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AB Kabi Patents
Assignee:
AB Kabi
Address:
Stockholm, SE
No. of patents:
31
Patents:












Patent Number Title Of Patent Date Issued
RE30149 Preparation of antifibrinolytically active isomer of 4-aminomethylcyclohexane carboxylic acid November 13, 1979
Disclosed and claimed is the preparation of the 4-aminomethyl-cyclohexane carboxylic acid isomer assaying at least about 90% antifibrinolytically active material from specific para-disubstituted cyclohexane starting material. For example, in 4-aminomethyl-cyclohexane methanol such as its
4276375 Determination of serine proteases June 30, 1981
Serine proteases in a substance such as blood are determined by contacting the substance with a novel chromogenic or fluorgenic substrate for serine proteinases and spectrophotometrically measuring the quantity of a chromophore or fluorescent compound released from the substrate by serin
4252715 Chromogenic enzyme substrates February 24, 1981
New chromogenic substrates suitable for serine proteases, specially suitable for diagnostic determination of factor Xa, which are represented by the following formula:or its salts, where R.sub.1 is selected from the group of hydrogen, alkanoyl having from 1 to 12 carbon atoms, cyclohexyl
4247454 Novel chromogenic thrombin substrates January 27, 1981
A chromogenic substrate having the formula ##STR1## and salts thereof wherein R.sub.1 is H or OH, R.sub.2 is a chromophoric group, and n is 1, 2 or 3.
4242329 Bradykinin-inhibiting tripeptide derivatives December 30, 1980
Tripeptide derivatives of the formulain whichX is selected from the group consisting of Pro and PheY is selected from the group consisting of O--R.sub.1 and NH--R.sub.2 in whichR.sub.1 is selected from the group consisting of straight, branched and cyclic alkyl group with 1-12 C atoms, andR.
4235772 Novel peptides having growth promoting activity November 25, 1980
Described are novel growth promoting peptides of the general formula:whereP is hydrogen, or Phe-Asn-Val-Asp-Lys-Lys-;Q is selected from -Gln-, or -Ser-Tyr-Tyr-Gln-Ser-Asn-, or -Tyr-Thr-Ala-Glu-; andR is selected from -Thr, -Lys-Pro-Gln-Val-Thr, or -Asp-Glu-Leu;and of the corresponding reduced li
4218476 Anti-thrombotic N-alkylthioakylamino benzenesulfonamides August 19, 1980
New compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 each independently represent an alkyl group containing 1 to 4 carbon atoms, or an alkoxy group containing 1 to 3 carbon atoms, or halogen, R.sup.3 represents hydrogen, halogen, an alkyl group containing 1
4218472 Geminally disubstituted indene derivatives August 19, 1980
New geminally disubstituted indenes are of general formula I ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a direct bond or an alkylene group --(CH.sub.2).sub.n --, in which n is an integer from 1 to 4, R.sup.3 is hydrogen, C.sub.1-3 -a
4214049 Assay of serine proteases using novel chromogenic enzyme substrates July 22, 1980
Method for the quantitative determination of serine proteases which includes contacting the substance for which the determination is desired with a diagnostically active chromogenic substrate with good stability and high specificity to serine proteases having the formula: H--D--A.sub.1
4207232 Specific chromogenic enzyme substrates June 10, 1980
Chromogenic or fluorogenic enzyme substrates for serine proteases containing the amino acid sequence Ile-A-Gly-Arg wherein A is Asp or Glu substituted in the carboxylic group by esterification or amidation, a method of preparation thereof, and use thereof.
4172093 Pharmacodynamically active indan derivatives October 23, 1979
The present invention relates to new pharmacodynamically active compounds of the general structure ##STR1## as well as the corresponding amine oxides, quarternary ammonium compounds and salts with physiologically acceptable acids. In formula I R.sup.1 signifies hydrogen, halogen
4169015 Novel chromogenic thrombin substrates September 25, 1979
Process for determining thrombin and thrombin-like enzymes employing a substrate having the formula: ##STR1## and salts thereof, wherein R.sub.1 is H or OH; R.sub.2 is a chromophoric group; the N-terminal amino acid is in the D configuration and n is 1, 2 or 3 provided along with
4168300 Method of removal of hepatitis virus September 18, 1979
Hepatitis virus is removed from a biological material contaminated with the virus by contact with a preparation. The preparation may be agarose gel or beaded polyacrylamide plastic coupled with a variety of hydrophobic ligands.
4168146 Immunoassay with test strip having antibodies bound thereto September 18, 1979
A test strip for carrying out immunoassays. The test strip is a bibulous carrier to which antibodies are bound. The immunoassay is carried out by wetting the test strip with the aqueous solution containing a suspected antigen. The test strip is then contacted with an aqueous solution
4162941 Method for determining a proteolytic enzyme July 31, 1979
The proteolytic enzyme designated as factor Xa is diagnostically determined by contacting the enzyme with a chromogenic substrate represented by the formulaor its salts, where R.sub.1 is hydrogen or alkanoyl having from 1 to 12 carbon atoms or cyclohexylcarbonyl or benzoyl or benzoyl sub
4138287 Purifying and isolating method for hepatitis virus to use in preparing vaccine February 6, 1979
Hepatitis B virus (detectable as its surface antigen HB.sub.s Ag) is produced in a purification preferably suitable for use in preparing a hepatitis vaccine, by contacting a crude biological starting material containing hepatitis B virus with a water-insoluble cross-linked sulfated p
