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A&G Pharmaceutical, Inc. Patents
Assignee:
A&G Pharmaceutical, Inc.
Address:
Columbia, MD
No. of patents:
15
Patents:












Patent Number Title Of Patent Date Issued
8088373 Autocrine growth factor receptor antibodies and methods January 3, 2012
Disclosed herein are antitumor compositions and methods of interfering with the biological activity of PC cell derived growth factor (PCDGF), anti-PCDGF receptor antibodies, fragments thereof, and methods of making anti-PCDGF receptor antibodies. The methods involve inhibiting the pr
8007997 Methods and compositions for inhibiting the growth of hematopoietic malignant cells August 30, 2011
Disclosed herein are compositions and methods for reducing the growth of hematopoietic malignant cells (e.g., B-cell leukemia cells). The methods involve reducing the growth of hematopoietic malignant cells by contacting hematopoietic malignant cells with GP88 antagonists. GP88 is an
7815906 Compositions and methods for restoring sensitivity to treatment with HER2 antagonists October 19, 2010
Methods and compositions for restoring growth inhibition sensitivity to a tumor cell resistant to growth inhibition by HER2 antagonists. The methods involve administering a PCDGF antagonist to the cell in an amount effective to stimulate or restore growth inhibition sensitivity to HER2
7674460 Compositions and methods for restoring sensitivity to treatment with HER2 antagonists March 9, 2010
Methods and compositions for restoring growth inhibition sensitivity to a tumor cell resistant to growth inhibition by HER2 antagonists. The methods involve administering a PCDGF antagonist to the cell in an amount effective to stimulate or restore growth inhibition sensitivity to HER2
7651854 Methods for increasing the proliferation of B cells January 26, 2010
Disclosed herein are methods of increasing the proliferation of non-tumorigenic B cells. The methods involve administering PCDGF and optionally other B cells stimulators (e.g., IgM, LPS) to B cells resulting in an increase in B cell proliferation. The methods of the invention can be
7592318 88kDa tumorigenic growth factor and antagonists September 22, 2009
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88 KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expressi
7560095 Cancer specific monoclonal antibodies July 14, 2009
Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of normal human tissues. The corresponding cancer-specific antigen or antigens with an app
7411045 Autocrine growth factor receptor antibodies and methods August 12, 2008
Disclosed herein are antitumor compositions and methods of interfering with the biological activity of PC cell derived growth factor (PCDGF), anti-PCDGF receptor antibodies, fragments thereof, and methods of making anti-PCDGF receptor antibodies. The methods involve inhibiting the pr
7368428 Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and induc May 6, 2008
Methods and compositions for restoring sensitivity to the antitumorigenic effects of antiestrogen therapy and/or cytotoxic therapy and inducing cell apoptosis are provided. Contacting tumor cells to GP88 antagonists (e.g., anti-GP88 antibodies, anti-GP88 antisense nucleic acids, GP88
7183384 Monoclonal antibody 7H11 reactive with human cancer February 27, 2007
Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of normal human tissues. The corresponding cancer-specific antigen with an apparent molecu
7091047 Methods and kits for diagnosing tumorigenicity August 15, 2006
Methods and kits for diagnosing tumorigenicity by measuring the concentration of GP88 in blood, plasma, serum, saliva, urine and other biological fluids. The methods and kits detect GP88 in biological fluids at a concentration as low as about 0.1 to 10 nanograms per milliliter and ar
6881548 Methods and kits for diagnosing tumorigenicity and determining resistance to the antineoplastic April 19, 2005
Methods and kits for diagnosing tumorigenicity and for determining whether a cancer patient is resistant to the pharmacological effects of antiestrogen therapy. Increased levels of the PCDGF (GP88) growth factor are indicative of tumorigenicity and resistance to the pharmacological e
6824775 88kDa tumorigenic growth factor and antagonists November 30, 2004
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expressing or action. Antagonists to an 88 KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expressi
6720159 88KDA tumorigenic growth factor and antagonists April 13, 2004
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88 KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expressi
6670183 88kDa tumorigenic growth factor and antagonists December 30, 2003
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88 KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expressi

 
 
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