| Patent Number |
Title Of Patent |
Date Issued |
| 5633386 |
Commercial process for the manufacture of fluconazole and intermediates useful in the manufactur |
May 27, 1997 |
| A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: ##STR1## |
| 5610292 |
Process for producing 2,2'-o-cyclonucleosides nucleosides, and analogs thereof |
March 11, 1997 |
| A novel process is provided for producing a nucleoside, such as cytarabine, or a nucleoside analogue, comprising the step of reacting 2,2'-O-cyclonucleoside or an analogue thereof with an amine. Preferably, the process is conducted in the presence of an aqueous solvent. A novel proce |
| 5596093 |
Process for preparing halogenated 2,3-O-cyclocytidine derivatives |
January 21, 1997 |
| A process from preparing 5-halogenated 2,3-O-cyclocytidine derivatives comprising reacting 2,3-O-cyclocytidine with a halogenating reagent, preferably N-bromosuccinimide, in the presence of an acid such as acetic or trifluoroacetic. |
| 5559229 |
Method for the manufacture of benzothiazepine |
September 24, 1996 |
| A process for the manufacture of Diltiazem or deacetyl-Diltiazem, which comprises the use of MIBK as solvent and NaOH as base. |
| 5536824 |
Organosulfonyl salts of 2,3'-O-cyclocytidine |
July 16, 1996 |
| Compounds of Formula IV: ##STR1## are described. In the compounds of Formula IV, R.sup.6 is selected from a trifluoromethyl group, a C.sub.1 -C.sub.6 alkyl group and a C.sub.6 -C.sub.9 aryl group, and R.sup.1 is selected from hydrogen, trityl, methoxytrityl, dimethoxytrityl, acet |
| 5527782 |
5-halo-2,3'-O-cyclocytidines |
June 18, 1996 |
| A 5'-halo-2,3'-O-cyclocytidine of Formula I: ##STR1## wherein: X is a bromide, chloride, or iodide;Y is halide, sulfate, acetate, tosyl, mesyl, benzoate, and phosphate;R.sup.1 is hydrogen; andR.sup.2 is a hydroxy protecting group.Pharmaceutical compositions containing the above compounds exh |
| 5523423 |
Form of form 1 Ranitidine |
June 4, 1996 |
| Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics, said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent having 3-4 carbon atoms, adding an |
| 5519129 |
Complex of guanidine and AZT |
May 21, 1996 |
| A composition of a 1:1 molar complex of guanidine and 3'-azido-3'-deoxythymidine (AZT) which is generated at about pH above 9 and disrupted by pH below about 9. This complex is a useful intermediate in the purification of AZT. |
| 5508423 |
Methods for the manufacture of fluconazole |
April 16, 1996 |
| A process for making Fluconazole comprising the steps of: ##STR1## |
| 5399682 |
Process for preparing 2,3'-O-cyclocytidine |
March 21, 1995 |
| A process for preparing 2,3'-O-cyclocytidine wherein 3'-deoxy-3'-organosulfonyl cytidine is refluxed in the absence of base. 2,3'-cyclocytidine is an intermediate in the preparation of 1-(B-D-xylo-pentofuranose) cytosine, an inhibitor of DNA synthesis. |
| 5387677 |
Recovery of AZT by guanidine precipitation |
February 7, 1995 |
| A process for recovering 3'-azido-3'-deoxythymidine (AZT) or a salt thereof from a mixture of chemicals involving the reaction of the AZT with guanidine to form a salt precipitate. The salt precipitate is then acidified to pH of less than about 9 to yield free AZT, which can then be |
| 5319141 |
Process of making nadolol |
June 7, 1994 |
| A process for making 5-(d-3-(tert-butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-1-cis-2,3 naphthalenediol of the formula ##STR1## by reacting ##STR2## in an essentially water free environment with (a) M'IO.sub.3 wherein M' represents a suitable ion for forming the salt |