4137225 Novel chromogenic enzyme substrates January 30, 1979
Diagnostically active chromogenic substrate with good stability and high specificity to serine proteases having the formula: H-D-A.sub.1 -A.sub.2 -A.sub.3 -NH-R or salts thereof, wherein A.sub.1 is Gly, Ala, Val, Leu, Ile, Pip, Pro, or Aze; A.sub.2 is Gly, Ala, Val, Leu, Ile, Pip, Pro, A
4123543 Derivatives of substituted indoline lactans with effect on the central nervous system October 31, 1978
New pharmacodynamically active nitrogen-containing heterocyclic compounds of the general formula ##STR1## as well as methods of preparing the same; and pharmacodynamical compositions containing the same, preferably for treating psychiatric and psychosomatic diseases.
4119774 Heparin purification method October 10, 1978
Crude clinically used heparin preparations having a low specific activity, for example, about 130 heparin units per milligram are purified by contacting such liquid crude heparin preparations with a gel matrix complexed with (i.e. having linked to it) antithrombin or inter-alpha-tryp
4117144 Derivatives of substituted isoindolines with effect on the central nervous system September 26, 1978
New pharmacodynamically active nitrogen-containing heterocyclic compounds of the general formula ##STR1## as well as methods of preparing the same; and pharmacodynamical compositions containing the same, preferably for treating psychiatric and psychosomatic diseases.
4089957 Therapeutic compositions against recurrent thrombosis May 16, 1978
Disclosed is (1) a method of resisting as well as suppressing recurrent venous thrombosis in a human susceptible to or having said thrombosis, which method comprises administering to said human a recurrent venous thrombosis-combatting effective dose of a pharmaceutical composition co
4072576 Method for studying enzymatic and other biochemical reactions February 7, 1978
Method for studying biochemical reactions in which a substance, whose activity or concentration is to be determined, affects a substrate specific for the biochemical reaction which includes providing electrodes coated with the substrate, determining as the control value, the capacita
4066408 Chromogen-reactive-indicator preparations containing A 3,3'-di(carbonyloxy- or sulfonyloxy-group January 3, 1978
An analytical test, color change reagent preparation comprising peroxidase, an oxygen-oxidoreductase specific to a particular substance to be tested and a chromogen-reactive-indicator formula selected from (a) those having the general formula ##STR1## wherein X is the divalent ca
4061625 Novel chromogenic thrombin substrates December 6, 1977
Substrate with high specificity to thrombin and thrombin-like enzymes having the formula: ##STR1## and salts thereof, wherein R.sub.1 is H or OH; R.sub.2 is nitrophenyl; and n is 1, 2 or 3 provided along with the method of use.
4058512 Synthetic peptides having growth promoting activity November 15, 1977
Novel synthetic peptides of the general formula ##STR1## and the corresponding reduced, linear form. The cyclic form of the peptide is produced by oxidation of the corresponding linear compound thereby providing the divalent dithio group --S--S-- joining the beta carbon of each o
4054557 Growth promoting polypeptides and preparation method October 18, 1977
The application discloses (A) a growth-promoting polypeptide having molecular weight from about 5,000 to about 7,000 chromatographic mobility under electrophoresis from about 0.25 to about 0.37 relative to lysine at pH 5 and from about 0.17 to about 0.43 relative to aspartic acid at pH
4028318 Chromogenic enzyme substrates June 7, 1977
Chromogenic substrates for serine proteases, represented by the formula:or its salts, where R.sub.1 is hydrogen or alkanoyl having from 1 to 12 carbon atoms or cyclohexylcarbonyl or benzoyl or benzoyl substituted with one or two halogen atoms, methylamine or phenyl groups or benzene sulp
4022758 Isolation of coagulation factors I and VIII from biological material May 10, 1977
The blood coagulation factors I (fibrinogen) and VIII (antihemophilia factor, abbreviated AHF) are isolated in high yields from animal tissue materials such as blood or blood products (e.g. plasma) or plasma fractions by a procedure involving the essential step of adsorption (as in a
4008267 3,3'-Di(sulfonyloxy-group-containing)substituted benzidine derivatives February 15, 1977
Disclosed are benzidine derivatives substituted in each of the 3,3'-positions by the substituent ##STR1## wherein W is hydrogen or an alkali metal, the subscript n is zero when A is the divalent branched chain alkylene having from 2 to about 7 carbon atoms, and n is one when A is
3953290 Polypeptides as vitro active cell growth enhancing factors and methods of use April 27, 1976
Disclosed are in vitro active cell growth factors that stimulate deoxyribonucleic acid synthesis in the cells, are polypeptide in chemical structure, having a molecular weight range of from 4,000 to 6,000 and an isoelectric range of from pH 4.3 to 5.3, are inert to about 72% aqueous
3947451 Derivatives of substituted isoquinoline 1,3-diones March 30, 1976
New pharmacodynamically active nitrogen containing heterocyclic compounds of the general formula ##SPC1##As well as methods of preparing the same; andPharmacodynamical compositions containing the same, preferrably for treating psychiatric and psychosomatic diseases.

 
 
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