly, an osmotic delivery system with a flow modulator assembly, and a method of assembling an osmotic delivery system. The osmotic delivery system flow modular assembly includes a body having a hole located through the body and communica |
| 7390780 |
Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification |
June 24, 2008 |
| A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic a |
| 7381201 |
Reusable, spring driven autoinjector |
June 3, 2008 |
| The present invention provides a reusable spring driven autoinjector. The drive mechanism of the autoinjector of the present invention includes one or more drive springs formed of a shape memory alloy. Therefore, by alternating the shape memory alloy forming the one or more drive springs |
| 7338663 |
Expandable osmotic composition and coating suspension |
March 4, 2008 |
| The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using |
| 7329242 |
Trocar for inserting implants |
February 12, 2008 |
| An implant retention trocar includes a cannula for puncturing the skin of an animal and an obturator for delivering the implant beneath the skin of the animal. The implant retention trocar has a cannula distal tip design which causes a minimum of trauma and tearing of tissue during impla |
| 7323191 |
Transdermal warfarin system |
January 29, 2008 |
| Composition of matter for application to a body surface or membrane to administer warfarin by permeation through the body surface or membrane, the composition comprising warfarin to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhanc |
| 7318936 |
Minimization of drug oxidation in drug irradiated excipients formulations |
January 15, 2008 |
| This invention relates to compositions and methods for preventing oxidation of beneficial agents. |
| 7303760 |
Method for treating multi-drug resistant tumors |
December 4, 2007 |
| Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a lipid, through a cleava |
| 7302293 |
Device for transdermal electrotransport delivery of fentanyl and sufentanil |
November 27, 2007 |
| The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (e.g., fentanyl hydrochloride), preferably in a hydrogel formulation, for use in an electrotranspo |
| 7287319 |
Method of making a housing for drug delivery |
October 30, 2007 |
| An electrotransport reservoir housing which contains, integrally formed therein, at least one region of conductive material which allows for a liquid and moisture tight barrier, while at the same time providing a means for conducting an electric current therethrough. |
| 7285622 |
Releasable linkage and compositions containing same |
October 23, 2007 |
| A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described. |
| 7279179 |
Liposome-entrapped topoisomerase inhibitors |
October 9, 2007 |
| A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining an aqueous liposome compartment, and being composed o |
| 7276248 |
Conjugate having a cleavable linkage for use in a liposome |
October 2, 2007 |
| Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its original form. The li |
| 7258869 |
Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
August 21, 2007 |
| This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold |
| 7244449 |
Liposome-entrapped topoisomerase inhibitors |
July 17, 2007 |
| A composition for administration of a therapeutically effective dose of a topoisomerase inhibitor I or topoisomerase I/II inhibitor is described. The composition includes liposomes having an outer surface and an inner surface defining an aqueous liposome compartment, and being composed o |
| 7241457 |
Osmotically driven active agent delivery device providing an ascending release profile |
July 10, 2007 |
| In one aspect, the present invention is directed to an osmotic pump that automatically provides an ascending release rate of active agent as the osmotic pump functions in an environment of operation and may be designed for implantation within a desired animal or human subject. An osmotic |
| 7238368 |
Releasable linkage and compositions containing same |
July 3, 2007 |
| A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The |
| 7235068 |
Osmotic delivery system having space-efficient piston |
June 26, 2007 |
| An osmotic delivery system having a space-efficient piston is provided. The enclosure has an interior holding the piston, a protein or peptide, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior |
| 7212853 |
Electrotransport agent delivery method and apparatus |
May 1, 2007 |
| An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (I.sub.c) at which |
| 7207982 |
Osmotic pump with means for dissipating internal pressure |
April 24, 2007 |
| The present invention includes an osmotic pump that includes a means for venting an osmotic composition included in the pump before the internal pressure of the pump has the opportunity to build to such an extent that the pump is structurally compromised, such as when one or more compone |
| 7184826 |
Device and method for enhancing transdermal flux of agents being delivered or sampled |
February 27, 2007 |
| A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing and anchoring to the skin for increasing transdermal flux of an agent and for improving the attachment of the device to the skin. |
| 7169409 |
Method for preventing crystal formation in a dispersion of a liquid in a matrix |
January 30, 2007 |
| An improved method for the manufacture of transdermal drug delivery devices comprising liquid dispersions of a liquid in an aqueous or nonaqueous matrix is disclosed. More particularly, the invention relates to preventing the formation of a crystalline structure in such liquid disper |
| 7163688 |
Osmotic implant with membrane and membrane retention means |
January 16, 2007 |
| An osmotic delivery system for controlled delivery of a beneficial agent includes an implantable capsule containing a beneficial agent and an osmotic engine that swells on contact with water, thereby causing the release of the beneficial agent over time. The osmotic delivery system h |
| 7160554 |
Enhanced circulation effector composition and method |
January 9, 2007 |
| A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one |
| 7156257 |
Compressed gas cylinder |
January 2, 2007 |
| The present invention provides a compressed gas cylinder that is capable of storing a compressed fluid at high pressures. The cylinder of the present invention includes a body terminating in an inwardly domed cap. The dome included in the cap of the compressed gas cylinder of the pre |
| 7150882 |
Enhanced circulation effector composition and method |
December 19, 2006 |
| A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one |
| 7147867 |
Dosage form comprising liquid formulation |
December 12, 2006 |
| A dosage form is disclosed comprising a drug formulation that self-emulsifies in the drug formulation. |
| 7136698 |
Electrotransport agent delivery apparatus |
November 14, 2006 |
| An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein the length of the applied current pulses is at least 5 msec and preferably |
| 7131960 |
Apparatus and method for piercing skin with microprotrusions |
November 7, 2006 |
| A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicat |
| 7122202 |
Therapeutic liposome composition and method of preparation |
October 17, 2006 |
| Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, |
| 7112337 |
Liposome composition for delivery of nucleic acid |
September 26, 2006 |
| A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a h |
| 7112335 |
Minimally compliant, volume-efficient piston for osmotic drug delivery systems |
September 26, 2006 |
| An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable |
| 7108863 |
Liposome composition for improved intracellular delivery of a therapeutic agent |
September 19, 2006 |
| A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also inclu |
| 7097634 |
Injection device providing automatic needle retraction |
August 29, 2006 |
| The present invention includes an automatic injection device that reliably provides automatic needle retraction even when manufactured with part and assembly tolerances typical of low-cost and high-volume manufacturing processes. The injector of the present invention includes a body, a |
| 7097631 |
Self-actuating applicator for microprojection array |
August 29, 2006 |
| An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicator to be used by patie |
